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  1. 8581

    Research Progress of Liver Cancer Recurrence Based on Energy Metabolism of Liver Cancer Stem Cells by Wu M, Wang H, Wu X, Zeng H, Miao M, Song Y

    Published 2025-03-01
    “…Mingming Wu,1,2,* Huayu Wang,2,3,* Xiangxiang Wu,1,2 Huahui Zeng,1,2 Mingsan Miao,1,2 Yagang Song1,2 1Academy of Chinese Medical Sciences, Henan University of Chinese Medicine, Zhengzhou, Henan, 450046, People’s Republic of China; 2Collaborative Innovation Center of Research and Development on the Whole Industry Chain of Yu-Yao, Zhengzhou, Henan, 450046, People’s Republic of China; 3College of Pharmacy, Henan University of Chinese Medicine, Zhengzhou, Henan, 450046, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yagang Song, Academy of Chinese Medical Sciences, Henan University of Chinese Medicine, Zhengzhou, Henan, 450046, People’s Republic of China, Tel/Fax +86-0371-65962546, Email songyagang1016@163.comObjective: The aim of this study is to investigate the recurrence and progression of liver cancer by focusing on the energy metabolism of liver cancer stem cells.Methods: A comprehensive literature search was conducted using databases including CNKI, PubMed, Wanfang, and Citexs to analyze the etiology and treatment of hepatocellular carcinoma (HCC), the factors and mechanisms contributing to HCC recurrence, and the impact of energy metabolism in HCC stem cells on the development of HCC. …”
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  2. 8582

    LncRNA MALAT1/Calpain-1 Axis in ATO Induced hERG Channel Deficiency by Yan C, Li Y, Li X, Li Y, Zhang Y, Sun J, Ding Q, Zhao X, Li B

    Published 2025-02-01
    “…Furthermore, it sought to identify pharmacological agents that could mitigate the cardiotoxic effects of ATO and establish viable intervention targets for the prevention and management of acLQTS.Methods: First, we employed gene chip arrays to identify target long noncoding RNAs (lncRNAs). …”
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  3. 8583

    Glymphatic System Dysfunction in Elderly Patients with Late-Onset Epilepsy and Comorbid Chronic Insomnia Revealed by Diffusion Tensor Imaging Along the Perivascular Space (DTI-ALPS... by Wang Y, Hu J, Zhang YY, Wang FY, Wu JC, Wang L

    Published 2025-08-01
    “…Yu Wang,1,2,* Jie Hu,2,3,* Yue-Yu Zhang,2,3 Fu-Yu Wang,4 Jun-Cang Wu,2 Long Wang2 1Graduate School of Wan Nan Medical College, Wuhu, Anhui, 241002, People’s Republic of China; 2Department of Neurology, The Second People’s Hospital of Hefei, Hefei, Anhui, 230011, People’s Republic of China; 3The Fifth Clinical Medical College of Anhui Medical University, Hefei, Anhui, 230032, People’s Republic of China; 4Department of Pharmacy, The Second People’s Hospital of Hefei, Hefei, Anhui, 230011, People’s Republic of China*These authors contributed equally to this workCorrespondence: Long Wang, Department of Neurology, The Second People’s Hospital of Hefei, Hefei, Anhui, 230011, People’s Republic of China, Email guxindao606@126.comPurpose: This study assessed the influence of glymphatic system (GS) dysfunction on cognitive decline in patients with late-onset epilepsy (LOE) and comorbid chronic insomnia utilizing diffusion tensor imaging along the perivascular space (DTI-ALPS).Methods: Clinical data were collected from 42 elderly LOE patients, 17 with and 25 without chronic insomnia, as well as from 22 healthy controls (HCs) matched for age and sex. …”
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  4. 8584

    Opioid-Free versus Opioid-Sparing Anesthesia for Postoperative Pain and Early Recovery After Laparoscopic Cholecystectomy: A Randomized Controlled Trial by Xiong M, Liu Y, Liang Y, Wang H, Zhang L, Zhang Z, Fang M

    Published 2025-04-01
    “…This study compared the efficacy of OFA and OSA in managing postoperative pain and recovery after laparoscopic cholecystectomy (LC).Patients and Methods: A single-center, randomized controlled trial was conducted with 86 adults undergoing LC. …”
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  5. 8585

