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8601
Exploring Factors Influencing Dietary Management in Chinese Chronic Kidney Disease Patients Based on the COM-B Model: A Qualitative Study
Published 2025-06-01“…Given this knowledge gap, we aimed to explore the factors influencing dietary management in patients with chronic kidney disease based on the capability, opportunity, motivation, and behavior (COM-B) model and provide culturally suitable insights for the creation of focused interventions.Methods: Semi-structured interviews were conducted between September and November 2024 at the Department of Nephrology, Affiliated Central Hospital of Jiangnan University, with 45 participants, including 19 patients with chronic kidney disease, 10 caregivers, and 16 healthcare professionals. …”
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8602
Synaptic Structure and Transcriptomic Profiling of Reward and Sensory Brain Areas in Male Mice of Fentanyl Addiction
Published 2024-12-01“…The side effects of fentanyl abuse have been well recognized, yet the underlying molecular adaptations across brain regions upon fentanyl exposure remain elusive.Methods: The transmission electron microscopy (TEM) and next-generation RNA-sequencing (RNA-seq) were used to investigate the ultrastructure synaptic alterations and transcriptional profiling changes of reward and sensory brain regions in mice after fentanyl exposure.Results: The naloxone-precipitated acute withdrawal symptoms were observed in mice exposed to fentanyl. …”
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8603
Research Trends and Hotspots of Acupuncture Therapy on Allergic Diseases From 2004 to 2024: A Bibliometric Analysis
Published 2025-07-01“…Yanrong Lv,1,* Ziyi Jiang,1,* Jingwen Zhang,2 Xiaoyan Zheng,1 Xiaoping Tian,1 Jia Liu,2 Jie Yang1,2 1Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, People’s Republic of China; 2Department of Traditional Chinese Medicine, West China Second University Hospital of Sichuan University, Chengdu, Sichuan, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jie Yang, Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, 37 Shierqiao Road, Chengdu, Sichuan, 610075, People’s Republic of China, Tel +86 13882296714, Email jenny_yang_jie@126.com Jia Liu, Department of Traditional Chinese Medicine, West China Second University Hospital of Sichuan University, 24, Southern Section1, 1st Ringroad, Chengdu, Sichuan, People’s Republic of China, Email 5214400@qq.comBackground: Over the past two decades, acupuncture has increasingly been applied in the treatment of allergic diseases, with a corresponding increase in the number of published articles.Objective: To investigate the hotspots and frontiers of global scientific output in acupuncture research for allergic diseases over the past two decades.Methods: The Web of Science Core Collection was used to collect literature on acupuncture therapy for allergic diseases, which spanned from 2004 to 2024. …”
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8604
Causal Associations Between Sleep Traits and Delirium: A Bidirectional Two-Sample Mendelian Randomization Study
Published 2024-12-01“…This bidirectional two-sample Mendelian randomization (MR) study was conducted to examine the possible causal relationships between sleep traits and delirium.Patients and Methods: Utilizing genome-wide association studies (GWAS), we identified ten sleep traits: chronotype, sleep duration, short sleep duration, long sleep duration, daytime napping, daytime sleepiness, insomnia, number of sleep episodes (NSE), sleep efficiency, and rapid eye movement sleep behavior disorder (RBD). …”
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8605
In Vitro Fertilization and Dichorionic-Diamniotic Twin Pregnancies in Nulliparous Women: A Retrospective Cohort Study Comparing Pregnancy Outcomes Between Advanced and Younger Mate...
