Jiawei Erzhiwan Ameliorates Androgenetic Alopecia by Regulating the SIRT1/JNK/p38 MAPK Pathway by Huang Z, Li Y, Xie Y, Fu H, Weng Z, Yuan J, Wu L, Lin W, Cao Y, Ding B

“…However, the underlying mechanisms is still unknown.Patients and Methods: In this study, the phytochemical ingredients in WJWE were characterized via UPLC‒MS/MS analysis. …”
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Using Network Pharmacology and in vivo Experiments to Uncover the Mechanisms of Radix Paeoniae Rubra and Radix Angelicae Sinensis Granules in Treating Diabetes Mellitus-Induced Ere... by Wang J, Guo Y, Huang J, Yan J, Ma J

“…This study investigates the mechanisms and targets of Radix Paeoniae Rubra and Radix Angelicae Sinensis Granules (RAG) in treating DMED using network pharmacology and animal models.Methods: We identified RAG’s active ingredients and potential targets from the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform. …”
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Rbms3 Upregulation in Mesenchymal Stem Cells Impairs Fracture Healing in Type 2 Diabetes Mellitus by Liu C, Yu Y, Tian L, Liu Y, Zhang D, Yu A

“…Although some research has been conducted to address this, the specific mechanisms remain poorly understood and warrant further exploration.Methods: We downloaded transcriptomic and single-cell RNA sequencing (scRNA-seq) data, performed multiple analyses (differential expression, ssGSEA, co-expression, GO, KEGG, GSEA, and cell clustering identification), and utilized tools (GeneMINIA and Metascape) to investigate alterations in MSCs under diabetic condition. …”
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Impact of implant abutment materials on force damping response and marginal fit of implant supported restoration by Amr Mohammed Hussein Elmesery, Amany Mohammed Korsel, Waleed Elshahawy

“…The study offers novel insights into stress distribution and marginal gaps, aiming to optimize implant-supported restoration outcomes. Methods Forty implant abutments were divided into four equal groups: Shofu HC, Tessera, BioHPP, and Titanium. …”
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The association between the vitamin B1 intake and risk of non-melanoma skin cancer in U.S. adults: a cross-sectional study by Shiyi Huang, Lungang Shi, Yang Ma, Yuebin Zhu, Yingshi Liang, Haofeng Huang

“…Therefore, this study aims to explore the potential association between vitamin B1 consumption and the risk of developing NMSC.MethodsThe authors conducted a cross-sectional study utilizing data from six cycles of the National Health and Nutrition Examination Survey (NHANES) database spanning 2005 to 2016. …”
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Research on Equivalent Circuit Model of Flat Linear Induction Electromagnetic Pump Considering End Effect by BAI Yifan1, YAN Xin2, BI Keming2, YANG Chunwei1, DING Ming1

“…The developed analytical calculation methods and equivalent circuit model were tested against experimental data from FLIP found in a publicly available paper, indicating that the equivalent circuit model accurately predicts the FLIP’s performance parameters, with mean relative errors for head and efficiency around 5.38% and 7.91%, respectively. …”

Prevalence, Diagnosis, and Treatment of Generalized Anxiety Disorder in Working Individuals: A Cross-Sectional Study Using Health Claims and Survey Data in Japan by Matsuyama S, Otsubo T, Nomoto K, Misago R, Higa S

“…This study was, therefore, conducted targeting individuals with probable GAD, to estimate the prevalence of probable GAD as the primary outcome, and to assess medical consultation behavior, diagnosis, treatment, quality of life (QOL), severity of depression symptoms, and work productivity as secondary outcomes.Patients and Methods: This was conducted as a cross-sectional study focusing on individuals with probable GAD, using a database comprising medical claims data from May 2022 to November 2022, and linked survey data collected in November 2022, provided by DeSC Healthcare, Inc. …”
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When Technology Meets Anxiety:The Moderating Role of AI Usage in the Relationship Between Social Anxiety, Learning Adaptability, and Behavioral Problems Among Chinese Primary Schoo... by Ma G, Tian S, Song Y, Chen Y, Shi H, Li J

