Development of quality indicators for hand osteoarthritis care – Results from an European consensus study by Daniel H. Bordvik, Yeliz Prior, Rachael Bamford, Francis Berenbaum, Mathilda Björk, Thalita Blanck, Barbara Slatkowsky Christensen, Krysia Dziedzic, John Edwards, Nazemin Gilanliogullari, Carol Graham, Ida K. Haugen, Margreet Kloppenburg, Hellen Laheij, Marco J.P.F. Ritt, Tanja Stamm, Anne Therese Tveter, Nina Østerås, Ingvild Kjeken

“…Design: We used the OA-QI v.2. set as a starting point and adapted it to reflect hand OA care. A literature search was performed to identify potential QIs for hand OA following the Rand/UCLA Appropriateness method. …”
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Four novel Loci (19q13, 6q24, 12q24, and 5q14) influence the microcirculation in vivo. by M Kamran Ikram, Xueling Sim, Richard A Jensen, Mary Frances Cotch, Alex W Hewitt, M Arfan Ikram, Jie Jin Wang, Ronald Klein, Barbara E K Klein, Monique M B Breteler, Ning Cheung, Gerald Liew, Paul Mitchell, Andre G Uitterlinden, Fernando Rivadeneira, Albert Hofman, Paulus T V M de Jong, Cornelia M van Duijn, Linda Kao, Ching-Yu Cheng, Albert Vernon Smith, Nicole L Glazer, Thomas Lumley, Barbara McKnight, Bruce M Psaty, Fridbert Jonasson, Gudny Eiriksdottir, Thor Aspelund, Global BPgen Consortium, Tamara B Harris, Lenore J Launer, Kent D Taylor, Xiaohui Li, Sudha K Iyengar, Quansheng Xi, Theru A Sivakumaran, David A Mackey, Stuart Macgregor, Nicholas G Martin, Terri L Young, Josh C Bis, Kerri L Wiggins, Susan R Heckbert, Christopher J Hammond, Toby Andrew, Samantha Fahy, John Attia, Elizabeth G Holliday, Rodney J Scott, F M Amirul Islam, Jerome I Rotter, Annie K McAuley, Eric Boerwinkle, E Shyong Tai, Vilmundur Gudnason, David S Siscovick, Johannes R Vingerling, Tien Y Wong

“…Changes in retinal vascular caliber reflect early microvascular disease and predict incident cardiovascular events. …”
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“Equity” in genomic health policies: a review of policies in the international arena by Prabhathi Basnayake Ralalage, Prabhathi Basnayake Ralalage, Tala Mitchell, Claire Zammit, Gareth Baynam, Gareth Baynam, Emma Kowal, Libby Masey, Julie McGaughran, Tiffany Boughtwood, Misty Jenkins, Gregory Pratt, Angeline Ferdinand

“…Insights and experiences in achieving healthcare equity in HICs and LMICs can offer valuable lessons for each other.…”
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Systematic Review and Meta-Analysis on Prevalence and Antimicrobial Resistance Patterns of Important Foodborne Pathogens Isolated from Retail Chicken Meat and Associated Environmen... by Haris Ayoub, Murthy Suman Kumar, Zunjar Baburao Dubal, Kiran Narayan Bhilegaonkar, Hung Nguyen-Viet, Delia Grace, Sakshi Thapliyal, Ekkoruparambil Sethurajan Sanjumon, Elisetty Naga Pavana Sneha, Dharavath Premkumar, Vinodh Kumar Obli Rajendran, Ram Pratim Deka

“…A sensitivity analysis was subsequently conducted to assess the impact of influential studies, and the pooled prevalence of each pathogen was recalculated after removing these studies to ensure the robustness of the results. …”
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Effectiveness of Chlorine Against Tulane Virus, A Human Norovirus Surrogate, and Escherichia coli in Preharvest Agricultural Water by Ashlyn Lake, Nuradeen Garba Yusuf, Mya Maybank, Sarah Johnson, Christopher K. Mutch, Alexander P. Mueck, Simon S. Riley, Arie H. Havelaar, Naim Montazeri

“…Water samples from two Florida farms were collected and inoculated with each microbial type, then treated with different free chlorine dosages (2, 4, 10, 15, 20, 30, and 40 ppm) for 5 and 10 min. …”
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Longitudinal study of COPD phenotypes using integrated SPECT and qCT imaging by Frank Li, Frank Li, Xuan Zhang, Xuan Zhang, Alejandro P. Comellas, Eric A. Hoffman, Eric A. Hoffman, Michael M. Graham, Ching-Long Lin, Ching-Long Lin, Ching-Long Lin, Ching-Long Lin

“…CT scans were performed at each visit and qCT-based variables were derived to measure the structural and functional characteristics of the lungs, while the SPECT-based variables were used to quantify lung ventilation heterogeneity. …”
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Multi-model quantitative MRI of uterine cancers in precision medicine’s era—a narrative review by Marco Gennarini, Rossella Canese, Silvia Capuani, Valentina Miceli, Federica Tomao, Innocenza Palaia, Valentina Zecca, Alessandra Maiuro, Ilaria Balba, Carlo Catalano, Stefania Maria Rita Rizzo, Lucia Manganaro

