Modeling a mesenchymal cell state by bioprinting for the molecular analysis of dormancy in melanoma by Sonja K. Schmidt, Stefan Fischer, Zubeir El Ahmad, Rafael Schmid, Eric Metzger, Roland Schüle, Claus Hellerbrand, Andreas Arkudas, Annika Kengelbach-Weigand, Melanie Kappelmann-Fenzl, Anja K. Bosserhoff

“…Melanoma cells in CIB 3D culture reflect a quiescent and migratory active cell state e.g. by revealing significant downregulation of genes associated with replication and cell cycle progression in this setting. …”
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Convergent-beam attosecond x-ray crystallography by Henry N. Chapman, Chufeng Li, Saša Bajt, Mansi Butola, J. Lukas Dresselhaus, Dmitry Egorov, Holger Fleckenstein, Nikolay Ivanov, Antonia Kiene, Bjarne Klopprogge, Viviane Kremling, Philipp Middendorf, Dominik Oberthuer, Mauro Prasciolu, T. Emilie S. Scheer, Janina Sprenger, Jia Chyi Wong, Oleksandr Yefanov, Margarita Zakharova, Wenhui Zhang

“…We show that with dispersive optics, such as multilayer Laue lenses of high numerical aperture, it becomes possible to encode time into the resulting diffraction pattern with deep sub-femtosecond precision. Each snapshot diffraction pattern consists of Bragg streaks that can be mapped back to arrival times and positions of X-rays on the face of a crystal. …”
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Ward AdmiSsion of Haematuria: an Observational mUlticentre sTudy (WASHOUT) – study protocol by Graeme Maclennan, Kevin Gallagher, John McGrath, Veeru Kasivisvanathan, James Catto, Maria Ribal, Aqua Asif, Alexander Ng, Ben Challacombe, Arjun Nathan, Nikki Kerdegari, Nikita Bhatt, Kevin Byrnes, Simona Ippoliti, Raghav Varma, Bing Jie Chow, Quentin Mak, Ben Lamb, Sinan Khadhouri

“…Patient and public involvement (PPI) has been integral to the study design, ensuring that outcomes reflect patient priorities and that the research addresses key areas of concern.Ethics and dissemination Ethical and regulatory approvals will be obtained as required in each participating region. …”
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Am I attached? A patient-partnered approach to creating infographics about attachment to primary care in Ontario, Canada by Maggie MacNeil, Aya Tagami, Peter Sheffield, Vivian R. Ramsden, Joan Barker, Jennifer Boyle, Clare Cruickshank, Eliot Frymire, Richard H. Glazier, Anita Gombos Hill, Michael E. Green, Mary Huang, Marijke Jurriaans, Caron Leid, Melissa McCallum, Sarah Precious, Jo-Ann Stans, Julie Vizza, Murray Walz, Sue Wilkins, Rebecca Ganann

“…In 2021, INSPIRE-PHC released Primary Care Data Reports - publicly available summaries of administrative billing data about how populations in each of Ontario’s 60 health teams use primary care services. …”
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Utilizing multidisciplinary mobile outreach clinics to provide comprehensive diabetic foot care to patients experiencing homelessness by Kris M. Boelitz, MD, Jaeyoung Lee, BS, Michael D. Pepin, BS, Yiming Zhang, MS, Mallory Gibbons, MSN, NP, Frances J. Lagana, DPM, Shahida Balaparya, EdD, MBA, RVT, Lindsey Carr, Jessin Varghese, BS, NP, Caitlin Sorensen, MD, Jessica P. Simons, MD, MPH, Douglas Jones, MS, MD, Andres Schanzer, MD, Tammy T. Nguyen, MD, PhD

“…All patients received health resources and donated items including new socks and shoes. Each clinic was fully staffed with over 50 volunteer medical providers. …”
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Talking placebo: a qualitative study of patients’ attitudes toward open-label placebo implementation into clinical practice by Antje Frey Nascimento, Berfin Bakis, Jens Gaab, Tobias Schneider, Athina Papadopoulou, Athina Papadopoulou, Milena Ritter, Michael H. Bernstein, Michael H. Bernstein, Charlotte R. Blease, Charlotte R. Blease, Cosima Locher, Cosima Locher

“…Thus, we studied patients’ attitudes, concerns, and ideas toward OLP implementation into clinical practice with focus group discussions (FGDs).MethodsIn 2022, three exploratory online FGDs, each including two patients with the same condition, were conducted with adult patients affected by chronic back pain (n = 2), chronic migraine (n = 2), or chemotherapy-induced emesis/nausea (n = 2). …”
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Molecular and hydraulic responses of grapevine to water status and phenology under long-term differential irrigation treatments by Miguel Damásio, Clara Pinto, Julio Salguero, Maria Victoria Alarcón, João de Deus, Teresa Soares David, José Silvestre, Luísa C. Carvalho, Olfa Zarrouk

