Granulomatous lymphocytic interstitial lung disease in common variable immune deficiency: an in-depth clinical, immunological, functional and radiological exploration with a focus... by Mattia Moratti, Mattia Moratti, Gioacchino Schifino, Francesco Baccelli, Francesco Baccelli, Simona Ferrari, Elisabetta Magrini, Mirna Bassi, Aldo Guerrieri, Maurizio Zompatori, Marcello Lanari, Marcello Lanari, Francesca Conti, Francesca Conti

“…CMV infection in patients with GLILD on immunosuppressants resulted in favorable outcomes, underscoring the importance of personalized treatment strategies.ImplicationsThis study highlights novel immunological markers and clinical-radiological patterns as potential predictors for GLILD, advocating for their integration into diagnostic and monitoring frameworks to reduce reliance on invasive histopathology. …”
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Spatial and temporal epidemiology of SARS-CoV-2 virus lineages in Teesside, UK, in 2020: effects of socio-economic deprivation, weather, and lockdown on lineage dynamics by Moss, E.D., Rushton, S.P., Baker, P., Bashton, M., Crown, M.R., dos Santos, R.N., Nelson, A., O’Brien, S.J., Richards, Z., Sanderson, R.A., Yew, W.C., Young, G.R., McCann, C.M., Smith, D.L.

“…Methods: We examined the spatial and temporal patterns of COVID-19 in the Teesside sub-region of the UK, from January to December 2020, capturing the first two waves of the epidemic. …”
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Chemical Composition and Biological Activities of <i>Lagopsis supina</i> Extract: Antioxidant, Adipogenic, and Ani-Inflammatory Effects by Juhyun Choi, Duc Dat Le, Nayoung Roh, Jiseok Lee, Deumaya Shrestha, Thientam Dinh, Vinhquang Truong, Badamtsetseg Bazarragchaa, Soo-Yong Kim, Sung-Suk Suh, Mina Lee, Jong Bae Seo

“…It significantly enhanced the differentiation of 3T3-L1 preadipocytes into mature adipocytes during early and intermediate stages by upregulating adipogenic transcription factors such as PPARγ, C/EBPα, and C/EBPβ, along with promoting cyclin E expression. …”
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The origin and dissemination of HIV-1 subtype B on Hainan Island, South China, 2007–2024 by Chunyun Lu, Kaokao Zhu, Nengde Zhang, Mu Li, Shanmei Zhong, Cai Qin, Tong Luo, Rongjing Zhang, Jing Zhang, Yi Ning, Hao Liang, Li Ye, Bingyu Liang, Dee Yu

“…The analysis of viral migration patterns among risk subgroups revealed that subtype B was introduced to the island by MSMs (BF > 100). …”
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Long COVID and its associations with burnout, anxiety, and depression among U. S. healthcare workers in the United States by Thanh-Huyen T. Vu, Miao Jenny Hua, Cerina Dubois, Judith T. Moskowitz, Amisha Wallia, Amisha Wallia, Amisha Wallia, Lisa R. Hirschhorn, Lisa R. Hirschhorn, John T. Wilkins, John T. Wilkins, Charlesnika T. Evans, Charlesnika T. Evans, Charlesnika T. Evans

“…Multivariable linear regression analyses revealed that Long COVID was significantly associated with higher OLBI scores (β = 2.20, p = 0.004), PROMIS anxiety scores (β = 2.64, p = 0.001) and PROMIS depression scores (β = 1.98, p = 0.011) compared to those who had COVID-19 but not Long COVID. Similar patterns of associations were observed when comparing the Long COVID group to those who never had COVID-19. …”
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A machine learning approach to risk-stratification of gastric cancer based on tumour-infiltrating immune cell profiles by Yanping Hu, Bo Wang, Chao Shi, Pengfei Ren, Chengjuan Zhang, Zhizhong Wang, Jiuzhou Zhao, Jiawen Zheng, Tingjie Wang, Bing Wei, He Zhang, Rentao Yu, Yihang Shen, Jie Ma, Yongjun Guo

“…Kaplan–Meier’s curves were used to determine the prognosis during a 920-day-long median follow-up period (interquartile range: 834–1071 days). …”
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Rapid escalation and release of risks to forest ecosystems triggered by warming: Insights from tree growth synchrony in temperate forests by Liangjun Zhu, Danyang Yuan, J. Julio Camarero, David J. Cooper, Mai-He Li, Shuguang Liu, Xiaochun Wang, Paolo Cherubini