    Efficacy of external warming in attenuation of hypothermia in surgical patients by Zeba Snježana, Šurbatović Maja, Marjanović Milan, Jevđić Jasna, Hajduković Zoran, Karkalić Radovan, Jovanović Dalibor, Radaković Sonja

    Published 2016-01-01
    “…The aim of this study was to evaluate the efficiency of external warming system in alleviation of cold stress and hypothermia in patients who underwent major surgical procedures. Methods. The study was conducted in the Military Medical Academy in Belgrade. …”
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  6. 8586

    Construction of a Nomogram Model for Predicting Prognosis in Breast Cancer Patients Based on the Expression of THRSP and ACACA Proteins Tissues by Wei B, Li F, Yan H, Shen J

    Published 2025-07-01
    “…In addition, a nomogram model to predict the prognosis of breast cancer patients was constructed in this study.Methods: Retrospective analysis of 202 cases of breast cancer patients who underwent surgical treatment in our hospital from October 2019 to March 2021, and collection of patients’ cancer tissues and non-Tumor tissue specimens. …”
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  7. 8587

    Development and Evaluation of Aloperine-Loaded Nanostructured Lipid Carriers for the Treatment of Pulmonary Arterial Hypertension by Liu H, Liu S, Ma P, Ma L, Liu Y, Zhao F, Zhou R

    Published 2025-01-01
    “…Hui Liu,1,* Siyun Liu,1,* Pengsheng Ma,1 Long Ma,1 Yuxin Liu,1 Fang Zhao,2 Ru Zhou1,3,4 1School of Pharmacy, Ningxia Medical University, Yinchuan, 750004, People’s Republic of China; 2General Hospital of Ningxia Medical University, Yinchuan, 750004, People’s Republic of China; 3NHC Key Laboratory of Metabolic Cardiovascular Diseases Research, Ningxia Medical University, Yinchuan, 750004, People’s Republic of China; 4Ningxia Characteristic Traditional Chinese Medicine Modernization Engineering Technology Research Center, Ningxia Medical University, Yinchuan, 750004, People’s Republic of China*These authors contributed equally to this workCorrespondence: Ru Zhou, School of Pharmacy, Ningxia Medical University, Xingqing, Ningxia, Yinchuan, 750004, People’s Republic of China, Email zhou-ru926@163.com Fang Zhao, General Hospital of Ningxia Medical University, Xingqing, Ningxia, Yinchuan, 750004, People’s Republic of China, Email ysj119zf@163.comObjective: This study focuses on the development and evaluation of nanostructured lipid carriers (NLCs) loaded with aloperine as a potential therapeutic approach for the treatment of pulmonary arterial hypertension.Methods: The NLCs were designed to enhance the solubility, stability, and bioavailability of aloperine, a compound with vasodilatory and anti-inflammatory properties. …”
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  8. 8588

    The Prevalence, Characteristics, and Factors Associated with Chinese Herbal Medicine Use Among Chinese Middle-Aged and Older Adults with Chronic Lung Disease: A Cross-Sectional Stu... by Tian H, Zhu X, Liu H, Liao Y, Cui K, Liu J, Gong X

    Published 2024-11-01
    “…This study aims to examine the prevalence and influencing factors of CHM use among middle-aged Chinese patients with CLD.Patients and Methods: The data analyzed in this study were extracted from the China Health and Retirement Longitudinal Study in 2018. …”
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  9. 8589

    Study of the Chemical Composition and Anti-Inflammatory Mechanism of Shiyiwei Golden Pill Based on UPLC-Q-TOF/MS and Network Pharmacology by Han C, Chen J, Shen C, Liang Q, An Y, Zhou C, Liu K, Xia Q, He Q, Zhang H

    Published 2025-04-01
    “…This study aimed to investigate the chemical composition and anti-inflammatory effects of SYW, as well as its potential mechanisms.Methods: The components of SYW were identified using ultrahigh-performance liquid chromatography with quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF/MS). …”
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  10. 8590

    Behavioral Changes During COVID-19 Omicron Variant Infection on Children with Autism Spectrum Disorder in China by Ye F, Hou X, Chen J, Qin H, Xu X, Liu D, Liu J, Sun Q, Liu H, Hu F, Zhou Y, Xu P, Zhang Q

