Reciprocal METTL3-PAX5 regulation in maintaining B-cell identity and promoting B-cell hyperreactivity in SLE by Yiying Yang, Ying Zhang, Shasha Xie, Ke Liu, Meidong Liu, Yisha Li, Hui Luo, Xiaoxia Zuo, Huali Zhang, Muyao Guo

“…MeRIP-seq analysis identified distinct m6A methylation patterns among B-cell subsets, particularly in key transcription factors critical for B-cell activation and differentiation. …”
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Global burden of diphtheria, 1990–2021: a 204-country analysis of socioeconomic inequality based on SDI and DTP3 vaccination differences before and after the COVID-19 pandemic (GBD... by Zilun Wu, Zilun Wu, Liyu Lin, Liyu Lin, Jinbu Zhang, Jinbu Zhang, Jirui Zhong, Jirui Zhong, Donglan Lai, Donglan Lai, Donglan Lai

“…This study provides the first systematic quantification of spatiotemporal diphtheria burden patterns, offering critical evidence for the WHO 2030 Diphtheria Elimination Roadmap. …”
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AI-driven pharmacovigilance: Enhancing adverse drug reaction detection with deep learning and NLP by Dr. Bharti Khemani, Dr. Sachin Malave, Samyukta Shinde, Mandvi Shukla, Razzaq Shikalgar, Harshita Talwar

“…This study aims to address the challenge of accurately detecting Serious Adverse Events (SAEs) in pharmacovigilance, a critical component in ensuring drug safety during and after clinical trials. The key problem lies in the underreporting and delayed detection of Adverse Drug Reactions (ADRs) due to the heterogeneous nature of medical data, class imbalance, and the limited scope of traditional monitoring techniques. …”
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In situ U-Pb dating and trace elements of magmatic rutile from Mujicun Cu-Mo deposit, North China Craton: Insights into porphyry mineralization by Fan Yang, Jing-wen Mao, Wei-dong Ren, Jia-run Tu, Gilby Jepson, Si-yuan Meng, Zhi-min Wang

“…Rutile trace element data show flat-like REE patterns characterized by relatively enrichment LREEs and depleted HREEs, which could be identified as magmatic rutile. …”
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The Running Performance of Elite Youth Football Players in Matches with a 1-4-3-3 Formation in Relation to Their Playing Position by Yiannis Michailidis, Andreas Stafylidis, Lazaros Vardakis, Angelos E. Kyranoudis, Vasilios Mittas, Vasileios Leftheroudis, Spyridon Plakias, Athanasios Mandroukas, Thomas I. Metaxas

“…This variation between playing positions emphasizes the need for individualized loading of players during the training microcycle.…”
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Markers of T cell activation and exhaustion in plasma are associated with persistent symptoms up to 18 months following mild SARS-CoV-2 infection by Thor Ueland, Thor Ueland, Thor Ueland, Rebecca Jane Cox, Rebecca Jane Cox, Rebecca Jane Cox, Annika E. Michelsen, Annika E. Michelsen, Elisabeth Berg Fjelltveit, Elisabeth Berg Fjelltveit, Kari Otterdal, Tuva Dahl, Fan Zhou, Rebecca Elyanow, Pål Aukrust, Pål Aukrust, Pål Aukrust, Bjørn Blomberg, Bjørn Blomberg, Bente E. Halvorsen, Bente E. Halvorsen, Nina Langeland, Nina Langeland

“…(ii) Cases with memory problems at 12–18 months had increased sLAG-3 iii) sCD25 correlated with SARS-CoV-2 antibody titers and microneutralization titers only in cases with PCC while sTIM-3 correlated with these parameters irrespectively of symptoms. iv) Although hospitalized patients had markedly elevated levels of T cell activation/exhausting markers during follow-up, there was no relation to PCC symptoms.ConclusionOur study indicates a role for T cell activation/exhaustion in PCC following home isolated COVID-19 infection, with somewhat different patterns of sCD25, sTIM-3 and sLAG-3, but not in hospitalized COVID-19 patients where disease severity may be more important.…”
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Integrating community perspectives to improve survey completion rates in public health research by refining controversial survey elements by Arleth A. Escoto, Angel Lomeli, Maria Linda Burola, Breanna Reyes, Ana Perez-Portillo, Scarlet Flores, Kayleigh Kornher, Norma Porras, Ariel Cohen, Linda Salgin, Borsika A. Rabin, Louise C. Laurent, Marva Seifert, Nicole A. Stadnick

“…This study used cognitive interviews (CIs), a methodological tool that can aid in developing and refining elements for multi-faceted assessments, and previous survey response patterns to refine, streamline, and increase response rates of RADx-UP Common Data Elements (CDEs) for survey/questionnaire use. …”
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Genome-wide identification and characterization of soybean GH9 endo-1,4-β-glucanases by Weimin Zhan, Huijuan Huang, Zaipan Cai, Zhenwei Zhao, Xuefu Lin, Yize Peng, Zhicheng Dong, Di Qin, Di Qin, Li Jiang

“…The GmGH9B/C members display complex splicing patterns. GmGH9As contain typical transmembrane structural domains, while GmGH9Cs uniquely includes the carbohydrate-binding module 49 (CBM49) and signal peptide. …”
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Insights into bloodstream infections in South African paediatric burn patients: Implications for antimicrobial stewardship by Dr Michael Christie, Professor Theunis Avenant, Dr Zeenat Bhikhoo