“…Aquaporin gene expression was both genotype- and phenology-dependent, with high activity during early stages followed by progressive down-regulation, aligned with changes in stomatal conductance and Kleaf and reflecting each variety iso-/anisohydric behaviour. …”
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Compliance with antimicrobial stewardship guidelines in surgery: an observational, multidisciplinary, cohort study by Salomé Goncalves, Neyla Mohammedi, François Antonini, Alexandre Bleibtreu, Marwan Bouras, François Depret, Pierre Fillatre, Marc Garnier, Rémy Gauzit, Djamel Mokart, Véronique Mondain, Laurent Muller, Bruno Pastene, Mathilde Puges, Philippe Amabile, Cyrille Bastide, Stéphane V. Berdah, Xavier B. D’Journo, Xavier Flecher, Pierre-Hugues Roche, Gabriel Birgand, Carole Eldin, Marc Leone

“…A pair of experts assessed the clinical vignettes to decide the compliance of each criterion. The secondary aims were to assess whether a 100% compliance rate was associated with positive outcomes. …”
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Discovery of differentially expressed lncRNAs in porcine ovaries with smaller and bigger litter size by Saixing Duan, Falei Li, Libing Meng, Shimei Cheng, Huangqi Shi, Yingjie Qu, Chaoyue He, Shengyu Gao, Jian Li, Shiduo Sun, Yong Liu, Gaoxiao Xu, Gaoxiao Xu

“…IntroductionThe number of litters is an important reproductive trait, which is one of the main indicators reflecting the production level and economic benefit of the pig farm. …”
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Relationship of the oxidative balance score with the risk of frailty and mortality in patients with asthma: a mediation analysis of NHANES by Minghao Liang, Hongling Jia, Lili Sun, Wenjing Xi, Feilong Guan, Di Huang, Yifei Xu, Guangfeng Chen, Xianhai Chen, Minyan Jin, Zhanjun Qiu

“…Oxidative stress is an important mechanism in the pathogenesis of asthma, and the oxidative balance score (OBS) is a new index reflecting the state of oxidative homeostasis in the body that integrates dietary and physical activity factors. …”
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Levels of neurotrophins in the brain of female rats in an experimental model of malignant tumor growth under conditions of hypothyroidism by E. I. Surikova, E. M. Frantsiyants, V. A. Bandovkina, I. V. Kaplieva, I. V. Neskubina, Yu. A. Pogorelova, L. K. Trepitaki, N. D. Cheryarina, L. A. Nemashkalova, A. Yu. Arakelova, A. M. Salatova

“…An experiment was performed on 47 white non-linear female rats: 10 rats each in the intact group, control group 1 (induced hypothyroidism), control group 2 (subcutaneous growth of Guerin’s carcinoma), main group (combination of pathologies); 7 rats in the group with subcutaneous tumor growth to assess life expectancy. …”
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Supporting rotational grazing systems with virtual fencing: paddock transitions, beef heifer performance, and stress response by N.A. Grinnell, D. Hamidi, M. Komainda, F. Riesch, J. Horn, I. Traulsen, R. Palme, J. Isselstein

“…The study was conducted over 8 weeks, subdivided into two grazing cycles, with 32 heifers in four groups. Each experimental pasture was subdivided into four paddocks. …”
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Application of Hilbert Huang Transform Method Based on CEEMD in Forest Boundary Layer Turbulence by Yanqi WANG, Yu ZHANG, Youqi SU, Qian ZHANG, min YE

