Hsa_circ_0005571 promotes the proliferation and invasion of colorectal cancer cells by Haipeng Ge, Jiaxuan Zhang, Ran Tao, Li Ding, Song Jiang, Jiale Shen, Longjun Bian, Jun Qin

“…Abstract Dysregulated expression of circular RNAs (circRNAs) has been implicated in the initiation and progression of various diseases, including cancer. …”
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LncRNA GTF3C1 promotes diabetic corneal wound healing by regulating GABARAP and PTEN to augment autophagy by Danling Liao, Wenqu Chen, Yuyang Deng, Shijia Wei, Li Wang, Jianzhang Hu

“…Functional validation included mechanistic studies on lncRNA GTF3C1, miR-542-3p, and autophagy-related targets. …”
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Low Activation of CD8+ T Cells in response to Viral Peptides in Mexican Patients with Severe Dengue by Tania Estrada-Jiménez, Lilian Flores-Mendoza, Laura Ávila-Jiménez, Carlos Francisco Vázquez-Rodríguez, Gilma Guadalupe Sánchez-Burgos, Verónica Vallejo-Ruiz, Julio Reyes-Leyva

“…In addition, higher expression of FOXP-3 and reduced functional cytotoxic T cells (CD8+perforin+) were observed in DHF patients. …”
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Emerging perspectives on osteonecrosis of the femoral head: the role of circular RNAs and long non-coding RNAs - a systematic review by Feifei Lin, Shicheng Zhou, Min Yi, Qingyu Wang

“…This study aimed to investigate the association between dysregulated lncRNAs and circRNAs and their functions in ONFH.MethodsWe performed a systematic literature review of PubMed, MEDLINE, and Web of Science for all publicly available data. …”
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MiR-147b-3p promotes osteogenesis by targeting NDUFA4 and PI3K/AKT pathway by Yuanyuan Guo, Kai Shen, Zhijie Li, Changchun Niu, Yang Luo

“…Therefore, further investigation is warranted to elucidate the function and underlying mechanism of miR-147b-3p in osteogenic differentiation. …”
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Unravelling the transcriptomic characteristics of bronchoalveolar lavage in post-covid pulmonary fibrosis by Mohammad Shadab Ali, Vijay Hadda, Sonia Verma, Anita Chopra, Saurabh Mittal, Karan Madan, Pawan Tiwari, Tejas Menon Suri, Anant Mohan

“…Real-time validation further supported these findings. …”
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N6-methyladenosine-modification of USP15 regulates chemotherapy resistance by inhibiting LGALS3 ubiquitin-mediated degradation via AKT/mTOR signaling activation pathway in hepatoce... by Ronghuan Fang, Zhigang Jia, Yuhang Xin, Kai Zhao, Wei Qin, Haoran Lu, Yi Zhou, Yongsheng Yang, He Fang

“…Immunohistochemistry and high-throughput sequencing analyses of tumor and adjacent normal tissue samples from 52 patients with HCC were conducted. Functional analyses of immortalized human liver and HCC cell lines were conducted, including quantitative real-time PCR; western blot; plasmid, lentivirus, and siRNA transfection; co-immunoprecipitation; mass spectrometry; MeRIP-qPCR; and ubiquitination, cell growth, colony formation, and spheroid formation assays. …”
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Small Extracellular Vesicle (sEV) Uptake from Lung Adenocarcinoma and Squamous Cell Carcinoma Alters T-Cell Cytokine Expression and Modulates Protein Profiles in sEV Biogenesis by Hafiza Padinharayil, Jinsu Varghese, Pulikkottil Raphael Varghese, Cornelia M. Wilson, Alex George

“…Results: Cancer-derived sEVs were efficiently internalized by immune cells, reducing T-cell viability. The real-time PCR analysis showed downregulation of KI67, BCL2, BAX, TNFA, IL6, TGFβ, and IL10, suggesting reduced proliferation, dysregulated apoptosis, and impaired inflammatory and immunosuppressive signaling, and the upregulation of GZMB and IL2 suggests retained cytotoxic potential but possibly dysfunctional T-cell activation. …”
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Exploration of biomarkers for predicting the prognosis of patients with diffuse large B-cell lymphoma by machine-learning analysis by Shifen Wang, Hong Tao, Xingyun Zhao, Siwen Wu, Chunwei Yang, Yuanfei Shi, Zhenshu Xu, Dawei Cui

“…The validation of the hub genes expressions was confirmed by quantitative real-time polymerase chain reaction (qRT-PCR) and immunohistochemistry (IHC) tests. …”
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GSTM1 suppresses cardiac fibrosis post-myocardial infarction through inhibiting lipid peroxidation and ferroptosis by Kai-Jie Chen, Yue Zhang, Xin-Yi Zhu, Shuo Yu, Yao Xie, Cheng-Jiang Jin, Yi-Min Shen, Si-Yu Zhou, Xiao-Ce Dai, Sheng-An Su, Lan Xie, Zheng-Xing Huang, Hui Gong, Mei-Xiang Xiang, Hong Ma

