Surface functionalization of titanium implants with controlled-release glutathione conjugate for antioxidant and osteogenesis by Huichuan Xu, Kosuke Nozaki, Ziniu Yu, Nobuyuki Kawashima, Takeshi Ueno, Huaze Wu, Hao Wu, Noriyuki Wakabayashi

“…The oxidative stress microenvironment simulated using hydrogen peroxide (H2O2) showed that Ti substrates immobilizing VPA-GSH conjugates efficiently scavenged H2O2 and rescued cell viability owing to the controlled release of GSH. …”
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Frenemy: adaptive temperate phage_SAP_1432 supports Staphylococcus aureus survival in changing temperatures by Ting-ting Liu, Peng-cheng Gao, Jie-wen Cui, Wu-bin Wang, Fu-ying Zheng, Xue-rui Li, Yue-feng Chu

“…Thermal host performance curves at a multiplicity of infection of 0.001 showed that the phage killed the bacterium efficiently from 20 to 39°C and from 47 to 50°C. However, the phage resulted in a 41.2% increase in the maximal growth rate for the host bacterium from 1.53 (95% confidence interval [CI]: 1.42–1.63) in the absence of phage_SAP_1432 to 2.16 (95% CI: 2.02–2.37) in its presence, along with a shift in the optimum temperature from 41.0°C to 44.1°C. …”
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MXenes as catalysts for lightweight hydrogen storage materials: A review by Jiayi Deng, Yun Li, Hua Ning, Peilin Qing, Xiantun Huang, Hui Luo, Liang Zhang, Guangxu Li, Cunke Huang, Zhiqiang Lan, Wenzheng Zhou, Jin Guo, Xinhua Wang, Haizhen Liu

“…Introduction of catalysts or constructing nanostructures are two of the feasible methods that can efficiently tailor the hydrogen storage properties of the materials. …”
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Electrochemical Precipitation of Struvite from Wastewater: A Sustainable Approach for Nitrogen Recovery by Rúbia Mores, Anildo Cunha Junior, Fabiane Goldschmidt Antes, Marco Di Luccio, Carolina E. Demaman Oro, Marcus V. Tres, Clarice Steffens, Juliana Steffens, Airton Kunz, Rogério Marcos Dallago

“…Findings suggest that optimizing current density and electrode distance can improve nitrogen and phosphorus recovery efficiencies, making electrochemical struvite production a viable, sustainable approach for nutrient recycling. …”
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Biogeochemical cycling of sedimentary organic carbon and benthic nutrient fluxes in the semi-enclosed Jinhae Bay, Korea: insights into benthic-pelagic coupling by Sung-Uk An, Sung-Uk An, Kyung-Tae Kim, Sung-Han Kim, Sung-Han Kim, Ju-Wook Baek, Ju-Wook Baek, Hyun-Jeong Jeong, Hyun-Jeong Jeong, Chul-In Sun, Jin Young Choi, Jin Young Choi, Sokjin Hong, Dae In Lee, Jae Seong Lee, Jae Seong Lee

“…The burial flux into the sediment ranged from 3.96 ± 1.00 to 7.17 ± 1.64 mmol C m–2 d–1, and burial efficiencies were 4.25 to 15.8%, which indicated that deposited organic carbon was either mineralized in surface sediment before burial or laterally transferred by resuspension. …”
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A human monoclonal antibody isolated from Japanese encephalitis virus vaccine-vaccinated volunteer neutralizing various flaviviruses by Dong Chen, Dong Chen, Dong Chen, Jiayi Zhang, Jiayi Zhang, Jiayi Zhang, Yusha Liu, Jiayang Zhu, Jie Chen, Hongxia Ni, Jinsheng Wen

