A ‘torn bag mechanism’ of small extracellular vesicle release via limiting membrane rupture of en bloc released amphisomes (amphiectosomes) by Tamás Visnovitz, Dorina Lenzinger, Anna Koncz, Péter M Vizi, Tünde Bárkai, Krisztina V Vukman, Alicia Galinsoga, Krisztina Németh, Kelsey Fletcher, Zsolt I Komlósi, Csaba Cserép, Ádám Dénes, Péter Lőrincz, Gábor Valcz, Edit I Buzas

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Mediator kinase inhibition suppresses hyperactive interferon signaling in Down syndrome by Kira A Cozzolino, Lynn Sanford, Samuel Hunter, Kayla Molison, Benjamin Erickson, Meaghan CS Courvan, Taylor Jones, Deepa Ajit, Matthew D Galbraith, Joaquín M Espinosa, David Bentley, Mary Ann Allen, Robin D Dowell, Dylan J Taatjes

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Mechanical forces pattern endocardial Notch activation via mTORC2-PKC pathway by Yunfei Mu, Shijia Hu, Xiangyang Liu, Xin Tang, Jiayi Lin, Hongjun Shi

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Maturation and detoxification of synphilin-1 inclusion bodies regulated by sphingolipids by Xiuling Cao, Xiang Wu, Lei Zhao, Ju Zheng, Xuejiao Jin, Xinxin Hao, Joris Winderickx, Shenkui Liu, Lihua Chen, Beidong Liu

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Flexibility in PAM recognition expands DNA targeting in xCas9 by Kazi A Hossain, Lukasz Nierzwicki, Modesto Orozco, Jacek Czub, Giulia Palermo

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Serum metabolome indicators of early childhood development in the Brazilian National Survey on Child Nutrition (ENANI-2019) by Marina Padilha, Victor Nahuel Keller, Paula Normando, Raquel M Schincaglia, Nathalia C Freitas-Costa, Samary SR Freire, Felipe M Delpino, Inês RR de Castro, Elisa MA Lacerda, Dayana R Farias, Zachary Kroezen, Meera Shanmuganathan, Philip Britz-Mckibbin, Gilberto Kac

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Multimodal mismatch responses in mouse auditory cortex by Magdalena Solyga, Georg B Keller

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Multi-tissue network analysis reveals the effect of JNK inhibition on dietary sucrose-induced metabolic dysfunction in rats by Hong Yang, Cheng Zhang, Woonghee Kim, Mengnan Shi, Metin Kiliclioglu, Cemil Bayram, Ismail Bolar, Özlem Özdemir Tozlu, Cem Baba, Nursena Yuksel, Serkan Yildirim, Shazia Iqbal, Jihad Sebhaoui, Ahmet Hacımuftuoglu, Matthias Uhlen, Jan Boren, Hasan Turkez, Adil Mardinoglu

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NPRL2 gene therapy induces effective antitumor immunity in KRAS/STK11 mutant anti-PD1 resistant metastatic non-small cell lung cancer (NSCLC) in a humanized mouse model by Ismail M Meraz, Mourad Majidi, Renduo Song, Feng Meng, Lihui Gao, Qi Wang, Jing Wang, Elizabeth J Shpall, Jack A Roth

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Alzheimer-mutant γ-secretase complexes stall amyloid β-peptide production by Parnian Arafi, Sujan Devkota, Emily Williams, Masato Maesako, Michael S Wolfe

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Auditory confounds can drive online effects of transcranial ultrasonic stimulation in humans by Benjamin R Kop, Yazan Shamli Oghli, Talyta C Grippe, Tulika Nandi, Judith Lefkes, Sjoerd W Meijer, Soha Farboud, Marwan Engels, Michelle Hamani, Melissa Null, Angela Radetz, Umair Hassan, Ghazaleh Darmani, Andrey Chetverikov, Hanneke EM den Ouden, Til Ole Bergmann, Robert Chen, Lennart Verhagen

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Correction: Impairment of cocaine-mediated behaviours in mice by clinically relevant Ras-ERK inhibitors by Alessandro Papale, Ilaria Maria Morella, Marzia Tina Indrigo, Rick E Bernardi, Livia Marrone, Francesca Marchisella, Andrea Brancale, Rainer Spanagel, Riccardo Brambilla, Stefania Fasano

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Impairment of cocaine-mediated behaviours in mice by clinically relevant Ras-ERK inhibitors by Alessandro Papale, Ilaria Maria Morella, Marzia Tina Indrigo, Rick Eugene Bernardi, Livia Marrone, Francesca Marchisella, Andrea Brancale, Rainer Spanagel, Riccardo Brambilla, Stefania Fasano

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Immunogenicity and safety of a live-attenuated SARS-CoV-2 vaccine candidate based on multiple attenuation mechanisms by Mie Suzuki Okutani, Shinya Okamura, Tang Gis, Hitomi Sasaki, Suni Lee, Akiho Kashiwabara, Simon Goto, Mai Matsumoto, Mayuko Yamawaki, Toshiaki Miyazaki, Tatsuya Nakagawa, Masahito Ikawa, Wataru Kamitani, Shiro Takekawa, Koichi Yamanishi, Hirotaka Ebina

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Artesunate, EDTA, and colistin work synergistically against MCR-negative and -positive colistin-resistant Salmonella by Yajun Zhai, Peiyi Liu, Xueqin Hu, Changjian Fan, Xiaodie Cui, Qibiao He, Dandan He, Xiaoyuan Ma, Gongzheng Hu

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Il-6 signaling exacerbates hallmarks of chronic tendon disease by stimulating reparative fibroblasts by Tino Stauber, Greta Moschini, Amro A Hussien, Patrick Klaus Jaeger, Katrien De Bock, Jess G Snedeker

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Oversized cells activate global proteasome-mediated protein degradation to maintain cell size homeostasis by Shixuan Liu, Ceryl Tan, Chloe Melo-Gavin, Miriam B Ginzberg, Ron Blutrich, Nish Patel, Michael Rape, Kevin G Mark, Ran Kafri

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Decoding the physics of observed actions in the human brain by Moritz F Wurm, Doruk Yiğit Erigüç

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