Utilization of drug checking services in Austria: a cross-sectional online survey by Alexandra Karden, Tobias Fragner, Cornelia Feichtinger, Julian Strizek, Daragh T. McDermott, Igor Grabovac

“…In addition, reasons for not using these services are explored. Methods A secondary data analysis of the Austrian data from the European Web Survey on Drugs (EWSD), a targeted survey conducted between March and May 2021 was performed. …”
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Adaptation to Sodium Hypochlorite and Potassium Permanganate May Lead to Their Ineffectiveness Against <i>Candida albicans</i> by Tomasz M. Karpiński, Marzena Korbecka-Paczkowska, Marcin Ożarowski, Donald Włodkowic, Marzena Liliana Wyganowska, Agnieszka Seremak-Mrozikiewicz, Judyta Cielecka-Piontek

“…This study aimed to preliminarily investigate the potential for <i>Candida albicans</i> adaptation to eight antiseptics. <b>Methods:</b> The minimal inhibitory concentration (MIC), drug susceptibility, adaptation to antiseptics, and Karpinski Adaptation Index (KAI) of <i>C. albicans</i> strains were assessed. …”
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The Effectiveness of Multisensory-Based Perceptual-Motor Exercises on Quality of Life and Daily Living Activities in Older Adults with Mild Cognitive Impairment: A Clinical Trial by Maryam Binesh, Jamil Eslami, Shima Shahrokhi, Hossein Mirzabeigi, Ensieh Naimi, Mina Sadat Mirshoja

“…This study aimed to investigate the effects of multisensory-based sensorimotor exercises on quality of life and performance in daily activities in this population. Materials and methods: This study employed a quasi-experimental design with a pre-test–post-test framework, featuring control and intervention groups, and was conducted as double-blind research. …”
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miR-424-5p Promotes Proliferation, Migration and Invasion of Colorectal Cancer Cells via the Targeting TXNIP/Hippo Axi by Zhang F, Zhu KL, Chen R, Su F

“…The study was designed to clarify the function of miR-424-5p and thioredoxin interacting protein (TXNIP) in the progression of CRC.Methods: The expression pattern of TXNIP and miR-424-5p was detected by immunohistochemistry, qRT-PCR and/or Western blotting. …”
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Cluster-randomized trial of the implementation of the Responses to Illness Severity Quantification (RISQ) system in children with acute malnutrition 6 to 59 months of age in Ngouri... by Nancy M. Dale, Youssouf Djidita Hagre, Susan Shepherd, George Tomlinson, Stanley Zlotkin, Masra Ngaradoum, Mahmat Bechir, Marius Madjissem, Charles Tehoua, Christopher Parshuram

“…The objective of the CRIMSON study is to estimate the effect of implementation of the RISQ System on mortality and processes of care in a nutritional program. Methods A cluster randomized trial will compare the RISQ System to usual care. …”
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Prevalence of EGFR Mutations in Vietnamese Patients with Resected Early Stage Non-Small Cell Lung Cancer: EARLY-EGFR Study by Dao TV, Dinh VL, Doan TV, Phuong TL

“…Tu Van Dao,1,2,&ast; Van Luong Dinh,3,4,&ast; Thanh Vinh Doan,5 Tri Le Phuong6 1Cancer Research and Clinical Trials Center, Department of Optimal Therapy, Vietnam National Cancer Hospital, Hanoi, Vietnam; 2Oncology Department, Hanoi Medical University, Hanoi, Vietnam; 3Lung Transplant Center, National Lung Hospital, Hanoi, Vietnam; 4TB and Lung Diseases Department, Hanoi Medical University, Hanoi, Vietnam; 5Oncology Department, Pham Ngoc Thach Hospital, Ho Chi Minh City, Vietnam; 6Medical Affairs, AstraZeneca Vietnam, Ho Chi Minh City, Vietnam&ast;These authors contributed equally to this workCorrespondence: Tu Van Dao, Cancer Research and Clinical Trials Center, Department of Optimal Therapy, Vietnam National Cancer Hospital, Hanoi, Vietnam, Email daovantu@hmu.edu.vnIntroduction: Comprehensive profiling of mutations in the EGFR gene is vital for selecting patients eligible for EGFR targeted therapies.Methods: We investigated the prevalence of EGFR mutations and treatment patterns in patients with early stage non-small cell lung cancer (NSCLC) in Vietnam as a part of EARLY-EGFR (Clinical Trial Identifier: NCT04742192), a global, real-world study. …”
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Comparison of TNF-α Levels in Alcoholic Liver Disease Patients with and without Hepatitis: A Cross-sectional Study in Coastal Karnataka, India by TM Anuraghi, Krishnamoorthy Srilatatha, Jinsha Fathima, Yassir Shaheena

