Local Recurrence of Rectal Cancer After Transanal Total Mesorectal Excision and Risk Factors: A Nationwide Multicenter Cohort Study in Japan by Takeru Matsuda, MD, PhD, Ichiro Takemasa, MD, PhD, Hideki Endo, MD, MPH, Shinichiro Mori, MD, PhD, Suguru Hasegawa, MD, PhD, Koya Hida, MD, PhD, Takuya Tokunaga, MD, PhD, Keitaro Tanaka, MD, PhD, Toshiki Mukai, MD, PhD, Jun Watanabe, MD, PhD, Junichiro Kawamura, MD, PhD, Kei Kimura, MD, PhD, Yoshihiro Kakeji, MD, PhD, Masahiko Watanabe, MD, PhD, Seiichiro Yamamoto, MD, PhD, Takeshi Naitoh, MD, PhD, Ta-Ta-Mi study group collaboratives in Japan Society of Laparoscopic Colorectal Surgery

“…A high LR rate with a multifocal pattern early after TaTME has been reported in Norway and the Netherlands, causing controversy over the oncological safety of this technique. …”
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Eye-brain connection: an altered profile of spatial attention in myopia by Elie De Lestrange-Anginieur, Elie De Lestrange-Anginieur, Elie De Lestrange-Anginieur, Elie De Lestrange-Anginieur, Elie De Lestrange-Anginieur, Feng Pan, Feng Pan, Feng Pan, Feng Pan, Feng Pan, Benjamin Thompson, Benjamin Thompson, Kin Yau Wong

“…Degraded visual input may cause individuals with refractive errors to deploy greater attentional resources during visual tasks. We tested the hypothesis that myopia alters the pattern of visual attention.MethodsTwenty participants (10 near-emmetropes) performed an acuity discrimination task at random visual field locations (eccentricity range: 1–10°; spacing: 1°; polar coordinates of 0°, 90°, 180°or 270°) under conditions of neutral attention (no information on the stimulus position) and focused attention (target presentation in a single meridian), while fully optically corrected. …”
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Construction of Ancestral Chromosomes in Gymnosperms and the Application in Comparative Genomic Analysis by Haoran Liao, Lianghui Zhong, Yujie He, Jie He, Yuhan Wu, Ying Guo, Lina Mei, Guibing Wang, Fuliang Cao, Fangfang Fu, Liangjiao Xue

“…Chromosome rearrangements during plant evolution can lead to alterations in genome structure and gene function, thereby influencing species adaptation and evolutionary processes. …”
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IGSF10 mutations dysregulate gonadotropin‐releasing hormone neuronal migration resulting in delayed puberty by Sasha R Howard, Leonardo Guasti, Gerard Ruiz‐Babot, Alessandra Mancini, Alessia David, Helen L Storr, Lousie A Metherell, Michael JE Sternberg, Claudia P Cabrera, Helen R Warren, Michael R Barnes, Richard Quinton, Nicolas de Roux, Jacques Young, Anne Guiochon‐Mantel, Karoliina Wehkalampi, Valentina André, Yoav Gothilf, Anna Cariboni, Leo Dunkel

“…Self‐limited delayed puberty (DP) segregates predominantly in an autosomal dominant pattern, but the underlying genetic background is unknown. …”
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Novel tau biomarkers phosphorylated at T181, T217 or T231 rise in the initial stages of the preclinical Alzheimer’s continuum when only subtle changes in Aβ pathology are detected... by Marc Suárez‐Calvet, Thomas K Karikari, Nicholas J Ashton, Juan Lantero Rodríguez, Marta Milà‐Alomà, Juan Domingo Gispert, Gemma Salvadó, Carolina Minguillon, Karine Fauria, Mahnaz Shekari, Oriol Grau‐Rivera, Eider M Arenaza‐Urquijo, Aleix Sala‐Vila, Gonzalo Sánchez‐Benavides, José Maria González‐de‐Echávarri, Gwendlyn Kollmorgen, Erik Stoops, Eugeen Vanmechelen, Henrik Zetterberg, Kaj Blennow, José Luis Molinuevo, for the ALFA Study, Annabella Beteta, Raffaele Cacciaglia, Alba Cañas, Carme Deulofeu, Irene Cumplido, Ruth Dominguez, Maria Emilio, Carles Falcon, Sherezade Fuentes, Laura Hernandez, Gema Huesa, Jordi Huguet, Paula Marne, Tania Menchón, Grégory Operto, Albina Polo, Sandra Pradas, Anna Soteras, Marc Vilanova, Natalia Vilor‐Tejedor

