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    Marked differences in the effects of levetiracetam and its analogue brivaracetam on microglial, astrocytic, and neuronal density in the rat model of kainic acid-induced temporal lo... by Krisztina Kelemen, Krisztina Kelemen, Krisztina Kelemen, Máté Sárosi, Ágnes Csüdör, Károly Orbán-Kis, Hanga Kelemen, Hanga Kelemen, László Bába, Zsolt Gáll, Eszter Horváth, István Katona, István Katona, Tibor Szilágyi

    Published 2025-03-01
    “…Epileptic groups received KA in the right lateral ventricle, which induced status epilepticus followed by a 3-week recovery and latent period. Rats then underwent 3 weeks of oral brivaracetam, levetiracetam or placebo treatment with continuous video monitoring for seizure analysis. …”
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    An open dataset and machine learning algorithms for Niacin Skin-Flushing Response based screening of psychiatric disorders by Xuening Lyu, Rimsa Goperma, Dandan Wang, Chunling Wan, Liang Zhao

    Published 2025-08-01
    “…The core of our methodology involves a novel algorithm featuring an Efficient-Unet based Deep Learning model for the precise segmentation of NSR areas. …”
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  19. 31639

    YPEL2 regulates the efficacy of BRD4-EZH2 dual targeting in EZH2Y641mut germinal center-derived lymphoma by Aránzazu Chamorro-Jorganes, Núria Profitós-Pelejà, Clara Recasens-Zorzo, Juan G Valero, Diana Reyes-Garau, Laura Magnano, Ray Butler, Antonio Postigo, Patricia Pérez-Galán, Marcelo Lima Ribeiro, Gaël Roué

    Published 2025-03-01
    “…Gene expression profile, exploratory data analysis, and siRNA screening identified the PI3K/AKT-regulated gene and mitosis regulator, YPEL2, as a crucial factor involved in the efficacy of MYC/EZH2 dual targeting both in vitro and in vivo. …”
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  20. 31640

    Effective Dose of Oliceridine Fumarate Co-Administered with Remimazolam in Suppressing Gastroscope Insertion Responses for Adults by Yang W, Zhou R, Zhou X, Chen X, Zhou D, Zhang X

    Published 2025-06-01
    “…ED50 and ED95 were calculated using the modified Dixon’s up-and-down method and Probit regression analysis. Vital signs, adverse events, anesthesia induction time, recovery time, and satisfaction scores (patients, anesthesiologists, and endoscopists) were recorded.Results: When combined with 0.3 mg/kg remimazolam, the ED50 and ED95 of oliceridine for suppressing insertion responses were 12.717 ug/kg and 18.818 ug/kg, respectively. …”
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