Multidose Dalbavancin Population Pharmacokinetic Analysis for Prolonged Target Attainment in Patients Requiring Long-Term Treatment by Giammarco Baiardi, Michela Cameran Caviglia, Silvia Boni, Antonello Di Paolo, Valeria Marini, Giuliana Cangemi, Alessia Cafaro, Emanuele Pontali, Francesca Mattioli

“…<b>Methods:</b> Pharmacokinetic analysis was based on a nonlinear mixed effects modelling approach performed in NONMEM v7.5/Pirana, while R was used for data management and graphical summaries. …”
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The effect of oral probiotics on CD4 count in patients with HIV infection undergoing treatment with ART who have had an immunological failure by Masoud Mortezazadeh, Saeed Kalantari, Nooshin Abolghasemi, Mitra Ranjbar, Saeedeh Ebrahimi, Abbas Mofidi, Babak Pezeshkpour, Ensieh Sadat Mansouri, Seyed Zia Tabatabaei, Mehdi Kashani

“…Probiotics play an important role in stimulating natural killer T cells, strengthening the functional gut barrier, and reducing systemic inflammation. Methods This study was a randomized double‐blind clinical trial involving 30 patients treated with antiretroviral therapy who had experienced immunological failure despite HIV viral suppression. …”
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HOMESIDE: home-based family caregiver-delivered music and reading interventions for people living with dementia: protocol of a randomised controlled trial by Sabine Braat, Felicity Anne Baker, Imogen Clark, Young-Eun Claire Lee, Thomas Wosch, Helen Odell-Miller, Nicola Lautenschlager, Jodie Bloska, Anna Bukowska, Ming H Hsu, Tone Kvamme, Agnieszka Smrokowska-Reichmann, Karette A Stensaeth

“…Our project aims to address the need for improved informal care by training cohabiting family CGs to implement music interventions that target BPSD, and the quality of life (QoL) and well-being of people with dementia (PwD) and CGs.Methods and analysis A large international three-arm parallel-group randomised controlled trial will recruit a sample of 495 dyads from Australia, Germany, UK, Poland and Norway. …”
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Universal Bacterium-Vectored COVID-19 Vaccine Expressing Early SARS-CoV-2 Conserved Proteins Cross-Protects Against Late Variants in Hamsters by Qingmei Jia, Helle Bielefeldt-Ohmann, Saša Masleša-Galić, Richard A. Bowen, Marcus A. Horwitz

“…In this study, we evaluate the efficacy of rLVS Δ<i>capB</i>/MN and an enhanced version, rLVS Δ<i>capB</i>::RdRp/MN, which additionally expresses the conserved RNA-dependent RNA polymerase (RdRp) protein from the same strain, in a hamster model. <b>Methods:</b> Both vaccine candidates were administered orally or intranasally to golden Syrian hamsters (equal numbers of males and females) and evaluated against intranasal challenge with SARS-CoV-2 Delta (B.1.617.2-AY.1) and Omicron (BA.5) variants. …”
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Invasive minimal Microvascular Resistance Is a New Index to Assess Microcirculatory Function Independent of Obstructive Coronary Artery Disease by Guus A. de Waard, Sukhjinder S. Nijjer, Martijn A. van Lavieren, Nina W. van der Hoeven, Ricardo Petraco, Tim P. van de Hoef, Mauro Echavarría‐Pinto, Sayan Sen, Peter M. van de Ven, Paul Knaapen, Javier Escaned, Jan J. Piek, Justin E. Davies, Niels van Royen

“…In this study we propose minimal microvascular resistance (mMR) as a new measure of microcirculatory dysfunction and aim to determine whether mMR is influenced by CAD. Methods and Results We obtained 482 simultaneous measurements of intracoronary Doppler flow velocity and pressure. …”
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6-Gingerol, an active compound of ginger, attenuates NASH-HCC progression by reprogramming tumor-associated macrophage via the NOX2/Src/MAPK signaling pathway by Qiurui Li, Meng Wang, Xuekuan Huang, Shang Wang, Chunli Li, Pan Li, Wei Xiang, Ling Yao, Chengdan Deng, Mingming Zhang, Jianwei Wang

“…The therapeutic effects and underlying mechanisms of NASH-HCC, however, remain poorly understood. Methods Network pharmacology, bioinformatics, single-cell RNA sequencing analysis, and molecular docking were used to identify the main active compounds, targets, and possible mechanisms of ginger in treating NASH-HCC. …”
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Q-Ball high-resolution fiber tractography: Optimizing corticospinal tract delineation near gliomas and its role in the prediction of postoperative motor deficits– A proof of concep... by Pavlina Lenga, Moritz Scherer, Robin Peretzke, Peter Neher, Jessica Jesser, Andreas W. Unterberg, Sandro Krieg, Daniela Becker

