DNA methylation in esophageal cancer: technological advances and early detection clinical applications by Jiyu Tang, Jiyu Tang, Xiaoming Shi, Xiaoming Shi, Chao Song, Chao Song, Wenjing Zhang, Wenjing Zhang, Yan Yan, Yan Yan, Linchao Dai, Linchao Dai, Di Wu, Di Wu, Jie Qiu, Jie Qiu, Jiahuan Liu, Jiahuan Liu, Tao Wang, Tao Wang, Zuhong Lu, Zuhong Lu, Zuhong Lu

“…DNA methylation, a key epigenetic modification, has emerged as a significant biomarker for early detection of EC. …”
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Development of artificial intelligence-assisted deprescribing chatbot for patients with cystic fibrosis discontinuing proton pump inhibitors by Kristin M. Zimmerman, Samantha Hillen, Dayanjan Wijesinghe, Nicole E. Omecene

“…Iterative testing and modifications were conducted until simulated interactions met satisfaction. …”
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Pure data correction enhancing remote sensing image classification with a lightweight ensemble model by Huaxiang Song, Hanglu Xie, Yingying Duan, Xinyi Xie, Fang Gan, Wei Wang, Jinling Liu

“…Existing advanced methods often require substantial modifications to model architectures to achieve optimal performance, resulting in complex frameworks that are difficult to adapt. …”
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Modifying M‐44s to reduce risk of activation by swift fox by Julie K. Young

“…Modifying the height of M‐44s appears to reduce activation risk for nontarget canids, but also reduces the rate of activation by coyotes. Thus, height modifications to M‐44s may not be practical or efficient in areas with little or no risk to nontarget canids because of compromised coyote activation rates, but should be considered as an option to enable use of M‐44s for coyote management in areas where M‐44s are not currently used because nontarget, small canids may co‐occur. …”
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22 Advancing clinical trial reporting and AI integration: Optimizing protocol data extraction using LLMs and regulatory best practices by Ramya Sri Baluguri, Nicholas Anderson

“…Discussion/Significance of Impact: Our system fosters collaboration, efficient review, and compliance with clinical trial reporting standards. …”
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Exploring nanoparticle dynamics in binary chemical reactions within magnetized porous media: a computational analysis by Saleem Nasir, Abdallah Berrouk, Asim Aamir

“…Abstract Artificial Neural Networks are incredibly efficient at handling complicated and nonlinear mathematical problems, making them very useful for tackling these challenges. …”
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Relationship between tooth macrowear and jaw morphofunctional traits in representative hypercarnivores by Z. Jack Tseng, Larisa R. G. DeSantis

“…In bone cracking spotted hyenas carnassial biting mechanical efficiency increases significantly with increasing tooth wear, with no significant change in mandibular stress. …”
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Selection and Identification of a Model of Elasto-Viscoplasticity of the Filled Fluorocomposite according to Free and Constrained Compression Tests by D. S. Petukhov, A. A. Adamov, I. E. Keller

“…For this purpose, an efficient search algorithm based on the simplex method of minimizing the discrepancy was implemented. …”
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High-precision positioning of robotic systems on programme trajectories using satellite navigation measurements by S. V. Sokolov, A. I. Okhotnikov, D. V. Marshakov, I. V. Reshetnikova

“…This requires new algorithms for processing stochastic information more efficient than the least squares method, in particular, based on the theory of nonlinear stochastic filtration. …”
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Design of optimized single-switch capacitor cell balancing for EV battery management by Anjan N. Padmasali, Savitha G. Kini, Arun P. Parameswaran

“…However, there are possible modifications to them that may lead to algorithms with improved results. …”
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Bio-Based Nanomaterials for Groundwater Arsenic Remediation: Mechanisms, Challenges, and Future Perspectives by Md. Mahbubur Rahman, Md. Nizam Uddin, Md Mahadi Hassan Parvez, Md. Abdullah Al Mohotadi, Jannatul Ferdush

