Variation within and between digital pathology and light microscopy for the diagnosis of histopathology slides: blinded crossover comparison study by David RJ Snead, Ayesha S Azam, Jenny Thirlwall, Peter Kimani, Louise Hiller, Adam Bickers, Clinton Boyd, David Boyle, David Clark, Ian Ellis, Kishore Gopalakrishnan, Mohammad Ilyas, Paul Kelly, Maurice Loughrey, Desley Neil, Emad Rakha, Ian SD Roberts, Shatrughan Sah, Maria Soares, YeeWah Tsang, Manuel Salto-Tellez, Helen Higgins, Donna Howe, Abigail Takyi, Yan Chen, Agnieszka Ignatowicz, Jason Madan, Henry Nwankwo, George Partridge, Janet Dunn

“…Each sample was assessed twice by four pathologists (once using light microscopy, once using digital pathology, the order randomly assigned and a 6-week gap between viewings). Random-effects logistic regression models, including crossed random-effects terms for case and pathologist, estimated percentage clinical management concordance. …”
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The oxidation of Fe in riebeckite at 0.7 GPa by G. Della Ventura, G. Della Ventura, G. Della Ventura, R. Oberti, V. Misiti, F. Radica, G. J. Redhammer, S. Bernardini, M. Boiocchi, B. Mihailova

“…</p> <p>In this work, we address the effect of pressure on the oxidation of Fe in riebeckite, a process that is irreversible for temperatures above <span class="inline-formula">∼</span> 377 °C at 1 atm pressure, under oxidizing conditions. …”
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Characterization of recurrent UMOD variants (p.C255Y y p.Q316P) in a Galician cohort: genotype-phenotype correlation and clinical implications by Eloísa Sánchez-Cazorla, Borja Temes-Álvarez, Pilar Oliveros-Martínez, Pedro Fortes-González, María García-Murias, Ana Barcia de la Iglesia, Noa Carrera, Miguel Ángel García-González

“…In the Galician population there are recurrent mutations in this gene, this study aims to phenotypically characterize the recurrent variants to improve the prognosis and management strategies of affected patients. Methods: In a Galician population characterized by high genetic conservation, a retrospective cohort study was conducted with 37 patients from 15 families carrying recurrent variants in UMOD (p.C255Y and p.Q316P, from transcript NM_001008389.3). …”
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The clinical utility and safety of biomarker-guided immunosuppression withdrawal in liver transplantation: the LIFT prospective RCT by Julien Vionnet, Rosa Miquel, Juan G Abraldes, Juan-Jose Lozano, Pablo Ruiz, Miquel Navasa, Aileen Marshall, Frederik Nevens, William Gelson, Joanna Leithead, Steven Masson, Elmar Jaeckel, Richard Taubert, Phaedra Tachtatzis, Dennis Eurich, Kenneth Simpson, Eliano Bonaccorsi-Riani, James Ferguson, Alberto Quaglia, Maria Elstad, Marc Delord, Abdel Douiri, Alberto Sánchez-Fueyo

“…The majority of liver transplant patients need to take the anti-rejection drugs for life, which can be problematic due to their many side effects. However, years after transplantation, a small group of patients can stop their anti-rejection drugs without undergoing rejection. …”
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Caracterización de variantes recurrentes de UMOD (p.C255Y y p.Q316P) en una cohorte gallega: correlación genotipo-fenotipo e implicaciones clínicas by Eloísa Sánchez-Cazorla, Borja Temes-Álvarez, Pilar Oliveros-Martínez, Pedro Fortes-González, María García-Murias, Ana Barcia de la Iglesia, Noa Carrera, Miguel Ángel García-González

“…Both variants affect highly conserved domains with low tolerance to amino acid changes, which alters protein function and has clinical effects in patients. Hyperuricaemia was observed in 76% of p.C255Y carriers and 50% of p.Q316P carriers, while only the first variant was associated with episodes of gout. …”
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基于临床特征、SPECT/CT脑灌注显像参数和颈动脉超声斑块特征的多因素模型对无症状性颈动脉狭窄患者认知功能下降的风险评估(Risk Assessment of Cognitive Decline in Asymptomatic Carotid Artery Stenosis Patients: A Multifactor Model Based on Cl... by 王梦蝶，韩硕，刘志翔，谢海(WANG Mengdie, HAN Shuo, LIU Zhixiang, XIE Hai)