“…Methods Multi-omics approaches (proteomics/scRNA-seq) identified GSTM1 as a dysregulated target in post-MI fibroblasts. Using a murine coronary ligation model, we assessed GSTM1 dynamics via molecular profiling, such as Western blotting, immunofluorescence, and real-time quantitative polymerase chain reaction. …”
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Next generation bioelectronic medicine: making the case for non-invasive closed-loop autonomic neuromodulation by Imanuel Lerman, Yifeng Bu, Rahul Singh, Harold A. Silverman, Anuj Bhardwaj, Alex J. Mann, Alik Widge, Joseph Palin, Christopher Puleo, Hubert Lim

“…Knowledge gaps remain and likely contribute to the lack of available closed loop autonomic neuromodulation systems, namely, (1) significant exogenous and endogenous noise that must be filtered out, (2) potential drift in the signal due to temporal change in disease severity and/or therapy induced neuroplasticity, and (3) confounding effects of exogenous therapies (e.g., concurrent medications that dysregulate autonomic nervous system functions). Leveraging continuous feedback and real-time adjustments may overcome many of these barriers, and these next generation systems have the potential to stand at the forefront of precision medicine, offering new avenues for individualized and adaptive treatment.…”
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Effects of PGK1 on immunoinfiltration by integrated single-cell and bulk RNA-sequencing analysis in sepsis by Yu Liu, Weijie Li, Lei Lei, Yaoliang Zhou, Mingcheng Huang, Yide Li, Xiaoying Zhang, Yingyu Jiang, Haiqi Wu, Zhihua Zheng, Kongyang Ma, Chun Tang

“…BackgroundSepsis, a life-threatening organ dysfunction caused by a dysregulated immune response to infection, remains a significant global health challenge. …”
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Decreased Serum microRNA-21, microRNA-25, microRNA-146a, and microRNA-181a in Autoimmune Diabetes: Potential Biomarkers for Diagnosis and Possible Involvement in Pathogenesis by Yiwen Liu, Minglei Ma, Jie Yu, Fan Ping, Huabing Zhang, Wei Li, Lingling Xu, Yuxiu Li

“…Previous studies have revealed dysregulated circulating microRNAs (miRNAs) in patients with type 1 diabetes (T1D). …”
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Circulating miR-200a is a novel molecular biomarker for early-stage renal cell carcinoma by Cheng Wang, Meng Ding, Yuan-Yuan Zhu, Jicheng Hu, Cuiping Zhang, Xiaolan Lu, Jingping Ge, Jun-Jun Wang, Chunni Zhang

“…Methods The serum levels of three miR-200 miRNAs (miR-200a, miR-200b and miR-200c) were firstly measured in 26 RCC patients and 26 noncancer controls of the training phase using quantitative real-time polymerase chain reaction (RT-qPCR). Markedly dysregulated miRNAs in RCC patients were subsequently verified by RT-qPCR in an independent validation phase that consist of 73 patients and 73 controls. …”
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Predictive value of microRNA-122 in obesity and metabolic syndrome by Aisha H. Abdelhafez, Wafaa M. Abdel Fattah, Nora Seliem, Eman F. Mohamed

“…Background and aim Metabolic syndrome (MetS) is a collection of metabolic dysregulations such as hypertension, insulin resistance, atherogenic dyslipidemia, and central obesity. …”
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Using fuzzy decision support to create a positive mental health environment for preschoolers by Xinyue Li

“…Future work should explore integrating real-time data collection methods like wearable devices or mobile applications to gather more comprehensive and dynamic behavioural data.…”
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Upregulation of miR-21 in cisplatin resistant ovarian cancer via JNK-1/c-Jun pathway. by Ileabett M Echevarría-Vargas, Fatma Valiyeva, Pablo E Vivas-Mejía

“…Dysregulation of miRNAs have been associated with cancer initiation, progression and drug resistance. …”
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Divergent immediate and delayed effects of juvenile exposure to doxorubicin on the thymus in C57BL/6 mice by Benu George, Korbyn J. V. Dahlquist, Marianne K. O. Grant, Mary R. Daniel, Declan M. Smith, Ian Ahlberg, Karim T. Sadak, Davis Seelig, Christina D. Camell, Beshay N. Zordoky

“…Abstract The long-term effects of doxorubicin (DOX) chemotherapy on thymic immune function in childhood cancer survivors remain inadequately understood. …”
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Effect of conditioned medium from miRNA-34a transfected gastric cancer-associated fibroblast on peripheral blood mononuclear cells by Mozhgan Esmaili, Narjes Jafari, Fatemeh Ahmadzadeh, Seyed Mohammad Valizadeh Toosi, Saeid Abediankenari

“…Therefore, this study aimed to evaluate the function of miRNA34a in CAF cells in gastric carcinoma. …”
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NSUN2 knockdown ameliorates hepatic glucose and lipid metabolism disorders in type 2 diabetes mellitus through the Inhibition of ACSL6 m5C methylation by Xianshu Jiang, Xuelan Cheng, Qiu Wan

“…Glucose metabolism was assessed via glucose metabolism function tests. Lipid metabolic parameters were evaluated through pathological analysis and measurements of biochemical indicators in HFD-fed mice. …”
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