In-depth analysis of the safety of CAR-T cell therapy for solid tumors by Jiayi Dong, Jiayi Dong, Jiayi Dong, Jiayi Dong, Jiexiong Wu, Ye Jin, Ye Jin, Ye Jin, Ye Jin, Ye Jin, Zhu Zheng, Zhu Zheng, Zhu Zheng, Zhu Zheng, Zhu Zheng, Ting Su, Ting Su, Ting Su, Ting Su, Ting Su, Lijuan Shao, Lijuan Shao, Lijuan Shao, Lijuan Shao, Lijuan Shao, Jiaxin Bei, Jiaxin Bei, Jiaxin Bei, Jiaxin Bei, Size Chen, Size Chen, Size Chen, Size Chen, Size Chen

“…However, the effectiveness of CAR-T therapy in solid tumors is often hampered by the challenging tumor microenvironment (TME). The complex TME includes dense stroma that obstructs T cell infiltration, abnormal blood vessel structures leading to hypoxia, and an acidic pH, all of which hinder CAR-T cell function. …”
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Stress resilience in Coffea arabica and Coffea canephora under harsh drought and/or heat conditions: selected genes, proteins, and lipid integrated responses by José C. Ramalho, José C. Ramalho, Isabel Marques, Isabel P. Pais, Isabel P. Pais, Jean Armengaud, Duarte Gouveia, Ana P. Rodrigues, Danielly Dubberstein, Danielly Dubberstein, Danielly Dubberstein, António E. Leitão, António E. Leitão, Miroslava Rakočević, Paula Scotti-Campos, Paula Scotti-Campos, Sónia Martins, Sónia Martins, Magda C. Semedo, Magda C. Semedo, Fábio L. Partelli, Fernando C. Lidon, Fábio M. DaMatta, Ana I. Ribeiro-Barros, Ana I. Ribeiro-Barros

“…Overall, we revealed newly shared and specific (genotype or stress) responses of a complex network supporting Coffea spp. resilience. …”
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Designing the outsourcing model in central government organizations by Mahnaz Moradi, Morteza Ghasemi, Maryam Majidi, Gholamreza Amjadi

“…These changes have led to increasing competition, complexity, dynamism and environmental uncertainty. …”
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The implementation of Safety Management Systems in healthcare: a systematic review and international comparison by Zhivko Zhelev, Sian de Bell, Alison Bethel, Maria Clarke, Rob Anderson, Jo Thompson Coon

“…Topic-related factors concerned the perceived complexity of a theme and its connection with existing projects or guidelines. …”
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The Circular Kitchen by Bas Jansen

“…However, existing methods do not fully incorporate the complex, multiple use cycles inherent in circular products and components. …”
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Providing a customer satisfaction model of non-attendance services in the social security organization by Hossein Barzgar, Vahid Sanavi Garoosiyan, ali hossein zadeh

“…Innovation is recognized as an important factor in enabling companies to maintain perceived customer value and maintain competitive advantage in a highly complex and rapidly changing environment. Innovation is the key factor in the success or failure of organizations in the field of competition and the main source of competitive advantage. …”
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A LEAP Forward in Wildlife Conservation: A Standardized Framework to Determine Mortality Causes in Large GPS‐Tagged Birds by Connor T. Panter, Carina Nebel, Maximilian Raab, Verena Strauss, Clara Freytag, Manuel Wojta, Hannah Böing, Patrick Hacker, Rainhard Raab, Jendrik Windt, Annika Posautz, Anna Kuebber‐Heiss, Patrick Scherler, Martin U. Grüebler, Urs G. Kormann, Martin Kolbe, Alexandre Millon, Javier de laPuente, Javier Viñuela, Duncan Orr‐Ewing, Oliver Krone, Torsten Langgemach, Susanne Åkesson, Brady Mattsson, Petra Sumasgutner, Manuel Alcántara de la Fuente, Ernesto Alvarez, Juan Arizaga, Albert Bach Pagès, Ana Bermejo, Guido Ceccolini, Nayden Chakarov, Peter Derpmann‐Hagenström, Marek Dostál, Gerd Fabian, Wolfgang Fiedler, Manuel Galán, Clément Ganier, Andreas Gärtner, Liza Glesener, Alfonso Godino, Zuzana Guziová, László Haraszthy, Caka Karlsson, Katharina Klein, Ivan Literák, Nicolas Lorenzini, Manuela Löwold, Christopher Lüning, Boris Maderič, Karel Makoň, Kerstin Mammen, Ubbo Mammen, Torsten Marczak, Hynek Matušík, Aymeric Mionnet, Sara Morollón, Jakub Mráz, Winfried Nachtigall, Bernd Nicolai, Marta Olalde Fernández, Meinolf Ottensmann, María Jesús Palacios González, Jean‐Yves Paquet, Vladimír Pečeňák, Lubomír Peške, Thomas Pfeiffer, Robert Pudwill, Dušan Rak, Tim Maximilian Rapp, Alexander Resetaritz, Stef vanRijn, Romain Riols, Arturo Rodríguez, Luisa Scholze, Laura Schulte, Aurélie deSeynes, Jan Škrábal, Péter Spakovszky, Eike Steinborn, Ján Svetlík, Samuel Talhoet, Miklós Vaczi, Anne‐Gaelle Verdier, Zdenĕk Vermouzek, Diego Villanúa Inglada, Jörg Westphal, Rainer Raab