“…The epitopes on E proteins of JEV/ZIKV recognized by mAb LZY3412 were analyzed using molecular docking and constructing E protein mutants.ResultsOur results show that recombinant mAb LZY3412 has high-affinity with the E proteins of three viruses, with the kinetically derived binding affinity (KD) values of 440 and 482.5 nM against JEV-E protein and ZIKV-E protein, respectively; recombinant mAb LZY3412 can efficiently neutralize JEV and ZIKV infections in vitro, with the NT50 values of 19.9 ng/mL and 631 ng/mL, respectively; application of recombinant mAb LZY3412 can significantly improve the percentage survival and reduce the serum viral loads of neonatal mice infected with JEV or ZIKV. …”
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A novel IgG-based FLT3xCD3 bispecific antibody for the treatment of AML and B-ALL by Melanie Märklin, Gundram Jung, Jonas S Heitmann, Joseph Kauer, Helmut R Salih, Stefanie Mueller, Bochong Li, Latifa Zekri, Naveen K Mehta, Martin Pfluegler, Kristan Meetze, Isabelle Sindel, Fabian Vogt, Lukas Osburg, Hans-Jörg Bühring, Sebastian Hörner, Patrick A Baeuerle, Jennifer S Michaelson

“…AML cell lines expressing a broad range of surface levels of FLT3 were efficiently lysed on treatment with subnanomolar concentrations of CLN-049, whereas FLT3-expressing hematopoietic progenitor cells and dendritic cells were not sensitive to CLN-049 killing. …”
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A halophilic metalloprotease from Salinivibrio sp. YH4 and its application in antioxidant peptide production by Dan Liu, Yuyang Xiao, Yuyang Xiao, Yingying Wei, Maojia Xie, Yu Huang, Chaoyu Gan, Hailun He, Hailun He

“…The enzyme retained >80% activity under high salinity conditions (1 M NaCl) and exhibited strict substrate specificity for hydrophobic residues (Phe/Leu) at the P1’ position. It efficiently hydrolyzed both soluble and insoluble collagens. …”
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Recent Progress in Polyolefin Plastic: Polyethylene and Polypropylene Transformation and Depolymerization Techniques by Acácio Silva de Souza, Patricia Garcia Ferreira, Iva Souza de Jesus, Rafael Portugal Rizzo Franco de Oliveira, Alcione Silva de Carvalho, Debora Omena Futuro, Vitor Francisco Ferreira

“…Companies like Shell and ExxonMobil are investing heavily to overcome these barriers and improve recycling efficiencies. By leveraging these transformative strategies, we can reimagine the lifecycle of plastics and address one of the most pressing environmental challenges of our time. …”
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Individualized supplement of water-soluble vitamins: the influence of inflammation and renal function on circulating concentrations in critically digestive disease patients by Jingjing Wang, Jingjing Wang, Jing Yan, Jing Yan, Qi Chen, Linlin Shi, Ying Wang, Xiaoxiao Tian, Yumei Qi, Guoxun Li, Hailong Cao

“…Conventional vitamin supplementation may not efficiently alleviate vitamin C and B9 deficiency in patients with high inflammation, however, it may accelerate plasma vitamin B2, B5, and B6 accumulation with renal dysfunction.ConclusionWater-soluble vitamin levels were associated with inflammation and renal function. …”
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Panoramic spatial enhanced resolution proteomics (PSERP) reveals tumor architecture and heterogeneity in gliomas by Ziyan Xu, Yunzhi Wang, Tao Xie, Rongkui Luo, Heng-Li Ni, Hang Xiang, Shaoshuai Tang, Subei Tan, Rundong Fang, Peng Ran, Qiao Zhang, Xiaomeng Xu, Sha Tian, Fuchu He, Wenjun Yang, Chen Ding

“…We further demonstrated that combining tumor-specific peptides might enhance the efficacy of immunotherapy in both patient-derived cell (PDC) and patient-derived xenograft (PDX) models. PSERP efficiently retains precise spatial proteomic information within the tissue context and provides a deeper understanding of tissue biology and pathology at the molecular level.…”
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An electromagnetic-triboelectric hybrid generator (ETHG) for harvesting broadband and multi-directional vibration energy from transmission lines by Huicong Liu, Zizhao Wang, Yurui Shang, Zhenming Li, Wei Tang, Zhen Li, Wei Liu, Mingyang Liu, Yuyang Sun, Yongling Lu

