Extracellular PHF-tau modulates astrocyte mitochondrial dynamics and mediates neuronal connectivity by Valentin Zufferey, Aatmika Barve, Enea Parietti, Luc Belinga, Audrey Bringaud, Yvan Varisco, Kerstin Fabbri, Francesca Capotosti, Paola Bezzi, Nicole Déglon, Pierre Marquet, Nicolas Preitner, Kevin Richetin

“…Results ePHF-tau was efficiently cleared by astrocytes within two days in a 3D neuron-astrocyte co-culture model. …”
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Enhanced fetal hemoglobin production via dual-beneficial mutation editing of the HBG promoter in hematopoietic stem and progenitor cells for β-hemoglobinopathies by Prathibha Babu Chandraprabha, Manoj Kumar K. Azhagiri, Vigneshwaran Venkatesan, Wendy Magis, Kirti Prasad, Sevanthy Suresh, Aswin Anand Pai, Srujan Marepally, Alok Srivastava, Kumarasamypet Murugesan Mohankumar, David I. K. Martin, Saravanabhavan Thangavel

“…The developed approach can simplify and broaden applications that require the cointroduction of multiple nucleotide modifications in HSPCs.…”
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p27^Kip1 and Tumors: Characterization of <i>CDKN1B</i> Variants Identified in MEN4 and Breast Cancer by Debora Bencivenga, Emanuela Stampone, Jahanzaib Azhar, Daniela Parente, Waqar Ali, Vitale Del Vecchio, Fulvio Della Ragione, Adriana Borriello

“…Finally, the loss of p27^Kip1 ability in blocking cell proliferation was in part explained through the different binding efficiency that mutant p27^Kip1 forms exhibited with Cyclin/Cyclin-dependent Kinase complexes (or proteins involved indirectly in that binding) with respect to the WT.…”
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Examining How Technology Supports Shared Decision-Making in Oncology Consultations: Qualitative Thematic Analysis by Alan Yung, Tim Shaw, Judy Kay, Anna Janssen

“…However, this potential has not yet been fully realized, and significant modifications are required to optimize their usefulness in person-centered SDM. …”
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Naphthalimide-polyamine conjugates: a promising avenue for targeted anticancer therapy by Zhiyong Tian, Luyao Tian, Chaojie Wang

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Investigation on the plugging performance of polybutyl methacrylate as nano plugging agent used in the water-based drilling fluids by Cheng Ye, Linlin Zhang, Shengjiang Xu, Gang Xie, Kesheng Rong, Yang Bai, Luyi Wang

“…Permeability tests of filter cakes reveal that 1.5 wt% PBMA achieves a 75.2% plugging efficiency, reducing permeability to 3.79 × 10⁻⁶ μm2—a value comparable to the intrinsic permeability of shale, which suggests a dual mechanism combining physical pore blockage and chemical adsorption. …”
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Callus formation, organogenesis and microclonal reproduction in different species of the genus Linum L. in vitro by С. В. Міщенко, Л. М. Кривошеєва

“…Intensive organogenesis was pecular to L. tenue, L. bienne, L. flavum, L. austriacum and L. grandiflorum. The efficiency of somaclone obtaining was quite low in L. nervosum and L. campanulatum. …”
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Optimising Enzymatic Cross-Linking: Impact on Physicochemical and Functional Properties of Lupin Flour and Soy Protein Isolate by Teguh Santoso, Yusur Al-Shaikhli, Thao M. Ho, Mishenki Rajapakse, Thao T. Le

“…The growing demand for plant-based protein alternatives has driven interest in protein modifications to enhance their functional properties in food applications. …”
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Improving recombinant protein secretion in Aspergillus nidulans by targeting the N-glycosylation machinery by Jaqueline Aline Gerhardt, Marcelo Ventura Rubio, Cesar Rafael Fanchini Terrasan, Natalia Sayuri Wassano, Aryadne Rodrigues, Fernanda Lopes de Figueiredo, Everton Paschoal Antoniel, Fabiano Jares Contesini, Artur Hermano Sampaio Dias, Uffe Hasbro Mortensen, Munir Salomão Skaf, André Damasio

“…Genes involved in the fungal secretory pathway have been modified to address productivity barriers, including post-translational modifications such as N-glycosylation of proteins. N-glycosylation can significantly affect protein stability, production yield, and functionality. …”
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Tuning the photovoltaic potential of thiazole based materials via incorporation of selenophene and electron acceptors rings at peripheral positions: A DFT approach by Muhammad Khalid, Sadia Jamal, Ataualpa Albert Carmo Braga, Muhammad Haroon, Rajeh Alotaibi, Ke Chen