“…Polymicrobial and fungal BSIs occurred later during hospitalization, highlighting evolving infection patterns in burn patients. …”
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Condomless sexual encounters among female sex workers included in a longitudinal coital diary study in Zimbabwe by Galven Maringwa, Tatenda Kujeke, Memory Makamba, Gracious Madimutsa, Sungai T. Chabata, Harriet Jones, Fortunate Machingura, Elizabeth Fearon, Frances M. Cowan, James R. Hargreaves

“…We aimed to estimate the prevalence and patterns of condomless sex by partner type at the sexual encounter level, as well as identify factors associated with condomless sex among FSWs recruited into a diary study in Zimbabwe. …”
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Epidemiology of respiratory syncytial virus and its subtypes among cases of influenza like illness and severe acute respiratory infection: findings from nationwide sentinel surveil... by Adamu Tayachew, Zelalem Mekuria, Wolde Shure, Dawit Assefa Arimide, Ayele Gebeyehu, Tsegaye Berkesa, Melaku Gonta, Gizaw Teka, Mandefro Kebede, Daniel Melese, Mesfin Wossen, Melkamu Abte, Mesay Hailu, Nega Berhe, Patrik Medstrand, Nigatu Kebede

“…The age-specific and temporal patterns of RSV positivity identified in this study contribute to the understanding of RSV and its subtypes epidemiology in Ethiopia. …”
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Impact and elastic modulus of coal mining on terrestrial ecosystems by Jihong Dong, Wenting Dai, Jiren Xu, Hui Zhang, Yunpeng Li, Fei Xie

“…Using China’s open-pit coal mining as a case study: (1) the research examines the fundamental attributes and evolving patterns of spatial distribution among these mines within the country. …”
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Real-world data of Azvudine-induced hepatotoxicity among hospitalized COVID-19 patients in China: a retrospective case-control study by Yuanguo Xiong, Hao Xin, Cai Shi, Xianxi Guo, Ying Chen, Caifei Huang, Fuwang Ma, Ge Yang, Jian Yang

“…These findings underscored the importance of monitoring liver function during Azvudine treatment and caution against concomitant use of certain medications. …”
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A Prior Knowledge-Enhanced Deep Learning Framework for Improved Thermospheric Mass Density Prediction by Ling Li, Changyong He, Dunyong Zheng, Shaoning Li, Dong Zhao

“…Additionally, ResNet-MSIS effectively captured the horizontal TMD variations, including equatorial mass density anomaly (EMA) and midnight density maximum (MDM) structures, confirming its ability to learn complex spatiotemporal patterns. This work underscores the value of merging data-driven methods with domain-specific prior knowledge, offering a promising pathway for advancing TMD modeling in space weather and atmospheric research.…”
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Exploring the Feasibility of a 5-Week mHealth Intervention to Enhance Physical Activity and an Active, Healthy Lifestyle in Community-Dwelling Older Adults: Mixed Methods Study by Kim Daniels, Sharona Vonck, Jolien Robijns, Kirsten Quadflieg, Jochen Bergs, Annemie Spooren, Dominique Hansen, Bruno Bonnechère

“…Behavioral patterns such as user session duration, feature use frequency, and navigation paths were analyzed, focusing on engagement metrics and user interactions. …”
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Unveiling the Temporal Dynamics and Molecular Regulation Profiles of Neutrophil Extracellular Traps Following Spinal Cord Injury by Li J, Chang C, Li Y, Cui S, Bai J, Zhang C, Wang X, Li K, Jian F

“…Publicly available single-cell RNA sequencing data from the GEO database determined cell-specific expression patterns of key NRGs. Findings were validated through immunofluorescence, Western blot, and qPCR in a mouse SCI model. …”
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Meta-analysis of niacin and NAD metabolite treatment in infectious disease animal studies suggests benefit but requires confirmation in clinically relevant models by Colleen S. Curran, Xizhong Cui, Yan Li, Tom Gamble, Junfeng Sun, Samuel Minkove, Alicia A. Livinski, Peter Q. Eichacker, Parizad Torabi-Parizi

“…Abstract Disruption of nicotinamide adenine dinucleotide (NAD) biosynthesis and function during infection may impair host defenses and aggravate inflammatory and oxidative organ injury. …”
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Study on Calibration Method of Micromechanical Parameters for Discrete Element Model of Moderately Consolidated Sandstones by Wenhong Zhang, Zhengchao Ma, Hantao Zhao, Tianyu Wang, Panpan Zhang, Jiacheng Dai, Shouceng Tian

“…As an effective research tool, the discrete element method (DEM) encounters challenges during the modeling phase, such as a large number of micromechanical parameters, low modeling efficiency, and unclear coupling mechanisms among multiple parameters. …”
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Results of a 10-month Study on the Species Spectrum and Antimicrobial Resistance of Microorganisms in a Tertiary Care Hospital by O. Krektun, T. Kirichuk, L. Novak, N. Lekhniuk, S. Nedzelskyi, Y. Konechnyi, R. Lesyk

“…One of the methods to mitigate AMR is the microbiological monitoring of antibiotic-resistant strains of microorganisms within the framework of infection control with regular monitoring of resistance patterns. The aim of thе study. To determine the species diversity and antimicrobial resistance of microorganisms isolated in a tertiary care hospital over a 10-month period. …”
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Conventional in vitro fertilization enhances preimplantation genetic testing for aneuploidy outcomes in couples with non-male factor infertility by Xiaolan Li, Qian Li, Yajie Chang, Shujing He, Yanfang Wang, Xiaoyan Liang, Zhiqiang Zhang

“…To control for confounding factors, 578 PGT-A cycles with ICSI during the same period were selected as a control group. …”
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