Characterization of human living myocardial slices culture-induced adaptations: a translational perspective by Jort S.A. van der Geest, Ernest Diez Benavente, Willem B. van Ham, Pieter A. Doevendans, Linda W. van Laake, Teun P. de Boer, Vasco Sampaio-Pinto, Joost P.G. Sluijter

“…Heart failure involves complex pathophysiological processes, best studied in multicellular human cardiac tissues that reflect the native cellular composition and microenvironment. …”
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The Practical, Robust Implementation and Sustainability (PRISM)-capabilities model for use of Artificial Intelligence in community-engaged implementation science research by Nabila El-Bassel, James David, Trena I. Mukherjee, Maneesha Aggarwal, Elwin Wu, Louisa Gilbert, Scott Walters, Redonna Chandler, Tim Hunt, Victoria Frye, Aimee Campbell, Dawn A. Goddard-Eckrich, Katherine Keyes, Shoshana N. Benjamin, Raymond Balise, Smaranda Muresan, Eric Aragundi, Marc Chen, Parixit Davé, David Lounsbury, Nasim Sabounchi, Dan Feaster, Terry Huang, Tian Zheng

“…Abstract Background Community-engaged research (CER) leverages knowledge, insights, and expertise of researchers and communities to address complex public health challenges and improve community well-being. …”
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A secreted Tapasin isoform impairs cytotoxic T lymphocyte recognition by disrupting exogenous MHC class I antigen presentation by Robyn P. Seipp, Robyn P. Seipp, Guillaume Hoeffel, Alexander R. Moise, Alexander R. Moise, Siri Lok, Siri Lok, Anne-Claire Ripoche, Concepción Marañón, Anne Hosmalin, Wilfred A. Jefferies, Wilfred A. Jefferies, Wilfred A. Jefferies, Wilfred A. Jefferies, Wilfred A. Jefferies, Wilfred A. Jefferies, Wilfred A. Jefferies, Wilfred A. Jefferies

“…Endogenous and exogenous antigen processing and presentation through the MHC class I peptide-loading complex (PLC) are essential for initiating cytotoxic T lymphocyte responses against pathogens and tumors. …”
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Optimization of Lipoplexes Functionalized with a Sialic Acid Mimetic (F9-PEG) to Target the C1858T <i>PTPN22</i> Variant for Preclinical Assessment of a Novel Immunotherapy in Endo... by Simona Sennato, Giorgia Paldino, Cecilia Bombelli, Irene Mezzani, Stefania Petrini, Domenico Vittorio Delfino, Francesco Fiorentino, Carlotta Marianecci, Alessia Ciogli, Dante Rotili, Francesca Ceccacci, Alessandra Fierabracci

“…<b>Results</b>: The optimal charge ratio of +2/−1 (lipid/siRNA) ensured a greater stability of lipoplexes and complete complexation of siRNA. …”
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A Multinational, Multicenter Study Mapping Models of Kidney Supportive Care Practice by Seren Marsh, Amanda Varghese, Charlotte M. Snead, Barnaby D. Hole, Daniel V. O’Hara, Neeru Agarwal, Elizabeth Stallworthy, Fergus J. Caskey, Brendan J. Smyth, Kathryn Ducharlet

“…The scope of KSC service was wide-ranging and prioritized activities included symptom management, psychological support, complex future treatment planning and discussion, and care coordination. …”
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Bioherbicides: revolutionizing weed management for sustainable agriculture in the era of One-health by Taqi Raza, Muhammad Farhan Qadir, Shakeel Imran, Zobia Khatoon, Muhammad Yahya Khan, Mouna Mechri, Waleed Asghar, Muhmmad Ishaq Asif Rehmani, Sergio de los Santos Villalobos, Tooba Mumtaz, Rashid Iqbal

“…To develop an effective bioherbicide, specific and complex types of interaction have been developed between targeted weeds and biological agents. …”
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Use of Transcriptomics to Identify Candidate Genes for Hematopoietic Differences Between Wujin and Duroc Pigs by Peng Ji, Ping Wang, Qihua Li, Lin Gao, Yan Xu, Hongbin Pan, Chunyong Zhang, Jintao Li, Jun Yao, Qingcong An

“…Hematopoiesis is a complex physiological process that ensures renewal of blood cells to maintain normal blood circulation and immune function. …”
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An autonomous navigation method for field phenotyping robot based on ground-air collaboration by Zikang Zhang, Zhengda Li, Meng Yang, Jiale Cui, Yang Shao, Youchun Ding, Wanneng Yang, Wen Qiao, Peng Song

“…Compared with traditional GNSS-based navigation methods and single vision methods, this method shows significant advantages in adapting to the dynamic growth of crops and complex field environments, which not only ensures that the phenotyping robot accurately travels along the crop rows during field operations to avoid damage to the crops, but also provides an efficient and accurate means of data acquisition for crop phenotyping.…”
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Three Decades of Land Cover Dynamics in a Boreal Coastal Basin: A Multisensor Spectral Index and Machine Learning Approach Using Landsat Data and GB-SAR Data by Jinsong Zhang, Bochi Zou, Yifei Yuan, Asad Khan, Muhammad Bilawal Junaid, Qaiser Abbas, Rana Muhammad Zulqarnain, Nazih Y. Rebouh, Olga D. Kucher, Hassan Alzahrani

“…Boreal coastal habitats, with their complex hydrological, ecological, and geological functions, play a pivotal role in regulating regional climate, supporting biodiversity, and sustaining local communities. …”
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Aging Population and the Changing Paradigm of Hip Fracture Management by Amit Sharma