“…We discuss recent advancements in material design, surface modifications, and hybrid systems that enhance performance. …”
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Correlating Indoor Environmental Quality Parameters with Human Physiological Responses for Adaptive Comfort Control in Commercial Buildings by Haoyue Dai, Saba Imani, Joon-Ho Choi

“…By integrating environmental engineering and human physiology, this research offers empirical insights into the relationship between IEQ modifications and occupant well-being, particularly in the context of energy performance and efficiency. …”
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Comparative Evaluation of the Antimicrobial Activity of Different Antimicrobial Peptides against a Range of Pathogenic Bacteria. by Anna Ebbensgaard, Hanne Mordhorst, Michael Toft Overgaard, Claus Gyrup Nielsen, Frank Møller Aarestrup, Egon Bech Hansen

“…Thus, Cap18 is an excellent candidate for further development into practical use; however, modifications that should reduce the protease sensitivity would be needed. …”
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Transcriptomic and metabolomic profiling reveals genotype-dependent alkali tolerance in triticale roots: amino acid, flavonoid, and betalain metabolism linked to gene networks by Mingke Yan, Guodong Yang, Zhuoqi Liu, Dongming Yang, Xin Zhang, Chugang Mei

“…However, lack of molecular and metabolic data restricts the efficient breeding and field management of triticale cultivated in alkaline soils. …”
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Nanotechnology-Based Delivery of CRISPR/Cas9 for Cancer Treatment: A Comprehensive Review by Mohd Ahmar Rauf, Afifa Rao, Siva Sankari Sivasoorian, Arun K. Iyer

“…CRISPR/Cas9 (Clustered Regularly Interspaced Short Palindromic Repeats-associated protein 9)-mediated genome editing has emerged as a transformative tool in medicine, offering significant potential for cancer therapy because of its capacity to precisely target and alter the genetic modifications associated with the disease. However, a major challenge for its clinical translation is the safe and efficient in vivo delivery of CRISPR/Cas9 components to target cells. …”
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Effect of age on complexity and causality of the cardiovascular control: comparison between model-based and model-free approaches. by Alberto Porta, Luca Faes, Vlasta Bari, Andrea Marchi, Tito Bassani, Giandomenico Nollo, Natália Maria Perseguini, Juliana Milan, Vinícius Minatel, Audrey Borghi-Silva, Anielle C M Takahashi, Aparecida M Catai

“…The framework was applied to study age-related modifications of complexity and causality in healthy humans in supine resting (REST) and during standing (STAND). …”
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Unveiling the potential of a tri-seed synthesis approach: synthesis of zinc nanoparticles with enhanced antimicrobial properties by Aliyu Shehu, Oluwole Okunola Joshua, Uduma A. Uduma

“…This led to an absorbance peak of 1.33 nm, indicating efficient nanoparticle formation. Neem seed, black seed, and baobab seed extracts were used as reducing and stabilizing agents during synthesis. …”
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Scientific and technological challenges of recombinant egg protein production by Franziska Beck, Philipp Noll, Ute Schweiggert-Weisz, Marius Henkel

“…These challenges include posttranslational modifications, achieving functionality and cost parity to natural egg proteins, efficient resource bioconversion, and optimizing the bioprocess chain (upstream, bioproduction, and downstream processes). …”
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Ultra-compact quad-band half-mode SIW bandpass filter for Sub-6 GHz 5G applications by Reza Asgharivaskasi, Valiollah Mashayekhi, Nima Azadi-Tinat, Mohsen Koohestani

“…This configuration enables efficient and stable wave propagation even below the HMSIW cutoff frequency. …”
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Image-guided optimization of current steering in STN-DBS for Parkinson's disease by Atsushi Umemura, Atsushi Umemura, Hideki Mizuno, Mina Maki, Atsuo Masago

“…Motor function was evaluated via the Unified Parkinson's Disease Rating Scale part III (UPDRS III) before, 1 h after, and 3 months post-reprogramming.ResultsImage-guided current steering resulted in modifications in 29 of the 32 leads. Horizontal steering was newly introduced in 23 leads, while vertical adjustments were made in six leads. …”
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