Changes in the Profile of Phenolic Compounds and in the Antioxidant, Hypoglycemic, and Antidiabetic Activities of a Beverage Based on Sesame By-Product Caused by the Simulated Gast... by Jonhatan Carrasco-Chávez, María Fernanda Quintero-Soto, Rosalio Velarde-Barraza, Ignacio Alfredo Rivero-Espejel, Ismael Díaz-Peña, Martha Elena Vázquez-Ontiveros, Ramona Julieta Espinoza-Moreno, Luz Adriana Ontiveros-García, Jesús Mateo Amillano-Cisneros, Janitzio Xiomara K. Perales-Sánchez, Oscar Daniel Argüelles-López, Fernando Salas-López, Jennifer Vianey Félix-Medina

“…The results of this study not only improve the understanding of the impact of gastrointestinal digestion on the bioaccessibility of phenolic compounds but also suggest potential applications in formulating functional foods with enhanced antioxidant, hypoglycemic, and antidiabetic properties, contributing to the development of health-promoting food products.…”
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Targeting olfactory receptor OR2AT4: An innovative aptamer-based treatment for hair growth promotion by Manuel Mataix, Nuria Illera, Inés Hidalgo, Maria del Carmen de Arriba, Elena Martín, Gerónimo Fernández, Carlos González, Fernando Larcher, Victor M. González, Marcela del Rio, Francisco Jiménez, Marta Carretero

“…Importantly, the identified OR2AT4 aptamer was shown to be functional, leading to enhanced OR2AT4 expression in hair follicles, increased proliferation of hair matrix keratinocytes, and significant hair shaft elongation in organ-cultured human hair follicles. …”
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Polybutadiene polyurethane acrylate photosensitive resin and its application in 3D printing by Hang Ning, Shaoyun Chen, Yan'e Liu, Bo Qu, Yanyu Zheng, Xiaoying Liu, Wenjie Li, Rui Wang, Nairong Chen, Dongxian Zhuo

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Effect of chlorine atoms on binding between amide herbicides and soil enzymes: Molecular mechanism and structure-activity relationship by Chuanxi Yang, Xiaoning Wang, Jingyan Lin, Yongkun Wu, Ziheng Wan, Weiliang Wang

“…This study explores interactions between seven typical AHs and two SEs through molecular docking, density functional theory (DFT) calculations, and biotoxicity assessment to elucidate molecular mechanisms and structure-activity relationships (SAR) of these interactions. …”
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Vermicompost application improves leaf physiological activity, 2-acetyl-1-pyrroline, and grain yield of fragrant rice through efficient nitrogen assimilation under Cd stress by Anas Iqbal, Xiaoyuan Chen, Rayyan Khan, Maid Zaman, Aamir Hamid Khan, Marcin Kiedrzyński, Mohamed Ebaid, Abdulwahed Fahad Alrefaei, Sobhi F. Lamlom, Xiangru Tang, Muhammad Zeeshan, Muhammad Zeeshan

“…This study investigated the effects of VC on the soil chemical properties and the physio-biochemical functions of fragrant rice, as well as nitrogen (N) metabolism and assimilatory enzyme activities, 2-acetyl-1-pyrroline (2AP) content in rice grains, and the grain yields of fragrant rice cultivars, i.e., Xiangyaxiangzhan (XGZ) and.Meixiangzhan-2 (MXZ-2) under Cd stress condition. …”
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Cell-specific nanoengineering strategy to disrupt tolerogenic signaling from myeloid-derived suppressor cells and invigorate antitumor immunity in pancreatic cancer by Nilesh U. Deshpande, Anna Bianchi, Haleh Amirian, Iago De Castro Silva, Christine I. Rafie, Bapurao Surnar, Karthik Rajkumar, Akash Ashokan, Ifeanyichukwu C. Ogobuiro, Manan Patel, Erietta Stelekati, Shanta Dhar, Jashodeep Datta

“…Abstract Pancreatic ductal adenocarcinoma (PDAC) is characterized by intratumoral abundance of neutrophilic/polymorphonuclear myeloid-derived suppressor cells (PMN-MDSC) which exert anti-T-cell functions through multiple mechanisms, especially JAK2/STAT3-regulated arginase activity. …”
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Study on the changes in the microbiome before and after seed embryo after-ripening of Fritillaria cirrhosa by Wenshang Li, Wenshang Li, Can Zhao, Can Zhao, Qian Tao, Qian Tao, Weimin Zhang, Weimin Zhang, Hai Wang, Guiqi Han, Guiqi Han, Zhuyun Yan, Zhuyun Yan

