Gut microbiota-derived extracellular vesicles form a distinct entity from gut microbiota by Anna Kaisanlahti, Jenni Turunen, Jenni Hekkala, Surbhi Mishra, Sonja Karikka, Sajeen Bahadur Amatya, Niko Paalanne, Johanna Kruger, Anne M. Portaankorva, Jussi Koivunen, Arja Jukkola, Pia Vihinen, Päivi Auvinen, Sirpa Leppä, Peeter Karihtala, Vesa Koivukangas, Janne Hukkanen, Seppo Vainio, Anatoliy Samoylenko, Genevieve Bart, Leo Lahti, Justus Reunanen, Mysore V. Tejesvi, Terhi Ruuska-Loewald

“…Here, we show that machine learning models were able to accurately distinguish gut microbiota and respective microbiota-derived EV samples according to their taxonomic composition both within each data set (area under the curve [AUC] 0.764–1.00) and in a cross-study setting (AUC 0.701–0.997). …”
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Depressive symptoms, education, gender and history of migration - an intersectional analysis using data from the German National Cohort (NAKO) by Nico Vonneilich, Heiko Becher, Klaus Berger, Patricia Bohmann, Hermann Brenner, Stefanie Castell, Nico Dragano, Volker Harth, Stefanie Jaskulski, André Karch, Thomas Keil, Lilian Krist, Berit Lange, Michael Leitzmann, Janka Massag, Claudia Meinke-Franze, Rafael Mikolajczyk, Nadia Obi, Tobias Pischon, Marvin Reuter, Börge Schmidt, Ilais Moreno Velásquez, Henry Völzke, Christian Wiessner, Olaf von dem Knesebeck, Daniel Lüdecke

“…Results The analyses revealed an educational gradient in depressive symptoms, with differences within each educational group when gender and history of migration were introduced to the models. …”
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Nucleosome positioning sequence patterns as packing or regulatory. by Erinija Pranckeviciene, Sergey Hosid, Nathan Liang, Ilya Ioshikhes

“…However, there was no correlation between them and patterns in human apoptotic lymphocyte cells and yeast, but the latter two were highly correlated with each other. By their dinucleotide arrangements the analyzed NPS patterns classified into stable canonical WW/SS (W = A or T and S = C or G dinucleotide) and less stable RR/YY (R = A or G and Y = C or T dinucleotide) patterns and anti-patterns. …”
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Observations of Uranus at High Phase Angle as Seen by New Horizons by Samantha N. Hasler, L. C. Mayorga, William M. Grundy, Amy A. Simon, Susan D. Benecchi, Carly J. A. Howett, Silvia Protopapa, Heidi B. Hammel, Daniel D. Wenkert, S. Alan Stern, Kelsi N. Singer, Simon B. Porter, Pontus C. Brandt, Joel W. Parker, Anne J. Verbiscer, John R. Spencer, The New Horizons Planetary Science Theme Team

“…We performed aperture photometry on the New Horizons observations of Uranus to obtain its brightness in each photometric band. The photometry suggests that Uranus may be darker than predicted by a Lambertian phase curve in the blue and red filters. …”
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Understanding the Mindset of Protesting Women Regarding the Causes and Consequences of Protest Actions: A Qualitative Study of Imprisoned Female Protesters in Yazd by Ali Nikmanesh, Ali Ruhani, Seyed Alireza Afshani, Ahmad Kalateh Sadati

“…To enhance the credibility of the data, the researchers established effective communication and allocated ample time for each interview, with sessions lasting approximately 2 hours. …”
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Comprehensive Evaluation of Operation Safety of Earth-rock Dams Based on Weight Optimization-cloud Model by ZHANG Jianwei, WU Weitao, HOU Ge, HUANG Jinlin, WANG Bingpeng, LIU Hongze, HU Zixu

“…The membership degree was calculated by generating different numbers of cloud droplets through the forward cloud generators, which were taken as the model solution under each number of cloud droplets. The expected value of the membership degree was derived based on the normal distribution probability density function and was taken as the theoretical solution. …”
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A 3D Clinical Face Phenotype Space of Genetic Syndromes Using a Triplet-Based Singular Geometric Autoencoder by Soha S. Mahdi, Eduarda Caldeira, Harold Matthews, Michiel Vanneste, Nele Nauwelaers, Meng Yuan, Giorgos Bouritsas, Gareth S. Baynam, Peter Hammond, Richard Spritz, Ophir D. Klein, Michael Bronstein, Benedikt Hallgrimsson, Hilde Peeters, Peter Claes