    Published 2024-11-01
    “…Fang Ye,1,* Xiaonan Hou,1,* Jie Chen,1 Hui Qin,1 Xiaojing Xu,1 Die Liu,1 Jing Liu,2 Qi Sun,1 Haiyan Liu,3 Fang Hu,4 Yuwan Zhou,5 Pengfei Xu,1,* Qi Zhang1,* 1Department of Pediatrics, China-Japan Friendship Hospital, Beijing, People’s Republic of China; 2Graduate School of Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, People’s Republic of China; 3Department of Pediatrics, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi an, People’s Republic of China; 4Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou, 510623, People’s Republic of China; 5Department of Prevention Care, The First People’s Hospital of Yunnan Province, The Affiliated Hospital of Kunming University of Science and Technology, Kunming, Yunnan, People’s Republic of China*These authors contributed equally to this workCorrespondence: Pengfei Xu; Qi Zhang, Department of Pediatrics, China-Japan Friendship Hospital, No. 2 East Yinghua Road, Chaoyang District, Beijing, 100029, People’s Republic of China, Email xpf@263.net; zhangqi0355@sina.comPurpose: The objective of this study was to investigate the behavioral changes in the core features and challenging behaviors of children with Autism Spectrum Disorder (ASD) during the COVID-19 Omicron wave (from December 2022 to January 2023) in China.Patients and Methods: A total of 515 caregivers of children with ASD completed an online survey. …”
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  11. 8591

    Prevalence and Molecular Characteristics of 16S rRNA Methylase Genes in Clinical Isolates of Carbapenem-Resistant Enterobacterales by Li C, Zhang F, Li G, Wang W

    Published 2024-11-01
    “…Caiyun Li,1,* Fa Zhang,1,* Gang Li,2,3 Wen Wang2,3 1Department of Clinical Laboratory, Nanjing Pukou People’s Hospital, Nanjing, 211800, People’s Republic of China; 2Center of Medical Laboratory, General Hospital of Ningxia Medical University, Yinchuan, 750004, People’s Republic of China; 3Ningxia Key Laboratory of Clinical and Pathogenic Microbiology, General Hospital of Ningxia Medical University, Yinchuan, 750004, People’s Republic of China*These authors contributed equally to this workCorrespondence: Wen Wang, Email 42170662@qq.comObjective: To analyze the prevalence and molecular characteristics of 16S rRNA methylase genes in clinical isolates of carbapenem-resistant Enterobacterales, for clinical doctors provide a reference basis for the rational use of drugs.Methods: The Enterobacterales isolated from our hospital from 2020 to 2022 were selected and identified by VITEK 2 Compact automatic bacterial identification instrument. …”
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  12. 8592

    Assessing Racial and Gender Disparities in Asthma Education, Knowledge, and Healthcare Access Among Adolescents by Abballe A, Forman A, Jamet KE, Pant J

    Published 2025-07-01
    “…The goal is to identify gaps in asthma education and knowledge, as well as other barriers that may contribute to the underdiagnosis of asthma within these groups.Patients and Methods: This cross-sectional survey included adolescents aged 10– 18 years, with responses collected through Qualtrics. …”
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  13. 8593

    Level of physical activity of students from the police force academy in Bratislava by Gabriel Bujdos, Štefan Adamčák, Michal Marko, Anna Kozaňáková

    Published 2023-05-01
    “…The aim of our study was to find out the degree of satisfaction and the frequency of performing leisure activities among students of the Police Academy in Bratislava, Slovakia. Material and Methods. For the purpose of our study, we have used a short version of International Physical Activity Questionnaire (IPAQ) that consisted of 7 questions. …”
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  14. 8594

    Compound Probiotics Improve Neuropathic Pain Prognosis in a Murine Model of Chronic Constriction Injury by Wang X, Chen Y, Qian S, Kong J, Su Z, Wang Q, Liao L

    Published 2024-12-01
    “…This study aimed to investigate the efficacy of compound probiotic treatment on neuropathic pain.Methods: Thirty mice were randomly divided into three groups: 1) sham group, 2) mouse with chronic constrictive injury (CCI), and 3) probiotic gavage with CCI (CCI+Prob). …”
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  15. 8595

    Effect of Outdoor Cycling, Virtual and Enhanced Reality Indoor Cycling on Heart Rate, Motivation, Enjoyment and Intention to Perform Green Exercise in Healthy Adults by Luca Poli, Gianpiero Greco, Michele Gabriele, Ilaria Pepe, Claudio Centrone, Stefania Cataldi, Francesco Fischetti