“…Abstract In Alzheimer’s disease (AD), tau phosphorylation in the brain and its subsequent release into cerebrospinal fluid (CSF) and blood is a dynamic process that changes during disease evolution. The main aim of our study was to characterize the pattern of changes in phosphorylated tau (p‐tau) in the preclinical stage of the Alzheimer’s continuum. …”
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Research on Traditional Human Settlement Environment System in the Three-North Plain Driven by Water Conservancy Construction by Yingxue MA, Wei GUO

“…This is necessary for forming a holistic protection and management mindset that can give full play to the shaping of the spatial pattern of human settlements by water conservancy. …”
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Diagnostic work-up of anemia and associated health outcomes in people with heart failure by Guobin Su, Ruowei Xiao, Dongze Ji, Kaiyu He, Anna Hallert, Gianluigi Savarese, Lars H. Lund, Yang Xu, Juan Jesus Carrero

“…A large proportion of anemia events remained under-recognized and untreated, a pattern of care that warrants correction.…”
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Decadal transformations of antarctic sea ice modes by Benli Guo, Benli Guo, Benli Guo, Peng Yang, Peng Yang, Peng Yang, Jie Yuan, Jie Yuan, Jie Yuan, Honglian Xing, Honglian Xing, Honglian Xing, Wenjie Yuan, Wenjie Yuan, Wenjie Yuan, Yuanku Meng, Yuanku Meng, Yuanku Meng

“…The decline is particularly pronounced during autumn and winter, with rates of -7.1% and -6.5% per year, respectively. …”
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The Robust and Modulated Biomarker Network Elicited by the Plasmodium vivax Infection Is Mainly Mediated by the IL-6/IL-10 Axis and Is Associated with the Parasite Load by Allyson Guimarães da Costa, Lis Ribeiro do Valle Antonelli, Pedro Augusto Carvalho Costa, João Paulo Diniz Pimentel, Nadja Pinto Garcia, Andréa Monteiro Tarragô, Maria do Perpétuo Socorro Lopes dos Santos, Paulo Afonso Nogueira, Maria Izabel Ovellar Hekcmann, Aya Sadahiro, Andréa Teixeira-Carvalho, Olindo Assis Martins-Filho, Adriana Malheiro

“…Here, we examined the levels of serum biomarkers and their interaction during acute malaria. Material and Methods. Blood samples were collected from P. vivax-infected patients at admission and from healthy donors. …”
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Insulin Glargine U100 Utilization in Patients with Type 2 Diabetes in an Italian Real-World Setting: A Retrospective Study by Luca Degli Esposti, Valentina Perrone, Stefania Saragoni, Valerio Blini, Stefano Buda, Rosella D’avella, Gina Gasperini, Fabio Lena, Francesca Fanelli, Luca Gazzi, Francesco Giorgino

“…For each patient, we evaluated HbA1c levels both at baseline and during the follow-up period and the daily average dose of insulin. …”
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<i>Agave macroacantha</i> Transcriptome Reveals Candidate <i>CNGC</i> Genes Responsive to Cold Stress in Agave by Yubo Li, Xiaoli Hu, Dietram Samson Mkapa, Li Xie, Pingan Guo, Shibei Tan, Weiyi Zhang, Helong Chen, Xing Huang, Kexian Yi

“…However, low temperatures during winter can restrict its growth and even damage the leaves, causing a loss of ornamental appeal or affecting the fiber quality. …”
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Pain in women with and without bipolar spectrum disorder by Amanda L. Stuart, Michael Berk, Michael Berk, Michael Berk, Michael Berk, Julie A. Pasco, Julie A. Pasco, Julie A. Pasco, Julie A. Pasco, Mohammadreza Mohebbi, Shae E. Quirk, Lana J. Williams, Lana J. Williams

“…Mental disorders were confirmed by clinical interview (SCID-I/NP). Pain during the past week was determined by numeric rating scale (0–10, 10 = pain as severe as I can imagine) and deemed present if ≥5. …”
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Nonlinear Dynamics of TNFR1 and TNFR2 Expression on Immune Cells: Genetic and Age-Related Aspects of Inflamm-Aging Mechanisms by Alina Alshevskaya, Julia Zhukova, Julia Lopatnikova, Filipp Vasilyev, Ivan Khutornoy, Elena Golikova, Fedor Kireev, Sergey Sennikov

