Mitochondrial reactive oxygen species trigger metformin-dependent antitumor immunity via activation of Nrf2/mTORC1/p62 axis in tumor-infiltrating CD8T lymphocytes by Kazuhiro Kakimi, Hirokazu Matsushita, Masaaki Komatsu, Eiryo Kawakami, Mikako Nishida, Nahoko Yamashita, Taisaku Ogawa, Keita Koseki, Eiji Warabi, Tomoyuki Ohue, Katsuyuki Shiroguchi, Heiichiro Udono

“…Expressions of glucose transporter (Glut)-1, mitochondrial reactive oxygen species (mtROS), interferon (IFN)-γ, Ki67, autophagy markers, activation markers for NF-E2-related factor 2 (Nrf2), and mammalian target of rapamaycin complex 1 (mTORC1) in CD8+ tumor-infiltrating T lymphocytes (CD8TILs) were examined by flow cytometry analysis. …”
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Determination of the metabolites, eicosanoids derived from polyunsaturated fatty acids in Drosophila tissue with high performance liquid chromatography tandem mass spectrometry by TAN Liangliang, SHEN Lirong

“…Lipid signaling that complicates our understanding of fatty acid signaling is highly complex and fine-tuned in mammal species. Fortunately, the small genetic model Drosophila melanogaster is considered to be an ideal model to investigate the flexible nature of eicosanoids signaling pathways. …”
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Deep reinforcement learning applications and prospects in industrial scenarios by JING TAN, Ligang YANG, Xiaorui LI, Zhaolin YUAN, Yunduan CUI, Chao YAO, Zongjie WANG, Xiaojuan BAN

“…However, with the rapid advancements in Industry 4.0 and smart manufacturing, traditional control methods are increasingly inadequate to address the growing complexity, high dynamics, and real-time demands of modern industrial environments. …”
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Research on kd-tree Cache Optimization Based on Particle Index Sorting Algorithm by 张挺, 林震寰, 杨丁颖, 王宗锴, 陈轶凡

“…This efficiency is attributed to MAD-index-sort's ability to reorder particles based on the dimension with the greatest variance, ensuring that spatially close particles are assigned similar index values. …”
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Connecting the dots: a systematic review of explanatory factors linking contextual indicators, institutional culture and degree awarding gaps by Pallavi Banerjee

“…By conducting a systematic review of existing literature following the PRISMA protocol, this study seeks to uncover the complex web of explanatory factors that mediate the relationship between contextual indicators, institutional culture, and degree awarding disparities. …”
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Harnessing theta waves: tACS as a breakthrough in alleviating post-stroke chronic pain by Ningjing Song, Ningjing Song, Ningjing Song, Ningjing Song, Ling Long, Ling Long, Ling Long, Ling Long, Nianquan Liu, Nianquan Liu, Nianquan Liu, Nianquan Liu, Yujun Luo, Yujun Luo, Yujun Luo, Yujun Luo, Meng Wei, Meng Wei, Meng Wei, Meng Wei, Hai Huang, Hai Huang, Hai Huang, Hai Huang, Wan Liu, Wan Liu, Wan Liu, Wan Liu

“…Post-stroke chronic pain is a common and complex symptom that imposes significant physiological and psychological burdens on patients. …”
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Water Diplomacy by Implementing Energy Consumption Reduction Scenarios in the Sistan Region by Fazel Ghobeyshavi, Ali Sardar Shahraki, Mahdi Safdari, Neda Aliahmadi

“…Abstract Water scarcity and resource management challenges in the Helmand River watershed necessitate the adoption of a novel approach in water diplomacy for integrated management and effective policymaking to ensure sustainable water security in this region. …”
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Trends, outcomes and knowledge gaps in mobile apps for reproductive endocrinology and infertility: a scoping review protocol by Alba Regina de Abreu Lima, Emerson Roberto dos Santos, Aline Russomano de Gouvêa, Natália Almeida de Arnaldo Silva Rodriguez Castro, João Daniel de Souza Menezes, Matheus Querino da Silva, Helena Landin Gonçalves Cristóvão, Cíntia Canato Martins, Jéssica Gisleine de Oliveira, Patrícia da Silva Fucuta, Alexandre Lins Werneck, Gerardo Maria de Araújo Filho, Heloisa Cristina Caldas, Vânia Maria Sabadoto Brienze, Júlio César André, Antônio Hélio Oliani