“…GuangYuan Ma,1,* ShiQin Tian,1,* Yang Song,1 Yi Chen,1 Hui Shi,1 JingChi Li2 1School of Humanities and Management Science, Southwest Medical University, Luzhou, 646000, People’s Republic of China; 2Department of Orthopedics, the Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University, Luzhou, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yang Song; Yi Chen, Email fookyuen666@163.com; chenyiswmu@163.comObjective: This study aims to examine the relationships between social anxiety, learning adaptability, AI technology usage, and behavioral problems among primary school students, with a focus on the mediating role of learning adaptability and the moderating role of AI usage.Methods: A cross-sectional survey was conducted among 1240 primary school students aged 8– 15 in Luzhou, Sichuan Province. …”
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Association of GWAS-Reported Variant of Matrix Metalloproteinase 12 Gene with Susceptibility to Ischemic Stroke in Southern Chinese Population by Chen L, Liao K, Zhang Y, Zheng S, He J, Tang H, Wu H, Zhong W, Li S, Li Y

“…This study aims to assess the genetic predisposition of the MMP12 rs660599 G > A variant with regard to IS risk and short-term outcomes in individuals from Southern China.Methods: The Multiplex SNaPshot assay was used to genotype rs660599 in 1035 IS patients and 1061 age-matched healthy controls. …”
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The Impact of Triglyceride-Glucose Index Trajectories on Incidence and Recurrent Cardiovascular Events: Evidence from a Retrospective Cohort Study by Xu Y, Wu G, Jiang L, Yang X, Wen C, Yang Y, Hu H

“…., Nanchang, People’s Republic of China; 5Department of Ophthalmology, The Second Affiliated Hospital of Nanchang University, Nanchang, People’s Republic of China; 6Department of Health Management Center, The Second Affiliated Hospital of Nanchang University, Nanchang, People’s Republic of China*These authors contributed equally to this workCorrespondence: Hui Hu, Department of Health Management Center, The Second Affiliated Hospital of Nanchang University, Nanchang, People’s Republic of China, Email huhuiefy@163.comPatients and Methods: The study retrospectively collected 8086 clinical data from 2019 to 2021. …”
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Association of Diaphragmatic Mobility and Thickening Fraction with Postoperative Pulmonary Complications in Patients Undergoing Thoracic Surgery and Their Application in Prediction by Aisiaiti A, Ajiaikebaier A, Maimaitiming A, Geng Q, He B, Sun J, Zhang B

“…Abudushalamu Aisiaiti,* Aiwuzaili Ajiaikebaier,* Aini Maimaitiming, Qiang Geng, Bichen He, Jinhui Sun, Bing Zhang Center for Anesthesia and Perioperative Medicine, Xinjiang Medical University Affiliated Tumor Hospital, Urumqi, 830011, People’s Republic of China*These authors contributed equally to this workCorrespondence: Bing Zhang, Center for Anesthesia and Perioperative Medicine, Xinjiang Medical University Affiliated Tumor Hospital, No. 789, Suzhou East Road, Urumqi, 830011, People’s Republic of China, Tel +86-9917819021, Email zb1325769256@163.comPurpose: To investigate the association of diaphragmatic mobility and thickening fraction with postoperative pulmonary complications (PPCs) in patients undergoing thoracic surgery and evaluate their values in predicting PPCs.Patients and Methods: One hundred and nine consecutive patients undergoing thoracic surgery were prospectively enrolled. …”
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A Five-Gene Signature for the Prediction of Event-Free Survival of Both Pediatric and Adult Acute Myeloid Leukemia by Dechang Chen, Alvin J. Liu, Li Sheng, Zhenqiu Liu, Irina Elcheva

“…EFS represents the time patients survive without disease recurrence, progression, or further treatment, a crucial metric for evaluating drug efficacy and assessing the clinical benefits of treatment. <b>Methods:</b> We performed an integrated analysis of adult TCGA and pediatric TARGET expression datasets to pinpoint genes and pathways associated with EFS in both adult and pediatric AML. …”
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Influence of platelet-rich plasma on RANKL and IL-1 immunohistochemical expression in periodontitis-related bone cell proliferation and differentiation by Hana H. Mustafa, Snur M.A. Hassan, Sozan Ali Mohammed, Mardin O. Mohammed, Hadia Karim Zorab, Hardi Fattah Marif

“…A rat model of experimentally generated periodontitis was used to assess the impact of PRP preparation on the expression of the osteoclastogenic and pro-inflammatory markers respectively; RANKL and IL-1β. Material and Methods: To induce periodontitis by silk ligature, thirty-six adult male Sprague Dawleys rats were used and they were allocated into three equal groups (n = 12): group I consisted of intact periodontal tissue, group II; rat-induced periodontitis without treatment by PRP, and group III of periodontitis + 10 µL PRP injection. …”
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Inhibitory Effects of Paclitaxel-Loaded Iron Oxide Nanoparticles on Non-Small Cell Lung Cancer by Enhancing Autophagy-Dependent Ferroptosis and Apoptosis Pathways by Deng R, Liang G, Chen W, Nie Q, Wen J

