Resistance in Soybean Against Infection by <i>Phakopsora pachyrhizi</i> Is Induced by a Phosphite of Nickel and Potassium by Bianca Apolônio Fontes, Leandro Castro Silva, Bárbara Bezerra Menezes Picanço, Aline Vieira Barros, Isabela Maria Grossi Leal, Leonardo Packer Quadros, Fabrício Ávila Rodrigues

“…Collectively, these findings provide a global picture of the enhanced capacity of IR stimulus-sprayed plants to efficiently cope with fungal infection at both biochemical and physiological levels. …”
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Molecular identification of a Pm4 allele conferring powdery mildew resistance in durum wheat DR88 by Guohao Han, Lixian Xing, Tiantian Gu, Yuli Jin, Fengyu Shi, Hanwen Yan, Shiyu Zhuo, Zhipeng Shi, Jing Wang, Yilin Zhou, Wei Liu, Yelun Zhang, Diaoguo An

“…Two complementary DNA markers, including the dominant co-segregating marker JS717×JS718 and a newly developed closely-linked co-dominant marker WGRE77410, were confirmed to be available for efficiently transferring PmDR88 into the tested wheat backgrounds by marker-assisted selection (MAS) strategy. …”
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7aaRGD - a novel SPP1/integrin signaling-blocking peptide reverses immunosuppression and improves anti-PD-1 immunotherapy outcomes in experimental gliomas by Aleksandra Ellert-Miklaszewska, Paulina Pilanc, Katarzyna Poleszak, Adria-Jaume Roura, Salwador Cyranowski, Mitrajit Ghosh, Szymon Baluszek, Maria Pasierbinska, Bartłomiej Gielniewski, Julian Swatler, Yuliana Hovorova, Kamil Wojnicki, Bozena Kaminska

“…The effects of treatments on the tumor immune landscape were dissected using multiparameter flow cytometry, immunocytochemistry, cytokine profiling and RNA-seq analysis of sorted GAMs followed by CITE-seq based data deconvolution. Results 7aaRGD efficiently blocked microglia-dependent invasion of human and mouse glioma cells in vitro. …”
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Evolutionary dynamics of heparan sulfate utilization by SARS-CoV-2 by Shuhei Higuchi, Yafei Liu, Jun Shimizu, Chikako Ono, Yumi Itoh, Wataru Nakai, Hui Jin, Kazuki Kishida, Kazuo Takayama, Toru Okamoto, Yoshiko Murakami, Taroh Kinoshita, Yoshiharu Matsuura, Tatsuo Shioda, Hisashi Arase

“…Comparative analysis of heparan sulfate binding among Omicron subvariants—including BA.1, BA.2, BA.4, BA.5, XBB.1, and BA.2.86—revealed that most are likely to bind efficiently to heparan sulfate, but potential heparan sulfate binding sites of the spike protein have shifted from the early Omicron variants to more recent ones. …”
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Distribution of alkylamines in surface waters around the Antarctic Peninsula and Weddell Sea by A. Rocchi, A. Rocchi, M. F. Fitzsimons, P. Akenga, A. Sotomayor, E. L. Sà, Q. Güell-Bujons, M. Vila, Y. M. Castillo, M. Dall'Osto, D. Vaqué, C. Wohl, C. Wohl, C. Wohl, R. Simó, E. Berdalet

“…The only particulate form found was trimethylamine (TMA), detected for the first time in Antarctic waters at concentrations of 9.7 <span class="inline-formula">±</span> 4.6 <span class="inline-formula">nM</span>. We efficiently measured dissolved trimethylamine (TMA, 20.9 <span class="inline-formula">±</span> 15.2 <span class="inline-formula">nM</span>), dimethylamine (DMA, 32.3 <span class="inline-formula">±</span> 32.7 <span class="inline-formula">nM</span>) and diethylamine (DEA, 7.2 <span class="inline-formula">±</span> 1.7 <span class="inline-formula">nM</span>) across the surveyed area, while dissolved monomethylamine (MMA, 12.7 <span class="inline-formula">±</span> 0.1 <span class="inline-formula">nM</span>) remained below the detection limit in most samples. …”
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Analyse de la qualité de mise en œuvre et de la pérennité des modèles de Financement Basé sur les Résultats au Bénin en 2015 by Lamidhi Salami, Patrick Makoutodé Charles, Virginie Mongbo, Vignon Bédié, Charles Sossa Jérôme, Edgard-Marius Ouendo, Benjamin Fayomi

“…En somme, la réactivité et l’efficience étaient faibles dans le FBR_PRPSS tandis que la réactivité et l’indépendance étaient faibles dans le FBR_PASS. …”
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Predicting the strengths of basalt fiber reinforced concrete mixed with fly ash using AML and Hoffman and Gardener techniques by Kennedy C. Onyelowe, Viroon Kamchoom, Shadi Hanandeh, Ahmed M. Ebid, José Luis Llamuca Llamuca, Juan Carlos Cayán Martínez, Evlin Rose, Paul Awoyera, Siva Avudaiappan

