The effect of tactile versus auditory stimulation on reducing pain associated with invasive procedures among preterm neonates at NICUs by Entsar Shehata Mohammed, Seham Mohammed Elmwafie, Fatma Sayed Abdelaziz Mohamed, Safaa Salah Ismail

“…The study hypothesized that preterm neonates who receive tactile stimulation will exhibit lower pain scores than those who receive auditory stimulation. Methods A comparative (three-group) quasi-experimental design included 90 preterm neonates divided equally into three groups (tactile stimulation group = 30, auditory stimulation group = 30, and control group = 30) at NICU affiliated with Beni-Suef University Hospital. …”
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Focal Staphylococcus Aureus Septic Arthritis Elicits Age and TLR2-Dependent Periarticular Bone Loss by Schultz M, Hu Z, Deshmukh M, Henning P, Lerner UH, Mohammad M, Jin T

“…While intra-articular injections of S. aureus LPPs induces local bone resorption in mice, the influence of aging and TLR2 expression on bone mineral density (BMD) after S. aureus bacteremia remains unclear.Methods: We analyzed distal femoral BMD in young and old TLR2 knock-out and wild-type mice following intravenous S. aureus infection. …”
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Interleukin-6 as a Pan-Cancer Prognostic Inflammatory Biomarker: A Population-Based Study and Comprehensive Bioinformatics Analysis by Xie H, Wei L, Ruan G, Zhang H, Shi H

“…This study aimed to provide a comprehensive assessment of the prognostic value of IL-6 and its immunotherapeutic features using a population-based pan-cancer analysis and comprehensive bioinformatic analysis.Patients and Methods: In the cohort study, 540 patients were included to explore the prognostic value of serum IL-6 levels in cancer. …”
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TyG-WC Index as a Superior Predictor of Hyperuricemia Risk in the Hypertensive Population: A Prospective Cohort Study by Zhang Q, Liu J, Zhang R, Wang C, Song Y, Wang X, Zeng F

“…Qin Zhang,1,* Jian Liu,2,* Ruize Zhang,3 Changfen Wang,4 Yanyan Song,5 Xi Wang,2 Fanling Zeng6 1Department of Cardiology, Xi Chang People’s Hospital, Xi Chang, Sichuan Province, 615000, People’s Republic of China; 2Department of Cardiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, People’s Republic of China; 3Dougherty Valley High School, San Ramon, CA, 94582, USA; 4Department of Cardiology, People’s Hospital of Qianxinan Prefecture, Guizhou Province, People’s Republic of China; 5Department of Endocrinology, Chongqing Jianshe Hospital, Chongqing, People’s Republic of China; 6Health Management Ctr, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xi Wang; Fanling Zeng, The First Affiliated Hospital of Chongqing Medical University, No. 1 Youyi Road, Yuzhong District, Chongqing, 400016, People’s Republic of China, Email 201884@cqmu.edu.cn; zengfanling@hospital.cqmu.edu.cnObjective: To evaluate the predictive value of the triglyceride-glucose waist circumference index (TyG-WC) for hyperuricemia (HUA) risk in the hypertensive population.Methods: This prospective cohort study involved 831 hypertensive patients with normal uric acid levels, who underwent continuous health examinations for five years. …”
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Surgical outcomes of women undergoing radical resection of deep endometriosis of the sacral plexus: A prospective cohort study by Gernot Hudelist, Ezgi Darici Kurt, Gábor Szabó, Dominika Miklos, Theresa Hudelist, Attila Bokor

“…This study aims to report on the surgical outcomes in terms of pain and neurological symptom reduction in women undergoing surgical resection of SPE. Material and Methods Thirty premenopausal patients with histologically confirmed SPE who underwent surgical resection of the disease between 2018 and 2024 were included in this multicenter prospective analysis. …”
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The impact of retail-sector delivery of artemether-lumefantrine on malaria treatment of children under five in Kenya: a cluster randomized controlled trial. by Beth P Kangwana, Sarah V Kedenge, Abdisalan M Noor, Victor A Alegana, Andrew J Nyandigisi, Jayesh Pandit, Greg W Fegan, James E Todd, Simon Brooker, Robert W Snow, Catherine A Goodman

