Interferon and B-cell Signatures Inform Precision Medicine in Lupus Nephritis by Ioannis Parodis, Julius Lindblom, Daniel Toro-Domínguez, Lorenzo Beretta, Maria O. Borghi, Jessica Castillo, Elena Carnero-Montoro, Yvonne Enman, Chandra Mohan, Marta E. Alarcón-Riquelme, Guillermo Barturen, Dionysis Nikolopoulos, Lorenzo Beretta, Barbara Vigone, Jacques-Olivier Pers, Alain Saraux, Valérie Devauchelle-Pensec, Divi Cornec, Sandrine Jousse-Joulin, Bernard Lauwerys, Julie Ducreux, Anne-Lise Maudoux, Carlos Vasconcelos, Ana Tavares, Esmeralda Neves, Raquel Faria, Mariana Brandão, Ana Campar, António Marinho, Fátima Farinha, Isabel Almeida, Miguel Angel Gonzalez-Gay Mantecón, Ricardo Blanco Alonso, Alfonso Corrales Martínez, Ricard Cervera, Ignasi Rodríguez-Pintó, Gerard Espinosa, Rik Lories, Ellen De Langhe, Nicolas Hunzelmann, Doreen Belz, Torsten Witte, Niklas Baerlecken, Georg Stummvoll, Michael Zauner, Michaela Lehner, Eduardo Collantes, Rafaela Ortega-Castro, Ma Angeles Aguirre-Zamorano, Alejandro Escudero-Contreras, Ma Carmen Castro-Villegas, Norberto Ortego, María Concepción Fernández Roldán, Enrique Raya, Inmaculada Jiménez Moleón, Enrique de Ramon, Isabel Díaz Quintero, Pier Luigi Meroni, Maria Gerosa, Tommaso Schioppo, Carolina Artusi, Carlo Chizzolini, Aleksandra Zuber, Donatienne Wynar, Laszló Kovács, Attila Balog, Magdolna Deák, Márta Bocskai, Sonja Dulic, Gabriella Kádár, Falk Hiepe, Velia Gerl, Silvia Thiel, Manuel Rodriguez Maresca, Antonio López-Berrio, Rocío Aguilar-Quesada, Héctor Navarro-Linares

“…Conclusion: IFN upregulation and B and plasma cell gene dysregulation patterns revealed 3 subgroups of LN, which may not necessarily represent distinct disease phenotypes but rather phases of the inflammatory processes during a renal flare, providing a conceptual framework for precision medicine in LN.…”
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Dual nature of type I interferon responses and feedback regulations by SOCS1 dictate malaria mortality by Jiansen Lu, Zhiqiang Hu, Huaji Jiang, Zebin Wen, Hongyu Li, Jian Li, Ke Zeng, Yingchao Xie, Huadan Chen, Xin-zhuan Su, Chunmei Cai, Xiao Yu

“…Additionally, differential activation patterns of various transcriptional factors (TFs) synergistically regulate the distinct IFN-I responses. …”
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Identifying people with post-COVID condition using linked, population-based administrative health data from Manitoba, Canada: prevalence and predictors in a cohort of COVID-positiv... by Jennifer E Enns, Alan Katz, Alexander Singer, Yoav Keynan, Lisa Lix, Kendiss Olafson, Randy Walld, Nathan C Nickel, Okechukwu Ekuma, Sarvesh Logsetty, Marcelo Urquia, Diana C Sanchez-Ramirez, Leona Star, Rae Spiwak, Teresa Cavett, Marina Yogendran, Jillian Waruk, Surani Matharaarachichi

“…Additional PCC cases were identified using predictive modelling to assess patterns of health service use, including physician visits, emergency department visits and hospitalisation for any reason (n=4155).Outcomes We measured PCC prevalence as % PCC cases among Manitobans with positive tests and identified predictive factors associated with PCC by calculating odds ratios with 95% confidence intervals, adjusted for sociodemographic and clinical characteristics (aOR).Results Among 66 365 Manitobans with positive tests, we identified 15 471 (23%) as having PCC. …”
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Impact of sterile Aedes aegypti males releases on vector dynamics: insights from Malaysian field trials by Wasi Ahmad Nazni, Guat-Ney Teoh, Mohd Adnan Nuradila, Shaikh Ismail Shaikh Norman Hakimi, Maheswaran Tanusshni, Mohd Azam Muhammad Arif, Achim Nurfarahin Hanini, Irfan Ahmad Shazia, Aik-Meng Tan, Hamzah Rabizah, Mohamad Dzomir Ahmad Zainuri, Asim Hasnor Hadi, Ahmad Norazah, Han-Lim Lee, Hamidou Maiga, Jeremy Bouyer, Yoon-Ling Cheong

“…Spatial clustering revealed no initial clustering, though clustering patterns emerged over time in KT. Conclusions SIT effectively suppressed Ae. aegypti populations and supported dengue control. …”
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Optimizing fertilizer application and straw return to fields to minimize nitrogen and phosphorus runoff losses in double-rice cropping systems by Ying Zhang, Jian Zhu, Changjun Li, Hua Peng, Ji Liu, Yue Luo, Min Song, Yanjiao Dai, Kai Deng, Xionghui Ji