“…However, our understanding of how increasing temperature affects tree growth synchrony during rapidly and slowly warming periods in ecosystems with varying climatic conditions remains limited. …”
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Electroencephalographic differences between waking and sleeping periods in patients with prolonged disorders of consciousness at different levels of consciousness by Keke Li, Man Li, Wanqing Liu, Wanqing Liu, Yanzhi Wu, Fang Li, Jingwei Xie, Jingwei Xie, Jingwei Xie, Shaolong Zhou, Shaolong Zhou, Shaolong Zhou, Sen Wang, Yongkun Guo, Yongkun Guo, Yongkun Guo, Jiahui Pan, Xinjun Wang, Xinjun Wang, Xinjun Wang, Xinjun Wang

“…Notably, the HFD and PSD(δ) showed significantly better performance during wakefulness compared to sleep, while the TKEO was more prominent in the NREM2 stage. …”
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The cost effectiveness of a multidomain intervention on physical, cognitive, vascular, dietary and psychosocial outcomes among community dwelling older adults with cognitive frailt... by Pavapriya Ponvel, Suzana Shahar, Devinder Kaur Ajit Singh, Arimi Fitri Mat Ludin, Ponnusamy Subramaniam, Norhayati Ibrahim, Hasnah Haron, Aniza Ismail, Chin Ai-Vyrn, Mazlyfarina Mohamad, Hidayah Fadzil, Norhayati Mustafa Khalid, A’isyah Mohammad Safien, Jamilah Mohammad Hanipah, Azyana Ibrahim, Jenni Lehtisalo, Miia Kivipelto, Francesca Mangialasche

“…The intervention led to significant improvements in selected parameters of cognitive function, physical performance, anthropometry, and dietary patterns (for all parameters, p < 0.05 for interaction time*group in repeat-measures ANOVA). …”
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Vestibular Aqueduct and Temporal Bone Radioanatomy in Patients With and Without Meniere Disease: A Retrospective Cross-Sectional Analysis With Implications for Endolymphatic Sac Su... by Jeanne Bernard, Dario Ebode, Priya Vishnumurthy, Antonino Maniaci, Maria-Pia Tuset, Mario Lentini, Ralph Haddad, Giannicola Iannella, Mary Daval, Justin Michel, Stéphane Gargula

“…Cluster analysis identified three anatomical patterns, with 61.5% of intractable Meniere ears versus 14.5% of controls and 41.6% of contralateral ears falling into the cluster characterized by smaller VA dimensions, shorter PSCC–dura distances, and deeper operculum positions. …”
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Drought-driven shifts in Eucommia ulmoides rhizosphere mycobiota and metabolites mediate host tolerance by Chenglong Li, Shuangshuang Hou, Jinling Li, Xueqian Zhang, Qingsong Ran, Yanfeng Han, Zhijie Wang, Chunbo Dong

“…Our data indicate that drought stress considerably altered the species richness and community composition of the E. ulmoides seedling rhizosphere mycobiota, affecting the co-occurrence patterns and the composition of core fungal taxa within the mycobiota. …”
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Air pollution mapping and variability over five European cities by Karine Sartelet, Jules Kerckhoffs, Eleni Athanasopoulou, Lya Lugon, Jeni Vasilescu, Jian Zhong, Gerard Hoek, Cyril Joly, Soo-Jin Park, Camelia Talianu, Sef van den Elshout, Fabrice Dugay, Evangelos Gerasopoulos, Alexandru Ilie, Youngseob Kim, Doina Nicolae, Roy M. Harrison, Tuukka Petäjä

“…We confirm established seasonal and spatial patterns: spatial variability is more pronounced for PNC, NO2 and BC than PM2.5, and concentrations are higher during the winter periods. …”
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Machine learning and multi-omics analysis reveal key regulators of proneural–mesenchymal transition in glioblastoma by Can Xu, Jin Yang, Huan Xiong, Xiaoteng Cui, Yuhao Zhang, Mingjun Gao, Lei He, Qiuyue Fang, Changxi Han, Wei Liu, Yangyang Wang, Jin Zhang, Ying Yuan, Zhaomu Zeng, Ruxiang Xu

