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2641
Nanosensitizer-assisted sonodynamic therapy for breast cancer
Published 2025-04-01“…However, the clinical translation of SDT faces challenges, including the limited efficiency of sonosensitizers and resistance posed by the tumor microenvironment. …”
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2642
Minimizing DNA trapping while maintaining activity inhibition via selective PARP1 degrader
Published 2024-12-01“…By integrating protein degradation technology, we synthesized a PROTAC molecule 180055 based on the Rucaparib junction and VHL ligand, which efficiently and selectively degraded PARP1 and inhibited PARP1 enzyme activity without a noticeable DNA trapping effect. …”
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2643
A study of the applicability of a straw-fired batch boiler as a heat source for a small-scale cogeneration unit
Published 2016-12-01“…This is possible provided that an automatic fuel supply system is applied. Assuming that the efficiency of the electricity generation system is not less than 10%, it will be possible to generate 2-3 kW of electricity. …”
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2644
Synthesis of New DltA Inhibitors and Their Application as Adjuvant Antibiotics to Re-Sensitize Methicillin-Resistant <i>Staphylococcus aureus</i>
Published 2025-06-01“…The synthesis of a new acyclic and cyclic series of D-Ala-AMP analogues was reported. Chemical modifications were introduced on the carbohydrate, the sulfamate linker, and/or the amino-acid <i>N</i>-terminal moiety in order to increase <i>in vivo</i> stability and cell permeability. …”
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2645
Features of the Use of Personal Protective Equipment in the Foci of a New Coronavirus Infection
Published 2021-01-01“…As a result of using a whole range of disposable PPE of various modifications, the features and disadvantages of their operation in the field were established. …”
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2646
Commissioning a clinical proton pencil beam scanning beamline for pre-clinical ultra-high dose rate irradiations on a cyclotron-based system
Published 2024-11-01“…BackgroundThis manuscript describes modifications to a pencil beam scanning (PBS) proton gantry that enables ultra-high dose rates (UHDR) irradiation, including treatment planning and validation.MethodsBeamline modifications consisted of opening the energy slits and setting the degrader to pass-through mode to maximize the dose rate. …”
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2647
PRINCIPLES OF RE-ENGINEERING METHODOLOGY FOR TECHNOLOGICAL PROCESS IN PROCESSING OF RAW MATERIAL COMPONENTS WHILE PRODUCING CEMENT AND SILICATE PRODUCTS
Published 2014-10-01“…Grinding process is characterized by high energy consumption and low productivity. Nowadays efficiency of the ball mills applied for grinding is rather low. …”
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2648
ABA-induced alternative splicing drives transcriptomic reprogramming for drought tolerance in barley
Published 2025-04-01“…Transcriptomic analysis revealed that ABA pre-treatment primed plants for faster activation of stress-responsive pathways, with enhanced expression of genes related to chromatin modifications, RNA metabolism, and ABA signaling during drought. …”
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2649
Cyanobacteria: Photosynthetic cell factories for biofuel production
Published 2025-05-01“…Furthermore, they have higher photosynthetic efficiency, especially in CO2-rich environments, making them more desirable. …”
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2650
Tactics of Two-Stage IOL Implantation in Difficult Refractive Cases
Published 2021-10-01“…Our Sulcoflex IOL implantation experience has shown their high efficiency and safety.…”
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2651
Experience of Using New Technologies in Retail Trade
Published 2024-10-01“…Apart from that opportunities were studied that can offer new technologies for improving operational efficiency of retail trade enterprises. A conclusion was made that they are used insufficiently. …”
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2652
Review on heat transfer augmentation in helically coiled tube heat exchanger
Published 2024-11-01“…Their impact on overall system efficiency and size is substantial. A comprehensive review addressing passive heat transfer enhancement methods in HTHXs is notably absent. …”
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2653
TRENDS OF MODERNIZATION OF FOOD SERVICE INDUSTRY ENTERPRISES IN COUNTRYSIDE
Published 2015-06-01“…The peculiarities of the format modifications of the enterprise, its reconstruction , cateringand assortment are shown. …”
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2654
STUDY REGARDING USING SOLAR ENERGY FOR HOUSEHOLD`S SUFFICIENCY AND RURAL COMMUNITIES DEVELOPMENT IN UKRAINE
Published 2021-01-01“…The recent statistical data and market studies have shown that today Ukraine electricity market requires certain changes and modifications. Reform is necessary to build a new model of interaction between all participants in the energy market. …”
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2655
A hybrid Genetic Algorithm and Fuzzy Logic approach to ergonomic design of workstations in metal casting operations
Published 2024-12-01“…Real-time adjustments, such as desk height modifications and improved ventilation, effectively enhanced worker safety and comfort. …”
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2656
Using Burke's Dramatistic Pentad to Interpret Chinese "Gao-Kao" High Stakes Testing and Stressing - Paralelled Testing in the U.S. as Cross-Cultural Context
Published 2013-01-01“…In this study, we tried two modifications to the traditional test toconnect the assessment outcomes with school accountability. …”
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2657
Enhancing Solar Thermal Energy Storage via Torsionally Modified TPMS Structures Embedded in Sodium Acetate Trihydrate
Published 2025-06-01“…This study focuses on the numerical analysis of the impact of geometric modifications of sheet-gyroid structures on heat transfer in thermal energy storage systems utilizing sodium acetate trihydrate as a phase change material. …”
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2658
Development and Characterization of Nanoparticles for the Delivery of Gemcitabine Hydrochloride
Published 2014-01-01“…Percent entrapment efficiency of different formulations was around ∼54% to 65%. …”
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2659
Computational Study Using Tight-Binding Propagation Method: Optical Properties of Defected WS2 Monolayer
Published 2025-05-01“…The presence of defects generally reduces optical performance in the visible range, potentially limiting solar cell efficiency. However, the defect-induced modifications in the infrared region suggest a new potential for WS₂ monolayers in infrared sensing applications. …”
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2660
Dry Age Related Macular Degeneration – Oral Supplements, Which Combination and When ?
Published 2018-04-01“…Oxidative stress in the retina has been identified as an important predisposing factor which can be most efficiently modified by nutritional supplementation. …”
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