Genomic structural variations lead to dysregulation of important coding and non‐coding RNA species in dilated cardiomyopathy by Jan Haas, Stefan Mester, Alan Lai, Karen S Frese, Farbod Sedaghat‐Hamedani, Elham Kayvanpour, Tobias Rausch, Rouven Nietsch, Jes‐Niels Boeckel, Avisha Carstensen, Mirko Völkers, Carsten Dietrich, Dietmar Pils, Ali Amr, Daniel B Holzer, Diana Martins Bordalo, Daniel Oehler, Tanja Weis, Derliz Mereles, Sebastian Buss, Eva Riechert, Emil Wirsz, Maximilian Wuerstle, Jan O Korbel, Andreas Keller, Hugo A Katus, Andreas E Posch, Benjamin Meder

“…In a cohort of patients (n = 50) with dilated cardiomyopathy (DCM), 80,635 non‐protein‐coding elements of the genome are deleted or duplicated by SVs, containing 3,758 long non‐coding RNAs and 1,756 protein‐coding transcripts. 65.3% of the SV‐eQTLs do not harbor a significant SNV‐eQTL, and for the regions with both classes of association, we find similar effect sizes. …”
Get full text

Improving older people’s experiences and safety at transitions of care: the PACT mixed-methods study including RCT by Jenni Murray, Ruth Baxter, Jane O’Hara, Laura Sheard, Catherine Hewitt, Natasha Hardicre, Charles Vincent, Eirini Oikonomou, Gerry Richardson, Rosie Shannon, Kalpita Baird, Stephen Brealey, Robbie Foy, Laura Mandefield, Sarah Hampton, Ed Breckin, Lubena Mirza, Alfredo Palacios, Sally Moore, Jayne Marran, Jacqui Elliot, Jane Schofield, Alison Cracknell, Beth Woods, Sarah Cockayne, Thomas Mills, Yvonne Birks, Olivia Joseph, Rebecca Lawton

“…Work package 6: Cluster randomised controlled trial assessing the clinical effectiveness, cost-effectiveness and fidelity of Your Care Needs You with parallel process evaluation Clinical effectiveness trial data collection A cRCT of YCNY. …”
Get full text

TNFRSF13B VARIANTS ACT AS MODIFIERS TO CLINICAL PHENOTYPES IN COMMON VARIABLE IMMUNE DEFICIENCY DISORDERS by Sinem Fırtına, Aslı Kutlu, Begüm Işıkgil, Medinenur Yozlu, Beyza Nur Cepeci, Hülya Yılmaz, Yuk Yin Ng, Özden Hatırnaz Ng, Ayça Kıykım, Esra Özek Yücel, Elif Karakoç Aydıner, Safa Barış, Ahmet Oğuzhan Özen, Serdar Nepesov, Yıldız Çamcıoğlu, İsmail Reisli, Muhlis Cem Ar, Müge Sayitoğlu

“…An integrative bioinformatics approach was utilized to provide a plausible explanation for CVID associations from different perspectives and to investigate the associations from the clinical findings.Results: Fifty-eight percent (15/26) of the detected variants were altered regulatory elements, such as transcription factor binding, miRNA binding sites, splice site regions or the thermodynamic impact on protein. …”
Get full text

A portable biosensor for simultaneous diagnosis of TNF-<i>α</i> and IL-1<i>β</i> in saliva biomarkers using twin electronic devices by M. Monajjemi, F. Mollaamin, M. Dehghandar, S. Shahriari, P. Latifi, S. Mohammadi

“…This element selectively binds TNF-<span class="inline-formula"><i>α</i></span> and IL-1<span class="inline-formula"><i>β</i></span> to an electronics-based metal–oxide–semiconductor field-effect transistor/electrolyte-gated transistor (MOSFET/GT) bio-detector device and label-free biosensor, allowing for the rapid, simultaneous detection of both biomarkers. …”
Get full text

