Single-Cell Sequencing Combined with Transcriptome Sequencing to Explore the Molecular Mechanisms Related to Skin Photoaging by Hu X, Du S, Chen M, Yang H, He J, Zhang L, Tan B, Wu T, Duan X

“…However, the specific mechanism of skin photoaging is not yet completely elucidated.Methods: Gene expression profiles for photoaging patients were obtained from the Gene Expression Omnibus (GEO) collection. …”
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Multi-Omics Analysis Identifies Immune Regulatory Networks in Sepsis-Associated Liver Injury: Experimental Validation and Clinical Relevance by Hong Y, Chen Q, Xie H, Ma M, Gan S, Zhang Y, Xu Z

“…This study aimed to identify key immune-related genes (IRGs) driving T cell-mediated responses in SILI and evaluate their diagnostic potential.Methods: Cecal ligation and puncture (CLP) was performed to establish a murine sepsis model (n=7/group), with sham-operated controls. …”
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Uric Acid Metabolism and Its Relationship with Glucose and Lipid Metabolism in Overweight and Obese Children and Adolescents: A Cross-Sectional Study in South China by Tang B, Li Y, Lin J, Zhu Y, Chen D, Mou Y, Zhu S

“…This study aims to analyze the characteristics of serum uric acid (SUA) metabolism in overweight and obese children and adolescents in South China, exploring its associations with metabolic parameters.Methods: A single-center retrospective study was conducted, involving children and adolescents aged 3 to 18 years diagnosed with overweight and obesity. …”
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A Novel Inflammation-Marker-Based Prognostic Model for Advanced Pulmonary Lymphoepithelioma-Like Carcinoma by Chen X, Liu T, Mo S, Yang Y, Chen X, Hong S, Zhou T, Chen G, Zhang Y, Ma Y, Ma Y, Zhang L, Zhao Y

“…Xueyuan Chen,1,* Tingting Liu,1,* Silang Mo,1,* Yuwen Yang,1 Xiang Chen,1 Shaodong Hong,1 Ting Zhou,1 Gang Chen,1 Yaxiong Zhang,1 Yuxiang Ma,2 Yuanzheng Ma,1 Li Zhang,1 Yuanyuan Zhao1 1Medical Oncology Department, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-Sen University Cancer Center, Guangzhou, 510060, People’s Republic of China; 2Department of Clinical Research, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, 510060, People’s Republic of China*These authors contributed equally to this workCorrespondence: Li Zhang; Yuanyuan Zhao, Sun Yat-sen University Cancer Center, 651 Dong Feng Road East, Guangzhou, 510060, People’s Republic of China, Email zhangli@sysucc.org.cn; zhaoyy@sysucc.org.cnPurpose: This study aimed to investigate the prognostic value of inflammation markers for advanced pulmonary lymphoepithelioma-like carcinoma (PLELC) and develop an effective prognostic model based on inflammation markers to predict the overall survival (OS) of this population.Methods: Cox regression analysis was performed on 18 clinical and inflammation features, and a nomogram was created to predict overall survival (OS). …”
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Left atrial strain in assessing heart failure with preserved ejection fraction in hypertensive patients by E. S. Mazur, V. V. Mazur, N. D. Bazhenov, O. V. Nilova, T. O. Nikolaeva

“…To compare the results of diagnosing heart failure with preserved ejection fraction (HFpEF) in patients with hypertension (HTN) according left atrial (LA) strain values with the results obtained using the H2FPEF score and diastolic stress testing (DST).Material and methods. The study included 293 patients with previously established HTN who were examined due to complaints of shortness of breath and/or palpitations (men, 97 (33,5%), mean age, 62,0 (55,0; 67,0) years). …”
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Longitudinal Changes in Peripheral and Alveolar Monocyte and Inflammatory Biomarkers are Distinct in Hypercapnia Patients Following Pulmonary Sepsis-Induced ARDS by Zhao J, Ji Y, Li B, Yang K, Sun Q, Ma T, Xie K

“…Our study was designed to compare initial values and longitudinal changes in cellular composition and inflammatory biomarkers between pneumonia sepsis-induced ARDS patients without hypercapnia and hypercapnia patients.Methods: Between Dec 2022-Apr 2023, we prospectively studied 61 severe pneumonia patients. …”
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Exploring the Mechanisms of Lijin Fang on Treg/Th17 Cell Imbalance in COPD Based on Network Pharmacology by Li ZH, Chen SN, Pan L, Liu R, Liang W, Luo MQ, Liao HF, Feng J, Wang HZ, Huang YG, Zheng JH

