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    Enhanced rational protein engineering to reduce viscosity in high-concentration IgG1 antibody solutions by Tyler J. Lefevre, Jenna G. Caldwell, Austin Gallegos, Qun Du, Erin Houston, Gilad Kaplan, Reza Esfandiary

    Published 2025-12-01
    “…Here, we take an enhanced rational design approach to reduce RSA via protein engineering. Using hydrogen-deuterium exchange mass spectrometry (HDX-MS), we identified potential self-interaction hotspots on the surface of an in-house IgG1 which has known viscosity issues at high concentration. …”
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    Numerical and Experimental Investigation of Damage and Failure Analysis of Aero-Engine Electronic Controllers Under Thermal Shock by Fang Wen, Jinshan Wen, Jie Jin

    Published 2025-07-01
    “…The Engine Electronic Controller (EEC), as the core component of an aircraft engine control system, is vulnerable to rapid failure when exposed to thermal shock during engine fire incidents, potentially leading to catastrophic aviation accidents. …”
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    A self-growth convolution network for thermal and mechanical fault detection with very limited engine data by Gou Xin, Zhu Xiaolong, Wang Xinwei, Wang Hui, Zhang Junhong, Lin Jiewei

    Published 2024-12-01
    “…The self-growth scheme is proposed to disrupt the coadaptation between layers and that between kernels in order to mitigate the overfitting issue of small-sample cases. The SGNet is verified and implemented in the PHM of a heavy-duty diesel engine. …”
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  9. 289

    Assembly plant simulation to support decision-making n Layout Design considering safety issues. A case study. by Aída Sáez Más, José P. García-Sabater, Joan Morant Llorca, Julien Maheut

    Published 2016-12-01
    “…This paper presents a simulation model that has been created to support decision-making during the layout redesign of an engine and transmission assembly plant in the automotive sector. …”
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    Analysis of Stirling engine’s performance in recovering waste heat from wood pellet, coconut husk and bagasse by Nik Kechik Mujahidah NIK ABDUL RAHMAN, Syamimi SAADON, Abd Rahim ABU TALIB, Ezanee GIRES, Hanim SALLEH, Nasser ABDELLATIF

    Published 2025-03-01
    “…Nevertheless, a sizable portion of thermal energy is frequently lost to the environment as flue gas throughout the process. Stirling engine: a very efficient external combustion engine and little emissions as compared to other available engines, would be a good solution to overcome this issue as it can be used with any type of heat source. …”
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    Software sustainability of global impact models by E. Nyenah, P. Döll, P. Döll, D. S. Katz, R. Reinecke

    Published 2024-12-01
    “…We found that 29 % (32 out of 112) of the global impact models (GIMs) participating in the Inter-Sectoral Impact Model Intercomparison Project were accessible without contacting the developers. …”
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    Intranasal Delivery of BACE1 siRNA and Berberine via Engineered Stem Cell Exosomes for the Treatment of Alzheimer’s Disease by Sun C, Sha S, Shan Y, Gao X, Li L, Xing C, Guo Z, Du H

    Published 2025-05-01
    “…Keywords: Alzheimer’s disease, engineering exosomes, intranasal delivery…”
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    Fragility Analysis of Overturning Resistance of Hybrid Base-Isolated Structures in Diesel Engine Buildings of Nuclear Power Plants by Yunhui Xiao, Xiangyu Gao, Kuang Xu, Jinlai Zhou

    Published 2025-03-01
    “…This paper validates the effectiveness of the modeling approach based on the finite element analysis of shaking table tests, establishing finite element models for both a base-isolated structure and a hybrid base-isolated structure designed to address overturning issues in the diesel engine building of a nuclear power plant. …”
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