OP- 10 - NON-STEROIDAL ANTI-INFLAMMATORY DRUGS: A COMPARATIVE ANALYSIS BETWEEN THE SPANISH AND LATINDILI NETWORKS by FERNANDO BESSONE, Ismael Alvarez Alvarez, Nelia Hernandez, Maria Isabel Schinoni, Inmaculada Medina Caliz, Hugo Tanno, Hao Niu, Maria Virginia Reggiardo, Federico Tanno, Gabriel Rifrani, Ezequiel Ridruejo, Manuel Mendizabal, Raymundo Paraná, Eduardo Luis Fassio, Daiana Arnedillo, Antonella Cordone, Daniela Chiodi, Gisela Gualano, Javier Brahm, Maria Isabel Lucena Gonzalez, Raúl Jesus Andrade

“…We separately analyzed cases due to the most frequent culprits in each registry (ibuprofen and diclofenac). Notably, one patient died and one patient underwent liver transplantation linked to ibuprofen in the Spanish DILI Registry, while no death nor liver transplants were recorded in the LATINDILI due to ibuprofen. …”
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Moisture Content Vegetation Seasonal Variability Based on a Multiscale Remote Sensing Approach by Filippe L. M. Santos, Gonçalo Rodrigues, Miguel Potes, Flavio T. Couto, Maria João Costa, Susana Dias, Maria José Monteiro, Nuno de Almeida Ribeiro, Rui Salgado

“…Furthermore, the Random Forest (RF) classifier, a machine learning model, was used to estimate the LFMC considering each sensor approach. MSI sensor presented the best results (R² = 0.94) due to the presence of bands on the Short-Wave Infrared Imagery region. …”
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Factors associated with tobacco use among Saudi Arabian youth: Application of the Theory of Planned Behavior by Mosa A. Shubayr, Anwar S. Alhazmi, Mervat M. El Dalatony, Eman D. El Desouky, Abdulmohsen H. Al-Zalabani, Sarah S. Monshi, Ahmed A. Elkhobby, Shaikha K. Aldukhail, Mohammed M. Alqahtani, Mohammed S. Aldossary

“…Negative attitudes toward tobacco were inversely associated with usage (AOR=0.97; 95% CI: 0.970–0.974). Subjective norms, reflecting perceived social pressure, were positively associated with tobacco use (AOR=1.17; 95% CI: 1.170–1.176). …”
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Characterization of Pulmonary Sclerosing Pneumocytoma Assessed by 18F‐FDG PET/CT by Jie Xu, Xing Wan, Shudan Zhai, Shuai Yuan, Songyi Li, Wengui Xu, Mengran Fan, Lei Zhu

“…Results The 46 tumors were randomly distributed in each lobe of both lungs. The mean maximum diameter of these lesions was 2.2 cm (range: 0.6 to 6.5 cm). …”
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Advancing sustainability in low-resource settings: development and validation of a sustainability tool for evidence-based interventions and programs by Chisom Obiezu-Umeh, Divya S. Subramaniam, Ucheoma Nwaozuru, Titilola Gbaja-biamila, Titilola Gbaja-biamila, Lateef Akeem Blessing, Thembekile Shato, David Oladele, David Oladele, Lisa R. Hirschhorn, Enbal Shacham, Hong Xian, Oliver Chukwujekwu Ezechi, Juliet Iwelunmor

“…Existing sustainability measures developed in high-income countries may not reflect determinants unique to the sustainability of interventions in low- and middle-income countries (LMICs), including African countries. …”
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Decreased basal thermogenesis is associated with the downregulation of cellular metabolic activity of organs and serum thyroid hormones in fasting Eurasian Tree Sparrows (Passer mo... by Hong Jin, Qi Xia, Ziqing Gao, Yujie XuanYuan, Beibei Dong, Ming Li, Qingjian Liang, Jinsong Liu

“…Basal metabolic rate (BMR) reflects the energy expended by endothermic animals for basic physiological processes and constitutes a major part of their daily energy budget. …”
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Tilt-induced changes in f-wave characteristics during atrial fibrillation: an experimental and computational investigation by Mostafa Abdollahpur, Chiara Celotto, Chiara Celotto, Carlos Sánchez, Carlos Sánchez, Felix Plappert, Sten Östenson, Pyotr G. Platonov, Pablo Laguna, Pablo Laguna, Esther Pueyo, Esther Pueyo, Frida Sandberg