“…We further proved the usefulness of each component of the proposed framework, highlighting their individual impact. …”
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Increased coupling between global grey matter and CSF-derived fMRI signal in young adults after partial sleep deprivation – evidence from the sleepy brain study by Cornelius Berberich, Leander Müller, Benedikt Zott, Rachel Nuttal, Gerhard Schneider, Claus Zimmer, Christian Sorg, Dennis M. Hedderich, Juliana Zimmermann

“…We examined gGM-CSF coupling twice in each subject, in the evening following a night of normal sleep and after a night of partial sleep deprivation (≤ 3 h of sleep).Our results revealed significantly increased gGM-CSF coupling after sleep deprivation compared to normal sleep (mean r = -0.30 ± 0.19 vs. -0.25 ± 0.14; t(62) = 2.05, p = 0.045). …”
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Evaluation of Soil Aggregate Sieving: The Impact of Field Moisture Content on Size Distribution and Stability by Jie Liu, Yuping Yang, Jian Zhou, Xintong Feng, Yuan Li, Yuze Li, Junlin Zi, Chunru Wang, Enli Wang, Yuehui Jia

“…Cluster analysis, based on soil properties, identified six distinct soil groups, each demonstrating a significant correlation between the characteristic values of DOSA and SRWC, with determination coefficients (R²) above 0.717. …”
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Clinical decision support for pharmacologic management of treatment-resistant depression with augmented large language models by Roy H. Perlis, Pilar F. Verhaak, Joseph Goldberg, Cristina Cusin, Michael Ostacher, Gin S. Malhi, Carlos A. Zarate, Richard C. Shelton, Dan V. Iosifescu, Mauricio Tohen, Manish Kumar Jha, Martha Sajatovic, Michael Berk

“…Each vignette was evaluated by 2 expert psychopharmacologists to determine and rank the 5 best next-step pharmacologic interventions, as well as contraindicated or poor next-step treatments. …”
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Insights from fifteen years of real-world development, testing and implementation of youth digital mental health interventions by Shane Cross, Shaminka Mangelsdorf, Lee Valentine, Shaunagh O'Sullivan, Carla McEnery, Isabelle Scott, Tamsyn Gilbertson, Shona Louis, Jon Myer, Ping Liu, Niel Mac Dhonnagáin, Tom Wren, Eleanor Carey, Daniela Cagliarini, Ross Jacobs, Roos Pot-Kolder, Imogen Bell, Jennifer Nicholas, Lucia Valmaggia, John Gleeson, Mario Alvarez-Jimenez

“…Drawing on the work of Orygen Digital, we outline the evolution of interventions including the Moderated Online Social Therapy (MOST) platform, the Mello app, and a suite of virtual reality-based therapies; all developed to meet the complex clinical, developmental, and service needs of youth aged 12 to 25.We identify ten key challenges and opportunities encountered in designing, developing and implementing these DMHIs: (1) meaningful co-design; (2) sustained user engagement; (3) personalization and transdiagnostic targeting; (4) optimizing intensities of human support; (5) leveraging peer support and social networking; (6) embedding DMHIs in clinical services; (7) blending digital and face-to-face care; (8) building data infrastructure and learning health systems; (9) developing sustainable and scalable business models; and (10) preparing DMHIs for large language models. Each theme reflects both achievements and persistent challenges, and is illustrated through a synthesis of the current evidence and real-world insights from our clinical trials and national-scale service implementations.Our approach is grounded in various frameworks including clinical staging, self-determination theory, supportive accountability, and minimally disruptive medicine. …”
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Social Confrontation with Menstruation: A Feminist Ethnography of Menstrual Experience among Female Instagram Users by Rana Mohammad Taghinejad Esfahani, Majid Movahed, Halimeh Enayat, Aliyar Ahmadi

“…Discussion of Results & ConclusionWe analyzed the social experiences of our participants, each of which, while unique, shared commonalities with others. …”
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The Effectiveness of Psychological Well-Being Training based on the PERMA Model for 14 to 16-Year-Old Girls with Anxiety Symptoms Zahra Daneshian: M.A. Student of Child and Adoles... by zahra danesian, Shahriar Shahidi, Saeed Ghanbari