“…Obtaining required information to determine these causes is complex, and standardized approaches can overcome these limitations. …”
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Evaluating the level of digitalization of the innovation process with artificial intelligence approach in the digital transformation of knowledge-based companies by ali Bagheri, reza radfar, sepehr ghazinoory

“…The relevance of innovation to ensure the competitiveness of companies has been confirmed among researchers and professionals (Schiuma, 2012). …”
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Pramipexole in addition to mood stabilisers for treatment-resistant bipolar depression: the PAX-BD randomised double-blind placebo-controlled trial by Hamish McAllister-Williams, Nicola Goudie, Lumbini Azim, Victoria Bartle, Michael Berger, Chrissie Butcher, Thomas Chadwick, Emily Clare, Paul Courtney, Lyndsey Dixon, Nichola Duffelen, Tony Fouweather, William Gann, John Geddes, Sumeet Gupta, Beth Hall, Timea Helter, Paul Hindmarch, Eva-Maria Holstein, Ward Lawrence, Phil Mawson, Iain McKinnon, Adam Milne, Aisling Molloy, Abigail Moore, Richard Morriss, Anisha Nakulan, Judit Simon, Daniel Smith, Bryony Stokes-Crossley, Paul Stokes, Andrew Swain, Zoë Walmsley, Christopher Weetman, Allan H Young, Stuart Watson

“…Qualitative analysis identified barriers to recruitment and retention including the complexity of BD, difficulty accessing eligible participants, inadequate research prioritisation and the COVID-19 pandemic. …”
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Estimation and evaluation of iron reserves in the eastern area of Eileh1 mine, Razavi Khorasan province by Hamid Esmati Daroneh, Maryam Gholamzadeh

“…The studied area is part of the Eileh 1 iron ore mine complex, located 49 km southwest of Taibad city in Razavi Khorasan province, covering an area of 240 hectares. …”
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Enhancing Sustainable Manufacturing in Industry 4.0: A Zero-Defect Approach Leveraging Effective Dynamic Quality Factors by Rouhollah Khakpour, Ahmad Ebrahimi, Seyed Mohammad Seyed Hosseini

“…The empirical insights, drawn from the real-life case study of this research, indicate the challenges and complexities that arise in the path of achieving zero defect product and sustainability improvement. …”
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Protecting the Autonomy of Patients with Severe Mental Illness Through Psychiatric Advance Directive Peer-Facilitation by Nicholas Karasik

“…Specifically, a network of peer-support facilitators may be able to mitigate resource concerns of the system level, provider fears, reluctance, and lack of knowledge of PADs at the health-professional level, and a lack of trust and support among those with SMI within the service-user level.[10] Although the Patient Self-Determination Act mandated protections for patient autonomy, the law did not provide a sufficient mechanism to ensure the broad use of those protections. Much of the logistical burden falls on those living with SMI to educate themselves and initiate the completion of a PAD.[11] However, many of those living with SMI already face additional burdens that prevent their successful navigation of a complex healthcare system, including poverty, marginal housing, and food insecurity.[12] In addition, individuals with SMI tend to be more socially isolated, with few others to trust besides their providers.[13] Efforts to promote the uptake of PADs by those living with SMI that neglect these additional burdens risk exacerbating health inequities faced by those with SMI. …”
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EasyMetagenome: A user‐friendly and flexible pipeline for shotgun metagenomic analysis in microbiome research by Defeng Bai, Tong Chen, Jiani Xun, Chuang Ma, Hao Luo, Haifei Yang, Chen Cao, Xiaofeng Cao, Jianzhou Cui, Yuan‐Ping Deng, Zhaochao Deng, Wenxin Dong, Wenxue Dong, Juan Du, Qunkai Fang, Wei Fang, Yue Fang, Fangtian Fu, Min Fu, Yi‐Tian Fu, He Gao, Jingping Ge, Qinglong Gong, Lunda Gu, Peng Guo, Yuhao Guo, Tang Hai, Hao Liu, Jieqiang He, Zi‐Yang He, Huiyu Hou, Can Huang, Shuai Ji, ChangHai Jiang, Gui‐Lai Jiang, Lingjuan Jiang, Ling N. Jin, Yuhe Kan, Da Kang, Jin Kou, Ka‐Lung Lam, Changchao Li, Chong Li, Fuyi Li, Liwei Li, Miao Li, Xin Li, Ye Li, Zheng‐Tao Li, Jing Liang, Yongxin Lin, Changzhen Liu, Danni Liu, Fengqin Liu, Jia Liu, Tianrui Liu, Tingting Liu, Xinyuan Liu, Yaqun Liu, Bangyan Liu, Minghao Liu, Wenbo Lou, Yaning Luan, Yuanyuan Luo, Hujie Lv, Tengfei Ma, Zongjiong Mai, Jiayuan Mo, Dongze Niu, Zhuo Pan, Heyuan Qi, Zhanyao Shi, Chunjiao Song, Fuxiang Sun, Yan Sun, Sihui Tian, Xiulin Wan, Guoliang Wang, Hongyang Wang, Hongyu Wang, Huanhuan Wang, Jing Wang, Jun Wang, Kang Wang, Leli Wang, Shao‐kun Wang, Xinlong Wang, Yao Wang, Zufei Xiao, Huichun Xing, Yifan Xu, Shu‐yan Yan, Li Yang, Song Yang, Yuanming Yang, Xiaofang Yao, Salsabeel Yousuf, Hao Yu, Yu Lei, Zhengrong Yuan, Meiyin Zeng, Chunfang Zhang, Chunge Zhang, Huimin Zhang, Jing Zhang, Na Zhang, Tianyuan Zhang, Yi‐Bo Zhang, Yupeng Zhang, Zheng Zhang, Mingda Zhou, Yuanping Zhou, Chengshuai Zhu, Lin Zhu, Yue Zhu, Zhihao Zhu, Hongqin Zou, Anna Zuo, Wenxuan Dong, Tao Wen, Shifu Chen, Guoliang Li, Yunyun Gao, Yong‐Xin Liu