“…Transient phase is defined as the initial 2-minute interval following each postural change, reflecting immediate autonomic adaptation, whereas steady phase refers to the subsequent interval (from 3 minutes post-change until phase end) representing a stable autonomic state.MethodsOur primary aim is to investigate how the two branches of the autonomic nervous system (ANS) influence the f-wave frequency time series (f(m)). …”
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Subgrouping suicidal ideations: an ecological momentary assessment study in psychiatric inpatients by Stephanie Homan, Zachary Roman, Anja Ries, Prabhakaran Santhanam, Sofia Michel, Anna-Marie Bertram, Nina Klee, Carlo Berther, Sarina Blaser, Marion Gabi, Philipp Homan, Hanne Scheerer, Michael Colla, Stefan Vetter, Sebastian Olbrich, Erich Seifritz, Isaac Galatzer-Levy, Tobias Kowatsch, Urte Scholz, Birgit Kleim

“…A key challenge is that SI can fluctuate over time, potentially reflecting different subgroups that may offer important insights for suicide risk prediction. …”
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Freshwater and Estuarine Diatom Composition and Seasonal Variation: Influence of Environmental Factors and its Forensic Application by Mariana Torres Portugal, Áurea Madureira-Carvalho, Cláudia Ribeiro, Cristina Couto, Sandra Leal, Ana Sousa

“…Results: Diatoms showed distinct seasonal variation in each environment. In the stream, differences were observed between the two sampling points, with genus such as Pinnularia predominating in more alkaline conditions. …”
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Cost-effectiveness analysis of two integrated early childhood development programs into Bangladeshi primary health-care servicesResearch in context by Sheikh Jamal Hossain, Tom Palmer, S.M. Mulk Uddin Tipu, Syeda Fardina Mehrin, Shamima Shiraji, Mohammed Imrul Hasan, Mohammad Saiful Alam Bhuiyan, Nur-E Salveen, Fahmida Tofail, Helen Baker-Henningham, Hassan Haghparast-Bidgoli, Jena D. Hamadani

“…Intervention costs were estimated rom the provider perspective over the time horizon of each study (21 months for the group-based intervention; 24 months for the pair-based intervention). …”
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Splenic macrophage functional profile and its role in the immunopathogenesis of canine visceral leishmaniasis by Tainã Luís de Souza, Tainã Luís de Souza, Marta de Almeida Santiago, Francini Neves Ribeiro, Francini Neves Ribeiro, Fabiano Borges Figueiredo, Artur Augusto Velho Mendes Junior, Rodrigo Caldas Menezes, Renato Porrozzi, Fernanda Nazaré Morgado

“…Immunostaining demonstrated the presence of NOS2+, Arginase 1+, pSTAT3+, CD206+, and TGF-β+ cells, reflecting the engagement of both M1 and M2 macrophage subsets in the immune response, with a predominance of M1 profile. …”
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A robust automated segmentation method for white matter hyperintensity of vascular-origin by Haoying He, Jiu Jiang, Sisi Peng, Chu He, Tianqi Sun, Fan Fan, Hao Song, Dong Sun, Zhipeng Xu, Shenjia Wu, Dongwei Lu, Junjian Zhang

“…Our initial dataset comprised 126 participants with varying WMH burdens due to SVD, each with manually segmented WMH masks used for training and testing. …”
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Impact of chemical composition on metabolizable energy and its prediction models in brewer's spent grains for broilers at different ages by Mingqiang Song, Kai Tian, Cong Ren, Youyou Liu, Xiaomeng Ye, Yuming Wang, Jingjing Xie, Feng Zhao

“…Broilers aged 11 to 14 days or 25 to 28 days were fed 11 experimental diets (one basal diet and 10 diets supplemented with BSG) in a 2 × 11 completely randomized factorial arrangement. Each experimental diet was assigned to 6 replicates of 4 broilers, either 11 to 14 days or 25 to 28 days of age. …”
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Safety, tumor trafficking and immunogenicity of chimeric antigen receptor (CAR)-T cells specific for TAG-72 in colorectal cancer by Jeffrey Schlom, Carl H. June, George A. Fisher, John J. Nemunaitis, Kristen M. Hege, Emily K. Bergsland, Robert S. Warren, James G. McArthur, Andy A. Lin, Stephen A. Sherwin