“…Participants noted that exercises related to positive emotions, such as gratitude and reflecting on positive experiences, were the most frequently used (22%). …”
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Form follows function: Morphological and immunohistological insights into epithelial–mesenchymal transition characteristics of tumor buds by Kathrin Enderle-Ammour, Moritz Bader, Theresa Dorothee Ahrens, Kai Franke, Sylvia Timme, Agnes Csanadi, Jens Hoeppner, Birte Kulemann, Jochen Maurer, Philip Reiss, Oliver Schilling, Tobias Keck, Thomas Brabletz, Elmar Stickeler, Martin Werner, Ulrich Friedrich Wellner, Peter Bronsert

“…In cancer biology, the architectural concept “form follows function” is reflected by cell morphology, migration, and epithelial–mesenchymal transition protein pattern. …”
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The Acoustic Index User's Guide: A practical manual for defining, generating and understanding current and future acoustic indices by Tom Bradfer‐Lawrence, Brad Duthie, Carlos Abrahams, Matyáš Adam, Ross J. Barnett, Amy Beeston, Jennifer Darby, Benedict Dell, Nick Gardner, Amandine Gasc, Becky Heath, Nia Howells, Magnus Janson, Maria‐Viktoria Kyoseva, Thomas Luypaert, Oliver C. Metcalf, Anna E. Nousek‐McGregor, Frederica Poznansky, Samuel R. P.‐J. Ross, Sarab Sethi, Siobhan Smyth, Emily Waddell, Jérémy S. P. Froidevaux

“…Currently, the specifics of each index's background, methodology and the soundscape patterns they are designed to summarise, are spread across multiple sources. …”
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Deep learning‐based analysis of EGFR mutation prevalence in lung adenocarcinoma H&E whole slide images by Jun Hyeong Park, June Hyuck Lim, Seonhwa Kim, Chul‐Ho Kim, Jeong‐Seok Choi, Jun Hyeok Lim, Lucia Kim, Jae Won Chang, Dongil Park, Myung‐won Lee, Sup Kim, Il‐Seok Park, Seung Hoon Han, Eun Shin, Jin Roh, Jaesung Heo

“…Our model estimates the probability of EGFR prevalence in each patch by partitioning the WSI based on multiple‐instance learning and predicts the presence of EGFR mutations at the slide level. …”
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Divergent priorities in flood adaptation by Jennifer Niemann-Morris, A R Siders, Miyuki Hino, Caroline M Kraan, Armen Agopian, Christopher Samoray, Katharine J Mach

“…Despite the difficulties of buyouts, the systematic-review literature largely reflects positive perceived outcomes (79.4% of outcome sentiments, weighing each buyout location equally), but nonprofit organizations and residents perceive largely negative outcomes. …”
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Public health risks of traditional zootherapeutic practices in Africa by Léa Fourchault, Abdallah Lamane, Nguinwa Mbakop Dimitri Romaric, Ganiyat Temidayo Saliu, Sophie Gryseels, Erik Verheyen, Farid Dahdouh-Guebas, Katharina Kreppel

“…We then created a categorical score reflecting the risk of zoonotic pathogen spillover for each recorded practice and compared this risk between regions and demographic groups. …”
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Soybean productivity can be enhanced by understanding rhizosphere microbiota: evidence from metagenomics analysis from diverse agroecosystems by Honglei Ren, Huilong Hong, Bire Zha, Sobhi F. Lamlom, Hongmei Qiu, Yongqiang Cao, Rujian Sun, Haorang Wang, Junkui Ma, Hengbin Zhang, Liping Sun, Qing Yang, Changjun Zhou, Xiulin Liu, Xueyang Wang, Chunlei Zhang, Fengyi Zhang, Kezhen Zhao, Rongqiang Yuan, Ahmed M. Abdelghany, Bixian Zhang, Yuhong Zheng, Jiajun Wang, Wencheng Lu

“…Principal coordinate analysis (PCoA) indicated distinct clustering patterns of microbial communities, reflecting the unique environmental conditions and agricultural practices of each location. …”
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Quantitative SISCOM assessment for epileptogenic zone localization: insights from a multicenter study comparing two software platforms in temporal lobe epilepsy by Carla Oliveira Young, Brunno Machado de Campos, Edna Marina de Souza, Sergio Querino Brunetto, Maria Julia de Oliveira Santos Gualberto, Leonardo Alexandre-Santos, Marcos Geraldo Merichelo de Oliveira, Marina Koutsodontis Machado Alvim, Fernando Cendes, Elba Etchebehere, Lauro Wichert-Ana, Bárbara Juarez Amorim

“…Concordance between the two methods was poor (Kappa = 0.0179), reflecting methodological differences.ConclusionThis study evidences technical differences between SISCOM performed with SPM and Analyze, but with similar sensitivity (70%) for EZ localization. …”
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