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2541
Eco-friendly microencapsulation of Lacticaseibacillus paracasei using Ficus pumila seed extract: A novel plant-based delivery system enhancing probiotic stability and gastrointesti...
Published 2025-07-01“…The system exhibited pH-responsive swelling and controlled release, reaching 89.17% cumulative release in intestinal fluid. …”
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State-of-the-art literature review of Recovery College evaluative studies between 2013-2024
Published 2025-08-01“…MethodsA state-of-the art literature review was conducted with no date limits on peer-review articles in MEDLINE and Scopus electronic databases. The good practice guide for a systematic literature review published by Siddaway et al. was used, in combination with a structured multi-stage process. …”
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2543
Inhibition of angiotensin Ⅱ type 1 receptor on Renal Fibrosis and Podocyte Damage in Angiotensin Ⅱ-induced Hypertensive Nephropathy
Published 2022-04-01“…ObjectiveTo explore the effect of targeted inhibition of angiotensin Ⅱ type 1 receptor (AGTR1) on renal fibrosis and podocyte damage in angiotensin Ⅱ-induced hypertensive nephropathy.MethodsThe murine experimental groups include normal control group,normal saline group,model group and drug group (<italic>n</italic>=10 each).Normal control group was not treated,normal saline group underwent unilateral nephrectomy plus microosmotic pump infusion of normal saline,model group unilateral nephrectomy plus micro-osmotic pump perfusion with angiotensin Ⅱ,drug group unilateral nephrectomy plus an intraperitoneal injection of 50 mg/kg of Losartan 30 min before perfusion of angiotensin Ⅱ with a micro-osmotic pump.Blood pressures were measured for each group at pre-modeling and 2/4 weeks post-modeling.At 4 weeks post-modeling,enzyme-linked immunosorbent assay was employed for detecting 24 h urinary protein (24 h UP),serum creatinine (Scr) and urea nitrogen (BUN); hematoxylin-eosin (HE) staining for observing the pathological morphology of kidney tissue; Masson staining for detecting renal tissue fibrosis,observing the ultrastructural changes of podocytes with transmission electron microscope,immunofluorescent staining for detecting the expression of nephrin in podocytes of renal tissue,Western blot for detecting the expressions of α-smooth muscle actin (α-SMA),type Ⅰ/Ⅲ collagen (collagen-Ⅰ/Ⅲ),nephrin,podocin and synaptopodin.ResultsCompared with normal control group,blood pressure rose after modeling [modeling for 2 weeks:(148.92±12.56) mmHg <italic>vs </italic>(109.18±9.43) mmHg; modeling for 4 weeks:(150.92±13.74) mmHg <italic>vs</italic> (117.68±10.73) mmHg,1 mmHg = 0.133 kPa] and 24 h UP [(2.02±0.18) mg/24h <italic>vs</italic> (3.88±0.34) mg/24h <italic>vs</italic> (0.37±0.02) mg/24h],Scr [(11.34±0.97) μmol/L <italic>vs</italic>(13.92±1.16) μmol/L <italic>vs</italic> (9.18±0.87) μmol/L] and BUN [(11.34±1.09) mmol/L <italic>vs</italic> (14.55±1.30) mmol/L <italic>vs</italic> (7.71±0.73) mmol/L] spiked in normal saline and model groups,renal tubules appeared atrophic and necrotic with vacuolar degeneration,and epithelial cells sloughed off,heavy infiltrate of inflammatory cells,accompanied by obvious fibrosis,podocyte foot process thickened and merged,slit membrane disappeared,fluorescent intensity of nephrin declined,protein expression levels of α-SMA and collagen-Ⅰ/Ⅲ spiked while protein expression levels of nephrin,podocin and synaptopodin declined (<italic>P</italic><0.01).Compared with model group,blood pressure of drug group dropped [2 weeks of modeling:(125.08±10.79) mmHg <italic>vs </italic>(148.92±12.56) mmHg; 4 weeks of modeling:(122.78±10.07) mmHg <italic>vs</italic>(150.92±13.74) mmHg],24 h UP [(1.25±0.11) mg/24h <italic>vs </italic>(3.88±0.34) mg/24h],Scr [(10.33±0.84) μmol/L <italic>vs </italic>(13.92±1.16) μmol/L] and BUN [(8.96±0.81) mmol/L <italic>vs </italic>(14.55±1.30) mmol/L] decreased,renal tubular atrophy,necrosis and vacuolar degeneration were alleviated,minimal infiltration of inflammatory cell,degree of fibrosis lessened,foot process thickened and fusion phenomenon improved.At the same time,fluorescent intensity of nephrin increased,rotein expression levels of α-SMA and collagen-Ⅰ/Ⅲ dropped while protein expression levels of nephrin,podocin and synaptopodin spiked (<italic>P</italic><0.01).ConclusionInhibition of AGTR1 may reduce renal fibrosis in a murine model of hypertensive nephropathy induced by angiotensinⅡand at the same time reduce podocyte damage.…”
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Microstructure Evolution and Work Hardening Behavior of Hot-Rolled DP780 Ferrite/Bainite Dual-Phase Steel
Published 2023-01-01“…In this article, by optimizing the alloy composition, the DP780 grade hot-rolled duplex steel was obtained by TMCP (thermo-mechanical control process) combined with medium temperature coiling procedure. …”
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Methods and results used in the development of a consensus-driven extension to the Consolidated Standards of Reporting Trials (CONSORT) statement for trials conducted using cohorts...