“…A power management circuit (PMC) is proposed to efficiently manage the electromagnetic-triboelectric hybrid signals, increasing the EMG and TENG charging speeds by 172 and 333%, respectively, compared to a rectifier bridge scheme. …”
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Myristic acid beneficially modulates intervertebral disc degeneration by preventing endplate osteochondral remodeling and vertebral osteoporosis in naturally aged mice by Yan Gong, Yuzhuo Zhang, Xingda Chen, Zelin Zhou, Weicheng Qin, Yanchi Gan, Jiahui He, Jizhi Ma, Guifeng Chen, Qi Shang, Kai Tang, Honglin Chen, Yu Liu, De Liang, De Liang, Gengyang Shen, Xiaobing Jiang, Zhaojun Cheng, Zhaojun Cheng, Zhaojun Cheng

“…At the molecular level, MA efficiently reduced the expressions of osteoclast marker genes like ACP-5, CTSK, and DC-STAMP.ConclusionThe findings of this research suggest that MA is capable of inhibiting endplate osteochondral remodeling and vertebral osteoporosis, diminishing osteoclastogenesis to preserve bone mass, and consequently delaying IDD in naturally aged mice. …”
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<i>Vismia guianensis</i> Improves Survival of <i>Tenebrio molitor</i> and Mice During Lethal Infection with <i>Candida albicans</i> by Arthur André Castro Costa, Elizangela Pestana Motta, Aluísio Silva Oliveira, Pamela Gomes Santos, Josivan Regis Farias, Danielle Cristine Gomes Franco, Mayara Cristina Pinto Silva, Nicolle Teixeira Barbosa, Simone Batista Muniz, Luís Douglas Miranda. Silva, Lucilene Amorim Silva, Claudia Quintino Rocha, Flavia Raquel Fernandes Nascimento, Rosane Nassar Meireles Guerra

“…Treatment with EHVG efficiently improved the survival of the larvae after lethal infection (60%), probably due to the reduction in CFUs. …”
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Development of a Conditional Generative Adversarial Network Model for Television Spectrum Radio Environment Mapping by Oluwatobi Emmanuel Dare, Kennedy Okokpujie, Emmanuel Adetiba, Olabode Idowu-Bismark, Abdultaofeek Abayomi, Raymond Jules Kala, Emmanuel Owolabi, Udeme Christopher Ukpong

“…To efficiently use the finite wireless communication resource (radio spectrum), a Radio Environment Map (REM) is needed to monitor, analyse and provide rich awareness of spectrum activities in a radio propagating environment. …”
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Adjuvant combination and antigen multimerization shape neutralizing antibody and T cell responses to a SARS-CoV-2 RBD subunit vaccine by João Pedro da Silva Nunes, Mariângela de Oliveira Silva, Juliana de Souza Apostolico, Isabela Pazotti Daher, Rodolfo Ferreira Marques, Marcio Massao Yamamoto, Alexia Adrianne Venceslau Brito Carvalho, Maria Fernanda de Castro-Amarante, Edison Luiz Durigon, Carsten Wrenger, Luiz Mario Ramos Janini, Edmarcia Elisa de Souza, Robert Andreata-Santos, Juliana Terzi Maricato, Edecio Cunha-Neto, Edecio Cunha-Neto, Edecio Cunha-Neto, Jorge Kalil, Jorge Kalil, Silvia Beatriz Boscardin, Silvia Beatriz Boscardin, Daniela Santoro Rosa, Daniela Santoro Rosa