“…Unknown of long-term patterns of losses and mechanisms driving runoff N and P in double-rice cropping systems limited the development of effective mitigation strategies. …”
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Lassa virus in novel hosts: insights into the epidemiology of lassa virus infections in southern Nigeria by Anise Nkenjop Happi, Olusola Akinola Ogunsanya, Akeemat Opeyemi Ayinla, Ayotunde Elijah Sijuwola, Femi Mudasiru Saibu, Kazeem Akano, Cecilia Nwofoke, Obineche Tobias Elias, Olivia Achonduh-Atijegbe, Richard Olumide Daodu, Oluwatobi Abel Adedokun, Abraham Adeyemo, Kehinde Ebenezer Ogundana, Omolola Zaheedat Lawal, Edyth Parker, Iguosadolo Nosamiefan, Johnson Okolie, Zahra F. Parker, Melanie D. McCauley, Leigh Anne Eller, Kara Lombardi, Abdulwasiu Bolaji Tiamiyu, Michael Iroezindu, Edward Akinwale, Thierry Lamare Fouapon Assedi Njatou, Tsedal Mebrahtu, Erica Broach, Anastasia Zuppe, Petra Prins, Jenny Lay, Mihret Amare, Kayvon Modjarrad, Natalie D. Collins, Sandhya Vasan, Cynthia Tucker, Sharon Daye, Christian Tientcha Happi

“…Identification of the diverse animal hosts responsible for spill-over events from animals to humans is crucial for comprehending the transmission patterns of emerging infectious diseases, which pose significant public health risks. …”
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Influence of structural setting, depositional environment and differential diagenesis on reservoir quality of the Xixiangchi formation in the central and southern Sichuan Basin, Ch... by Shizhen Chen, Shizhen Chen, Shizhen Chen, Huaguo Wen, Huaguo Wen, Huaguo Wen, Xiang Li, Xiang Li, Xiang Li, Fei Huo, Bowen Mo, Bowen Mo, Bowen Mo, Jintong Liang, Jintong Liang, Jintong Liang, Lian Duan, Lian Duan, Lian Duan

“…All dolomite types exhibit rare earth element patterns and isotopic signatures (δ13C: −1.39‰ ± 0.67‰ to - 1.23‰ ± 0.71‰; δ18O: −8.62‰ ± 1.18‰ to - 8.15‰ ± 0.98‰) comparable to coeval micritic limestones, indicating formation from evaporatively-concentrated seawater or marine-derived fluids. …”
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Histopathologic Progression and Metastatic Relapse Outcomes in Small Cell Neuroendocrine Carcinomas of the Urinary Tract by Mohammad Jad Moussa, Georges C. Tabet, Arlene O. Siefker‐Radtke, Lianchun Xiao, Nathaniel R. Wilson, Jianjun Gao, Christopher J. Logothetis, Petros Grivas, Byron Lee, Amishi Y. Shah, Pavlos Msaouel, Roger Li, Leticia Campos Clemente, Jianping Zhao, Nizar M. Tannir, Ashish M. Kamat, Donna E. Hansel, Charles C. Guo, Matthew T. Campbell, Omar Alhalabi

“…Here, we evaluate the predictors and patterns of relapse after surgery. Materials and Methods We identified a definitive‐surgery cohort (n = 224) from an institutional database of patients with cT1‐T4NxM0 SCNEC‐URO treated in 1985–2021. …”
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Rainfall-induced Landslide Susceptibility Prediction Considering Spatial Heterogeneity by ZHANG Xingfu, JIANG Yuanjun, ABI Erdi

“…Inputs such as terrain features, soil characteristics, vegetation indices, and rainfall patterns were utilized to train and evaluate the models. …”
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Application of Concentration-Area fractal modeling and artificial neural network to identify Cu, Zn±Pb geochemical anomalies in Hashtjin area, NW of Iran by Ali Imamalipour, Hamed Ebrahimi, Amir reza Abdollahpur

“…This neural network automatically and through unsupervised learning identifies patterns, complex structures, and high-level features of the input data. …”
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The optimal strategy for seasonal influenza vaccination to prevent high-intensity level of influenza epidemics in Zhejiang, China: an integrated transmission-dynamic and health-eco... by Mengsha Chen, Mengya Yang, Rui Yan, Zhengwei Liu, Can Chen, Rongrong Qu, Wenkai Zhou, Jiaxing Qi, Kexin Cao, Jiani Miao, Xiaoyue Wu, Jiaxin Chen, Qianqian Feng, HuiHui Zhang, Anqi Dai, Yi Yang, Jingtong Zhou, Qin Chen, Jimin Sun, Shigui Yang