Published 2025-08-01“…Mei Ping He,* Wen Qian Jian,* Chun Lan Yuan, Shi Mei He, Mei Rong He, Jian Yan, Jian Chun Huang, Kai Sun Zhao Department of Obstetrics, The Third Affiliated Hospital of Guangxi Medical University, The Second Nanning People’s Hospital, Nanning, Guangxi, 530031, People’s Republic of China*These authors contributed equally to this workCorrespondence: Kai Sun Zhao, Department of Obstetrics, The Third Affiliated Hospital of Guangxi Medical University, The Second Nanning People’s Hospital, No. 13, Dancun Road, Jiangnan District, Nanning City, Guangxi Zhuang Autonomous Region, People’s Republic of China, Tel +86 13737085418, Email 339609234@qq.com Jian Chun Huang, Department of Obstetrics, The Third Affiliated Hospital of Guangxi Medical University, The Second Nanning People’s Hospital, No. 13, Dancun Road, Jiangnan District, Nanning City, Guangxi Zhuang Autonomous Region, People’s Republic of China, Tel +86 13207801809, Email huangjc3081@163.comObjective: To compare pregnancy outcomes between advanced maternal age (AMA, ≥ 35 years) and younger maternal age (YMA, 20– 34 years) nulliparous women with IVF-conceived dichorionic-diamniotic (DCDA) twin pregnancies.Methods: We conducted a retrospective analysis on 141 nulliparous women undergoing cesarean delivery at The Second Nanning People’s Hospital (2020– 2024). …”
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8606
Co-Assembled Nanoparticles Comprising Sorafenib and Hederagenin Derivative for Enhanced Anti-Hepatic Fibrosis Activity
Published 2025-07-01“…Recent findings suggest that targeting the STING signaling pathway may provide an alternative strategy for slowing the progression of fibrosis.Methods: We synthesized liver-targeted co-assembled SHG nanoparticles (SHG NPs) that incorporate sorafenib and a hederagenin derivative (Hed), which acted as a STING pathway inhibitor. …”
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8607
Association Between High-Sensitivity C-Reactive Protein Trajectories and the Incidence of Metabolic Syndrome:A Retrospective Cohort Study
Published 2024-11-01“…JianJiang Pan,1,* XiXuan Cai,1,* JieRu Chen,1 MingYing Xu,1 JingYu Hu,1 YueChun Mao,1 Tao Chen,2 LuSha Li,1 MengQi Jin,1 LiYing Chen1 1Department of General Practice, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, 310020, People’s Republic of China; 2Department of General Practice, Jianqiao Community Health Service Center, Hangzhou, Zhejiang, 310021, People’s Republic of China*These authors contributed equally to this workCorrespondence: LiYing Chen, Department of General Practice, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, People’s Republic of China, Email 3197020@zju.edu.cnPurpose: Understanding the role of systemic inflammation in the development of Metabolic Syndrome (MetS) is crucial for identifying individuals at a higher risk of this cluster of conditions that increase the risk of heart disease, stroke, and diabetes.Patients and Methods: A retrospective cohort study was conducted with 4,312 participants who were free from MetS at the study’s onset and had high-sensitivity C-reactive protein (hsCRP) levels measured. …”
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8608
Clinical and Microbiological Characteristics of Carbapenem-Resistant Klebsiella pneumoniae Associated Recurrent Urinary Tract Infections
Published 2025-04-01“…Investigating its features in rUTIs may provide insights into effective prevention strategies.Methods: We analyzed a cohort of patients with rUTIs caused by Klebsiella pneumoniae from April 2020 to April 2024. …”
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8609
Clinical Features and Outcomes of Pediatric Intraspinal Paragonimiasis
Published 2025-03-01“…This study aimed to provide experience for diagnosis and treatment strategies of pediatric intraspinal paragonimiasis.Methods: We performed a retrospective clinical analysis of patients hospitalized for intraspinal paragonimiasis between January 1, 2015, and December 31, 2021.Results: Nine patients were included. …”
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8610
Lean Mass Longitudinally Confounds Sedentary Time and Physical Activity With Blood Pressure Progression in 2513 Children
Published 2024-12-01“…This study examined the longitudinal effect of sedentary time (ST), light PA (LPA) and MVPA on BP in 11‐year‐old children followed up for 13 years to determine the confounding and mediating role of body composition. Methods Data included 2513 children from the Avon Longitudinal Study of Parents and Children (ALSPAC), UK birth cohort who had data on at least one time‐point measure of accelerometer‐based movement behaviour across the follow‐up and complete BP measures at ages 11, 15 and 24 years. …”
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8611
Antimicrobial-Resistant <i>Staphylococcus</i> spp. Harbored by Hedgehogs (<i>Erinaceus europaeus</i>) in Central Italy
Published 2025-07-01“…Background/Objectives: European hedgehogs (<i>Erinaceus europaeus</i>) are present in areas where there is human activity; therefore, they can be a source of pathogens for other animals and humans. Methods: Eighteen hedgehog carcasses were collected and analyzed for <i>Staphylococcus</i> spp. …”
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8612
The Recovery of Ciprofol, Remimazolam and Remimazolam-Flumazenil for General Anesthesia Undergoing Fundus Surgery: A Single-Center, Prospective, Randomized, Controlled Clinical Stu...