“…These models benefit from advanced ensemble techniques that efficiently handle non-linear patterns and noise. SVR also performs admirably, whereas GEP and GMDHNN exhibit weaker predictive capabilities due to limitations in handling complex data dynamics. …”
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A Potential Antitumor Effect of Dendritic Cells Fused with Cancer Stem Cells in Hepatocellular Carcinoma by Ye-Bin Pang, Jian He, Bi-Yu Cui, Sheng Xu, Xi-Lei Li, Man-Ya Wu, Rong Liang, Yan Feng, Xing Guo, Xue-Hui Zhang, Xiao-Ling Luo

“…These results suggested that CD90+HepG2/DC fusion cells could efficiently stimulate T lymphocytes to generate specific CTLs targeting CD90+HepG2 cells. …”
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Mitochondria-tropic radioconjugates to enhance the therapeutic potential of terbium-161 by Joana F. Santos, Camille Van Laere, Catarina D. Silva, Irwin Cassells, Célia Fernandes, Paula Raposinho, Ana Belchior, Catarina I. G. Pinto, Filipa Mendes, Christopher Cawthorne, Maarten Ooms, Michiel Van de Voorde, Frederik Cleeren, António Paulo

“…Both [161Tb]Tb-TPP-PSMA and [161Tb]Tb-TPP-G3-PSMA showed high radiochemical stability and were efficiently internalized by PSMA-positive cells, while showing minimal uptake in PSMA-negative cells. …”
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Therapeutic potential of T-cell receptor targeting the HLA-A*11:01-restricted KRASG12V neoantigen without cross-recognition of the self-antigen RAB7B in solid tumors by Wang Wang, Jingjing Huang, Yanan Hao, Lin Zou, Xiaxia Han, Tong Chen, Meiying Shen, Bozhi Wang, Luo Li, Siyin Chen, Shengchun Liu, Xiaojian Han, Aishun Jin

“…Significantly, KT18 TCR-T cells efficiently mediated tumor regression in multiple xenograft models of solid tumors.Conclusions These findings highlight significant differences in peptide-HLA binding affinity and stability across public neoantigen-HLA pairings. …”
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Plasma membrane-coated nanoparticles and membrane vesicles to orchestrate multimodal antitumor immunity by Yang Li, Toshiaki Yoshikawa, Yusuke Ito, Satoshi Inoue, Takahiro Nakashima, Noriko Nakamura, Tetsuya Matsukawa, Seiichi Ohta, Yuki Kagoya, Hitomi Kasuya, Mirei Kataoka, Haosong Zhang, Chitose Oneyama

“…MVs loaded with BsAbs, 4-1BBL, IL-15, and IL-21 induced NK-cell cytotoxic activity in an antigen-specific manner.Conclusions We developed antitumor NPs and MVs that efficiently induced antitumor immune responses in vivo by simultaneously delivering multiple immunostimulatory signals to endogenous T cells. …”
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Identification and validation of reference genes for qPCR of Pseudomonas aeruginosa L10 under varying n-hexadecane concentrations by Huan Wang, Xiaobing Wang, Juntao Chen, Yumiao Zhang, Junhua Liu, Fangliang Xia, Jian Li, Tao Wu, Longxiang Liu

“…Abstract Pseudomonas aeruginosa can efficiently degrades petroleum hydrocarbons, but its degradation rate is affected by hydrocarbon pollutant concentrations, which must be neither too high nor too low. …”
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Formation and Characterization of Xylitol-Modified Glycidyl Methacrylate-<i>co</i>-Ethyl Methacrylate Matrices for Controlled Release of Antimicrobial Compounds by Adam Chyzy, Przemysław Gnatowski, Edyta Piłat, Maciej Sienkiewicz, Katarzyna Wozniak, Marta Wojnicka, Krzysztof Brzezinski, Marta E. Plonska-Brzezinska

“…The hydrogels with the APIs efficiently inhibit bacteria growth with low doses of drugs, and our findings are statistically significant, confirmed with ANOVA analysis at <i>p</i> = 0.05. …”
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Urban Tree Canopy Mapping and Analysis Using Iterative Annotation Method and Deep Learning: A Case Study in Beijing by Yulong Ding, Ximin Cui, Zhengchao Chen, Zeqing Wang, Debao Yuan, Xiang Meng, Xuan Yang, Yue Xu, Xiangyu Tian