“…Functional validation revealed that most culturable fungi with sharply increased relative abundance had cellulase-degrading abilities, while most of the bacterial isolates were capable of absorbing and utilizing C, N, S, P, and Fe elements. …”
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Nanostructured GelMA colloidal gels as bioinks for freeform multi-mode 3D printing: better replacement for the classical GelMA polymeric inks by Qifan Wang, Kaiwen Chen, Yonggang Zhang, Fei Shao, Xiangyuan Tan, Qiwei Ying, Libin Wang, Changle Ren, Lijun Zhang, Huanan Wang

“…Methacrylated gelatin (GelMA) hydrogels have been well-recognized as a widely-used natural polymer for biofabrications due to the adaptability for multiple crosslinking schemes, desirable biocompatibility and biodegradability, and ease of chemical functionalization. …”
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Issues of Interpretation and Application of the Notion of “International Legal Legitimation” by A. M. Korzhenyak

“…On the basis of integrative (multidimensional) approach to scientific legal research, taking into account such principles of scientific cognition as theoretical novelty and scientific relevance, the study was guided, in particular, by hermeneutic, formal-legal, formallogical, structural-functional and systematic methods, as well as methods of analysis and synthesis, legal modelling, legal construction and strategic planning.RESEARCH RESULTS. …”
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Single-cell transcriptome analysis reveals the malignant characteristics of tumour cells and the immunosuppressive landscape in HER2-positive inflammatory breast cancer by Juan Huang, Yongwei Zhu, Wenjing Zeng, Yulong Zhang, Weizhi Xia, Fan Xia, Liyu Liu, Kuansong Wang, Yidi Guan, Taohong Shen, Bingjian Jiang, Lunquan Sun, Ayong Cao, Shouman Wang, Zhi Li

“…Methods In this study, we used single-cell transcriptome technology (scRNA-seq) to investigate the molecular features of the TME of HER2 + IBC patients and performed a comprehensive and detailed comparison of the cellular components and molecular phenotypes of the TME between IBC patients and noninflammatory breast cancer (nIBC) patients to elucidate the cell types that are specifically enriched in the TME of IBC patients, as well as the molecular features that are responsible for the preferential remodelling of the cellular functional state in the TME. …”
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Co-Designing, Developing, and Testing a Mental Health Platform for Young People Using a Participatory Design Methodology in Colombia: Mixed Methods Study by Laura Ospina-Pinillos, Débora L Shambo-Rodríguez, Mónica Natalí Sánchez-Nítola, Alexandra Morales, Laura C Gallego-Sanchez, María Isabel Riaño-Fonseca, Andrea Carolina Bello-Tocancipá, Alvaro Navarro-Mancilla, Jaime A Pavlich-Mariscal, Alexandra Pomares-Quimbaya, Carlos Gómez-Restrepo, Ian B Hickie, Jo-An Occhipinti

“…Additional elements included user-friendly follow-up graphs, telecounseling integration, customizable well-being nudges, an emergency button, and gamification components to enhance engagement. …”
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HCAR2 Exerts Anti-Depressive Effects on Corticosterone-Induced Depression in Mice by Modulating Microglial Activity by Zhao Pan, Li Jiang, Jiacheng Chen, Sicong Xu, Ping Zhang, Yili Yi, Yangzhi Xie, Yongjun Chen

“…Hydroxy-carboxylic acid receptor 2 (HCAR2) functions as a receptor for various diet-derived metabolites. …”
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Click on Click: Click-Flavone Glycosides Encapsulated in Click-Functionalised Polymersomes for Glioblastoma Therapy by Nuno M. Saraiva, Ana Alves, Ana Isabel Barbosa, Andreia Marinho, Salette Reis, Marta Correia-da-Silva, Paulo C. Costa

“…Biological assays performed on L929 fibroblast cell lines and human glioblastoma astrocytoma U-251 cell lines indicated cytocompatibility with fibroblasts and reduced metabolic activity of GBM cells in the presence of compound <b>5b</b> and <b>5c</b>. To enhance therapeutic effect, improve local drug delivery, and overcome solubility issues of these high molecular weight compounds, the synthesised compounds were encapsulated in polymeric particles (polymersomes, PMs) composed of polylactic acid-polyethylene glycol (PEG-PLA) functionalized, once more by click chemistry, with 0.1 mol% transferrin mimetic (T7—HRPYIAH) peptide. …”
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Efficiency evaluation of product oil pipeline under transportation market by Hao ZHANG, Renfu TU, Xu ZHANG, Xinyi YANG, Yiwei SU, Yuheng XIA, Jun YAN, Rui QIU

