High-Resolution Tracking of Aging-Related Small Molecules: Bridging Pollutant Exposure, Brain Aging Mechanisms, and Detection Innovations by Keying Yu, Sirui Yang, Hongxu Song, Zhou Sun, Kaichao Wang, Yuqi Zhu, Chengkai Yang, Rongzhang Hao, Yuanyuan Cao

“…Among them, AQDs show unique advantages in real-time monitoring of ROS fluctuations and intervention of oxidative damage by virtue of their ultra-high specific surface area, controllable surface modification, and free radical scavenging ability. …”
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Is colloidal oat an effective emollient ingredient for the prevention and treatment of atopic dermatitis in infants? by Joseph F. Fowler, Lin Ma, James Bergman, Paul Horowitz, Tina Lavender, Lawrence F. Eichenfield, Zoe Draelos, Simon G. Danby, Michael J. Cork

“…Background Atopic dermatitis (AD) is a chronic inflammatory skin condition characterized by barrier dysfunction and immune dysregulation, often leading to increased allergen penetration, sensitization, and secondary infections. …”
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Exosomes Secreted from Adipose-Derived Stem Cells Are a Potential Treatment Agent for Immune-Mediated Alopecia by Yanqiao Li, Guangxing Wang, Qian Wang, Yun Zhang, Lei Cui, Xin Huang

“…Etiologically, infection (bacterial and fungal infection), inflammation, and immune dysregulation are the main causes of immune-mediated hair loss. …”
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Downregulation of AKT-mediated p27Kip1 phosphorylation with shift to sphingomyelin synthesis in CLN3 disease by Fatima Bilal, Jihane Soueid, Sara Saab, Nadine Makhoul, Zeinab Hamze, Lara El-Bazzal, Joelle Makoukji, Rose-Mary Boustany

“…Transcriptomic analysis of gene expression using microarrays, validation by Western blot and real-time PCR, demonstrate that AKT is downregulated in CLN3-deficient cells and Cln3Δex7/8 mouse brain. …”
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Blocking the SIRPα-CD47 axis promotes macrophage phagocytosis of exosomes derived from visceral adipose tissue and improves inflammation and metabolism in mice by Yun-kai Lin, Yu-fei Pan, Tian-yi Jiang, Yi-bin Chen, Tai-yu Shang, Meng-you Xu, Hui-bo Feng, Yun-han Ma, Ye-xiong Tan, Hong-yang Wang, Li-wei Dong

“…In obesity, the lipidome profile of AT-Exos was significantly altered, and diet can modify the miRNA content and function within these exosomes, influencing lipid metabolism and inflammatory pathways that contribute to metabolic dysregulation. …”
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Shapley additive explanations based feature selection reveals CXCL14 as a key immune-related gene in predicting idiopathic pulmonary fibrosis by Bin Chen, Lu Huan, Junyu Lu, Jinhe Yuan

“…BackgroundIdiopathic pulmonary fibrosis (IPF) is a progressive lung disease marked by excessive fibrous tissue accumulation in the lung interstitium, leading to a gradual deterioration of respiratory function and significantly impairing patients’ quality of life. …”
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Identification and experimental validation of ulcerative colitis-associated hub genes through integrated WGCNA and lysosomal autophagy analysis by Yuanpei Zhao, Yijun Li, Qingwen Xu, Lili Ding, Weiming Li, Qinghua Zou, Yichen Hu, Kaiwen Shi, Hongyuan Liu

“…Our findings suggest that these genes may function as critical regulators of lysosomal autophagy in UC.…”
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Ethyltoluenes Regulate Inflammatory and Cell Fibrosis Signaling in the Liver Cell Model by Suryakant Niture, Sashi Gadi, Hieu Hoang, Leslimar Rios-Colon, Wanda Bodnar, Keith E. Levine, Deepak Kumar

“…Acute exposure to induvial ETs and in combination or chronic 2-ET exposure alone modulates cell fibrosis markers such as <i>AST, FGF-23, Cyt-7 p21, TGFβ, TIMP2,</i> and <i>MMP2</i> in liver cell models, suggesting that ETs target liver cells and may dysregulate liver function.…”
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Follicular fluid-derived extracellular vesicles miR-34a-5p regulates granulosa cell glycolysis in polycystic ovary syndrome by targeting LDHA by Xueying Cui, Xiaocan Lei, Tao Huang, Xueyan Mao, Zhiwei Shen, Xiuli Yang, Wanting Peng, Jingjing Yu, Shun Zhang, Peng Huo

“…Targets of miR-34a-5p were identified by dual-luciferase reporter assays, and quantitative real-time polymerase chain reaction and western blotting were performed to determine gene and protein expression. …”
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In vitro and in-vivo exploration of physostigmine analogues to understand the mechanistic crosstalk between Klotho and targets for epilepsy by Mansi Dahalia, Mansi Dahalia, Haya Majid, Mohd Junaid Khan, Akshat Rathi, Mohd Ashif Khan, Imran Ahmd Khan, Mohammed Samim, Sayeed Ur Rehman, Md Salik Noorani, Divya Vohora, Nidhi