“…GBM undergoes proneural–mesenchymal transition (PMT) during its evolution or in response to changes in the microenvironment or therapeutic interventions. …”
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Evaluating the level of digitalization of the innovation process with artificial intelligence approach in the digital transformation of knowledge-based companies by ali Bagheri, reza radfar, sepehr ghazinoory

“…The scientific study of algorithms and statistical models are used by computer systems that use patterns and inference to perform tasks rather than using clear instructions. …”
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Differentiation-associated ISG expression of NK cells in chronic viral infection by Franziska Keller, Robert Lorenz Chua, Timo Trefzer, Katharina Jechow, Liane Bauersfeld, Fabian Beier, Sagar, Özlem Sogukpinar, Giuseppe Rusignuolo, Marta Rizzi, Roland Eils, Andreas Pichlmair, Marco Binder, Bertram Bengsch, Christoph Neumann-Haefelin, Volker Lohmann, Tobias Boettler, Christian Conrad, Robert Thimme, Maike Hofmann

“…We analyzed NK cells from healthy donors and patients with chronic HBV or HCV and found conserved expression patterns of interferon-stimulated genes (ISGs) such as IFITM3, IRF1, IFIT2, and ISG20 that correlated with NK cell differentiation state. …”
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Allergen immunotherapy in Italy: How, when, and why—A real-world study conducted through a patient association by Giovanni Paoletti, MD, Emanuele Nappi, MD, Maria Chiara Bragato, MD, Paola Valli, MD, Mattia Giovannini, MD, Domenico Gargano, MD, Luca Pecoraro, MD, Deborah Diso, MSc, Simona Barbaglia, MSc, Giorgio Walter Canonica, MD, Enrico Heffler, MD, PhD

“…Understanding AIT utilization patterns might disclose information about why it is underused, thus providing valuable insights on how to broaden the positive impact it can have on the population. …”
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Seasonal Variations in the Structure and Function of the Gut Flora in Adult Male Rhesus Macaques Reared in Outdoor Colonies by Longbao Lv, Feiyan Zhang, Haimei Zhou, Wenxian Xiao, Yingzhou Hu, Wenchao Wang, Zhu Zhu, Fangming Zhu, Dongdong Qin, Xintian Hu

“…The seasonal variations that occur in the gut microbiota of healthy adult rhesus monkeys kept in outdoor groups under conventional rearing patterns and how these variations are affected by environmental variables are relatively poorly understood. …”
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Differential Cortical Responses of Functional and Sensory Electrical Stimulation in Closed-Loop Tremor Suppression for Parkinson&#x2019;s Disease by Xiaoqi Zhao, Tinglan Huang, Mengyue Jin, Hongbo Zhao, Yu Shi, Yanlin Wang, Xiao Shen, Zhen Li, Qingqing Shi, Xiaodong Zhu, Lin Meng

“…This study investigated the differential cortical effects of FES and SES during closed-loop tremor suppression in PD patient, aiming to identify neurophysiological biomarkers for guiding personalized neuro modulation strategies. …”
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Crop-livestock-climate nexus: intensification pathways under different climate realizations in the Sahel, West Africa by Seyni Salack, Sheick Ahmed Khalil S B Sangare, Elidaa K Daku, Koufanou Hien, Aminou Mohamed Sawadogo, Safiétou Sanfo, Kehinde O Ogunjobi

“…Competition between crops and livestock farming systems escalates due to changing land use patterns driven by climate change in the Sahel of West Africa’s, particularly the Volta and Niger River basins. …”
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Widening gap in life expectancy between patients with heart failure living in most and least deprived areas: a longitudinal cohort study by O. I. Brown, M. Drozd, H. MacGowan, M. McGinlay, R. Burgess, S. Straw, A. D. Simms, V. K. Gatenby, A. Sengupta, A. M. N. Walker, C. Saunderson, M. F. Paton, K. I. Bridge, J. Gierula, K. K. Witte, R. M. Cubbon, M. T. Kearney

“…Recruitment period was split into 3-year intervals (2006–2008, 2009–2011 and 2012–2014). Results During a median follow-up of 5.0 years, 1302 participants (72.3%) died. …”
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