“…Abstract: Objective To construct a multifactor prediction model integrating clinical features, SPECT/CT cerebral perfusion imaging parameters, and carotid ultrasound plaque characteristics for assessing the risk of cognitive decline in patients with asymptomatic carotid artery stenosis. Methods A retrospective analysis was conducted on patients with asymptomatic carotid artery stenosis treated at the Affiliated Hospital of Shandong Second Medical University from January 1, 2021, to December 31, 2022. …”
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Mitigating Algorithmic Bias in AI-Driven Cardiovascular Imaging for Fairer Diagnostics by Md Abu Sufian, Lujain Alsadder, Wahiba Hamzi, Sadia Zaman, A. S. M. Sharifuzzaman Sagar, Boumediene Hamzi

“…<b>Conclusions</b>: The findings validate the effectiveness of fairness-aware algorithms in addressing cardiovascular predictive model biases. …”
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Multimodal versus non-contrast computed tomography for assessment of acute ischaemic stroke: the PRACTISE RCT by Keith W Muir, Salwa El Tawil, Alex McConnachie, Alicia Murray, Ian Ford, Grant Mair, Joanna Wardlaw

“…The reduction in thrombolysis was the opposite effect from what was predicted, but treatment rate was much higher than originally estimated. …”
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Evaluation of prognostic models to improve prediction of metastasis in patients following potentially curative treatment for primary colorectal cancer: the PROSPECT trial by Vicky Goh, Susan Mallett, Manuel Rodriguez-Justo, Victor Boulter, Rob Glynne-Jones, Saif Khan, Sarah Lessels, Dominic Patel, Davide Prezzi, Stuart Taylor, Steve Halligan

“…The number of patients undergoing additional histopathological analysis was relatively small, as the study was not specifically powered to detect an effect for these variables, but if a beneficial effect on prediction exists, it is likely to be small. …”
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Global Methane Budget 2000–2020 by M. Saunois, A. Martinez, B. Poulter, Z. Zhang, Z. Zhang, P. A. Raymond, P. Regnier, J. G. Canadell, R. B. Jackson, P. K. Patra, P. K. Patra, P. Bousquet, P. Ciais, E. J. Dlugokencky, X. Lan, X. Lan, G. H. Allen, D. Bastviken, D. J. Beerling, D. A. Belikov, D. R. Blake, S. Castaldi, M. Crippa, B. R. Deemer, F. Dennison, G. Etiope, G. Etiope, N. Gedney, L. Höglund-Isaksson, M. A. Holgerson, P. O. Hopcroft, G. Hugelius, A. Ito, A. K. Jain, R. Janardanan, M. S. Johnson, T. Kleinen, P. B. Krummel, R. Lauerwald, T. Li, X. Liu, K. C. McDonald, J. R. Melton, J. Mühle, J. Müller, F. Murguia-Flores, Y. Niwa, Y. Niwa, S. Noce, S. Pan, R. J. Parker, C. Peng, C. Peng, M. Ramonet, W. J. Riley, G. Rocher-Ros, J. A. Rosentreter, M. Sasakawa, A. Segers, S. J. Smith, S. J. Smith, E. H. Stanley, J. Thanwerdas, J. Thanwerdas, H. Tian, A. Tsuruta, F. N. Tubiello, T. S. Weber, G. R. van der Werf, D. E. J. Worthy, Y. Xi, Y. Yoshida, W. Zhang, W. Zhang, B. Zheng, B. Zheng, Q. Zhu, Q. Zhu, Q. Zhuang

“…Since 2012, global direct anthropogenic CH<span class="inline-formula">₄</span> emission trends have been tracking scenarios that assume no or minimal climate mitigation policies proposed by the Intergovernmental Panel on Climate Change (shared socio-economic pathways SSP5 and SSP3). Bottom-up methods suggest 16 % (94 Tg CH<span class="inline-formula">₄</span> yr<span class="inline-formula">⁻¹</span>) larger global emissions (669 Tg CH<span class="inline-formula">₄</span> yr<span class="inline-formula">⁻¹</span>, range 512–849) than top-down inversion methods for the 2010–2019 period. …”
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Human motor control during movements with high demands by Paul Kaufmann, Willi Koller, Elias Wallnöfer, Basilio Goncalves, Clara Scheer, Juliana Exel, Olivia Froschauer, Catherine Hlavac, Mathias Wiplinger, Lorenz Zweier, Arnold Baca, Hans Kainz

“…Thirdly, it was observed that psychological stress had an effect on temporal-spatial gait parameters, but not on synergies. …”
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Queering canons. Methodological heteronormativities and queer inquietudes by Cirus Rinaldi

“…Particular emphasis will be highlighting the needs to reconsider <em style="mso-bidi-font-style: normal;">queerly</em> sociological oriented methods and methodology, paying attention to researcher’s <em style="mso-bidi-font-style: normal;">ambiguous</em> role, her body and emotions in the permanent reflexive research process and in encounters with the (co)-researched.…”
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