“…Results DCE-MRI provides valuable quantitative biomarkers such as Ktrans and Ve, which reflect microvascular characteristics and tumor aggressiveness, outperforming T2-weighted imaging in detecting critical factors like myometrial and cervical invasion. …”
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Machine learning applications in vascular neuroimaging for the diagnosis and prognosis of cognitive impairment and dementia: a systematic review and meta-analysis by Valerie Lohner, Amanpreet Badhwar, Flavie E. Detcheverry, Cindy L. García, Helena M. Gellersen, Zahra Khodakarami, René Lattmann, Rui Li, Audrey Low, Claudia Mazo, Amelie Metz, Olivier Parent, Veronica Phillips, Usman Saeed, Sean Y. W. Tan, Stefano Tamburin, David J. Llewellyn, Timothy Rittman, Sheena Waters, Jose Bernal

“…Nearly 60% of studies were published in the past two years, reflecting a growing interest in using CSVD markers in ML-based diagnosis and prognosis of neurodegenerative diseases, especially Alzheimer’s dementia. …”
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A combined nutritional index and mortality in patients with peritoneal dialysis by Wenjun Lin, Juan Wu, Xiaojiang Zhan, Yueqiang Wen, Xiaoyang Wang, Xiaoran Feng, Fenfen Peng, Na Tian, Ning Su, Qingdong Xu, Niansong Wang, Xiangwei Liao, Xianfeng Wu

“…Notably, the hazard ratio (HR) of TC/BA (per-1.0 increase) was 1.32 (95% CI 1.23–1.41), 1.29 (95% CI 1.19–1.41), and 1.25 (95% CI 1.22–1.27) times higher than the HR of body mass index (per-1.0 decrease), total cholesterol (per-10 increase), and serum albumin (per-1.0 decrease), respectively.Conclusions TC/BA was positively linearly related to mortality and may outperform each index in assessing CAPD patient prognosis. The combined nutritional index may more comprehensively and favorably evaluate CAPD patients’ prognosis.…”
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Predictive Modeling of Climate-Driven Crop Yield Variability Using DSSAT Towards Sustainable Agriculture by Safa E. El-Mahroug, Ayman A. Suleiman, Mutaz M. Zoubi, Saif Al-Omari, Qusay Y. Abu-Afifeh, Heba F. Al-Jawaldeh, Yazan A. Alta’any, Tariq M. F. Al-Nawaiseh, Nisreen Obeidat, Shahed H. Alsoud, Areen M. Alshoshan, Fayha M. Al-Shibli, Rakad Ta’any

“…Yield projections under each scenario were further analyzed using machine learning algorithms—random forest and gradient boosting regression—to quantify the influence of individual climate variables. …”
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ExerG – an exergame-based training device for the rehabilitation of older adults: a functional model usability study by Jane Muheim, Isabella Hotz, Franziska Kübler, Silvia Herren, Simon Sollereder, Katharina Kruszewski, Anna Lisa Martin‑Niedecken, Alexandra Schättin, Frank Behrendt, Sonja Böckler, Stefan Schmidlin, Roman Jurt, Stephan Niedecken, Yanick Riederer, Christian Brenneis, Leo H. Bonati, Barbara Seebacher, Corina Schuster‑Amft

“…For qualitative data, a thematic analysis (TA) using an inductive, data-driven approach was carried out to develop themes for each user group. Results We interviewed 20 PEUs (13 healthy older adults, 7 patients) and 22 SEUs at two rehabilitation centres in Austria and Switzerland. …”
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ChatGPT-o1 Preview Outperforms ChatGPT-4 as a Diagnostic Support Tool for Ankle Pain Triage in Emergency Settings by Pooya Hosseini-Monfared, Shayan Amiri, Alireza Mirahmadi, Amirhossein Shahbazi, Aliasghar Alamian, Mohammad Azizi, Seyed Morteza Kazemi

“…To replicate typical patient inquiries, questions were crafted in simple, non-technical language, requesting three possible differential diagnoses for each scenario. The second phase involved designing case vignettes reflecting scenarios typical for triage nurses or physicians. …”
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Estimation of chlorophyll-a in uncrewed aircraft systems imagery using autonomous surface vessel data with machine learning algorithms and feature selection techniques by Mohammad Shakiul Islam, Padmanava Dash, Abduselam M. Nur, Hafez Ahmad, Rajendra M. Panda, Jessica S. Wolfe, Gray Turnage, Lee Hathcock, Gary D. Chesser, Jr, Robert J. Moorhead

“…To ensure the algorithms were developed using accurate remote sensing reflectance data, the spectral response function of the UAS was applied to the radiometer measurements. …”
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Younger adult brain utilizes interhemispheric strategy via ipsilateral dorsal premotor cortex for fine control of dexterous finger movements, unlike the aging brain by Gen Miura, Gen Miura, Tomoyo Morita, Tomoyo Morita, Jihoon Park, Jihoon Park, Eiichi Naito, Eiichi Naito