The soluble epoxide hydrolase inhibitor TPPU alleviates Aβ-mediated neuroinflammatory responses in Drosophila melanogaster and cellular models of alzheimer’s disease by Xiaowen Sun, Hongxiang Liu, Wei Li, Lin Li, Qian Tian, Qingyang Cao, Yun Meng, Yan Shen, Fengyuan Che, Joanna C. Chiu, Jixu Yu, Bruce D. Hammock

“…Methods We established an Aβ42-transgenic Drosophila melanogaster model using the galactose-regulated upstream promoter element 4 (GAL4) / upstream active sequence (UAS) expression system and investigated the protective and anti-neuroinflammatory effects of TPPU against Aβ toxicity. …”
Get full text

Modeling regional aboveground carbon stock dynamics affected by land use and land cover changes by A.D. Malik, M.C.W. Arief, S. Withaningsih, P. Parikesit

“…In that massive construction and agricultural expansion are ongoing, it is critical to detect the potential changes in carbon stocks in the region. …”
Get full text

INTERACTION BETWEEN DENTO-MAXILLOFACIAL ANOMALIES AND GENERAL-SOMATIC HUMAN CONDITION (LITERATURE REVIEW) by L.V. Smaglyuk, H.V. Voronkova, A.Ye. Karasiunok, A.V. Liakhovska, V.I. Smaglyuk

“…Impaired growth and development of the dento-facial system was detected in case of juvenile rheumatoid arthritis. …”
Get full text

Analysis of molecular mechanisms of the development of experimental diabetes in Wistar rats under conditions of intermittent hypoxia by T. V. Ivanenko

“…This approach holds promise for effectively managing and enhancing diabetes outcomes, as it has the potential to influence metabolism and physiological processes within the body significantly. …”
Get full text

Implementation of a Biologically Inspired Responsive Joint Attention System for a Social Robot by Jesús García‐Martínez, Juan José Gamboa‐Montero, José Carlos Castillo, Álvaro Castro‐González, Miguel Angel Salichs

“…The concept of joint attention holds significant importance in human interaction and is pivotal in establishing rapport, understanding, and effective communication. Within social robotics, enhancing user perception and fostering a sense of natural interaction with robots becomes a central element. …”
Get full text

The Role of Vanadium in Metallodrugs Design and Its Interactive Profile with Protein Targets by Otávio Augusto Chaves, Francisco Mainardi Martins, Carlos Serpa, Davi Fernando Back

“…Their design requires a multidisciplinary approach, combining principles of inorganic chemistry, pharmacology, and molecular biology to create effective and safe therapeutic agents. Vanadium, the element of the fifth group of the first transition series (3d metals), has been already detected as a crucial species in the biological action of some enzymes, e.g., nitrogenases and chloroperoxidase; furthermore, vanadium-based compounds have recently been described as physiologically stable with therapeutic behavior, e.g., having anticancer, antidiabetic (insulin-mimicking), antiprotozoal, antibacterial, antiviral, and inhibition of neurodegenerative disease properties. …”
Get full text

Examination and Tracing of Stable Isotopes of Carbon and Hydrogen in Diesel Oil from Different Regions by Han-yu ZHANG, Zhao-wei JIE, Han-yang ZHENG, Xiao-han ZHU, Wei-ya XIE, Can HU, Zhan-fang LIU, Hong-ling GUO, Jun ZHU, Hong-cheng MEI

“…Stable isotope analysis is a method for detecting molecular elements at the element level. …”
Get full text

Hazard Analysis for Massive Civil Aviation Safety Oversight Reports Using Text Classification and Topic Modeling by Yaxi Xu, Zurui Gan, Rengang Guo, Xin Wang, Ke Shi, Pengfei Ma

“…In recent years, pre-trained language models have been applied to various text mining tasks and have proven to be effective. The aim of this paper is to apply text classification to the mining of these narrative texts and to show that text classification technology can be a critical element of the aviation safety oversight report analysis. …”
Get full text