“…Aim: To compare TNF-α levels in Alcoholic Liver Disease (ALD) patients with or without hepatitis. Materials and Methods: This cross-sectional study was conducted at Yenepoya Medical College Hospital, Mangaluru, Karnataka, India from October 2021 to June 2022. …”
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Prevalence and risk factors of post-kidney transplant hyperparathyroidism: a single-center study by O. N. Vetchinnikova, M. Yu. Ivanova

“…Objective: to assess the prevalence of hyperparathyroidism (HPT) and the factors affecting its development in kidney transplant recipients. Materials and methods. The single-center observational cohort study included 97 kidney transplant recipients – 40 men, 57 women, age 50 ± 9 years. …”
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Association Between Advanced Lung Cancer Inflammation Index and Mortality in US Adults with Chronic Obstructive Pulmonary Disease by Su X, Rao H, Zhao C, Zhang X, Li D

“…This study evaluated the association between ALI and all-cause and cause-specific mortality in COPD patients.Patients and Methods: Data from 4616 adults with COPD in the National Health and Nutrition Examination Survey (1999– 2018) were analyzed. …”
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Morphometric correlates of the physical development structure of combat athletes in the process of ensuring special work capacity by Oleksandr Pryimakov, Marek Sawczuk, Nataliya Mazurok, Olena Omelchuk

“…This study aims to examine the interrelations of key parameters within the physical development (PD) structure of highly skilled combat athletes in the process of ensuring special work capacity. Material and Methods. Between 30 and 83 wrestlers of different weight categories and skill levels, all members of the national teams of Ukraine in freestyle and Greco-Roman wrestling, and judo, participated in various studies. …”
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Gegen Qinlian Decoction Ameliorated DSS-Induced Colitis by Attenuating Inflammation, Restoring Intestinal Mucosal Barrier and Modulating Gut Microbiota by Wang Y, Yan R, Ye L, Tang C, Zhou H, Zhao G

“…However, the specific mechanisms by which GQD exerts its effects remain poorly understood, limiting its application in UC treatment.Purpose: In this study, we utilized a dextran sodium sulfate-induced colitis model in mice to evaluate the efficacy of GQD and to elucidate its underlying mechanisms.Methods: Network pharmacology was employed to explore the potential targets and signaling pathways of GQD, which were subsequently validated using Western blot. …”
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Prevalence, characteristics and management of migraine patients with triptan failure in primary care: the EMR France-Mig study by M. Lanteri-Minet, C. Casarotto, O. Bretin, C. Collin, M. Gugenheim, V. Raclot, A. Cases, P. A. Squara, W. Aissani, A. Saighi, H. Lefebvre

“…The aim of the France-Mig study was to quantify the population with triptan failure due to ineligibility or resistance, in the primary care setting, and describe their therapeutic management. Methods The France-Mig study was a retrospective analysis of a cohort of patients suffering from migraine in 2022 identified using data from the IQVIA electronic medical records (EMR). …”
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Tanshinone I Ameliorates Psoriasis-Like Dermatitis by Suppressing Inflammation and Regulating Keratinocyte Differentiation by Wang Q, Luo X, Su Y, Jin Y, Kuang Q, Li S, Shen W, Zhu Y

“…Tanshinone I (Tan-I) has recently been discovered to have immunomodulatory properties, but its role and mechanisms in treating psoriasis remain unclear.Objective: To evaluate the efficacy of Tan-I in the treatment of psoriasis and to determine the mechanisms involved.Methods: An imiquimod (IMQ)-induced psoriasis-like mouse model was treated topically with Tan-I (7.5 mg/kg/d) or a vehicle. …”
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Genetic Variants in the Adhesive G Protein-Coupled Receptor ADGRG6 are Associated with Increased Susceptibility to COPD in the Elderly Han Chinese Population of Southern China by Chen F, Zhao J, Mo R, Ding X, Zhang Y, Huang L, Xie T, Ding Y