“…Introduction Infertility is a complex condition that affects millions worldwide, with significant physical, emotional and social implications. …”
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A Concurrent, Mixed-Methods Evaluation of the Four Supports Intervention in ICUsTake-Home Points by Taylor E. Lincoln, MD, Rachel A. Butler, MHA, MPH, Anne-Marie Shields, MSN, RN, Kate Petty, MD, Tracy Campbell, MD, Johanna Bellon, PhD, CFA, Praewpannarai Buddadhumaruk, MS, RN, Jennifer B. Seaman, PhD, RN, Kimberly J. Rak, PhD, Caroline Pidro, BS, Rachel M. Gustafson, DNP, RN, Kristyn Felman, MPH, CPH, MSW, Wendy Stonehouse, MSN, RN, Mary Beth Happ, PhD, RN, Mi-Kyung Song, PhD, RN, Charles F. Reynolds, III, MD, Jennifer Q. Morse, PhD, Seth Landefeld, MD, Derek Angus, MD, MPH, FRCP, Robert M. Arnold, MD, Douglas B. White, MD, MAS

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從工具示能性與關係行動主體之觀點 探討偏鄉教育系統賦能策略之研究 Investigating the Construction of Empowerment Action Models in Remote Educational Systems Through the Lenses of Tool Affordance and Relational Age... by 陳佩英 Peiying Chen, 洪琴雯 Chin-Wen Hung

“…Conclusion In conclusion, the complex problems embedded in rural schools in terms of structure and system still require policy support. …”
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Feasibility of Rescinding a Condition Embedded in a Contract While Preserving the Contract by Mohammad Hadi Javaherkalam, Seyyed Fazel Seyyedi

“…‌ ∴ Introduction ∴ ‌Contracts serve as a foundational mechanism through which individuals and entities engage in transactions, ensuring that their rights and obligations are clearly defined and legally enforceable. …”
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Identification of strengths and weaknesses of the healthcare system for persons living with rare diseases in Catalonia (Spain), and recommendations to improve its comprehensive att... by José Hernández-Rodríguez, Fernando Martínez-Valle, Xènia Acebes, Carmen Alerany, Jordi Antón, Gonzalo Calvo, Marian Corral, Jordi Cruz, M. Antònia Mangues-Bafalluy, José Mateo, Josefa Rivera, Albert Salazar, Roser Francisco, Cristina Mallol, Rita Reig-Viader, Ariadna Tigri-Santiña, Assumpta Ricart, Francesc Palau

“…Abstract Background Rare diseases (RDs) are a heterogeneous group of complex and low-prevalence conditions in which the time to establish a definitive diagnosis is often too long. …”
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Wuzhuyu Decoction Relieves Chronic Migraine by Regulating 5-HT1A and 3A Receptors-Mediated CREB Signaling Pathway in Brain and Intestine by Zhimin Song, Meijing Li, Ziwei Zhou, Xiaomeng Guo, Qi Wang, Zekuan Zhang, Keshu Wang, Qixiang Zheng, Wenjing Gou, Sha Wu, Hui Zhao, Muxin Gong

“…<b>Background:</b> Chronic migraine (CM) is a common complex nervous system disease, often accompanied by symptoms of the digestive tract that interact with each other, leading to prolonged and difficult-to-cure migraines. …”
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Agricultural Policies and Practices: Pathways for Transformation by Hari Sharma Neupane, Bikram Acharya, Pradeep Wagle, Buddhi Raj Gyawali

“…The symposium highlighted the importance of innovative policies and practices that can help transform agriculture and ensure its sustainability for future generations. …”
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Construction and Application of Monitoring System for Green Tarpaulin Cover Net in Mega Cities by Yang SUN, Dawei GAO, Haoye JIANG, Wanguang DU

“…This mode allows professionals to verifies and correct the preliminary segmentation results of the model, especially in complex scenes or areas with fuzzy edges. Manual intervention can significantly improve the reliability of the results. …”
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3D virtual reconstruction of the Gauzón Castle (Castrillón, Principado de Asturias) by Pablo Aparicio-Resco, Alejandro García Álvarez-Busto, Iván Muñiz-López, Noelia Fernández-Calderón

“…We continued with the texturing and addition of details of the surrounding terrain using particle systems, which has been one of the most complex phases to carry out given the level of realism that we set ourselves as a goal. …”
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Application of chest wall perforator flaps in oncoplastic breast-conserving surgery by Li Xie, Xiangyi Kong, Dongcai Lin, Jiarui Song, Xiaoqi Chen, Pu Huang, Jidong Gao

“…All tumors were located more than 2 cm from the nipple-areola complex (NAC), and intraoperative frozen sections confirmed negative margins behind the NAC. …”
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Thinking- Skins by Jens Böke

“…Façade features are diverse and with the increasing integration of building services, both the scope of fulfilled façade functions and the complexity of today’s façades increase. One challenge is the coordination of adaptive functions to ensure effective reactions of the façade as a complete system. …”
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A Participatory Governance Model for Comprehensive Conservation of Historical Buildings and Urban Fabric: A Grounded Theory Approach by Somayyeh Ghadimzadeh, Elnaz Abizadeh, Mahdiyeh Rahnemay Toori

“…Discussion of Results & Conclusion The findings revealed a multifaceted governance framework that effectively addressed the complex challenges of cultural heritage conservation. …”
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