“…As the global population ages, adopting and enhancing these strategies is essential to ensure that hip fracture care meets the complex needs of elderly patients. …”
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A real-world study based on the FAERS database evaluating adverse drug reactions in three amphotericin B lipid formulations by Binliang Tong, Jiaqi Wang, Yanjing Zhang, Yan Liu, Jing Wang, Liguang Duan, Yuhang Yan, Qixuan Sun, Yueyao Luan, Jing Yu, Chunhua Zhou

“…These findings highlight the need for individualised treatment strategies based on drug-specific safety characteristics and patient-specific clinical conditions to ensure optimal drug selection and patient safety.…”
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BREAST-RANKNet: a fuzzy rank-based ensemble of CNNs with residual learning for enhanced breast cancer detection from ultrasound and mammogram images by Sohaib Asif, Lingying Zhu, Dane Yan, Luman Xu, Zhengqiu Huang, Haimin Xu, Ruxuan Yan, Linghong Cai, Changfu Zheng, Jiamei Lin, Enyu Wang

“…We enhance the dataset by employing fuzzy contrast enhancement, which improves image quality and ensures better feature extraction for more accurate breast cancer detection. …”
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Protocol for the development of Polish clinical guidelines for the management of patients with systemic lupus erythematosus by Joanna Makowska, Brygida Kwiatkowska, Magdalena Krajewska-Włodarczyk, Bogdan Batko, Marcin Stajszczyk, Jerzy Świerkot, Zbigniew Żuber, Piotr Leszczyński, Agata Sebastian, Magdalena Władysiuk, Irena Walecka, Michał Chmielewski, Mariusz Stasiołek, Maria Maślińska

“…Introduction Systemic lupus erythematosus (SLE) is a complex, chronic autoimmune disease that causes multi-organ inflammation and damage. …”
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Domestication of the African regional biosafety and biosecurity legislative framework – Lessons learned from the first four countries: Zambia, Botswana, Lesotho, and Sierra Leone by Christine Fortunate Rebecca Mutesi, Talkmore Maruta, Noelina Nantima, Jacqueline Lichoti Kasiiti, Zikan Koroma, Kilinda Imanuel Kilie, Tsaletseng Siimane, Mosito Tsoeunyane, Maruping Maruping, Patrick Masokwane, Samantha Letsholo, Powell Chonga, Musonda Mandona, Jaures Arnaud Kenfack Noumedem, Idosie Kenfack, Patricia Nabwami, Agnes Asele, Laura Ngumama’anwi Ambe, Donewell Bangure, Bethlehem Arega, Yenew Kebede Tebeje

“…Countries made varying progress in implementing the legislation, addressing the identified gaps, and developing roadmaps for implementation.Discussion Challenges such as resource constraints and coordination issues have highlighted the complex nature of BSBS governance during domestication. …”
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Indoor air quality and airborne transmission under the One Health lens: A scoping review by Gil Correia, Daniela Calheiros, Nuno Rosa, Lisa Rodrigues, Sandra Cunha, Luiz Miguel Santiago, José Costa, Manuel Gameiro da Silva, Teresa Gonçalves

“…Findings indicate that the One Health approach effectively addresses the complex challenge of airborne microbiological contamination. …”
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Empowering cancer research in Europe: the EUCAIM cancer imaging infrastructure by Luis Martí-Bonmatí, Ignacio Blanquer, Manolis Tsiknakis, Gianna Tsakou, Ricard Martinez, Salvador Capella-Gutierrez, Sara Zullino, Janos Meszaros, Esther E. Bron, Jose Luis Gelpi, Katrine Riklund, Linda Chaabane, Heinz-Peter Schlemmer, Mario Aznar, Patricia Serrano Candelas, Peter Gordebeke, Monika Hierath, the EUCAIM Consortium, European Society of Radiology

“…However, the development of new AI algorithms requires access to large and complex real-world datasets. Although such datasets are constantly being generated, access to them is limited by data fragmentation across numerous repositories and sites, heterogeneity, lack of annotations, and potential privacy issues. …”
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From traditional medicine to modern medicine: the importance of TCM regulatory science (TCMRS) as an emerging discipline by Hua Hua, Jian-Yuan Tang, Jun-Ning Zhao, Ting Wang, Jun-Hua Zhang, Jiang-Yong Yu, Chang-Ming Yang, Yan-Ling Ai, Qiao-Xian Luo

“…Key challenges for TCMRS implementation include reconciling traditional epistemologies with modern pharmaceutical paradigms, standardizing complex herbal formulations, and developing rigorous evaluation protocols for decoctions and compound preparations. …”
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Trajectory optimization of a flapping-wing robot in a wind field by Xiaoyang WU, Zhiguo ZHANG, Wei HE, Jingyan QIN, Junhai ZHANG, Tingting MENG

“…In the simulation, the robot’s design is simplified, with some complex structures removed, to reduce computational costs and model complexity. …”
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Modeling the effects of land use change on agricultural carrying capacity and food security by R. Harini, R. Rijanta, E.H. Pangaribowo, R.F. Putri, I. Sukri

“…Proactive approaches are needed to ensure food security and sustainable agricultural development. …”
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Numerical simulation optimization analysis and field test for large deformation control of soft rock in Tabaiyi Tunnel by Jieli LI, Jiaguo ZHANG, Quansheng CHEN, Rui AO, Jihao SUN, Pengxiao GUAN

“…Taking Yunnan Tabaiyi Tunnel as the background of the research project, as the most complex tunnel in the whole line, its complexity is manifested as follows: the tunnel site area is a tectonic dissolution and erosion area, the geological condition is variable, crossing a number of faults and fracture zones, the local passage is water-rich, the rock weathering is serious, and the influence of tectonic stress is intense, etc. …”
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