From Gene to Intervention: NLRC4 and WIPI1 Regulate Septic Acute Lung Injury Through Autophagy by Yang X, Sun Z, Liu Z, Chen H, Fang Y, Tao W, Zhao N, Ouyang X, Liu F, Qian K

“…Although autophagy is crucially involved in the inflammatory response, its precise molecular mechanisms in SALI remain unclear, forming the basis of this study.Methods: Herein, two microarray datasets (GSE33118 and GSE131761) and three single-cell sequencing datasets (SCP43, SCP548, and SCP2156) derived from human samples were used to ascertain the interrelationship between Differentially Expressed Autophagy-Related Genes (DEARGs) and SALI. …”
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The allocation and fairness of hospital pharmacist human resources in China: a time-series study by Hengfan Ni, Ma Yuan, Peng Wan, Qiu Xiang, Du Hongling, Tang Minghai, Li Jian

“…The study aims to analyze the supply and demand of pharmacist human resources in Chinese healthcare institutions and evaluate the equity of their distribution to provide a reference for the rational management of pharmacist resources. Methods This was a time-series study that was conducted using data obtained from Health and Health Statistical Yearbook that is performed every year by the National Health Commission of the People’s Republic of China. …”
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Ultrasonic Parameters as Biomarkers for Tumor Staging and Aggressiveness in Breast Cancer: Correlation with GP73 and miR-27a by Tao ZY, Rong R, Zhou LP

“…Zi-Yu Tao,1,* Rong Rong,2,* Lei-Ping Zhou3 1Obstetrics and Gynecology Hospital Fudan University, Shanghai, 200233, People’s Republic of China; 2Department of Clinical Laboratory, The Second People’s Hospital of Hefei, Hefei Hospital Affiliated to Anhui Medical University, Hefei, 230000, People’s Republic of China; 3Department of Ultrasound, International Peace Maternity and Child Health Hospital, Shaghai, 200063, People’s Republic of China*These authors contributed equally to this workCorrespondence: Lei-Ping Zhou, Department of Ultrasound, International Peace Maternity and Child Health Hospital, Shaghai, 200063, People’s Republic of China, Tel +86-13761708810, Email Zhouleiping68@163.comObjective: To investigate correlations between CEUS parameters and serum GP73/miR-27a in breast cancer.Methods: In the study, 117 highly suspected breast cancer diagnosed and treated in our hospital during March 2022 to April 2024 were included. …”
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SEMAGLUTIDE: Weight loss, glycaemic control and safety profile in obese patients with and without type-II diabetes-An experience from Karachi, Pakistan by Muhammad Y. Memon, Tasnim Ahsan, Rukhshanda Jabeen, Saba Latif, Saeeda F. Qasim, Paras Imran

“…Objective To assess the efficacy and safety of Semaglutide (a GLP-1 receptor agonist) in obese patients with and without Type-II Diabetes Mellitus. Methods This observational analytic cohort study was conducted in a private medical institute in Karachi Pakistan; from August 2022 to January 2023. …”
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Comparing the Prognostic Value of Lactate to the Neutrophil to Lymphocyte Ratio Among Sepsis Patients: A Prospective Cohort Study by Bou Chebl R, Haidar S, Kattouf N, Assaf M, Alwan JS, Khamis MM, Abdeldaem K, Makki M, Tamim H, Abou Dagher G

“…This study compares the prognostic value of lactate and NLR in septic patients.Methods: This prospective cohort study included 874 adult septic or septic shock patients presenting to a tertiary care center’s Emergency Department between September 2018 and February 2021. …”
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Alkannin Induces G2/M-Phase Arrest, Apoptosis, and Inhibition of Invasion by Targeting GSK3β in Esophageal Squamous Cell Carcinoma by Ma H, Xu P, Jia Y, Zhou Y, Li X, Wang Y, Ma K

“…This study aims to investigate the therapeutic effects of Alkannin on ESCC and elucidate its potential targets and molecular mechanisms.Methods: Cell Counting Kit-8 (CCK-8) assays, colony formation assays, Hoechst 33342 staining, wound healing assays, Transwell migration assays, flow cytometry, and Western blotting were used to investigate the therapeutic effects of Alkannin on ESCC in vitro. …”
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Analysis of Electroacupuncture Parameters for Irritable Bowel Syndrome: A Data Mining Approach by Tang Y, Tang X, Wen Q

“…This study endeavors to identify effective EA parameters for IBS through data mining methodologies.Methods: To retrieve randomized controlled trials (RCTs) on EA for IBS published between 2013 and 2024, a comprehensive search was conducted across nine databases. …”
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MDT Reduces Perioperative Thrombotic Events in Elderly Orthopedic Patients by Chen T, Lei X, Tian J, Mai H, Yu Y, Wu W, Wen L, Saw PE, Zhang M