“…Results Between 2018 and 2020, influenza incidence in Zhejiang Province followed typical seasonal patterns. However, during the COVID-19 pandemic, these patterns became irregular, culminating in a high-intensity influenza season in 2022–2023. …”
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Data analytics for real-world data integration in TKI-treated NSCLC patients using electronic health records by L. Mazzeo, F. Corso, P. Baili, F. Scotti, V. Torri, M. Ganzinelli, V. Mišković, R. Leporati, L. Provenzano, A. Spagnoletti, C. Silvestri, C. Giani, C. Cavalli, R.M. di Mauro, M. Meazza Prina, C. Proto, M. Brambilla, M. Occhipinti, S. Manglaviti, T. Beninato, D. Miliziano, A.D. Dumitrascu, G. Di Liberti, T.S. Cassano, F.G.M. de Braud, Giuseppe Lo Russo, A. Cappozzo, A.M. Paganoni, F. Ieva, A. Prelaj

“…The framework has been applied to investigate real-world treatment patterns and clinical outcomes of patients with advanced non-small-cell lung cancer (aNSCLC) treated with tyrosine kinase inhibitors (TKIs). …”
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High-resolution analyses of the secretomes from murine C2C12 cells and primary human skeletal muscle cells reveal distinct differences in contraction-regulated myokine secretion by Pia Marlene Förster, Pia Marlene Förster, Julian Hogenkamp, Julian Hogenkamp, Moira Fee Pottgießer, Christian Binsch, Christian Binsch, Awovi Didi Humpert, Awovi Didi Humpert, Carolin Laura Brügge, Michelle Isabel Deatc, Regina Ensenauer, Alexandra Chadt, Alexandra Chadt, G. Hege Thoresen, G. Hege Thoresen, D. Margriet Ouwens, D. Margriet Ouwens, D. Margriet Ouwens, Sonja Hartwig, Sonja Hartwig, Stefan Lehr, Stefan Lehr, Hadi Al-Hasani, Hadi Al-Hasani

“…Previous studies with cultured rodent and human myotubes have revealed highly complex patterns of myokine secretion. However, the commonalities and differences in the secretory response of the different cell models have not been explored, limiting the interpretation of these results. …”
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Sport participation as an educational tool and a means of promoting physical, mental, and social well-being by Francesco Sgrò

“…Dropping out of sports during youth has negative effects on the development of basic skills and competencies (Kolunsarka et al., 2025) and leads to significant challenges in adopting an active lifestyle throughout their lifespan. …”
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Analysis of the Contextual Factors Influencing the Expansion of Construction Violations with an Emphasis on the Role and Position of Key Urban Stakeholders (Case Study: Isfahan Met... by Ahmad Shahivandi, Afsaneh Talebi Varnosfaderani

“…To prevent violations, supervisory authorities, including monitoring engineers and building police, are tasked with reporting any infractions they observe during construction and halting unauthorized work. …”
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Cladolosides of Groups S and T: Triterpene Glycosides from the Sea Cucumber <i>Cladolabes schmeltzii</i> with Unique Sulfation; Human Breast Cancer Cytotoxicity and QSAR by Alexandra S. Silchenko, Elena A. Zelepuga, Ekaterina A. Chingizova, Ekaterina S. Menchinskaya, Kseniya M. Tabakmakher, Anatoly I. Kalinovsky, Sergey A. Avilov, Roman S. Popov, Pavel S. Dmitrenok, Vladimir I. Kalinin

“…This suggests that the enzymatic processes of sulfation and <i>O</i>-methylation that occur during the biosynthesis of glycosides can compete with each other. …”
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Normative Database of Spatiotemporal Gait Metrics Across Age Groups: An Observational Case–Control Study by Lianne Mobbs, Vinuja Fernando, R. Dineth Fonseka, Pragadesh Natarajan, Monish Maharaj, Ralph J. Mobbs

“…The IMU was placed at the sternal angle of each participant to ensure optimal data capture during a 50 m walk along a flat, unobstructed pathway. …”
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Determinants and Experiences of Care‐Seeking for Childhood Pneumonia in a Rural Indian Setting: A Mixed‐Methods Study by Barsha Gadapani Pathak, Sarmila Mazumder, Yasir Bin Nisar, Aditya Bhatt, Mandeep Singh, Tarun Madhur, Ingvild Fossgard Sandøy

“…Data on socio‐demographic characteristics, health insurance, care‐seeking patterns and provider preferences were collected. Directed acyclic graphs (DAGs) identified potential confounders in the association between care‐seeking behaviour and key exposure variables. …”
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GUEST EDITORS’ NOTE by Piero Amodio, Edward W. Legg, Ljerka Ostojić

“…Finally, we thank the Editor-in-Chief and the Editorial Board for their assistance and support during the entire process. …”
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Path and Practice of Gap Management in National Parks: A Comparison Between China and the US and Inspirations Therefrom by Yun MA, Siyuan HE

“…As inholdings often originate from land transfers during the territorial expansion of the US, they create fragmented ownership patterns, complicating federal land management. …”
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