“…BackgroundEpilepsy and seizures are characterized by neuronal hyperexcitability and damage, influenced by metabolic dysregulation, neuroinflammation, and oxidative stress. …”
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2-Hydroxy-4-n-octyloxybenzophenone induces developmental neurotoxicity and multiple sclerosis-like symptoms through cacna1a regulated Ca2 + inward flow and microglial activation by Xinjia Li, Xin Gao, Siyuan Liu, Siyu Liu, Yanao Liu, Li Gao, Lijie Xia, Kechun Liu, Meng Jin

“…Gene expression was detected by transcriptome and real-time qPCR. The effect of UV-531 on calcium homeostasis was determined by measuring Ca2+ levels. …”
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Decreased expression of the m6A RNA methyltransferase METTL3 is associated with residual ridge resorption by Harini Sri Krishnamoorthy, Balachander Kannan, Dhanraj Ganapathy, Vijayashree Priyadharsini Jayaseelan, Paramasivam Arumugam

“…Conclusion: Our findings suggest that METTL3 dysregulation contributes to RRR pathogenesis. Further large-scale samples and functional studies are required to identify their therapeutic potential.…”
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Exploring novel molecular mechanisms underlying recurrent pregnancy loss in decidual tissues by Hui Ding, Yajie Gao, Yuan Gao, Yulu Chen, Ruimin Liu, Caili Wang, Yuqing Gao

“…Three RPL decidual tissue transcriptomic datasets (GSE113790, GSE161969, and GSE178535) were integrated for differential expression, weighted gene co-expression network analysis (WGCNA), and functional enrichment analyses. Machine learning (LASSO, SVM-RFE, RF) identified optimal feature genes, which were validated via real-time quantitative polymerase chain reaction (RT-qPCR) and immunohistochemistry (IHC). …”
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Bioinformatics analysis and preliminary validation of autophagy-related genes in asthma disease by Bo Sun, Huiman Huang, Ran An, Bing Wei, Xiaozhe Yue

“…The present study provides a new insight that autophagy dysregulation exists in asthma and may be involved in the etiology of asthma by participating in multiple pathways and biological functions. …”
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Clinical significance of altered expression of mitochondrial genome-derived LncRNA LIPCAR in colorectal cancer by Seyed Taha Nourbakhsh, Fatemeh Mohamadhashem, Mohammad Mehdi Naghizadeh, Amirnader Emami Razavi, Abdolreza Daraei, Faezeh Mohamadhashem

“…The SYBR green technique was applied in real-time PCR to analyze the expression profile of LIPCAR in CRC patients. …”
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Targeting DKC1/NF-κB axis suppresses tumorigenesis and enhances 5-FU sensitivity in gastric cancer by Tengkai wang, Hui Zhang, Yaoyao Feng, Yinrong Yang

“…The dyskeratosis congenita 1 (DKC1) gene has been reported to have diverse biological functions and prognostic values in several types of human cancers. …”
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Up-regulation of microRNA-190b plays a role for decreased IGF-1 that induces insulin resistance in human hepatocellular carcinoma. by Tzu-Min Hung, Cheng-Maw Ho, Yen-Chun Liu, Jia-Ling Lee, Yow-Rong Liao, Yao-Ming Wu, Ming-Chih Ho, Chien-Hung Chen, Hong-Shiee Lai, Po-Huang Lee

“…Here, we hypothesized that dysregulation of microRNAs (miRNA) in HCC can modulate IGF-1 expression post-transcriptionally.…”
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Differential Expression of LHR and FSHR in Canine Mammary Tumors: Correlation with Malignancy and Spay Status by Yujue Li, Siying Wang, Jiaxuan Gao, Xuerou Tu, Shihui Yu, Yang Liu, Zhaoxia Zhang, Yuan Cui, Yougang Zhong

“…Canine mammary tumors (CMTs) constitute one of the most prevalent malignancies in female canines, whereas the functional involvement of gonadotropin receptors—luteinizing hormone receptor (LHR) and follicle-stimulating hormone receptor (FSHR)—in these neoplasms remains uncharacterized. …”
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Unveiling pathogenesis of pelvic organ prolapse through transcriptomic and bioinformatic analyses in uterosacral ligament tissues of postmenopausal women by BingJie Rui, BingJie Rui, GuangHai Rui, YanFeng Yang, YanFeng Yang

“…Functional enrichment analyses revealed that these transcripts are primarily involved in cellular senescence, inflammation, ECM regulation, and cytoskeletal organization. …”
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Down-regulation of miR-125b by HPV16 E6 might promote cervical cancer progression through TAZ/TEAD by Yongli Hou, Lili Zhang, Wenhao Wang, Keyan Cheng, Hui Wang, Yanfei Ji, Xiaoqiang Su, Min Hao

“…BackgroundAbnormal gene expression due to the dysregulation of microRNAs (miRNAs) often occurred in the initiation or progression of cancers. …”
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