Effect of Ticagrelor Versus Clopidogrel After Off‐Pump Coronary Artery Bypass Grafting on Postoperative Atrial Fibrillation: A Cohort Study by Qin Jiang, Keli Huang, Lixue Yin, Hong Kong, Zhenglin Yang, Shengshou Hu

“…Background This study aimed to explore the effect of a P2Y12 inhibitor regimen on the occurrence of postoperative atrial fibrillation (POAF) after off‐pump coronary artery bypass graft surgery in carriers with the cytochrome P450 family 2 subfamily C member19 loss‐of‐function allele. Methods and Results From May 2019 to November 2023, patients containing the cytochrome P450 family 2 subfamily C member19*2 or *3 allele undergoing elective first‐time off‐pump coronary artery bypass graft surgery including aspirin 100 mg/d and ticagrelor 180 mg/d (AT group; n=95) versus clopidogrel 75 mg/d (aspirin and clopidogrel group; n=95) were prospectively followed. …”
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Submental tracheal intubation in oromaxillofacial surgery by Ramesh Kumar Sharma, Puneet Tuli, Chacko Cyriac, Atul Parashar, Surinder Makkar

“…Background: oromaxillofacial surgical procedures present a unique set of problems both for the surgeon and for the anesthesist. achieving dental occlusion is one of the fundamental aims of most oromaxillofacial procedures. oral intubation precludes this surgical prerequisite of checking dental occlusion. having the tube in the field of surgery is often disturbing for the surgeon too, especially in the patient for whom skull base surgery is planned. nasotracheal intubation is usually contraindicated in the presence of nasal bone fractures seen either in isolation or as a component of le fort fractures. we utilized submental endotracheal intubation in such situations and the experience has been very satisfying.materials and methods: the technique has been used in 20 patients with maxillofacial injuries and those requiring le fort i approach with or without maxillary swing for skull base tumors. initial oral intubation is done with a flexo-metallic tube. a small 1.5 cm incision is given in the submental region and a blunt tunnel is created in the floor of the mouth staying close to the lingual surface of mandible and a small opening is made in the mucosa. the tracheal end of tube is stabilized with magil′s forceps, and the proximal end is brought out through submental incision by using a blunt hemostat taking care not to injure the pilot balloon. at the end of procedure extubation is done through submental location only.results: the technique of submental intubation was used in a series of twenty patients from january 2005 to date. there were fifteen male patients and five female patients with a mean age of twenty seven years (range 10 to 52). seven patients had le fort i osteotomy as part of the approach for skull base surgery. twelve patients had midfacial fractures at the le fort ii level, of which 8 patients in addition had naso-ethomoidal fractures and 10 patients an associated fracture mandible. twelve patients were extubated in the theatre. eight patients had delayed extubation in the post-operative ward between 1 and 3 days postoperatively.conclusion: in conclusion, the submental intubation technique has proved to be a simple solution for many a difficult problem one would encounter during oromaxillofacial surgical procedures. it provides a safe and reliable route for the endotracheal tube during intubation while staying clear of the surgical field and permitting the checking of the dental occlusion, all without causing any significant morbidity for the patient. its usefulness both in the emergency setting and for elective procedures has been proved. the simplicity of the technique with no specialized equipment or technical expertise required makes it especially advantageous. this technique therefore, when used in appropriate cases, allows both the surgeon and the anesthetist deliver a better quality of patient care.…”
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Low-dose esketamine combined with propofol versus fentanyl-propofol for preventing hypoxemia during gastroscopy sedation in high-altitude residents: a randomized controlled trial by Hui Xue, Pan Wei, Yun Wen, Shuhua He, Lan Yuan, Wei Song

“…Abstract Objective The aim of this study is to evaluate the efficacy and safety of low-dose esketamine combined with propofol in reducing the incidence of hypoxemia during deep sedation for painless gastroscopy in patients residing at high altitude Additionally, the study sought to inform the optimization of sedation protocols in hypobaric environments. Methods A single-center, double-blind, randomized controlled trial was conducted involving 168 patients residing at an altitude of 3200 m who were scheduled for elective gastroscopy. …”
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Association of D-dimer to albumin ratio with adverse cardiovascular outcomes in ischaemic heart failure patients with diabetes mellitus: a retrospective cohort study by Xiaolong Lin, Jinghua Liu, Siyuan Chen, Qiuyu Li, Xiaowen Bo, Donghui Zhao, Qian Fan

“…The secondary outcomes were all-cause mortality, non-fatal myocardial infarction and any revascularisation.Methods These participants were grouped according to DAR tertiles. …”
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Preoperative Alcohol Use Disorder Associated with Increased Complications, Readmission, and Cost Following Ankle Arthrodesis by Weston E. McDonald BS, Joshua L. Morningstar BS, Sarah Jenkins MD, Christopher E. Gross MD, Daniel J. Scott MBA, MD