“…Genetic polymorphisms influenced correlation strength, but did not alter direction, demonstrating a conserved pattern of age-related receptor expression shifts. …”
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Advancement of a diagnostic prediction model for spatiotemporal calibration of earth observation data: a case study on projecting forest net primary production in the mid-latitude... by Eunbeen Park, Hyun-Woo Jo, Gregory Scott Biging, Jong Ahn Chun, Seong Woo Jeon, Yowhan Son, Florian Kraxner, Woo-Kyun Lee

“…For the case of DNPM, a prognostic NPP prediction model (PNPM) was set, using a multilinear regression on SPEI 3, temperature, and static environmental features extracted from topography and soil by a random forest. Subsequently, during the diagnostic process of DNPM, we calibrated the primary outcome based on the temporal pattern captured at the time-series residual of PNPM. …”
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Dose–response association between fluid overload and in-hospital mortality in critically ill patients: a multicentre, prospective, observational cohort study by Wei Li, Bin Du, Yan He, Li Jiang, Guangxu Liu, Meiping Wang, Jing Wen, Wen Li, Bo Zhu, Ying Wen, Xiuming Xi

“…Maximum FO was defined as the peak value of FO during the first 3 days of ICU admission. Logistic regression models with restricted cubic splines were used to explore the pattern and magnitude of the association between maximum FO and risk of in-hospital mortality. …”
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Preliminary study on the participation of TLR9 on erythrocyte surface combined with mtDNA in the monitoring of infectious diseases by Ling Xiao, Haixia Xu, Haixia Xu, Siwei Liu, Siwei Liu, Zhanrui Cheng, Zhanrui Cheng, Yujie Kong, Yujie Kong, Li Tian, Li Tian

“…The purpose of this study is to explore the role of TLR9 as a pattern recognition receptor combined with mtDNA in the monitoring of infectious diseases.MethodsTLR9 presence on the surface of red blood cells was assessed using flow cytometry in both healthy individuals and patients with bacterial infections. …”
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Insights in biomarkers complexity and routine clinical practice for the diagnosis of thyroid nodules and cancer by Maria de Lurdes Godinho de Matos, Mafalda Pinto, Ana Gonçalves, Sule Canberk, Maria João Martins Bugalho, Paula Soares

“…RAS mutations are found in a broad spectrum of thyroid neoplasm, from benign to malignant follicular-patterned tumors, but do not increase the ability to distinguish benign from malignant lesions. …”
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Species Distribution Model and Conservation of Mentaok (Wrightia javanica) in Indonesia by Sutomo, Nida Humaida, Luthfi Wahab, Muhammad Hadi Saputra, Fitri Kurniawati, Muhammad Bima Atmaja, Eko Pujiono, Jalma Giring Sukmawati, Aditya Hani, Rajif Iryadi, Wieke Herningtyas, Reni Setyo Wahyuningtyas

“…This study utilized species distribution models (SDMs) to investigate the species distribution pattern and assess its latest conservation status in Java and the Lesser Sunda Islands, Indonesia. …”
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Effects of urban sprawl on land use change in the peripheral villages of Tehran metropolis (case study: Tehran-Damavand axis) by ِAshkan Mohammadi, Naser Shafiei Sabet, Alireza Shakiba

“…In Tehran- Damavand axis, these changes have been made by various factors and forces during its uneven spatial expansion. Conclusion: In the study of spatial and land use changes, it is important to pay attention to which side effects are slowly changing and which side effects change more quickly. …”
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Urine microbiota in non-muscle-invasive bladder cancer and approaches to its detection by M. I. Kogan, Yu. L. Naboka, A. V. Ryzhkin, I. A. Gudima, A. G. Ivanov, S. N. Ivanov, O. N. Vasiliev, V. P. Glukhov, A. V. Ilyash, D. V. Sizyakin

“…To conduct a comparative assessment of the microbiota of bladder urine obtained during natural urination and bladder catheterization through standard and extended cultural studies in men with a presumptive diagnosis of non-muscle-invasive bladder cancer (NMIBC).Materials &amp; methods. …”
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