“…Additionally, RBD-trimer immunization more efficiently inhibited viral replication in the lungs of mice challenged with the ancestral Wuhan strain compared to the monomer. …”
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Machine learning prediction of HER2-low expression in breast cancers based on hematoxylin–eosin-stained slides by Jun Du, Jun Shi, Dongdong Sun, Yifei Wang, Guanfeng Liu, Jingru Chen, Wei Wang, Wenchao Zhou, Yushan Zheng, Haibo Wu

“…Conclusion Our AI model is able to directly predict HER2 expression through HE images with strong interpretability, and has a better ACC particularly in HER2-low breast cancers, which provides a method for AI evaluation of HER2 status and helps to perform HER2 evaluation economically and efficiently. It has the potential to assist pathologists to improve diagnosis and assess biomarkers for companion diagnostics.…”
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Delivery of dendritic cells targeting 3M2e-HA2 nanoparticles with a CpG adjuvant via lysosomal escape of Salmonella enhances protection against H9N2 avian influenza virus by Futing Jia, Wenfeng Wang, Yawen Tian, Ainul Zahra, Yingkai He, Chongbo Ge, Tongyu Zhang, Mingyue Wang, Jingshuo Gong, Gerui Zhang, Guilian Yang, Wentao Yang, Chunwei Shi, Jianzhong Wang, Haibin Huang, Xin Cao, Yang Zeng, Nan Wang, Zhannan Wang, Chunfeng Wang, Yanlong Jiang

“…All the constructed plasmids were then transformed into the sifA gene-deficient Salmonella vector χYL56 for oral immunization.The results showed that sifA-deficient Salmonella could efficiently increase antigen-specific mucosal sIgA antibody titers, especially in alveolar lavage samples, whereas the presence of the phage-54 nanobody could dramatically increase intracellular IFN-γ mRNA levels, indicating its ability to enhance the Th1-type immune response. …”
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Metabolic-imaging of human glioblastoma live tumors: A new precision-medicine approach to predict tumor treatment response early by Mariangela Morelli, Francesca Lessi, Serena Barachini, Serena Barachini, Romano Liotti, Romano Liotti, Nicola Montemurro, Paolo Perrini, Orazio Santo Santonocito, Carlo Gambacciani, Matija Snuderl, Francesco Pieri, Filippo Aquila, Azzurra Farnesi, Antonio Giuseppe Naccarato, Paolo Viacava, Francesco Cardarelli, Gianmarco Ferri, Gianmarco Ferri, Paul Mulholland, Diego Ottaviani, Fabiola Paiar, Gaetano Liberti, Francesco Pasqualetti, Francesco Pasqualetti, Michele Menicagli, Paolo Aretini, Giovanni Signore, Sara Franceschi, Chiara Maria Mazzanti

“…This therapeutic standstill is primarily due to preclinical approaches that do not fully respect the complexity of GB cell biology and fail to test efficiently anti-cancer treatments. Therefore, better treatment screening approaches are needed. …”
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TCR-engaging scaffolds selectively expand antigen-specific T-cells with a favorable phenotype for adoptive cell therapy by Marco Donia, Özcan Met, Julie Westerlin Kjeldsen, Sine Reker Hadrup, Inge Marie Svane, Arianna Draghi, Anders Handrup Kverneland, Christina Heeke, Siri Amanda Tvingsholm, Marcus Svensson Frej, Vibeke Mindahl Rafa, Ulla Kring Hansen, Maria Ormhøj, Alexander Tyron, Agnete W P Jensen, Mohammad Kadivar, Amalie Kai Bentzen, Kamilla K Munk, Gitte N Aasbjerg, Jeppe S H Ternander, Tripti Tamhane, Christian Schmess, Samuel A. Funt, Søren Nyboe Jakobsen

“…The resulting T-cell products were assessed for phenotypic and functional characteristics.Results We identified an optimal Ag-scaffold for expansion of T-cells for ACT, carrying pMHC and interleukin-2 (IL-2) and IL-21, with which we efficiently expanded both virus-specific and tumor-specific CD8+ T cells from peripheral blood of healthy donors and patients, respectively. …”
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