“…This approach provides valuable insights of microbial diversity, interactions, and their roles in health and disease. However, the complexity of data processing and the need for reproducibility pose significant challenges to researchers. …”
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The role of Pakistan Medical & Dental Council in steering undergraduate medical curriculum reforms in Pakistan by Gohar Wajid, Lubna Baig, Syeda Kauser Ali, Usman Mahboob, Ahsan Sethi, Rehan Ahmed Khan

“…. • PM&DC must ensure that medical colleges has a comprehensive faculty develop program for the development and implementation of the new curriculum at the institutional level.…”
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Contextual Vulnerability Should Guide Fair Subject Selection in Xenotransplantation Clinical Trials by Gianna Strand

“…Xenografts are typically sourced from porcine animals (domestic pigs) or non-human primates (baboons) and range from simple tissues like corneas to complex vital organs like hearts, lungs, or kidneys. …”
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Distribution Characteristics and Ecological Risk Assessment of Heavy Metals in Typical Soil Profiles of Muchuan County, Sichuan Province by Bixia LIAO, Wenling SHEN, Ling HE

“…According to the research results, it is suggested to carry out further research on the accumulation of heavy metals in soil, rationally assess its ecological harm, and ensure the safe use of land.…”
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INTERBLOCK ZONES IN THE CRUST OF THE SOUTHERN REGIONS OF EAST SIBERIA: TECTONOPHYSICAL INTERPRETATION OF GEOLOGICAL AND GEOPHYSICAL DATA by K. Zh. Seminsky, N. O. Kozhevnikov, A. V. Cheremnykh, E. V. Pospeeva, A. A. Bobrov, V. V. Olenchenko, M. A. Tugarina, V. V. Potapov, R. M. Zaripov, A.S. Cheremnykh

“…In general, in comparison with blocks, the zones are distinguished by the relief lowering, anomalous water exchange conditions, gas anomalies that are positive and complex in shape, and low resistivity values both near the surface and at depth (Fig. 3–6, 8, and 11–16). …”
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Presenting the Model of Effective Factors on Smart Governance in the Country by Ghaem Gheiravani, Mohammad Montazeri, Shams Sadat Zahedi

“…Smart governance may also play an important role in smart city initiatives that require complex interactions between governments, citizens, and other stakeholders (Nasri & Tabarzad, 2020). …”
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An Economic Analysis of the Interaction between Third-Party Liability for Breach of Contract and Specific Performance: A Comparative Study of United States and Iranian Law by Hasan Alipour, Ahad Shahi Damanjani

“…Specific performance, as a remedy for breach of contract, ensures that the contract is executed as agreed, thereby safeguarding the promisees’ expectations. …”
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Understanding the effectiveness and underlying mechanisms of lifestyle modification interventions in adults with learning disabilities: a mixed-methods systematic review by Dikshyanta Rana, Sophie Westrop, Nishant Jaiswal, Evi Germeni, Arlene McGarty, Louisa Ells, Phillippa Lally, Michael McEwan, Craig Melville, Leanne Harris, Olivia Wu

“…Data were synthesised in the form of a programme theory regarding complex causal mechanisms and how these interact with social context to produce outcomes. …”
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