“…Tonghua Chen,1,* Xiaojun Lei,1,* Jingwei Tian,1,* Haochen Mai,1 Yuanfang Yu,1 Wenxia Wu,1 Liqiang Wen,1 Phei Er Saw,1 Meng Zhang1,2 1Department of General Practice, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, Guangdong, People’s Republic of China; 2Department of General Practice, Shenshan Medical Center, Sun Yat-sen Memorial Hospital, Shanwei, Guangdong, People’s Republic of China*These authors contributed equally to this workCorrespondence: Phei Er Saw; Meng Zhang, Email caipeie@mail.sysu.edu.cn; zhangm7@mail.sysu.edu.cnPurpose: To minimize the occurrence of acute thromboembolic events in elderly patients during the perioperative period and prevent adverse clinical outcomes, this study explores an efficient, and precise approach to the formulation of antithrombotic regimens under a multidisciplinary team (MDT) consultation model.Patients and Methods: This single-center retrospective study included elderly patients on long-term antithrombotic therapy who underwent orthopedic surgery in our hospital between January 2019 and May 2023. …”
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The Effects of HFOV-VG vs HFOV on Bronchopulmonary Dysplasia and Neurobehavioral Development in Preterm Infants with Perinatal Acute Respiratory Distress Syndrome by Tao M, Yan L, Hu Y, Shen L, Cai N

“…Min Tao,* Ling Yan,* Yuan Hu, Leilei Shen, Na Cai Department of Pediatrics, The First Hospital Affiliated to Army Medical University, Chongqing, 400038, People’s Republic of China*These authors contributed equally to this workCorrespondence: Na Cai, Department of Pediatrics, The First Hospital Affiliated to Army Medical University, No. 30, Gaotanyan Street, Chongqing, 400038, People’s Republic of China, Tel +86-23-68766213, Email caina@tmmu.edu.cnObjective: This study aimed to explore whether high-frequency oscillatory ventilation with volume-guarantee (HFOV-VG) strategy could reduce the incidence of bronchopulmonary dysplasia (BPD) and improve poor neurological prognosis in premature infants with perinatal acute respiratory distress syndrome (NARDS) compared with high-frequency oscillatory ventilation (HFOV) alone.Methods: This retrospective single-center study conducted in the neonatal intensive care unit (NICU) from January 2016 and December 2023. …”
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Robotic-assisted versus conventional hip arthroplasty: a comparative analysis of perioperative blood management and early outcomes by Annapareddy Adarsh, Jayakumar Tarun, Reddy Manideep, Mulpur Praharsha, Gurram Vijay Kumar Reddy, Prasad Vemaganti Badri Narayana, Gurava Reddy A. V.

“…Purpose: This study aimed to evaluate the impact of Robotic-Assisted Total Hip Arthroplasty (RATHA) versus Conventional Total Hip Arthroplasty (CTHA) on perioperative blood loss, blood transfusion requirements, and early clinical outcomes. Methods: A prospective cohort study was conducted at a high-volume tertiary care center from January 2021 to January 2023. …”
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Machine Learning-Driven Prediction of One-Year Readmission in HFrEF Patients: The Key Role of Inflammation by Ma F, Hu Y, Han P, Qiu Y, Liu Y, Ren J

“…Predicting one-year readmission risk is crucial for optimizing treatment and reducing costs.Methods: We conducted a single-center retrospective study on adult HFrEF patients admitted to the Cardiovascular Department of the First Affiliated Hospital, Zhejiang University School of Medicine on January 2020 and March 2023. …”
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Biaxial Flexural Strength of High-Translucence Monolithic Ceramics upon Various Thicknesses by Niwut Juntavee, Apa Juntavee, Sirintana Phetpanompond

“…This study evaluated the biaxial flexural strength of different ceramics as a result of varying thicknesses. Materials and Methods. Circular discs with varied thickness of 0.4, 0.6, 0.8, 1.0, 1.2, 1.4, 1.6, 1.8, and 2.0 mm were prepared from high-translucence yttria-partially stabilized zirconia (HTY-PSZ); Bruxzir® Anterior (Bc), and zirconia-reinforced lithium silicate (ZLS) including Celtra® DUO (Cc) and VITA Suprinity® (Vc) (n = 15 discs/group). …”
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High Humidity Alters Myeloid-Derived Suppressor Cells in Spleen Tissue: Insights into Rheumatoid Arthritis Progression by Wang H, Wang M, Wang T, Li X, Wen C, He Z, Huang L