“…This study explores the therapeutic potential of the traditional Chinese medicine(TCM) formula, Lijin Fang (LJF), focusing on its ability to restore Treg/Th17 balance.Methods: We employed bioinformatics and in vitro cell experiments to analyze the active components and targets of LJF. …”
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Development and validation of the health belief model scale for early childhood caries prevention behaviors of parents by Ketian Wang, Gillian Hiu Man Lee, Pei Liu, Hey Ching Wong, Xiaoli Gao, Samuel Yeung Shan Wong, May Chun Mei Wong

“…Specifically, the scale targeted parents with young children. Methods The initial item pool was set up by adapting existing HBM scales to assess parents’ health beliefs regarding their children’s ECC under six HBM domains and then underwent face and content validation. …”
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Deep learning-assisted analysis of biomarker changes after increase of dosing from aflibercept 2 mg to 8 mg in therapy-resistant neovascular age-related macular degeneration by Siegfried Priglinger, Jakob Siedlecki, Benedikt Schworm, Franziska Eckardt, Michael Hafner, Ben Asani, Caspar Liesenhoff, Alexander Kufner, Johannes Benedikt Schiefelbein

“…Unfortunately, not all patients respond equally well to the drugs, and some show recurrences during treatment. …”
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Association Between Systemic Immune-Inflammatory Indices and Severity of Coronary Artery Lesions in Patients With Coronary Artery Disease in Different Glucose Metabolic States by Jin X, Liu Y, Jia W, Xu R, Guan X, Cui M, Zhang H, Wu H, Wei L, Qi X

“…However, the relationship between SII and the severity of coronary artery lesions in participants with coronary artery disease (CAD) in different glucose metabolic states has not been fully elucidated.Methods: A total of 2727 patients with CAD were enrolled between January 2018 and April 2022. …”
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Predictive Value of Albumin to Fibrinogen Ratio and CALLY Index for Diagnosis of Ulcerative Colitis and Mucosal Healing After Vedolizumab Treatment by Su K, Xiao S, Wang M, Wang K, Fan Q, Sha S, Cheng Y, Liu X, Shi H

“…The aim of this study was to evaluate the clinical significance of AFR and CALLY index in UC.Methods: The study included 109 UC patients and 126 healthy controls. …”
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Associations Between Psychological Stress and the Risk of First Onset of Major Depression Disorder: Results from a Longitudinal Study in 6,985 Chinese First-Year Students by Wang F, Rong L, Luo L, Mu F, Qian L, Qian Y, Zhang X, Lang Y, Wang W, Liu Y, Zhang Y, Wang J

“…This study aimed to estimate the effect of psychological stress on the risk of first onset MDD in a sample of Chinese freshmen.Methods: Using a longitudinal design, 8079 Chinese first-year students were recruited at baseline, and 6985 were followed up one year later. …”
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Functional Liver Imaging Score to Predict Clinically Significant PHLF for Hepatocellular Carcinoma After Resection by Zheng X, Zhang Y, Huang H, Luo N

“…Xihua Zheng,* Yumin Zhang,* Huiying Huang, Ningbin Luo Departments of Radiology, Guangxi Medical University Cancer Hospital, Nanning, Guangxi Zhuang Autonomous Region, People’s Republic of China*These authors contributed equally to this workCorrespondence: Ningbin Luo, Departments of Radiology, Guangxi Medical University Cancer Hospital, Nanning, Guangxi Zhuang Autonomous Region, People’s Republic of China, Fax +860734-5312000, Email luoningbin2012@hotmail.comPurpose: To develop a model based on Functional Liver Imaging Score (FLIS) to estimate the risk of clinically significant post-hepatectomy liver failure (PHLF) for hepatocellular carcinoma (HCC) after resection.Patients and Methods: This retrospective study analyzed 885 patients with HCC who undergoing liver resection at our medical center between January 2017 and December 2021. …”
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Association of Metabolic Score for Visceral Fat (METS-VF) with Gout Risk in Patients with Hypertension and Hyperuricemia: A Multicenter Study Based on the Chinese Population by Ji L, Jiang W, Huang J, Xu Y, Zhou L, Zhao Z, Jiang C