“…This shortfall has had a detrimental effect on both the enhancement of pipeline transportation competitiveness and the long-term construction planning of pipelines. …”
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Artificial Intelligence in Medical Care – Patients' Perceptions on Caregiving Relationships and Ethics: A Qualitative Study by Jana Gundlack, Sarah Negash, Carolin Thiel, Charlotte Buch, Jan Schildmann, Susanne Unverzagt, Rafael Mikolajczyk, Thomas Frese, PEAK consortium

“…ABSTRACT Introduction Artificial intelligence (AI) offers several opportunities to enhance medical care, but practical application is limited. …”
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Lyophilized human platelet lysate: manufacturing, quality control, and application by Kerstin Wendland, Kerstin Wendland, Lea Koblin, Lea Koblin, Dirk Stobbe, Anna Dahms, Anna Dahms, Debora Singer, Debora Singer, Sander Bekeschus, Sander Bekeschus, Jan Wesche, Janosch Schoon, Konstanze Aurich

“…Cells differentiated in medium containing L-HPL showed a slightly higher capacity for osteogenic differentiation, while adipogenic differentiation and chondrogenic differentiation potentials remained unchanged.ConclusionWe successfully developed a method to produce well-applicable L-HPL. The comparison of L-HPL with HPL did not reveal any relevant differences regarding quality control parameters of routine testing, growth factor concentrations and hMSC functionality, demonstrating the suitability of L-HPL as a cell culture supplement. …”
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Comparative evaluation of sequencing platforms: Pacific Biosciences, Oxford Nanopore Technologies, and Illumina for 16S rRNA-based soil microbiome profiling by Vladimir Veselovsky, Mikhail Romanov, Polina Zoruk, Andrey Larin, Vladislav Babenko, Maxim Morozov, Aleksandra Strokach, Natalia Zakharevich, Sadokatkhon Khamidova, Albina Danilova, Aleksey Vatlin, Vsevolod Pavshintsev, Feng Chenguang, Denis Tsybizov, Nikita Mitkin, Olesya Galanova, Alexander Zakharenko, Kirill Golokhvast, Kirill Golokhvast, Ksenia Klimina

“…Soil microbiome profiling is crucial for understanding microbial diversity and its roles in ecosystem functioning and agricultural productivity. Recent advancements in high-throughput sequencing, particularly Pacific Biosciences (PacBio) and Oxford Nanopore Technologies (ONT), offer long-read sequencing capabilities that enhance microbial community analysis. …”
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Effect of eyestalk ablation and water temperature on the gonadal transcriptome of greasyback shrimp (Metapenaeus ensis) by Xinhe Ruan, Huitao Cheng, Jinhong Shan, Lihua Li, Zijie Xuan, Kaishan Liang, Xianze Jia, Jie Yu, Zongyang Li, Liyuan Luo, Xiaoling Zuo, Kun Wu, Qing Wang, Xiaobo Wen, Huihong Zhao

“…This study also demonstrated the capacity to regulate the expression of CHH and SPATA13 following eyestalk ablation, as well as the capacity to regulate the expression of HSP70 and MIH following temperature stress, subsequently impacting gonadal development. …”
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Comparative transcriptomics of atrazine-tolerant and sensitive alfalfa varieties under atrazine stress by Yingao Li, Chunyang Dong, Zeshan Zulfiqar, Haojie Wang, Jiading Lu, Xiaoxia Zhang, Jun Li, Yinghua Shi, Chengzhang Wang, Xiaoyan Zhu, Hao Sun

“…This differential gene expression helps JN5010 maintain stability in its functions under stress, demonstrating better adaptability. …”
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<i>PD-L1</i> and <i>PD-L2</i> gene expression in human glioblastoma cells resistant to chemo- and radiotherapy by A. A. Pinevich, N. L. Vartanyan, L. N. Kiseleva, I. I. Bode, I. Yu. Krutetskaya, A. V. Kartashev, V. E. Makarov, T. E. Poneza, I. V. Smirnov, M. P. Samoilovich

“…Membrane molecules PD-L1 and PD-L2, ligands of T lymphocytes PD1 receptor, perform immunoregulatory functions. Their binding to the receptor leads to inhibition of proliferation, reduction of cytokine production, cytotoxic response, and apoptosis of T lymphocytes. …”
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