“…The purpose of this study is to evaluate the influence of AUD on postoperative outcomes following AA. Methods: The Nationwide Readmissions Database (NRD) was queried from 2016-2020 to identify 26,705 patients undergoing primary elective AA as identified by International Classification of Diseases, Tenth Revisions (ICD-10), Procedure coding system (PCS) codes for ankle arthrodesis (OSGFXXX, OSGGXXX). …”
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Obstetric and neonatal conditions and associations with early skin-to-skin contact – a cross-sectional study by Joan Neergaard Larsen, Helena Hansson, Porntiva Poorisrisak, Laura E. Navne, Ane Lilleøre Rom, Hanne K. Hegaard, Jette Led Sørensen, Ragnhild Maastrup

“…We aimed to describe the frequency of obstetric and neonatal conditions in mother-infant pairs requiring postnatal care and to examine potential associations between these conditions and early SSC within six hours after birth with mother or co-parent. Methods This cross-sectional study included mother-infant pairs admitted to the Departments of Obstetrics and Neonatology. …”
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Efficacy of Transcutaneous Electrical Acupoint Stimulation Applied During the Post-Anesthesia Recovery Period in Improving Postoperative Recovery Quality After Gynecological Laparo... by Zhou Z, Yang X, Shi M, Huang L, Wu D, Yang H, Zhang X

“…This study investigated the impact of TEAS during the post-anesthesia recovery period on postoperative recovery quality in patients undergoing laparoscopic gynecological surgery.Patients and Methods: In this single-center, randomized, double-blinded, sham-controlled trial, 100 patients undergoing elective gynecological laparoscopic surgery were randomly allocated to receive either TEAS or sham stimulation at bilateral Hegu (LI4), Neiguan (PC6), Zusanli (ST36), and Sanyinjiao (SP6) acupoints for 30 minutes during the post-anesthesia recovery period in the post-anesthesia care unit (PACU). …”
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Clinical and Biochemical Effects of Preoperative Oral Carbohydrate Loading versus Fasting in Major Abdominal Surgeries: A Randomised Clinical Study by A Nanda Lakshmi, KP Biji, S Syamkumar, VK Prathapan, A Krishnadas, KR Radha, J Preetha

“…Patients undergoing elective major abdominal surgeries under general anaesthesia were randomly divided into two groups. …”
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Gradual Reperfusion in Cardioplegia-Induced Cardiac Arrest by Mascha von Zeppelin, Florian Hecker, Harald Keller, Jan Hlavicka, Thomas Walther, Anton Moritz, Mani Arsalan, Tomas Holubec

“…The aim of this study was to investigate whether gradual reperfusion with a slow increase in oxygen partial pressure leads to a reduction in reperfusion injury. <i>Materials and Methods</i>: Fifty patients undergoing elective cardiac surgery were included in this prospective randomized study. …”
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Inpatient Profile Evaluations Regarding a Pediatric Nephrology Unit Pre-Covid-19 and During by Aslı Kantar Özşahin, Betül Pehlivan Zorlu, Derya Özmen, Fatma Devrim, Şükran Keskin Gözmen, Erkin Serdaroğlu, Orhan Deniz Kara, Ebru Yılmaz, Nida Dincel

“…This study aims to evaluate the changes in hospitalization diagnoses of patients admitted to a nephrology unit before and during the COVID-19 pandemic. Methods: The study evaluates the inpatients admitted between March 2018- 2020 and March 2020-2022 in the Nephrology Unit of Izmir Behçet Uz Pediatrics and Surgery Training and Research Hospital, University of Health Sciences. …”
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Single-centre, single-blind, randomized, active-controlled phase-3 non-inferiority study to investigate the safety and efficacy of the cardioplegic solution Cardioplexol™ by Hendrik T. Tevaearai Stahel, Gabriel Weiss, Gabriel Weiss, Peter Landowski, Peter Landowski, Sandra Folkmann, Sandra Folkmann, Marieluise Harrer, Marieluise Harrer, Bernard Voet, Martin Grabenwöger, Martin Grabenwöger, Martin Grabenwöger

“…Aim of this study was to demonstrate, in line with an ongoing European registration procedure, the efficacy and safety of the new Cardioplexol™ solution.MethodsSingle-centre, single-blind, randomized, active-controlled phase-3 non-inferiority trial comparing Cardioplexol™ and Buckberg solutions during cardiac surgery. …”
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Impact of health literacy and primary language on the decision to pursue trial of labor after prior cesarean delivery by Daisy Leon-Martinez, Christine Dehlendorf, Molly Zeme, W. John Boscardin, Anjali J. Kaimal, William A. Grobman, Miriam Kuppermann

“…This study explores the impact of patient health literacy and primary language on the decision to pursue a TOLAC and on decision quality. Methods This is a secondary analysis of the Prior Cesarean Decision (PROCEED) trial, which examined the effect of a patient-centered decision support tool on rates of TOLAC and decision quality. …”
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The effect of esketamine combined with sufentanil based patient-controlled intravenous analgesia for postoperative pain in patients undergoing third molar surgery and maxillofacial... by Xue Li, Xin He, Mengya Li, Xiao Gu, Ping Wang, Yong Wu, Ying Chen