“…By leveraging a limited number of labeled pixels, this approach efficiently generates a extensive labeled data, enabling the rapid construction of a high-precision dataset. …”
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Patient and surgeon perspectives of a large-scale system for automated, real-time monitoring and feedback of shared decision-making integrated into surgical practice: a qualitative... by Leila Rooshenas, Jane M Blazeby, Andrew Smith, Angus G K McNair, Andrew Judge, Michael R Whitehouse, Christie Cabral, Jessica Preshaw, Barnaby Reeves, Shelley Potter, Kerry N L Avery, Philip Braude, Adam Williams, Ben Gibbison, Hilary L Bekker, Rhiannon C Macefield, Christin Hoffmann, Val Snelgrove, Della Hopkins, Shireen Hickey, Archana Lingampalli, Paul Cresswell, Timothy Beckitt, Timothy Whittlestone, Jon Aning

“…There was general support for real-time monitoring and feedback because of its perceived ability to efficiently address deficiencies in surgical patients’ SDM experience at scale, and its perceived benefits to patients, surgeons and the wider organisation. …”
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A 3D human iPSC-derived multi-cell type neurosphere system to model cellular responses to chronic amyloidosis by Stefan Wendt, Ada J. Lin, Sarah N. Ebert, Declan J. Brennan, Wenji Cai, Yanyang Bai, Da Young Kong, Stefano Sorrentino, Christopher J. Groten, Christopher Lee, Jonathan Frew, Hyun B. Choi, Konstantina Karamboulas, Mathias Delhaye, Ian R. Mackenzie, David R. Kaplan, Freda D. Miller, Brian A. MacVicar, Haakon B. Nygaard

“…Single nuclei RNA sequencing (snRNA-seq) was performed to profile Aβ and microglia driven transcriptional changes in neurons and astrocytes, providing a comprehensive analysis of cellular responses. Results Microglia efficiently phagocytosed Aβ inside neurospheres and significantly reduced neurotoxicity, mitigating amyloidosis-induced oxidative stress and neurodegeneration following different exposure times to Aβ. …”
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The miR-302 cluster-IRFs-IRF1AS axis regulates influenza A virus replication in a species-specific manner by Lingcai Zhao, Chenglin Hou, Xifeng Hu, Chenfeng Jiang, Shengmin Li, Jun Xia, Jihui Ping

“…Mechanistically, the CTNNB1-induced miR-302 cluster targeted various interferon regulatory factors (mainly IRF1 and IRF2) with varying affinities and silencing efficiencies, except for miR-302e and miR-302f. Furthermore, miR-302 cluster-IRFs triggered the induction of interferon-induced hub genes and hub lncRNAs defined through weighted gene co-expression network analysis. …”
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Ending preventable maternal deaths in Malawi: the stakeholders consensus approach to identify maternal health needs priorities by Mtisunge Joshua Gondwe, Leonard Mndala, Chifundo Kondoni, Annie Kuyere Khumalo, Bertha Maseko, Laura Munthali, Catherine Bamuya, Rosemary Bilesi, Henry Phiri, Fannie Kachale, Malangizo Mbewe, Jennifer Riches, Maria Lisa Odland, Effie Chipeta, Elizabeth Chodzaza, David Lissauer, Alinane Linda Nyondo-Mipando

“…Priority setting is a crucial concept that can benefit the healthcare system in Malawi by efficiently distributing limited resources and maximising gains in maternal healthcare. …”
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CaMKII-dependent non-canonical RIG-I pathway promotes influenza virus propagation in the acute-phase of infection by Shinichiro Hama, Miho Watanabe-Takahashi, Hiroki Nishimura, Jumpei Omi, Masakazu Tamada, Takashi Saitoh, Katsumi Maenaka, Yuta Okuda, Aoi Ikegami, Asami Kitagawa, Koudai Furuta, Kana Izumi, Eiko Shimizu, Takashi Nishizono, Makoto Fujiwara, Tomohiro Miyasaka, Shigeo Takamori, Hiroshi Takayanagi, Keizo Nishikawa, Toshihiko Kobayashi, Noriko Toyama-Sorimachi, Makoto Yamashita, Toshiya Senda, Takatsugu Hirokawa, Haruhiko Bito, Kiyotaka Nishikawa

“…Here, we originally identified CaMKII-inhibitory peptide M3, which efficiently inhibits IAV-lethality in vitro and in vivo. …”
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Construction of a transfer learning-based depression detection model for female breast cancer patients: text sentiment analysis by Jiaqi Fu, Shisi Deng, Wanting Zheng, Chunrao Zheng, Jianhong Liu, Wenji Li, Yinghua Zeng, Hongpo Xie, Yuchang Mai, Chaixiu Li, Jie Lai, Yujie Zhang, Zihan Guo, Jianyao Tang, Chuhan Zhong, Huihui Zhao, Yanni Wu

“…To address this, our research team employed transfer learning methods to efficiently process and analyze large-scale text data for depression detection. …”
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