Published 2025-05-01“…The primary objective of this study was to compare the recovery of HSK3486 with that of remimazolam during successful general anesthesia.Patients and Methods: This prospective, randomized, double-blind study included 93 patients who had undergone fundus surgery. …”
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8613
Bergenin Alleviates Myocardial Ischemia/Reperfusion Injury via Regulating SIRT1 Through Ferroptosis
Published 2025-04-01“…Lingmei Jia,1,* Siqi Yang,1,* Jun Yin,2 Ouhua Feng,2 Zhigang Wang,1 Min Jia,1 1Cardiovascular Medicine Department, The Second Hospital of Hebei Medical University, Shijiazhuang, People’s Republic of China; 2Cardiovascular Medicine Department, Jingxing County Hospital, Shijiazhuang, People’s Republic of China*These authors contributed equally to this workCorrespondence: Min Jia; Zhigang Wang, Cardiovascular Medicine Department, The Second Hospital of Hebei Medical University, Shijiazhuang, People’s Republic of China, Tel +86-13732219367 ; +86-15131127511, Email jiamin10086@163.com; 15131127511@163.comObjective: This study aimed to investigate the protective effect of bergenin on myocardial ischemia/reperfusion (I/R) injury and to elucidate its underlying mechanism.Methods: The in vivo model of myocardial I/R injury was established by transient ligation of the left anterior descending coronary artery in Sprague-Dawley rats, which were divided into sham, I/R, I/R+bergenin, and I/R+bergenin+erastin (an agonist of ferroptosis) groups.After the model was established, the rats underwent echocardiography to assess the cardiac function. …”
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8614
Clinical Characteristics Analysis of 30 Cases of Interferon-γ Autoantibody-Positive Patients with Concurrent Mycobacterial Infection: A 6-Year Retrospective Study
Published 2025-02-01“…Chun-Yan Zhao,1,2,* Chang Song,1,2,* Hua-Wei He,1,* Xian-Zhen Huang,1 Xia-Yan Meng,1 Ai-Chun Huang,1 Chao-Yan Xu,1 Li-Li Luo,1 Shao-Yong Xi,3 Yan-Qun Lan,1 Wei-Wen Li,1 Yan-Rong Lin,1 Qing-Dong Zhu1 1Department of Tuberculosis, The Fourth People’s Hospital of Nanning, Nanning, People’s Republic of China; 2Clinical Medical School, Guangxi Medical University, Nanning, People’s Republic of China; 3Department of Clinical Laboratory, The Fourth People’s Hospital of Nanning, Nanning, People’s Republic of China*These authors contributed equally to this workCorrespondence: Qing-Dong Zhu; Yan-Rong Lin, Department of Tuberculosis, The Fourth People’s Hospital of Nanning, No. 1 Changgang Two-Li, Xingning District, Nanning, 530023, People’s Republic of China, Tel +8615207717261 ; +860771-5636973, Email zhuqingdong2003@163.com; linyanrong2009@126.comPurpose: This study aimed to investigate and elucidate the clinical characteristics, immune status, infection types and patterns, treatment responses, and disease progression in patients with positive anti-interferon-gamma (IFN-γ) autoantibodies in combination with Mycobacterium infections.Patients and Methods: We conducted a retrospective analysis of clinical data from patients with positive anti-IFN-γ autoantibodies and concurrent Mycobacterial infections, including Mycobacterial infections (MTB) and non-tuberculous mycobacteria (NTM). …”
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8615
Immune pre-stimulation by injected yeast beta-glucan as a strategy to prevent calf diarrhea and bovine respiratory disease during the first 74 days of age