“…However, inhibitory effect and possible mechanism of IONP@ PTX on non-small-cell lung cancer (NSCLC) remain unclear.Objective: This work aimed to assess inhibitory effects and potential mechanisms of IONP@PTX on lung cancer A549 cells and further explore the nanomedicine delivery systems for applications in cancer therapies.Methods: Morphology features and qualities of IONP@PTX were directly assessed. …”
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Effectiveness and safety of direct oral anticoagulants versus vitamin K antagonists in atrial fibrillation patients with liver disease: a systematic review and meta-analysis by Qiang Zhou, Xiang Liu, Shuyu Liu, Zhichun Gu, Yanzi Wu, Yuansu Yang, Yingying Tao, Meng Wei

“…IntroductionPatients with atrial fibrillation (AF) and liver disease, particularly cirrhosis, are frequently excluded from anticoagulation trials, leaving the optimal therapeutic strategy uncertain.MethodsThis study aimed to compare the effectiveness and safety of direct oral anticoagulants (DOACs) and vitamin K antagonists (VKAs) in patients with AF and liver disease. …”
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Association of SCN1A Gene Polymorphisms with Sodium Valproate Resistance in Pediatric Epilepsy: A Retrospective Case-Control Study by Wang H, Geng T, Deng N

“…Elucidating the genetic mechanisms underlying sodium valproate resistance could revolutionize personalized treatment strategies, particularly in pediatric epilepsy.Objective: To explore the relationship between polymorphisms in the sodium channel α 1 subunit gene (SCN1A) and resistance to sodium valproate therapy in pediatric epilepsy patients.Methods: A retrospective analysis included 89 pediatric patients with sodium valproate-resistant epilepsy (resistant group) and 89 patients responsive to sodium valproate (responder group), and 89 healthy controls. …”
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Bibliometric and Visualized Analysis of Artemisinin and Its Derivatives in Cancer by Feng J, He Y, Bai T, You Q, Zhu H, Jia C, Liu B, Li S

“…Until now, there have been no systematic scientometrics studies to analyze the research trend of artemisinin and its derivatives in cancer.Aim of the Study: We conducted this bibliometric study with the aim of providing researchers in the field with an all-around summary of artemisinin and its derivatives in cancer, visualizing current research advances, identifying hotspots, and ultimately outlining cutting-edge trends for future development.Methods: A total of 927 relevant publications from 1990 to 2023 were accessed from the WOSCC database and analyzed bibliometrically utilizing software including CiteSpace VOSviewer and Microsoft Excel.Results: Global publications in artemisinin and tumor therapy have steadily increased. …”
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Association Between Four Non-Insulin-Based Insulin Resistance Indices and the Risk of Post-Stroke Depression by Wang P, Wang M, Xie Z, Zhi Z, Wang Y, Liu F, Liu Y, Zhao L

“…Therefore, we explored the relationship between four non-insulin-based IR indices and post-stroke depression (PSD).Patients and Methods: A total of 638 consecutive AIS patients were enrolled in this prospective cohort study. …”
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How does integrated knowledge translation work? A realist review by Anita Kothari, Shannon L. Sibbald, Chris McCutcheon, Whitney Berta, Robin Urquhart, Tanya Horsley, Leigha Comer, Ian D. Graham

“…We conducted a realist review to examine the key mechanisms thought to explain how IKT approaches work in relation to the generation of research in the healthcare sector. Methods The research question was the following: what are the necessary conditions (context) and key mechanisms that explain the success of IKT in the healthcare sector? …”
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Standard Triple Therapy versus Sequential Therapy in Helicobacter pylori Eradication: A Double-Blind, Randomized, and Controlled Trial by Jaime Natan Eisig, Tomás Navarro-Rodriguez, Ana Cristina Sá Teixeira, Fernando Marcuz Silva, Rejane Mattar, Decio Chinzon, Christiane Haro, Márcio Augusto Diniz, Joaquim Prado Moraes-Filho, Ronnie Fass, Ricardo Correa Barbuti

“…In Brazil, standard triple therapy is as equally effective as sequential therapy in eradicating Helicobacter pylori patients. …”
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