“…Research question: This study compares the results of conventional DTI-FT and q-ball (QBI)-high resolution FT with patient's postoperative morbidity, relating postoperative MD with the nearest distance from the lesion to the CST (nD-LCST). Materials and methods: In this ongoing prospective trial, we utilized probabilistic High-Resolution Fiber Tracking (HRFT) through q-ball imaging (QBI-FT) and conventional Diffusion Tensor Imaging Fiber Tracking (DTI-FT), based on equal and standard diffusion-weighted MRI. …”
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Features of Celiac Disease in children and adolescents with Down syndrome: a single-center experience of annual screening by Martina Lattuada, Paola Rebora, Paola Rebora, Chiara Fossati, Alessandra Lazzerotti, Lucia Paolini, Alessandro Cattoni, Alessandro Cattoni, Roberto Panceri, Maria Grazia Valsecchi, Maria Grazia Valsecchi, Andrea Biondi, Andrea Biondi, Giovanna Zuin

“…A secondary aim was to analyze the time needed for the normalization of anti-transglutaminase IgA (TGA-IgA) and anti-endomysium IgA (EMA-IgA) levels in DS compared to non-syndromic (NS) children.Materials and methodsThis retrospective monocentric cohort study included patients with DS under 18 years of age, diagnosed with CD between 2005 and 2022. …”
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Retrospective cohort of prenatal home ultrasound utilization and maternal-neonatal outcomes by Anat Pardo, Erkan Kalafat, Shira Hazon, Monica Pailis, Emilie Klochendler-Frishman, Or Lee Rak, Ofri Samueloff, Rachel Gomez-Tolub, Anat Shmueli, Noam Pardo, Tomer Sela, Leor Wolff, Asnat Walfisch, Arnon Wiznitzer, Eran Hadar

“…This service provides a handheld, app-connected ultrasound device for remote basic fetal monitoring, with its use determined at the discretion of the patient as a supplement - rather than a replacement - to standard prenatal care. Methods Retrospective analysis comparing maternal and neonatal outcomes among users versus non-users of the home ultrasound service, between January 2020 and December 2022. …”
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Investigating the prevalence of three medically important pathogens in Ixodes pacificus from southern Oregon by Andrew T. Partin, Emilio E. DeBess, Phillip Q. Spinks, Michael J. Yabsley, Michael J. Yabsley, Michael J. Yabsley, Kayla B. Garrett, Kayla B. Garrett, Kayla B. Garrett, James R. Clover, Geoffrey R. Taylor

“…Ixodes pacificus is common in southern Oregon yet there are few published studies on the distribution of tick-borne pathogens in this region. MethodsUsing real-time quantitative PCR, we assessed the prevalence of B. burgdorferi s.l., B. miyamotoi, and A. phagocytophilum among 2,463 unfed I. pacificus adults and nymphs combined into 260 pools (131 nymph, 129 adult) with nearly equal numbers of each life stage from 12 locations in Jackson County, Oregon. …”
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Adverse Drug Reactions to SGLT2i Reported by Type 2 Diabetes New Users: An Active Surveillance Study by Camelia Bucșa, Ioana Frenț, Ramona Stefan, Adriana Fodor, Georgeta Inceu, Andreea Farcaș, Adriana Rusu, Monica Negovan, Cristina Mogoșan

“…We aimed to prospectively follow-up on type 2 diabetes (T2D) patients who were new users of sodium-glucose co-transporter 2 inhibitors (SGLT2i) and to characterize the patient-reported ADRs within routine practice in Romania. <b>Methods</b>: T2D patients from ambulatory settings were interviewed over the phone based on standardized forms, at four time-points across 12 months. …”
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Acupuncture improves the symptoms, serum ghrelin, and autonomic nervous system of patients with postprandial distress syndrome: a randomized controlled trial by Zi-tong Fu, Cun-zhi Liu, Mi-Rim Kim, Yi-duo Liu, Yu Wang, Yi-Ming Fu, Jing-Wen Yang, Na-Na Yang

“…Objective This study aims to investigate the effects of acupuncture on symptoms, serum hormones, and ANS in PDS patients. Methods This randomized controlled clinical trial was conducted at Beijing Hospital of Traditional Chinese Medicine affiliated with Capital Medical University. …”
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OUR EXPERIENCE OF HYPERTHERMIC INTRAPERITONEAL CHEMOTHERAPY FOR PATIENTS WITH ADVANCED GASTRIC CANCER by A. D. Kaprin, V. M. Khomyakov, D. D. Sobolev, L. V. Bolotina, A. B. Ryabov, V. E. Khoronenko, M. M. Soboleva, L. V. Kramskaya