“…To address the modal aliasing phenomenon in traditional Empirical Mode Decomposition （EMD） algorithms， the Complementary Ensemble Empirical Mode Decomposition （CEEMD） and Mirror Extension algorithm were introduced to improve the shortcomings in EMD algorithm decomposition.This article selects case data from turbulence observations in the artificial forest area of Mount Si'e.Firstly， the differences between the two methods are compared and analyzed to clarify the advantages of the CEEMD algorithm； Then， case data of stable and unstable layers at different heights were selected， and the Hilbert Huang transformation method was applied to analyze the turbulent characteristics of the wind speed U and temperature T series under this case， exploring the application of the Hilbert Huang transformation method.The results indicate that the algorithm decomposition of CEEMD is more detailed， the mode aliasing defect of the modal function is better suppressed， the modal energy distribution is more focused， the Hilbert marginal spectrum has more energy spikes， and the energy distribution is clearer.Different modal functions have their own characteristic frequencies， and the decomposed modal functions contain motion of different scales， including turbulent motion in the inertial sub region with a slope of -2/3， and low-frequency large-scale modes corresponding to the energy containing region.The marginal spectral energy peaks obtained from CEEMD decomposition well reflect the energy containing characteristics of each modal function.Individual case analysis shows that the CEEMD algorithm can act as a typical binary filter.After CEEMD decomposition， there are gust fluctuations of about 3~6 minutes in the various modal functions of the U-wind in the turbulence signal of this case.The turbulence characteristics vary at different heights and stable layers.The Hilbert marginal spectral amplitude is higher in the unstable layer at noon compared to the stable layer at night， and the three-dimensional wind speed is better mixed at various heights.Moreover， due to the effect of the canopy， there is a crushing effect on large-scale turbulent vortices at lower altitudes， and the marginal spectrum exhibits low frequency small and high frequency large characteristics compared to other altitudes.In this case， the temperature T is different from the three-dimensional wind speed performance： turbulent vortices at different altitudes are better mixed under stable layer structures， while under unstable layer structures， the marginal spectrum amplitude at lower altitudes is higher due to differences in thermal absorption at different altitudes， and decreases with increasing altitude.Overall， this comparative analysis highlights the superior capabilities of the CEEMD algorithm in handling complex turbulence data， ensuring a more precise and insightful examination of atmospheric phenomena.…”
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Morphological, functional and biochemical differences in cardiac adaptation to endurance exercise among male and female amateur marathon runners by Zofia Lasocka-Koriat, Zofia Lasocka-Koriat, Zuzanna Lewicka-Potocka, Zuzanna Lewicka-Potocka, Anna Kaleta-Duss, Nikola Bulman, Ewelina Marciniak, Leszek Kalinowski, Leszek Kalinowski, Ewa Lewicka, Alicja Dąbrowska-Kugacka

“…Galectin-3 was the best biomarker to reflect overload changes. Cardiovascular screening in amateur runners should be implemented to identify subjects requiring further evaluation.…”
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Association between relative fat mass and risk of gallstones in adults by Jianjun Wang, Wei He, Ruizi Shi, Yu Huang, Chuan Qin, Xi Chen, Xintao Zeng, Yongwei Huang, Decai Wang

“…Relative fat mass (RFM) is an emerging, simple, and low-cost anthropometric index that reflects obesity (particularly abdominal obesity), and is associated with various obesity-related diseases. …”
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Evaluating associations between patient-to-nurse ratios and mortality, process of care events and vital sign documentation on paediatric wards: a secondary analysis of data from th... by Orsola Gawronski, Corrado Cecchetti, Emanuela Tiozzo, Marta Luisa Ciofi degli Atti, Massimiliano Raponi, Karen Dryden-Palmer, Christopher S Parshuram, George Tomlinson, Immacolata Dall'Oglio, Leah Szadkowski, Ari Robin Joffe

“…Secondary outcomes included five events reflecting the process of care, collected for all EPOCH patients; the frequency of documentation for each of eight vital signs on a random sample of patients; four measures describing nursing perceptions of care.Results A total of 217 714 patient admissions accounting for 849 798 patient days over the course of the study were analysed. …”
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The Running Performance of Elite Youth Football Players in Matches with a 1-4-3-3 Formation in Relation to Their Playing Position by Yiannis Michailidis, Andreas Stafylidis, Lazaros Vardakis, Angelos E. Kyranoudis, Vasilios Mittas, Vasileios Leftheroudis, Spyridon Plakias, Athanasios Mandroukas, Thomas I. Metaxas

“…This difference is likely due to the different tactical roles of each playing position. This variation between playing positions emphasizes the need for individualized loading of players during the training microcycle.…”
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Comprehensive and advanced T cell cluster analysis for discriminating seropositive and seronegative rheumatoid arthritis by Shinji Maeda, Hiroya Hashimoto, Tomoyo Maeda, Shin-ya Tamechika, Taio Naniwa, Akio Niimi

“…ObjectiveRheumatoid arthritis (RA) is classified into seropositive (SP-RA) and seronegative (SN-RA) types, reflecting distinct immunological profiles. This study aimed to identify the T cell phenotypes associated with each type, thereby enhancing our understanding of their unique pathophysiological mechanisms.MethodsWe analyzed peripheral blood T cells from 50 participants, including 16 patients with untreated SP-RA, 17 patients with SN-RA, and 17 healthy controls, utilizing 25 T cell markers. …”
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Integral Assessment of the Development Level of Electronic Business in the Regions of the Volga Federal District by M. V. Bikeeva, K. V. Belash

“…A similar situation is observed in most constituent entities of the Russian Federation and is due in many respects to specific reasons for each region. The timely fulfillment of the goals and objectives of digital transformations in the Russian Federation reflected in the Digital Economy of the Russian Federation Program and other regulatory documents will help to smooth out the existing imbalances.…”
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Species diversity of soil animals at different desert habitats in Baijitan region of Ningxia and its relationship with environmental factors by Zhang Jiao, Li Yuecheng, Zhang Dazhi

“…It can not only indicate the subtle variation of habitats, but also reflect the trend of ecological communities. Diversity of soil animals is an important part of biodiversity study of soil. …”
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