Comparative pharmacodynamics of intranasal and enteral administration of captopril for uncomplicated hypertensive crises by I. L. Kechyn, V. V. Hladyshev, I. О. Pukhalska

“…It has been established that the nasal dosage form of captopril provides for the reduction of the arterial pressure to the level recommended in the case of uncomplicated hypertensive crises for 4 hours more efficiently than the oral agent. Captopril nasal gel has been shown to have good tolerance and there are practically no side effects from its use.…”
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Unveiling GPT-4V's hidden challenges behind high accuracy on USMLE questions: Observational Study by Zhichao Yang, Zonghai Yao, Mahbuba Tasmin, Parth Vashisht, Won Seok Jang, Feiyun Ouyang, Beining Wang, David McManus, Dan Berlowitz, Hong Yu

“…However, significant shortcomings were observed in the quality of explanations when questions were answered incorrectly, particularly in the interpretation of images, which could not be efficiently resolved through expert interaction. These findings reveal hidden flaws in the image interpretation capabilities of GPT-4V, underscoring the need for more comprehensive evaluations beyond multiple-choice questions before integrating GPT-4V into clinical settings.…”
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Extracellular vesicle-bound S100A8/A9 is differentially expressed in septic shock and prompts acute lung injury by Jiangmei Wang, Weiliang Wu, Tingting Wen, Guoping Zheng, Guanguan Qiu, Huifeng Qian, Ruoyang Zhang, Jie Xia, Yaoqin Hu, Ruoqiong Huang, Ruoxi Zang, Zhenkai Le, Qiang Shu, Jianguo Xu

“…Septic shock EVs were efficiently taken up by alveolar macrophages in vivo, leading to a significant increase in S100A8/A9 levels, which was inhibited by preincubating the EVs with an S100A8/A9 neutralizing antibody. …”
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Aerosols in the Mixed Layer and Mid-Troposphere from Long-Term Data of the Italian Automated Lidar-Ceilometer Network (ALICENET) and Comparison with the ERA5 and CAMS Models by Annachiara Bellini, Henri Diémoz, Gian Paolo Gobbi, Luca Di Liberto, Alessandro Bracci, Francesca Barnaba

“…In the lower troposphere, mixing processes efficiently dilute particles in the major urban area of Rome, while mesoscale circulations act either as removal mechanisms (reducing the PM by up to 35% in Rome) or transport pathways (increasing the loads by up to 50% in Aosta). …”
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Characterization of a blaKPC-3-carrying plasmid in a clinical isolate of Klebsiella pneumoniae belonging to the emerging successful clone ST147 by Esther Recacha, Mercedes Delgado-Valverde, Marina R. Pulido, Elena Pérez-Nadales, Patricia Pérez-Palacios, Inés Portillo-Calderón, Juan Manuel Sánchez-Calvo, Irene Gracia-Ahufinger, Álvaro Pascual

“…ABSTRACT Klebsiella pneumoniae ST147 has emerged as a successful clone able to efficiently disseminate a number of carbapenemases, including blaKPC. …”
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Interpretable prediction model for hand-foot-and-mouth disease incidence based on improved LSTM and XGBoost by Xiao LI, Shuyu HE, Yan PENG, Rongxin YANG, Lu TAO, Tingqi LOU, Wenqi HE

“…By simulating the selection, crossover, and mutation mechanisms in biological evolution, the GA efficiently searches for optimal solutions in the parameter space, thereby optimizing the performance of XGBoost. …”
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Boron Phenylalanine-Modified Polydopamine Nanoparticles for Targeted Delivery of Danusertib in Non-Small Cell Lung Cancer by Xu Y, Chen X, Zhang L, Li P, He J, Zhu M, Makvandi P, Jin X

“…The in vivo distribution and anti-tumor effects of B-PDA@Danu were studied in a mouse lung carcinoma in situ model.Results: The synthesized B-PDA@Danu nanoparticles were spherical, negatively charged, with an average particle size of (172.96± 1.61) nm, exhibited good stability, and efficiently loaded Danu. B-PDA@Danu promoted cellular uptake in vitro, inhibited cell viability (P < 0.001), induced G2/M cell cycle arrest (P < 0.001), and increased apoptosis (P < 0.001). …”
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Menggagas Model Penerapan Prorogasi dalam Pemenuhan Asas Peradilan Sederhana, Cepat, dan Berbiaya Ringan by Fikri Rafi Musyaffa Abidin, Taupiqqurrahman Taupiqqurrahman