“…This study in western Kenya aimed to evaluate the impact of providing subsidized artemether-lumefantrine (AL) through retail providers on the coverage of prompt, effective antimalarial treatment for febrile children aged 3-59 months.<h4>Methods and findings</h4>We used a cluster-randomized, controlled design with nine control and nine intervention sublocations, equally distributed across three districts in western Kenya. …”
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Enhanced Antitumor Immunity Through T Cell Activation with Optimized Tandem Double-OX40L mRNAs by Deng Z, Tian Y, Wang J, Xu Y, Liu Z, Xiao Z, Wang Z, Hu M, Liu R, Yang P

“…This study investigates the use of mRNA-based cancer agents as promising tools to combat and reverse refractory TIME conditions.Methods: We optimized and engineered an mRNA cancer agent encoding double tandemly repeated sequences of the T cell costimulator Oxford 40 ligand (diOX40L). …”
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Shen-Qi-Jie-Yu-Fang exerts effects on a rat model of postpartum depression by regulating inflammatory cytokines and CD4+CD25+ regulatory T cells by Li J, Zhao R, Li X, Sun W, Qu M, Tang Q, Yang X, Zhang S

“…Aim: To further investigate the effect of SJF on the immune system, including the inflammatory response system and CD4+CD25+ regulatory T (Treg) cells. Materials and methods: Sprague Dawley rats were used to create an animal model of PPD by inducing hormone-simulated pregnancy followed by hormone withdrawal. …”
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Type II diabetes mellitus risk assessment using FINDRISC questionnaire in systemic lupus erythematosus patients by L. V. Kondratieva, T. V. Popkova

“…To evaluate the prevalence of traditional risk factors in systemic lupus erythematosus (SLE) patients, assess the 10-years risk of developing type 2 diabetes mellitus (DM) in SLE patients and identify those necessitating preventive interventions following altered glucose metabolism using the Finnish Type 2 Diabetes Risk Score (FINDRISK) questionnaire.Materials and methods. The study included 119 SLE patients (107 women, 12 men, with median age 39 [33; 47] years and mean disease duration 6 [1,12] years.The control group included 100 age and sex matched individuals without immune-mediated inflammatory rheumatic diseases and without previous DM history. …”
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Bibliometric Analysis of Exosome Research in Spinal Cord Injury (2000&amp;ndash;May 2024). Trends, Collaborations, and Emerging Insights by Wang Z, Bi H, Li D, Zhang W, Wang C, Yang J, Shen X, Yan R, He F, Duan H

“…The present study was conducted to provide a systematic bibliometric analysis of research trends related to SCI and exosomes.Patients and Methods: Publications on exosomes in SCI were identified from the Web of Science Core Collection using specific search criteria. …”
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Outcomes after Cortical Bone Trajectory Screw versus Traditional Pedicle Screw in Single-Level Lumbar Spine Surgery: A Systematic Review and Meta-Analysis of Randomized Controlled... by Muhammad Talal Ibrahim, Cole Veliky, Elizabeth Yu

“…The systematic review aims to compare randomized controlled trials comparing CBTS with PS in single-level lumbar spine fusion surgery. Methods: A systematic search was conducted on PubMed (MEDLINE), Scopus, Embase, Web of Science, and Cochrane. …”
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CECT-Based Radiomic Nomogram of Different Machine Learning Models for Differentiating Malignant and Benign Solid-Containing Renal Masses by Qian L, Fu B, He H, Liu S, Lu R

“…Lu Qian,1,&ast; BinHai Fu,2,&ast; Hong He,2 Shan Liu,1 RenCai Lu2 1Department of Pathology, the First People’s Hospital of Yunnan Province, The Affiliated Hospital of Kunming University of Science and Technology, Kunming, Yunnan, 650032, People’s Republic of China; 2Department of Nuclear Medicine, The First People’s Hospital of Yunnan Province, the Affiliated Hospital of Kunming University of Science and Technology, Kunming, Yunnan, 650032, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: RenCai Lu, Department of Nuclear Medicine, The First People’s Hospital of Yunnan Province, the Affiliated Hospital of Kunming University of Science and Technology, No. 157 Jinbi Road, Kunming, Yunnan, 650032, People’s Republic of China, Tel +86 087163614503, Email lrc_09@126.comObjective: This study aimed to explore the value of a radiomic nomogram based on contrast-enhanced computed tomography (CECT) for differentiating benign and malignant solid-containing renal masses.Materials and Methods: A total of 122 patients with pathologically confirmed benign (n=47) or malignant (n=75) solid-containing renal masses were enrolled in this study. …”
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Hamstring vs Peroneus Longus Tendon Autograft in Anterior Cruciate Ligament Reconstruction: A Comparative Study by Khadri M Khalid, Adarsh Vajrangi, Eswara Reddy, Nagesh Sherikar, Rakshith Chakravarthy Harish Yellappa, Ranganatha B Kurupati