Published 2021-04-01“…Objectives Randomised controlled trials conducted using cohorts and routinely collected data, including registries, electronic health records and administrative databases, are increasingly used in healthcare intervention research. …”
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Lead-I ECG for detecting atrial fibrillation in patients attending primary care with an irregular pulse using single-time point testing: A systematic review and economic evaluation...
Published 2019-01-01“…<h4>Purpose</h4>To assess the diagnostic test accuracy, clinical impact and cost effectiveness of single-time point lead-I ECG devices compared with manual pulse palpation (MPP) followed by a 12-lead ECG for the detection of AF in symptomatic primary care patients with an irregular pulse.<h4>Methods</h4>Electronic databases (MEDLINE, MEDLINE Epub Ahead of Print and MEDLINE In-Process, EMBASE, PubMed and Cochrane Databases of Systematic Reviews, Cochrane Central Database of Controlled Trials, Database of Abstracts of Reviews of Effects, Health Technology Assessment Database) were searched to March 2018. …”
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Preparation, Characterization, and Photocatalytic Applications of MWCNTs/TiO2 Composite
Published 2014-01-01“…The enhancement in photocatalytic activity performance of the MWCNTs/P25 composite is explained in terms of recombination of photogenerated electron-hole pairs. In addition, MWCNTs act as a dispersing support to control the morphology of TiO2 particles in the MWCNTs/TiO2 composite.…”
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2550
Design of the Converter Prototype for Powering the Hydrogen Electrolyzer
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2551
Insight into plasmonics: resurrection of modern-day science (invited)
Published 2024-02-01“…Plasmonics enables the control of light at the nanoscale, far beyond the diffraction limit of conventional optics. …”
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Influence of Water Content on the Mechanical Characteristics of Mudstone with High Smectite Content
Published 2022-01-01“…The complete stress–strain curves and UCS (unconfined compress strength) and E (Young’s modulus) of mudstone samples under different water contents were achieved by using the WEP-600 microcomputer-control screen universal testing machine. SEM (scanning electron microscope) test were carried out to study the microstructure characteristics of mudstone samples under different water contents. …”
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PLLA/GO Scaffolds Filled with Canine Placenta Hydrogel and Mesenchymal Stem Cells for Bone Repair in Goat Mandibles
Published 2024-10-01“…Thermography showed that PLLA/GO scaffolds with cpECM hydrogel performed effectively, similar to the control group. Computed tomography scans revealed bone calluses, suggesting an ongoing repair process. …”
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Adaptive Transverse Laser Shaping and Its Application in a Photocathode Gun
Published 2024-12-01“…The experiments conducted on the DC-SRF-II gun demonstrate a rapid and efficient QE measurement process, as well as a notable improvement in electron beam uniformity. …”
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The mechanisms and applications of friction energy dissipation
Published 2022-08-01“…The key to reducing energy consumption is to control the way of energy dissipation in the friction process. …”
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Experimental investigation of anionic and cationic surfactants performance in clay-rich sandstones
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Evaluating salivary MMP-8 as a biomarker for periodontal diseases: A systematic review and meta-analysis
Published 2024-11-01“…This systematic review and meta-analysis aims to evaluate the salivary MMP-8 level of periodontitis and gingivitis cases compared to healthy controls. Data: We evaluated all studies that compared different laboratory techniques for measuring salivary MMP-8 levels in periodontitis and gingivitis patients, alongside healthy controls. …”
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Aromatase reduces sperm motility by down-regulating the expression of proteins related to ATP synthesis in seminal plasma extracellular vesicles
Published 2025-03-01“…Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) items of DEPs are mainly enriched in ATP synthesis coupled electron transport, flagellated sperm motility, regulation of steroid biosynthetic process, and PI3K-Akt signaling pathway. …”
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Tetrahymena ATG8 homologs, TtATG8A and TtATG8B, are responsible for mitochondrial degradation induced by starvation
Published 2025-06-01“…Furthermore, we have successfully demonstrated the usefulness of Tetrahymena as an experimental system for studying mitochondrial quality control and turnover. Further studies of Tetrahymena will facilitate comparative studies among diverse biological systems on how eukaryotes other than opisthokonta (yeast, cultured cells, etc.) control their mitochondria.…”
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