“…The Supreme Court then created a simple claims institution to resolve cases where the value of the claim was not too large efficiently and reduce the flood of cases at the Supreme Court. …”
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Uji Parameter dan Arsitektur Convolutional Neural Network untuk Mendeteksi Citra Wajah Bermasker by Dewi Novita Sari, Muh. Arif Rahman, Randy Cahya Wihandika

“…Modeling can be done efficiently by knowing the relationship between the applied parameters. …”
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Small extracellular vesicles from human umbilical cord mesenchymal stem cells delivering miR-202-5p alleviate renal ischemia-reperfusion injury by targeting the GOLIM4/PI3K/AKT axi... by Xiang Peng, Xiang Peng, Wei Shi, Wei Shi, Haitao Yu, Haitao Yu, Zhenwei Feng, Zhenwei Feng, Zongjie Wei, Weiyang He, Xin Gou, Yongpeng Xie, Yongpeng Xie

“…Western blotting confirmed the presence of sEV markers CD9 and TSG101, and HucMSC-sEVs were efficiently taken up by HK-2 cells. In the OGD/R model, HucMSC-sEVs significantly reduced apoptosis, attenuated the expression of BAX and CC3, and promoted the upregulation of BCL-2. …”
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Comparison of the review models and regulatory timelines of seven countries participating in the ECOWAS-MRH initiative: identifying opportunities for improvement by Mercy Owusu-Asante, Mercy Owusu-Asante, Delese Mimi Darko, Seth Seaneke, Aminata Nacoulma, Oula Ibrahim Olivier Traore, Mojisola Christianah Adeyeye, Abayomi Akinyemi, Coulibaly Assane, Clarisse Épse Kaul Meledje Clamoungou, Oumy Kalsoum Ndao, Rokhaya Ndiaye Kande, James Komeh, Sheku Mansaray, Dalkoi Lamboni, Maheza Agba, Sam Salek, Sam Salek, Stuart Walker, Stuart Walker

“…The NRAs were included in the study based on their active participation in the regional initiative.MethodsThe Optimising Efficiencies in Regulatory Agencies (OpERA) questionnaire was completed by each of the NRAs to facilitate the assessment of the review models and regulatory timelines.ResultsThe authorities employ the three types of scientific review models, verification review (type 1), abridged review (type 2) and full review (type 3). …”
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RNF31 induces paclitaxel resistance by sustaining ALYREF cytoplasmic–nuclear shuttling in human triple‐negative breast cancer by Shumei Huang, Dongni Shi, Shuqin Dai, Xingyu Jiang, Rui Wang, Muwen Yang, Boyu Chen, Xuwei Chen, Lingzhi Kong, Lixin He, Pinwei Deng, Xiangfu Chen, Chuyong Lin, Yue Li, Jun Li, Libing Song, Yawei Shi, Weidong Wei

“…In paclitaxel‐sensitive TNBC, ALYREF was trapped in the cytoplasm by paclitaxel, while in paclitaxel‐resistant TNBC, ALYREF was efficiently transported into the nucleus to exert its function, allowing the export of the mRNAs encoding paclitaxel‐resistance‐related factors, including tubulin beta 3 class III (TUBB3), stathmin 1 (STMN1), and microtubule‐associated protein Tau (TAU), ultimately inducing paclitaxel resistance in TNBC. …”
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光皮梾木油的水解工艺优化与动力学模拟Optimization and kinetics modeling of the hydrolysis process of Swida wilsoniana oil by 匡曾敏1,2，张喻1，李昌珠2,3,4，肖静晶2,3,4，肖志红2,3,4,5， 李培旺2,3,4，聂素丽2，晁燕2 KUANG Zengmin1,2, ZHANG Yu1, LI Changzhu2,3,4, XIAO Jingjing2,3,4, XIAO Zhihong2,3,4,5, LI Peiwang2,3,4, NIE Suli2, CHAO Yan2

“…In conclusion, lipase Lipozyme RMIM can efficiently catalyze the hydrolysis of Swida wilsoniana oil.…”
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Community case study for surveillance and early case-detection of SARS-CoV-2 infections across high-risk key populations: the Sentinella programme by Maela Tebon, Ruth Joanna Davis, Alessia Savoldi, Nicola Soriolo, Sarah Elizabeth Jane Walters, Michela Nosè, Corrado Barbui, Giulia Turrini, Elisa Danese, Giuseppe Lippi, Riccardo Cecchetto, Annarita Mazzariol, Davide Gibellini, Gulser Caliskan, Pierpaolo Marchetti, Giuseppe Verlato, Andrea Princivalle, Stefano Porru, Evelina Tacconelli, Pasquale De Nardo