“…In this article, we will explore whether the peroneus longus (PL) graft can be a comparable alternative to the HT graft. Materials and methods: We conducted a prospective randomized study involving 80 patients who underwent ACLR. …”
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Photorefractive keratectomy with extended ablation zone for recurrent corneal erosion syndrome accompanied with refractive errors: a study of effectiveness, safety, and refractive... by Xinxin Yu, Chenchen Wang, Zuhui Zhang, Wuqi Zhang, Yizeng Yang, Shuangqing Wu

“…Trans-epithelial photorefractive keratectomy (TPRK) for the contralateral eyes and phototherapeutic keratectomy (PTK) for RCES patients without refractive errors were included for comparison.MethodsThe study enrolled a total of 79 eyes from 62 patients, comprising 16 eyes (16 patients) in the PRK group, 11 contralateral eyes (11 patients) in the TPRK group, and 52 eyes (49 patients) in the PTK group. …”
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From illiteracy to the University: The Institutional development of Albanian education in Kosovo 1945-1990 by Avni Rexha

“…On the other hand, the raising of the educational level influenced the articulation of Kosovo Albanians claims for political equality and national rights.…”
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Altered intra- and interregional synchronization in relapsing&amp;ndash;remitting multiple sclerosis: a resting-state fMRI study by Wu L, Zhang Y, Zhou F, Gao L, He L, Zeng X, Gong H

“…However, few studies have explored the local brain activity of RRMS patients in the resting state. Patients and methods: In this study, regional homogeneity (ReHo) and resting-state functional connectivity (FC) were used to investigate intra- and interregional synchronized activity in 22 patients with RRMS and 22 matched healthy controls (HCs). …”
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LASER THERAPY FOR MANAGEMENT OF CEREBRAL DYSFUNCTION IN CASES OF ACUTE SEVERE PANCREATITIS by A. P. Vlasov, D. Y. Timoshkin, M. A. Spirina, I. A. Chigakova, T. I. Vlasova, T. A. Muratova

“…Pancreatic encephalopathy is one of particular manifestations of this syndrome.Aim of study: to determine severity of cerebral dysfunction in cases of acute destructive pancreatitis, to assess the efficacy of laser therapy for this disease.Material and methods: The research is based on the results of clinical studies, carried out at the Republican Clinical Hospital No.3. …”
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Network Pharmacology and Metabolomics Reveal Anti-Ferroptotic Effects of Curcumin in Acute Kidney Injury by Liu X, Zhou Y, Lu Z, Yang F, Wang Y, Zhang S, Zhang J, Zou H, Lin M

“…However, the potential mechanism of Cur in alleviating AKI ferroptosis remains unknown.Objective: This study aims to investigate the effects of Cur on AKI ferroptosis.Methods: Folic acid (FA)-induced AKI mouse model and erastin/(rsl-3)-induced HK-2 model were constructed to assess the renoprotection of Cur. …”
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Construction and Comparison of Machine Learning-Based Risk Prediction Models for Major Adverse Cardiovascular Events in Perimenopausal Women by Chen A, Chang X, Bian X, Zhang F, Ma S, Chen X

“…Therefore, this study explores the factors influencing the occurrence of MACE in perimenopausal women and establishes a prediction model for MACE risk factors using three algorithms, comparing their predictive performance.Patients and Methods: A total of 411 perimenopausal women diagnosed with MACE at the Binzhou Medical University Hospital were randomly divided into a training set and a test set following a 7:3 ratio. …”
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Utility of the Basophil Reactivity Test in the Clinical Management of People with Severe Uncontrolled Asthma by García Ródenas MDM, Hernández Blasco LM, Fernández Sánchez FJ, Marco de la Calle FM, Pascual-Lledó JF, Sánchez Barbie Á, Fernández Aracil C

“…The aim of this study was to evaluate the utility of basophil reactivity, measured through the basophil activation test (BAT), as a marker of response to mAbs.Methods: We measured basophil reactivity, using anti-immunoglobulin E (anti-IgE) antibodies as a stimulus, in 72 consecutive patients with severe uncontrolled asthma before initiation of treatment with mAbs. …”
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