“…Methods In this single-center, prospective, double-blinded, randomized, parallel-controlled trial, 91 patients were randomly divided into two groups. …”
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Acute Mesenteric Ischemia in Critically Ill Patients. Possibilities of Laboratory Diagnostics. Systematic Literature Review and Meta-Analysis by A. D. Ponomaryova, I. N. Leyderman, I. Yu. Kasherininov

“…Background Acute mesenteric ischemia (ami) is diagnosed in 1 case per 5,000–15,000 operations associated with elective abdominal surgical intervention and in 1 case of 1,000 emergency laparotomies associated with the acute abdomen clinical features. …”
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Efficacy and Safety of Ciprofol Alone versus Ciprofol with Fentanyl for Upper Gastrointestinal Endoscopy: A Randomized, Double-Blind, Controlled Trial by Liu L, Li F, Wei Y, Luo L, Shen L, Li J, Sun N, Qian B, Sun D

“…This study aims to address this question.Objective: To determine whether ciprofol alone is non-inferior to ciprofol combined with fentanyl regarding sedation success and safety.Methods: In this randomized, double-blind trial, 344 adult patients (ASA I–II, aged 18– 70 years) undergoing elective upper gastrointestinal endoscopy were randomized to receive either ciprofol with saline (CS group) or ciprofol with fentanyl (CF group). …”
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Structural and functional indicators of the heart of patients with ischemic heart disease and type 2 diabetes mellitus. Rhythmoinotropic response isolated myocardium at different l... by D. S. Kondratieva, S. A. Afanasiev, O. V. Budnikova, I. N. Vorozhtsova, S. D. Akhmedov, B. N. Kozlov

“…However, until now, glycaemic targets in aged patients remain a subject of discussion, especially in the conditions of the combined development of Type 2 Diabetes Mellitus (T2DM) and ischemic heart disease (IHD).AIMS: To examine the structural and functional heart parameters in patients with IHD associated with T2DM and the rhythmoinotropic responses of their isolated myocardium depending on glycated hemoglobin level.MATERIALS AND METHODS: The study included 44 patients with a diagnosis of "chronic IHD associated with T2DM", of which 2 groups were formed. …”
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Evaluation of the efficacy of combined vitamin D3 and K2 therapy in reducing implant-associated complication risk and improving spinal fusion stability by Oleksii S. Nekhlopochyn, Iryna G. Vasylieva, Nataliia G. Chopyk, Vadim V. Verbov, Ievgen V. Cheshuk, Milan V. Vorodi

“…Objective: To investigate the relationship among vitamin D levels, BMD, and the incidence of implant-related failures in patients who have undergone stabilization procedures on the spine, as well as to evaluate the role of postoperative correction of vitamin D₃ and K2 deficiencies in enhancing fixation stability and reducing complication risks. Materials and Methods: A retrospective single-center cohort study was conducted in specialized departments of Romodanov Neurosurgery Institute NAMS of Ukraine, from January 2023 to December 2024. …”
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Intraoperative titration of positive end-expiratory pressure in urological patients undergoing laparoscopic procedures under lateral position: a randomized controlled trial by Lili Pan, Xing Wu, Lingling Gao, Zhanqi Zhao, Li Yang, Jun Zhang

“…Abstract Objective The study aimed to investigate the role of electrical impedance tomography (EIT)-guided individualized positive end-expiratory pressure (PEEP) in surgical patients under lateral position. Methods The urological patients undergoing elective laparoscopic surgery were randomly allocated to either the PEEPEIT (titrated with EIT) or PEEP5 (fixed PEEP = 5cmH₂O) groups. …”
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Planned Repeat Cesarean Section at Term and Adverse Childhood Health Outcomes: A Record-Linkage Study. by Mairead Black, Siladitya Bhattacharya, Sam Philip, Jane E Norman, David J McLernon

“…This study aimed to address the evidence gap on long-term childhood outcomes following repeat CS by comparing adverse childhood health outcomes after (1) planned repeat CS and (2) unscheduled repeat CS with those that follow vaginal birth after CS (VBAC).<h4>Methods and findings</h4>A data-linkage cohort study was performed. …”
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Correlation of Lumbar Spine Fat Thickness and Surgical Site Infection in Degenerative Lumbar Spine Surgery by Sami AlEissa, Faisal Konbaz, Fahad AlHelal, Majid Abalkhail, Mohammad AlSalman, Mutlaq AlMutlaq, Naila Shaheen, Abdullah AlMahayni, Fahad AlTheneyan, Tariq Jawadi

“…Our aim was to identify the correlation betweenlumbar fat thickness and SSI and determine its predictive value compared to other risk factors inpredicting the incidence of SSI. Methods: This retrospective cohort study involved all patients aged 18 and above who underwent primary elective degenerative lumbar spine surgery in National Guard Health Affairs (NGHA) from 2016 to 2020 at King Abdulaziz Medical City (KAMC), Riyadh, Saudi Arabia. …”
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