“…However, the impact of genetic variations in ADGRG6 on chronic obstructive pulmonary disease (COPD) susceptibility has not yet been evaluated.Methods: Considering the high prevalence of COPD among the elderly population in China, this study specifically targets the elderly Han population in Southern China as the study subject. …”
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Untrained perceptual loss for image denoising of line-like structures in MR images. by Elisabeth Pfaehler, Daniel Pflugfelder, Hanno Scharr

“…Therefore, automatic image denoising using deep learning methods is of high interest. In this work, we concentrate on image denoising of MR images containing line-like structures such as roots or vessels. …”
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Identifying Therapeutic Targets and Potential Drugs for Diabetic Retinopathy: Focus on Oxidative Stress and Immune Infiltration by Peng H, Hu Q, Zhang X, Huang J, Luo S, Zhang Y, Jiang B, Sun D

“…This study investigated biomarkers connected to DR and oxidative stress and their connection with immune cell infiltration using bioinformatics analysis and found possible therapeutic medications.Methods: The Gene Expression Omnibus (GEO) database was used to obtain the gene expression data for DR. …”
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Investigating Drug-Induced Thyroid Dysfunction Adverse Events Associated With Non-Selective RET Multi-Kinase Inhibitors: A Pharmacovigilance Analysis Utilizing FDA Adverse Event Re... by Meng Z, Song L, Wang S, Duan G

“…Zhuda Meng,1,&ast; Liying Song,2,&ast; Shuang Wang,3,&ast; Guosheng Duan4 1Department of Thyroid Surgery, Changzhi People’s Hospital, Changzhi, People’s Republic of China; 2Department of Thyroid Surgery, First Hospital of Shanxi Medical University, Taiyuan, People’s Republic of China; 3Department of Gastroenterology, Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Taiyuan, 030032, People’s Republic of China; 4Radiotherapy Department, Shanxi Provincial Peoples Hospital: Fifth Hospital of Shanxi Medical University, Taiyuan, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Zhuda Meng, Department of Thyroid Surgery, Changzhi People’s Hospital, Changzhi, 046000, People’s Republic of China, Email jzx23456m@163.comPurpose: This study aims to investigate the potential association between non-selective RET kinase inhibitors and thyroid dysfunction (TD) by conducting a pharmacovigilance analysis using data from the US FDA Adverse Event Reporting System (FAERS).Methods: Data for non-selective RET MKIs were obtained from the FAERS database, spanning the first quarter of 2015 to the fourth quarter of 2023. …”
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Retrograde Approach for Percutaneous Ventricular Septal Defect Closure: Is It Really Better Than Antegrade? by Nataliia S. Yashchuk, Igor O. Ditkivskyy, Alisa P. Soi, Bogdan V. Cherpak, Olha S. Borodinova, Yuliia V. Yermolovych

“…To the best of our knowledge, there is currently no published literature comparing the immediate and longterm outcomes of these two techniques for transcatheter VSD closure. Materials and methods. From August 2012 to January 2025, 254 patients underwent percutaneous ventricular septal defect closure using various devices. …”
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IMPACT OF VITAMIN D DEFICIENCY OR INSUFFICIENCY ON THE SEVERITY OF COVID-19 IN HOSPITALIZED PATIENTS by Olga A. Golubovska, Kyrylo O. Chalyy, Oleksandra V. Bezrodna, Anastasiia A. Holubovska

“…To analyze the frequency of detection of vitamin D deficiency or insufficiency in hospitalized patients with a laboratory-confirmed diagnosis of COVID-19, depending on the severity of the disease. Materials and methods. A retrospective analysis of medical records of 118 patients with COVID-19 (diagnosis was confirmed by PCR or rapid test for qualitative determination of the virus antigen) who were inpatients at the private clinic “Oberig” during 2020–2021 was conducted. …”
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Specnuezhenide Alleviates Senile Osteoporosis by Activating TGR5/FXR Signaling in Bone Marrow Mesenchymal Stem Cells and RANKL-Induced Osteoclasts by Deng X, Lin B, Xiao W, Wang F, Xu P, Wang N

“…In this study, the effects of SPN on d-galactose (d-gal)-induced mice, bone marrow mesenchymal stem cells (BMSCs), and nuclear factor-κB ligand-induced osteoclasts were examined.Methods: Micro-computed tomography was used to observe the bone microstructure. …”
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