“…The sensorimotor cortices (PMd, M1, S1, and Area 2) in each hemisphere were defined as regions-of-interest (ROIs), and contrast analysis, interparticipant correlation analysis with performance capacity, and interhemispheric functional connectivity analysis were performed.ResultsIn the younger group, all ipsilateral sensorimotor cortices were deactivated during the button-press task, whereas during the stick-rotation task, the PMd, S1, and Area 2 were activated, and the ipsilateral M1 remained deactivated. …”
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Meta-analyses of the effects of high-intensity interval training in elite athletes — part II: relationships between the mean effects on various performance measures by Hans-Peter Wiesinger, Hans-Peter Wiesinger, Hans-Peter Wiesinger, Will G. Hopkins, Nils Haller, Nils Haller, Julia Blumkaitis, Tilmann Strepp, Thomas Leonhard Stöggl, Thomas Leonhard Stöggl

“…There were substantial differences in time-trial speed/power between studies not explained by each predictor. Exercise economy had an unclear relationship with time-trial speed/power but a decisively negative relationship with V̇O2max. …”
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Global surveillance of circulating microRNA for diagnostic and prognostic assessment of acute myocardial infarction based on the plasma small RNA sequencing by Xiaomin Wang, Yaojun Lu, Ruiping Zhao, Bing Zhu, Jian Liu, Qiang Yue, Rina Wu, Shuwen Han, Yuanyuan Gao, Juan Chen, Jie Gong, Danna He, Teng Xu, Jianchao Ying

“…Differentially-circulated miRNAs were analyzed between each group. All detected circulating miRNAs were examined by ROC analysis and then LASSO dimension reduction to obtain an optimal panel for diagnosis of AMI. …”
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Experiences, impact, and enablers of involving young people and family caregivers in developing reporting guidelines for paediatric randomised trials: a case study by Ami Baba, Maureen Smith, Jennifer Preston, Begonya Nafria Escalera, Segolene Gaillard, Pamela Dicks, Matthew Prebeg, Amanda Doherty-Kirby, Kimberly Courtney, Lynn Mendonza, Tanya Chute Nagy, Lotty Hooft, Martin Offringa

“…Family caregiver advisors actively contributed to the Consensus Meeting and to the writing process of the guidelines’ Explanation and Elaboration (E&E) documents. After each project stage, YPFC feedback was collected. …”
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Identification of patient endotypes and adalimumab treatment responders in axial spondyloarthritis using blood-derived extracellular matrix biomarkers by Anne Gitte Loft, Inge Juul Sørensen, Mikkel Østergaard, Susanne J Pedersen, Morten Asser Karsdal, Ole Rintek Madsen, Anne-C Bay-Jensen, Peder Frederiksen, Signe Holm Nielsen, Helena Port, Frederik Christiansen, Sengul Seven

“…Biomarker data were log-transformed, standardised by mean centering and scaled by the SD prior to principal component analysis and K-means clustering.Results Based on all three studies, we identified two orthogonal dimensions reflecting: (1) inflammation and neutrophil activity (driven by C1M and CPa9-HNE) and (2) collagen turnover (driven by PRO-C2). …”
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Prevalence and correlates of anxiety, depression, and symptoms of trauma among Palestinian adults in Gaza after a year of war: a cross-sectional study by Mohamed R. Zughbur, Yaser Hamam, Ashraf Kagee, Majd Hamam, Yara M. Hijazi, Mohammed Hamam, Ola Abuolwan, Shameq Sayeed, Guido Veronese

“…The mean PCL-5 score was 48.16, reflecting a substantial burden of PTSD symptoms among participants. …”
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Enhancing Teamwork and Clinical Competence in Radiotherapy Education: Integrating TeamSTEPPS with PEARLS Structured Debriefing in Scenario-Based Simulations by Liu G, Lan T, E M, He Y, Hu H

“…Guohui Liu,1 Tian Lan,2 Mingyan E,1 Yunlong He,1 Hanqing Hu3 1Department of Radiation Oncology, Harbin Medical University Cancer Hospital, Harbin, 150040, People’s Republic of China; 2Department of Educational Administration, Harbin Medical University Cancer Hospital, Harbin, 150040, People’s Republic of China; 3Department of Colorectal Cancer Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, 150086, People’s Republic of ChinaCorrespondence: Hanqing Hu, Department of Colorectal Cancer Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, 150086, People’s Republic of China, Email huhanqing@hrbmu.edu.cnObjective: This study aimed to evaluate whether integrating the TeamSTEPPS model with PEARLS structured debriefing improves teamwork competencies and clinical decision-making among radiotherapy residents, compared to traditional simulation teaching, and to assess its broader applicability in medical education.Methods: From June to December 2023, 36 standardized training residents from the Radiotherapy Department of Harbin Medical University Cancer Hospital were selected and randomly assigned to an experimental group and a control group, each with 18 participants, using a random number table The experimental group underwent scenario-based simulation teaching incorporating the TeamSTEPPS model and PEARLS structured debriefing, while the control group received traditional simulation teaching. …”
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