“…Improvement of the results of treatment of patients with locally advanced and metastatic gastric cancer. Material and methods. From the 2010–2014 we performed 30 surgeries using techniques HICT. …”
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Role of laparoscopic surgery in blunt abdominal trauma; retrospective analysis in a tertiary trauma center by Rifan Alyami, Ahad E. Alotaibi, Leen Almohayya, Ajyad Al Jawad, Raghad Almukhayzim, Abeer Alhoumedan, Rakan S. Aldusari

“…This study aims to reduce unnecessary laparotomies and assess the effectiveness of laparoscopy in managing patients with blunt abdominal trauma. Methods The study is a descriptive retrospective study using the medical records of patients with blunt abdominal trauma who were managed with laparoscopy in the Department of General Surgery, King Abdulaziz Medical City in Riyadh. …”
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Identifying risk factors for loss to follow-up in adults living with HIV in a high-burden district in Ghana by Benedicta Ayiedu Mensah, Henrietta E. Mensah-Brown, Frederica D. Partey, Christabel Addo, Gertrude Buah, Gifty A. Afudego, Daniel Okyere, Mary Tetteh, Ernest Boateng, Michael Wilson, Elijah Paintsil

“…Thus, this study aimed to explore the risk factors influencing LTFU among PLWHIV in a high-burden district in Ghana. Methods A retrospective analysis was conducted using medical records of 401 patients who initiated Antiretroviral Therapy (ART) between January 1st, 2011, and December 31st, 2021, in a high-burden district in Ghana and data extraction period of January to December 2022. …”
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Distinct features of three clinical subtypes in 533 patients with primary hypertrophic osteoarthropathy by Xilei Cai, Xiujuan Yang, Pengyue Zhang, Ziyue Dou, Zilian Chen, Chongzhi Zhu, Weiwei Xu, Xinchen Wang, Xiaodan Hong, Zhenhua Zhang

“…This study aimed to determine the distribution of the three clinical subtypes of PHO and compare their clinical characteristics using a large global sample. Methods A systematic literature search was conducted in multiple databases to categorize cases into complete form (CO), incomplete form (IN), and fruste form (FR). …”
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Prescription dose and optimisation strategies in MR-guided online adaptive radiotherapy for kidney tumours: a two-step planning analysis by Takaya Yamamoto, Noriyoshi Takahashi, Shohei Tanaka, Rei Umezawa, Yu Suzuki, Keita Kishida, So Omata, Kazuya Takeda, Hinako Harada, Kiyokazu Sato, Noriyuki Kadoya, Keiichi Jingu

“…However, the ideal strategy for prescription dose selection and reoptimisation remains unclear. Methods This single-centre planning study evaluated kidney tumours located within 1 cm of gastrointestinal OARs. …”
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Vaccine-induced T cell responses correlate with reduced risk of severe COVID-19 in a placebo-controlled efficacy trialResearch in context by Nina Hertoghs, Sanne Roels, Matthias Brückner, Jerald Sadoff, Barbara L. Banbury, Nicholas K. Akers, Bryan Howie, Harlan S. Robins, Griet A. van Roey, Jeroen T.B.M. Tolboom, Veronica V. Rezelj, Jenny Hendriks, Hanneke Schuitemaker, Daniel J. Stieh, Mathieu Le Gars

“…The purpose of this study is to investigate whether signatures of the T-cell response contribute to protection against (severe) COVID-19. Methods: T cell receptor (TCR) sequencing was conducted using pre-vaccination and 29 days post-vaccination PAXgene samples from 396 participants in the phase 3 efficacy trial, ENSEMBLE. …”
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Tacrolimus concentration/dose ratio as a therapeutic drug monitoring strategy: The influence of gender and comedication by Rančić Nemanja, Dragojević-Simić Viktorija, Vavić Neven, Kovačević Aleksandra, Šegrt Zoran, Drašković-Pavlović Biljana, Mikov Momir

“…Methods. This prospective case series study included 54 patients, in which the unit of monitoring was outpatient examination (1,872) of the renal transplant patients. …”
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Machine learning-based ultrasound radiomics for predicting risk of recurrence in breast cancer by Wei Fan, Hao Cui, Xiaoxue Liu, Xudong Zhang, Xinran Fang, Junjia Wang, Zihao Qin, Xiuhua Yang, Jiawei Tian, Lei Zhang

“…PurposeTo develop a radiomics model based on ultrasound images for predicting risk of recurrence in breast cancer patients.MethodsIn this retrospective study, 420 patients with pathologically confirmed breast cancer were included, randomly divided into training (70%) and test (30%) sets, with an independent external validation cohort of 90 patients. …”
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