“…Visceral adipose tissue (VAT) plays a crucial role in cardiometabolic diseases, and the metabolic score for visceral fat (METS-VF) is a non-invasive tool for estimating VAT and predicting cardiometabolic risk.Methods: We conducted a multicenter cross-sectional study involving 8877 patients with hypertension and hyperuricemia from three Chinese medical centers between March 2021 and September 2024. …”
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Associations Between Postoperative Symptom Clusters and Functional Status in Lung Cancer Patients: A Cross-Sectional Study by Liu Y, Lin S, Bai M, Yi H

“…Yali Liu,1,* Siya Lin,2,* Meirong Bai,1 Huochun Yi3 1Department of Thoracic Surgery, Zhongshan Hospital Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian, 361004, People’s Republic of China; 2School of Nursing, Fujian Medical University, Fuzhou, Fujian, 350122, People’s Republic of China; 3Center of Clinical Laboratory, Zhongshan Hospital Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian, 361004, People’s Republic of China*These authors contributed equally to this workCorrespondence: Meirong Bai, Department of Thoracic Surgery, Zhongshan Hospital Xiamen University, School of Medicine, Xiamen University, 201 hubin South Road, Siming District, Xiamen, Fujian, 361004, People’s Republic of China, Email 157576198@qq.com Huochun Yi, Center of Clinical Laboratory, Zhongshan Hospital Xiamen University, School of Medicine, Xiamen University, 201 hubin South Road, Siming District, Xiamen, Fujian, 361004, People’s Republic of China, Email yhc1818@163.comBackground: Symptom clusters in cancer symptom management research, providing a scientific basis for developing effective strategies for symptom assessment and intervention aimed at improving patient quality of life and survival.Objective: To analyze symptom clusters in postoperative lung cancer patients, examine its influenced factor, and explore the relationship between postoperative symptom clusters and functional status in lung cancer patients.Methods: Between August 2023 and February 2024, 441 lung cancer patients who underwent surgical treatment in the Department of Thoracic Surgery at a tertiary hospital in Xiamen were selected. …”
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Construire des ressources relationnelles pour franchir des frontières multiples : Trajectoires de jeunes Tunisiens by Hasnia-Sonia Missaoui

“…This information was then analysed using methods relating to the analysis of social relations, in particular the so-called “name generator” protocol. …”
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Bioinformatics and Network Pharmacology Identify the Therapeutic Role of Guominkang in Allergic Asthma by Inhibiting PI3K/Akt Signaling by Zhang H, Zhang H, Wang L, Zhang Y, Hu L, Liu J, Zhou Y, Wang J

“…The aim of this study was to explored the mechanism of action through which GMK combats AA.Methods: Potential target genes for the compounds were identified from the database and subjected to functional enrichment analysis. …”
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Treatment of Psoriasis with II-17 Inhibitors: Comparison of Long-Term Effectiveness and Drug Survival of Secukinumab vs Ixekizumab in Real-World Practice by Lam J, Cazzaniga S, Seyed Jafari SM, Maul JT, Feldmeyer L, Bossart S, Yawalkar N, Heidemeyer K

“…The study aimed to compare the characteristics of patients treated with secukinumab or ixekizumab and in addition to analyze associated factors and independent predictors of drug survival in a real-world setting.Methods: This study was designed as a single-center retrospective study. …”
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A Nomogram Based on Tumor Response to Induction Chemotherapy and Plasma Epstein–Barr Virus DNA Level after Induction Chemotherapy to Explore Individualized Treatment of... by Liu F, Ma C, Chen M, Chen K, Zhu L, Li L, Zhu X, Qu S, Yan C

“…A nomogram was subsequently constructed to explore the individualized optimal cumulative cisplatin dose (CCD) in concurrent chemoradiotherapy (CCRT).Methods: A total of 581 LA-NPC patients were included, randomly divided into training and validation cohorts in a 7:3 ratio. …”
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Effect of Vitamin D Level on Female Vaginitis in Xi’an, China by Guan J, Dong Y, Zhang W, Gui Q, Luo D, Wen H, Dang X, Liang D, Hu S, Zhang Y, Liao G, Zhang L, Lu Z

“…Therefore, this study focused on the therapeutic effects of vitamin D on vaginitis.Methods: The study provided a statistical description of 5978 vaginitis patients who visited Shaanxi Provincial People’s Hospital, presenting data in absolute numbers (%) and mean ± standard deviation (median quartiles were used for non-normally distributed variables). …”
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