“…In both trials, a brief course of interferon-alpha (IFN-α) was given with each CART72 infusion to upregulate expression of TAG-72.Results Fourteen patients were enrolled in C-9701 and nine in C-9702. …”
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Continuous theta-burst stimulation demonstrates language-network-specific causal effects on syntactic processing by Chenyang Gao, Junjie Wu, Yao Cheng, Yuming Ke, Xingfang Qu, Mingchuan Yang, Gesa Hartwigsen, Luyao Chen

“…Thirty healthy adult Chinese native speakers underwent four continuous theta-burst stimulation (cTBS) sessions: stimulation over IFG, stimulation over IFG + pTL, stimulation over IFG + SPL, and sham stimulation over IFG + irrelevant region in a pseudo-randomized order. In each session, participants were required to label the syntactic categories of jabberwocky sequences retaining real Chinese function words (e.g., “ム了ウ” is labeled as a verb phrase (VP): “[VP [V了]N]”, similar to “ziff-ed a wug”, where “ziff” and “wug” are nonsense pseudowords, and the whole phrase is a VP). …”
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Metabolomic profiling reveals interindividual metabolic variability and its association with cardiovascular-kidney-metabolic syndrome risk by Meng Zhou, Wenxiu Sun, Yuhan Gao, Bei Jiang, Tianwei Sun, Rui Xu, Xiujuan Zhang, Qian Wang, Qiuhui Xuan, Shizhan Ma

“…Abstract Background and objective Cardiovascular-Kidney-Metabolic (CKM) syndrome reflects the interrelated pathophysiology of obesity, insulin resistance, type 2 diabetes, chronic kidney disease, and cardiovascular disease. …”
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Genome-wide identification and unveiling the role of MAP kinase cascade genes involved in sugarcane response to abiotic stressors by Ahmad Ali, Xue-Ting Zhao, Ji-Shan Lin, Ting-Ting Zhao, Cui-Lian Feng, Ling Li, Rui-Jie Wu, Qi-Xing Huang, Hong-Bo Liu, Jun-Gang Wang

“…Phylogenetic classification revealed that four subgroups were present in each ScMAPK and ScMAPKK family, and three sub-families (ZIK-like, RAF-like, and MEKK-like) presented in the ScMAPKKK family. …”
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Beyond BMI: a comprehensive approach to pediatric obesity assessment by Norma Cipatli Ayuzo Del Valle, Norma Cipatli Ayuzo Del Valle, Perla Pérez-Treviño, Ana Carla Cepeda Lopez, Ana Carla Cepeda Lopez, Regina M. Murillo-Torres, Elena Cristina Castillo, Diego Gutierrez-Cantu, Oscar Tamez-Rivera, Oscar Tamez-Rivera, Mayela Paez Flores, Isabella Flores-Ayuzo, Luis Alberto Luévano-Martinez, Sergio Javier Fernandez Ortiz, Sergio Javier Fernandez Ortiz, Noemí García, Leonardo Mancillas-Adame

“…Conversely, four participants initially categorized as obese by BMI were reclassified as non-obese, reflecting elevated lean mass rather than adiposity. …”
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Exploring Scientific Outputs about Globalization: A Conceptual Framework Study by Saleh Rahimi, Faramarz Soheili

“…Fourth Quadrant (Low Density, High Potential): Cluster 1 (globalization and economy) showed low centrality but high potential for future growth, reflecting globalization impact on national and international economies through concepts like economic growth and the KOF Globalization Index.This study underscored globalization as an interdisciplinary topic that spans foundational concepts and specialized applications. …”
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Uncovering the Understanding of the Concept of Patient Similarity in Cancer Research and Treatment: Scoping Review by Iryna Manuilova, Jan Bossenz, Annemarie Bianka Weise, Dominik Boehm, Marvin Döbel, Silke D Werle, Arsenij Ustjanzew, Niklas Reimer, Cosima Strantz, Philipp Unberath, Patrick Metzger, Thomas Pauli, Susann Schulze, Sonja Hiemer, Irmak Oguztürk, Leila Kamkar, Hans A Kestler, Hauke Busch, Benedikt Brors, Jan Christoph

“…Duplicate records were removed, and study selection was carried out in 3 phases: title and abstract screening, disagreement resolution, and full-text screening. Each step was independently performed by 2 reviewers in Rayyan, with conflicts resolved by a third reviewer. …”
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