“…Promotion of testing helped to prevent and contain more efficiently potential clusters through strategic planning, especially for PEH. …”
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Microbiome-producing SCFAs are associated with preterm birth via trophoblast function modulation by Lulu Meng, Meng Meng, Ruonan Zhang, Ayinisa Wubulikasimu, Hao Peng, Lu Zhang, Xinwen Chang, Guihai Ai, Gang Zou, Qizhi He, Kai Wang, Ming Liu, Tao Duan

“…The cervicovaginal microbiota and its active metabolites can be efficiently used to predict and diagnose PTB. Our findings enrich the microbiota–placenta axis theory and contribute to the development of microecological products for pregnancy.IMPORTANCEPreterm birth (PTB) is a leading cause of infant mortality and long-term health issues, affecting millions of families worldwide. …”
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Liver fibrosis progression analyzed with AI predicts renal decline by Dan-Qin Sun, Jia-Qi Shen, Xiao-Fei Tong, Ya-Yun Ren, Hai-Yang Yuan, Yang-Yang Li, Xin-Lei Wang, Sui-Dan Chen, Pei-Wu Zhu, Xiao-Dong Wang, Christopher D. Byrne, Giovanni Targher, Lai Wei, Vincent W.S. Wong, Dean Tai, Arun J. Sanyal, Hong You, Ming-Hua Zheng

“…Regional qFibrosis assessment may efficiently predict eGFR decline, thus highlighting the importance of assessing renal function in patients with MASLD with worsening liver fibrosis. …”
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Mapping rice-crayfish co-culture (RCC) fields with Sentinel-1 and -2 time series in China's primary crayfish production region Jianghan Plain by Wenxia Tan, Xingcheng Wang, Lin Yan, Jun Yi, Tian Xia, Zhe Zeng, Gongliang Yu, Min Chai, Naga Manohar Velpuri, Apichaya Thaneerat

“…The comparison of annual water-level time series and satellite-NDVI time series, combined with the RCC farming information collected in surveys, reveals how satellite observations vary in correspondences to on-ground biophysical processes in RCC fields; and importantly, it provides information on how RCC fields can be efficiently distinguished from other land covers using satellite data. …”
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GENERATION OF CD34+ DERIVED HUMAN MACROPHAGE EXPRESSING CHIMERIC ANTIGEN RECEPTORS FOR CANCER TREATMENT by Ian-Costa, Livia-Furquin, Viviane-Jennifer, Théo-Gremen, Samuel-Campanelli, Rafael-Almeida, Vanderson-Rocha, Rodrigo-Nalio

“…Beside that, MacCD34 can efficiently phagocyte pHrodo™ Zymosan microbeads and produce TNF-α (RP = 33.2%; SS = 24,0%) and IL-1β α (RP = 21.9%; SS = 10.4%) in response to LPS activation. …”
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Research on Model Reconstruction Methods for Partial Point Cloud Information Loss by Zhengping CHANG, Guoshuai YUAN, Jiuhua LI, Yang ZHAO, Zhongqi WANG

“…Although the local model was efficiently reconstructed, the absence regions of the point cloud were ensured to transform in alignment with the actual model, improving the reconstructed model’s fidelity.Results and Discussions This study employed the outer cylinder of the landing gear as an experimental object to verify the proposed model reconstruction method. …”
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Properties and sensory acceptability of creatine-fortified foods using ultra-micronized creatine monohydrate – the KREAFOOD Project by Julián Quintero-Quiroz, Sebastian Botero-Ramirez, Simon Jaramillo-Caro, Natalia Zuluaga, Diego A. Bonilla

“…The superior cohesiveness observed in the KreaFood pancake product was attributed to its ability to integrate efficiently into the solid matrix during cooking. Our pancake premix was preferred by 53.3% (8/15) and demonstrated a more favorable sensory profile in terms of foaminess, odor intensity, and sweet taste, which are attributes generally desirable in solid foods.Conclusion The KreaFood creatine-fortified foods using ultra-micronized creatine monohydrate (Creavitalis®) demonstrated significant advantages by improving cohesiveness and reducing perceived granularity, thereby optimizing the sensory quality of the final product. …”
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