Published 2025-05-01“…The CON group received an equal volume of sterile saline at the same time. …”
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8616
Impact of Probiotics Supplementation on Enteral Feed Tolerance in Very Low Birth Weight Neonates: An Open Label Randomised Controlled Trial
Published 2025-04-01“…Aim: To study the impact of probiotics supplementation on enteral feed tolerance in very low birth weight neonates. Materials and Methods: An open-label, randomised-controlled trial was conducted at the Neonatal Intensive Care Unit of a tertiary care center, PGIMS, Rohtak, Haryana. …”
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8617
Role of Antimicrobial Stewardship in Modulating Antibiotic Use and Mitigating Bacterial Resistance in a Tertiary Care Setting During COVID-19
Published 2025-03-01“…This study aimed to assess the impact of AMS at a Chinese tertiary care hospital on inpatient antimicrobial use and bacterial resistance during the COVID-19 outbreak.Methods: An interrupted time-series regression analysis was conducted to compare inpatient antimicrobial use between pre- and post-intervention periods. …”
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8618
Distribution of Pathogenic Bacteria and Drug Resistance in ICU of a Newly Built Hospital
Published 2024-11-01“…Hui Zeng,1,* Rong Liu,1,2,* Chuanli Cheng,2,* Nana Yang,2 Luwen Luo,1,2 Shengshuang Long,3 Renjia Zhou,4 Kai Yan,1 Huantao Huang1 1Nursing Department of the Second Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, 563000, People’s Republic of China; 2School of Nursing of Zunyi Medical University, Zunyi, Guizhou, 563000, People’s Republic of China; 3Infection Department of the Second Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, 563000, People’s Republic of China; 4ICU of the Second Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, 563000, People’s Republic of China*These authors contributed equally to this workCorrespondence: Hui Zeng, Email zenghui.1221@163.comObjective: This study investigated the distribution and resistance patterns of pathogens in the intensive care unit of a newly established hospital in Guizhou Province to promote the rational use of antibiotics to reduce multidrug resistance.Methods: A retrospective analysis was conducted on the distribution of pathogens and changes in drug resistance in the ICU of a newly built hospital in Guizhou Province from March 2019 to December 2023. …”
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8619
Differential Diagnosis Value of Neutrophil Gelatinase Associated Lipocalin as a Noninvasive Biomarker in Perianal Fistulizing Crohn’s Disease
Published 2025-03-01“…This study aimed to evaluate NGAL’s potential as a noninvasive diagnostic biomarker between pfCD and cryptoglandular (CG) perianal fistula, and its correlation with disease severity in pfCD.Methods: Serum, fecal, and fistula tissue samples were collected from 96 patients with pfCD and 97 patients with CG perianal fistula as controls. …”
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8620
Identification of Cuproptosis-Related Genes and Their Potential Role in COPD Pathogenesis: A Bioinformatics Analysis
Published 2025-04-01“…Imbalance in copper (Cu2+) metabolism is related to a series of diseases, but its role in COPD has not been specified.Methods: A dataset relevant to COPD was downloaded from Gene Expression Omnibus database, among which a total of 18 cuproptosis-related genes (CRGs) were screened. …”
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