“…Furthermore, there is a lack of evidence linking humidity to the worsening of RA symptoms in animal models.Methods: The Collagen-induced arthritis (CIA) mouse model was established using C57BL/6 mice. …”
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Change of the elasticity COEFFICIENT of the walls of the common carotid artery as a predictor of adverse cardiovascular events in hypertensive patients after ischemic hemispheric s... by O. A. Lisovaya

“…To evaluate the relationship between carotid artery elastic properties and risk of recurrent coronary and cerebral ischemic events in III grade arterial hypertension patients after ischemic stroke. Methods. 102 mild-to-moderate arterial hypertension patients were enrolled to the scrutiny in 3 weeks after ischemic stroke and then they had been being studied prospectively for 12 months period regarding survival rate and unfavorable clinical outcomes. …”
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Effect of Exercise and Nutrition Intervention for Older Adults with Impaired Physical Function with Preserved Muscle Mass (Functional Sarcopenia): A Randomized Controlled Trial by Ji S, Baek JY, Go J, Lee CK, Yu SS, Lee E, Jung HW, Jang IY

“…The effectiveness of a program combining exercise and nutritional support—known interventions for individuals with low muscle mass—was evaluated for its impact on older adults with functional sarcopenia.Methods: An unblinded, parallel-group randomized controlled trial was conducted in a public medical center in a rural Korean community. …”
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Evaluation of the Diagnosis Accuracy of the AWGS 2019 Criteria for “Possible Sarcopenia” in Thai Community-Dwelling Older Adults by Adulkasem N, Vanitcharoenkul E, Chotiyarnwong P, Asavamongkolkul A, Unnanuntana A

“…Our secondary aim was to explore the use of adjunct variables to improve the diagnostic accuracy of the “possible sarcopenia” criteria for detecting sarcopenia.Methods: This study is a secondary analysis of an epidemiological investigation of the prevalence of sarcopenia among Thai older adults that was conducted during 2021– 2022. …”
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Sanming Model of Medical Service Integration: Impact on Medical Expenditures, Service Provision, and Resource Allocation in China by Lin K, Liu X, Xiang L, Luo F

“…This study evaluates the model’s impact on medical expenditures, service provision, and resource allocation.Methods: We conducted an interrupted time series analysis on outcome variables related to medical expenditures, service provision, and resource allocation in Sanming City. …”
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Microleakage of high viscosity glass-ionomer and glass-carbomer with and without coating before and after hydrothermal aging by Asli Patır Münevveroğlu, Alev Ozsoy, beyza ballı akgol, ruhan bozatlioglu, pelin korkut, busra uysal, Mutlu Ozcan

“… Objective: The objective of this study was to evaluate the microleakage patterns of GIC and GGC with and without their protective surface coatings on enamel and dentin margins before and after aging. Material and Methods: Two rectangular cavities (height: 2 mm; width: 3 mm; depth: 1.5 mm) were prepared on each tooth at the cemento-enamel junction were prepared on human permanent molars (N=56) and the teeth were randomly assigned to be restored with one of the following: a) high viscosity glass-ionomer cement (GIC) (EQUIA Fil, C Corp., Tokyo, Japan) (n=28), b) glass-carbomer cement (GCC) (Glass Carbomer Products, Leiden, The Netherlands) (n=28). …”
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Clinical Significance of Abnormal Serum LGALS3BP Expression in Patients with Idiopathic Inflammatory Myopathies by Huang L, Huang X, Zhou W, Jiang Y, Zhu H, Lao Y, Deng Z, Tang Y, Wang J, Li X

“…The correlation between serum LGALS3BP levels, clinical features, and inflammatory markers in patients with IIM was also assessed.Methods: Based on the Gene Expression Omnibus (GEO) database, we used bioinformatics analysis to screen for overlapping extracellular protein-differentially expressed genes between any two groups of DM, ASS, IMNM, and healthy controls (HCs). …”
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Decoding Drug Interactions: Character and Degree of Pharmacokinetic Interactions Between Telmisartan and Sorafenib or Donafenib in Rats by Li Y, Du W, Shan C, Yu Z, An J, Dong Z

“…Therefore, this study aimed to evaluate these pharmacokinetic interactions in male Sprague-Dawley (SD) rats.Methods: The animals were divided into seven groups (n = 6) and treated with sorafenib, donafenib, or telmisartan as monotherapy (groups I–III), multi-dose sorafenib or donafenib with single dose telmisartan (groups IV and V), or multi-dose telmisartan with single dose sorafenib or donafenib (groups VI and VII). …”
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