Anatomical changes of the CNS in the course of schizophrenia and recurrent depression a review of current knowledge by Joanna Gmyz, Weronika Zubrzycka, Patrycja Grzech, Lena Kreczyńska

“…With the ability to observe the brains of patients with schizophrenia and recurrent depression, knowledge of its structure has expanded significantly. This is a key element in developing more targeted and effective therapies, both pharmacological and psychotherapeutic. …”
Get full text

User satisfaction with train fares: A comparative analysis in five Australian cities. by Puteri Paramita, Zuduo Zheng, Md Mazharul Haque, Simon Washington, Paul Hyland

“…In the public transport industry, travellers' perceived satisfaction is a key element in understanding their evaluation of, and loyalty to ridership. …”
Get full text

Domestication of different varieties in the cheese-making fungus Geotrichum candidum by Bennetot, Bastien, Vernadet, Jean-Philippe, Perkins, Vincent, Hautefeuille, Sophie, Rodríguez de la Vega, Ricardo C., O’Donnell, Samuel, Snirc, Alodie, Grondin, Cécile, Lessard, Marie-Hélène, Peron, Anne-Claire, Labrie, Steve, Landaud, Sophie, Giraud, Tatiana, Ropars, Jeanne

“…Within the cheese clade, we identified three genetically differentiated populations and we detected footprints of recombination and admixture. …”
Get full text

Assessment of Vibration Frequencies of Piezo-Actuated Panel by Model-Assisted Self-Mixing Interferometry by E. Bodo, L. Ciccarelli, V. Bello, S. Morganti, S. Merlo

“…The values of natural frequencies numerically obtained match the experimentally detected values, with a difference up to 3%, 6%, and 9% for Mode 1, Mode 4, and Mode 8, respectively, that are the three lowest modes with effective modal mass along the z-direction.…”
Get full text

Impact evaluation of a digital health platform empowering Kenyan women across the pregnancy-postpartum care continuum: A cluster randomized controlled trial. by Rajet Vatsa, Wei Chang, Sharon Akinyi, Sarah Little, Catherine Gakii, John Mungai, Cynthia Kahumbura, Anneka Wickramanayake, Sathyanath Rajasekharan, Jessica Cohen, Margaret McConnell

“…A limitation of our study was that outcomes were self-reported, and the study was not powered to detect effects on health outcomes.<h4>Conclusions</h4>Digital health tools indicate promise in addressing shortcomings in pregnant and postpartum women's health care, amidst systems that do not reliably deliver a minimally adequate standard of care. …”
Get full text

Design and modeling of a highly compact negative index floral shape metamaterial for flight navigation applications by M. Pallavi, Praveen Kumar, B. R. Shivakumar

“…Thus, CAS requires a focused multi-element radiator which can encompass the complete azimuth region. …”
Get full text

Eradication of Helicobacter pylori for prevention of aspirin-associated peptic ulcer bleeding in adults over 65 years: the HEAT RCT by CJ Hawkey, Anthony J Avery, Carol AC Coupland, Colin J Crooks, Jennifer S Dumbleton, FD Richard Hobbs, Denise Kendrick, Michael Moore, Clive Morris, Gregory Rubin, Murray Smith, Diane Stevenson

“…We used a decision tree model to account for other elements of the intervention: people refusing invitations to screen, people screened but returning a negative breath test and therefore not treated, and people with treatment side effects. …”
Get full text

Discussion on the Analysis Method of Iodide in Natural Water Samples by Xinyi SONG, Chunxue XU, Ziyi AN, Hongbin SUN, Zongding CHEN, Wei LIU, Yuqi ZHENG

“…Therefore, when the response value of iodide is high, the concentration value will be high.　　④ ICP-MS is only used to determine the total content of elements, and cannot be used for elemental speciation analysis. …”
Get full text