    Published 2024-10-01
    “…No significant differences were found between VRC and ERC in promoting intentions for outdoor activities, suggesting both technologies could be equally effective.…”
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  16. 8596

    Investigation of the Influence of Deletional and Non-Deletional Hemoglobin H Disease on Pregnancy Outcomes by Zhao KS, Pan QA, Yang HY, Su JY, Deng L

    Published 2025-01-01
    “…Kai Sun Zhao,1,* Qiao Ai Pan,2,* Hong Yan Yang,2 Jun You Su,2 Li Deng2 1Department of Obstetrics, The Second Nanning People’s Hospital (The Third Affiliated Hospital of Guangxi Medical University), Nanning, Guangxi, 530031, People’s Republic of China; 2Department of Obstetrics, The Second Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, 530007, People’s Republic of China*These authors contributed equally to this workCorrespondence: Li Deng; Junyou Su, Department of Obstetrics, The Second Affiliated Hospital of Guangxi Medical University, No. 166, Daxuedong Road, Xixiangtang District, Nanning, Guangxi Zhuang Autonomous Region, People’s Republic of China, Tel +86 13877105871 ; +86 15277199813, Email dengli@gxmu.edu.cn; sujunyou@sr.gxmu.edu.cnObjective: The study aimed to provide clinical evidence regarding the perinatal management of HbH disease by comparing and analyzing blood routine, anemia characteristics, and their influence on pregnancy outcomes in patients with common deletional and non-deletional HbH disease at various pregnancy stages.Patients and Methods: From May 2017 to October 2023, a comparative analysis was conducted on pregnant women undergoing treatment at the Second Affiliated Hospital of Guangxi Medical University and the Second Nanning People’s Hospital. …”
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  17. 8597

    Stress, Cortisol, and Lipid Profiles Among Rwandan Undergraduate Students: A Cross-Sectional Study by Mushumba P, Uwineza DN, Nsanzimana V, Mapira HT, Gori E, Musarurwa C

    Published 2025-06-01
    “…This study aimed to investigate the relationship between serum cortisol levels, lipid profiles, and stress among undergraduate students at the University of Rwanda’s Huye Campus.Methods: A cross-sectional study recruited 247 undergraduate students using stratified sampling. …”
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  18. 8598

    Massa Medicata Fermentata treated spleen deficiency constipation by mediating intestinal microbiota and serum peptide by Kangxiao Guo, Kangxiao Guo, Yuan Tang, Tao Yang, Yongwang Yan

    Published 2025-03-01
    “…ObjectivesTo investigate the correlation between the treatment of spleen deficiency constipation and the typical brain and intestinal peptides.MethodsA total of 18 male Kunming mice were randomly divided into three treatment groups (n = 6): normal group (CC), model group (CM), and Massa Medicata Fermentata intervention group (CG). …”
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  19. 8599

    Opening wedge high tibial osteotomy yields comparable to superior outcomes to unicompartmental knee arthroplasty at 2 years of follow‐up in patients suffering from Ahlbäck III knee... by Shintaro Onishi, Christophe Jacquet, Hiroshi Nakayama, Jean Noël Argenson, Matthieu Ollivier

    Published 2024-10-01
    “…Abstract Purpose To compare the clinical outcomes between opening wedge high tibial osteotomy (OWHTO) and unicompartmental knee arthroplasty (UKA) in patients with Ahlbäck Grade 3 medial compartmental knee osteoarthritis (OA) using a propensity score matching (PSM) analysis. Methods This retrospective study included all OWHTO and UKA procedures performed between 2016 and 2021 at a single institution. …”
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  20. 8600

    The Pendulum of Adherence: An Interpretative Phenomenological Analysis of Psoriasis Treatment Discontinuation by Xiao Z, Jiang Y, Samah NA, Zhou H, Wang J

    Published 2025-07-01
    “…Frequent treatment discontinuation often results in disease recurrence and poorer health outcomes, highlighting the need for a comprehensive understanding of psoriasis patients’ lived experiences concerning treatment adherence.Methods: A phenomenological research approach was employed to explore psoriasis patients’ lived experiences concerning treatment adherence. …”
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