“…Structural modifications were made via incorporating selenophene and extended acceptor units, to enhance photovoltaic response in the designed materials. …”
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Acousto-Electric Conversion Fiber Networks via Regional Activation of Schwann Cell-Derived Exosomes for Neurogenic Bone Regeneration by Weiwei Yi, Xiaoyu Han, Fan Wang, Qiuyu Tang, Huzhe Liu, Bo Liao, Jieliang Shen, Juan Wang, Wenguo Cui, Dingqun Bai

“…The incorporation of the piezoelectric polymer glycine imparts superior piezoelectric characteristics to the fiber network, while the conjugated π-electron motion within the conductive graphene network enhances internal electron transfer efficiency, thereby facilitating electrical conductivity. …”
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The impact of using advanced computer programs on the interior architectural design of the home أثر استخدام برامج الحاسوب المتقدمه في التصميم المعماري الداخلي للمسكن... by Mohamed Abdel Hamed

“…Additionally, it reviews the benefits of employing virtual reality techniques and virtual tours to foster user engagement and facilitate design exploration before implementation, thereby reducing time and costs associated with modifications during the early stages of a project. The study concludes that advancements in computer software represent a fundamental shift in the field of interior design, contributing to increased work efficiency and improved experiences for both users and designers, which positively influences housing quality and enriches the residents' living experience. …”
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Formation and mitigation of heterocyclic amines (HCAs) and polycyclic aromatic hydrocarbons (PAHs) in high temperature processed meat products: a review by Samuel Ayofemi Olalekan Adeyeye, Thiyagarajan Sivapriya, Palaniyandi Sankarganesh

“…Additionally, magnetic nanocomposites remove PAHs from food with remarkable efficiency (> 99%).…”
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Co-creation and evaluation of online care maps for children with medical complexity by Sherri Adams, Madison Beatty, Blossom G. Dharmaraj, Clara Moore, Arti D. Desai, Leah Bartlett, Erin Culbert, Eyal Cohen, Jennifer N. Stinson, Julia Orkin

“…In Phase 2 (Usability Testing), caregivers were monitored for errors and efficiency while completing a standardized task on the online care map. …”
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Prioritization of head and neck cancer patient care during the COVID-19 pandemic: a retrospective cohort study by Samuel S. Psycharis, Samer Salameh, Sena Turkdogan, Saad Razzaq, Kevin Zhao, Marco A. Mascarella, Keith Richardson, Alex M. Mlynarek, Michael P. Hier, Nader Sadeghi

“…The objective of this study is to assess the impact of COVID-19 guideline modifications on head and neck cancer (HNC) care at two tertiary care centers in Canada. …”
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Effect of Cs+ on Electrochemical Behavior of La3+ in LiCl-KCl by Wan LUO, Ji-dong MIAO, Da-wei YANG, Ya-lan LIU, Dong-dong WANG, Xiu-liang ZHAO

“…This behavior can be ascribed to competitive ion interactions and modifications in the electrochemical milieu, which impede the reduction efficiency of La3+ ions. …”
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The role of artificial intelligence in promoting health and developing preventive strategies for diabetes by Ameneh Marzban

“…These technologies empower individuals to make informed health decisions, adhere to recommended lifestyle modifications, and actively engage in their own care. …”
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Compact ultra-wide band two element vivaldi non-uniform slot MIMO antenna for body-centric applications by Sahar Saleh, Tale Saeidi, Nick Timmons, Bader Alali, Faroq Razzaz, Ayman A. Althuwayb

“…This innovative design, which optimizes antenna positioning and incorporates ground plane modifications, achieves remarkable improvements in BW, which covers multiple bands, including WLAN (2.4–2.485 GHz), X-band (8–12 GHz), and part of Ku band (12–18 GHz). …”
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Application of Ion Exchange Chromatography in the Development of Technology to Obtain Inactivated Poliovirus Vaccine by A. N. Piniaeva, A. A. Kovpak, Y. Y. Ivin, S. H. Sandzhieva, A. A. Shishova, I. O. Tсelykh, V. E. Vasilenko, K. V. Kaa, Zh. H. Mazhed, Yu. Kh. Khapchaev, A. A. Siniugina, A. A. Ishmukhametov

“…Multiplicity of infection was 0.02 ± 0.01 TCD50/cell. To evaluate the efficiency of ion-exchange chromatography we determined the degree of purification of fractions from ballast proteins, the degree of purification of fractions from residual cellular DNA, and the degree of extraction of the target antigen using specific formulas.Results and discussion. …”
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Propuesta y validación de un cuestionario para evaluar el rendimiento organizacional de las federaciones deportivas (Proposal and validation of a questionnaire to evaluate the orga... by Tamara Naval-Pesqué, Juan Carlos Guevara-Pérez, David Cabello-Manrique, Jordi Seguí-Urbaneja

“…Keywords: Sports federation; sports system; organizational performance; efficiency; validation; reliability; questionnaire. …”
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