Benefits of aldosterone receptor antagonism in chronic kidney disease: the BARACK-D RCT by F D Richard Hobbs, Richard McManus, Clare Taylor, Nicholas Jones, Joy Rahman, Jane Wolstenholme, Louise Jones, Jennifer Hirst, Sam Mort, Ly-Mee Yu

“…Although the risks of myocardial infarction and other manifestations of coronary artery disease are increased in CKD, the pattern of CVD is atypical, with a much greater incidence of heart failure and sudden cardiac death than in the general CVD population. …”
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A retinoic acid:YAP1 signaling axis controls atrial lineage commitment by Elizabeth Abraham, Aleksandra Kostina, Brett Volmert, Thomas Roule, Ling Huang, Jingting Yu, April E. Williams, Emily Megill, Aidan Douglas, Olivia M. Pericak, Alex Morris, Eleonora Stronati, Arantza Larrinaga-Zamanillo, Raquel Fueyo, Mikel Zubillaga, Mark D. Andrake, Naiara Akizu, Aitor Aguirre, Conchi Estaras

“…Accordingly, in hESC-derived patterned heart organoids, YAP1 regulates the formation of an atrial chamber but is dispensable for the formation of a ventricle. …”
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Clinical features of post-COVID-19 period. Results of the international register “Dynamic analysis of comorbidities in SARS-CoV-2 survivors (AKTIV SARS-CoV-2)”. Data from 6-month f... by G. P. Arutyunov, E. I. Tarlovskaya, A. G. Arutyunov, Yu. N. Belenkov, A. O. Konradi, Yu. M. Lopatin, A. P. Rebrov, S. N. Tereshchenko, A. I. Chesnikova, H. G. Hayrapetyan, A. P. Babin, I. G. Bakulin, N. V. Bakulina, L. A. Balykova, A. S. Blagonravova, M. V. Boldina, A. R. Vaisberg, A. S. Galyavich, V. V. Gomonova, N. Yu. Grigorieva, I. V. Gubareva, I. V. Demko, A. V. Evzerikhina, A. V. Zharkov, U. K. Kamilova, Z. F. Kim, T. Yu. Kuznetsova, N. V. Lareva, E. V. Makarova, S. V. Malchikova, S. V. Nedogoda, M. M. Petrova, I. G. Pochinka, K. V. Protasov, D. N. Protsenko, D. Yu. Ruzanau, S. A. Sayganov, A. Sh. Sarybaev, N. M. Selezneva, A. B. Sugraliev, I. V. Fomin, O. V. Khlynova, O. Yu. Chizhova, I. I. Shaposhnik, D. A. Shchukarev, A. K. Abdrahmanova, S. A. Avetisian, H. G. Avoyan, K. K. Azarian, G. T. Aimakhanova, D. A. Ayipova, A. Ch. Akunov, M. K. Alieva, A. V. Aparkina, O. R. Aruslanova, E. Yu. Ashina, O. Yu. Badina, O. Yu. Barisheva, T. I. Batluk, A. S. Batchayeva, R. A. Bashkinov, A. M. Bitieva, I. U. Bikhteyev, N. A. Borodulina, M. V. Bragin, A. M. Budu, G. A. Bykova, K. R. Vagapova, D. D. Varlamova, N. N. Vezikova, E. A. Verbitskaya, O. E. Vilkova, E. A. Vinnikova, V. V. Vustina, E. A. Gаlova, V. V. Genkel, E. I. Gorshenina, E. V. Grigorieva, E. Yu. Gubareva, G. M. Dabylova, I. A. Demchenko, O. Yu. Dolgikh, M. Y. Duyshobayev, D. S. Evdokimov, K. E. Egorova, A. N. Ermilova, A. E. Zheldybayeva, N. V. Zarechnova, Yu. D. Zimina, S. Yu. Ivanova, E. Yu. Ivanchenko, M. V. Ilina, M. V. Kazakovtseva, E. V. Kazymova, Yu. S. Kalinina, N. A. Kamardina, A. M. Karachenova, I. A. Karetnikov, N. A. Karoli, M. K. Karsiev, D. S. Кaskaeva, K. F. Kasymova, Zh. B. Kerimbekova, A. Sh. Kerimova, E. S. Kim, N. V. Kiseleva, D. A. Klimenko, A. V. Klimova, O. V. Kovalishena, E. V. Kolmakova, T. P. Kolchinskaya, M. I. Kolyadich, O. V. Kondriakova, M. P. Konoval, D. Yu. Konstantinov, E. A. Konstantinova, V. A. Kordukova, E. V. Koroleva, A. Yu. Kraposhina, T. V. Kriukova, A. S. Kuznetsova, T. Yu. Kuzmina, K. V. Kuzmichev, Ch. K. Kulchoroeva, T. V. Kuprina, I. M. Kouranova, L. V. Kurenkova, N. Yu. Kurchugina, N. A. Kushubakova, V. I. Levankova, N. A. Lyubavina, N. A. Magdeyeva, K. V. Mazalov, V. I. Majseenko, A. S. Makarova, A. M. Maripov, A. A. Marusina, E. S. Melnikov, N. B. Moiseenko, F. N. Muradova, R. G. Muradyan, Sh. N. Musaelian, A. O. Myshak, E. S. Nekaeva, N. M. Nikitina, B. B. Ogurlieva, A. A. Odegova, Yu. M. Omarova, N. A. Omurzakova, Sh. O. Ospanova, E. V. Pahomova, L. D. Petrov, S. S. Plastinina, V. A. Pogrebetskaya, D. V. Polyakov, D. S. Polyakov, E. V. Ponomarenko, L. L. Popova, N. A. Prokofeva, I. A. Pudova, N. A. Rakov, A. N. Rakhimov, N. A. Rozanova, S. Serikbolkyzy, A. A. Simonov, V. V. Skachkova, D. V. Soloveva, I. A. Soloveva, I. M. Sukhomlinova, A. G. Sushilova, D. R. Tagayeva, Yu. V. Titojkina, E. P. Tikhonova, D. S. Tokmin, A. A. Tolmacheva, M. S. Torgunakova, K. V. Trenogina, N. A. Trostianetckaia, D. A. Trofimov, M. A. Trubnikova, A. A. Tulichev, A. T. Tursunova, N. D. Ulanova, O. V. Fatenkov, O. V. Fedorishina, T. S. Fil, I. Yu. Fomina, I. S. Fominova, I. A. Frolova, S. M. Tsvinger, V. V. Tsoma, M. B. Cholponbaeva, T. I. Chudinovskikh, O. A. Shevchenko, T. V. Sheshina, E. A. Shishkina, K. Yu. Shishkov, S. Yu. Sherbakov, E. A. Yausheva

“…The highest mortality rate was observed in the first 3 months in the group of patients with class II-IV heart failure, as well as in patients with cardiovascular diseases and cancer. In the pattern of death causes in the post-hospitalization period, following cardiovascular causes prevailed (31,8%): acute coronary syndrome, stroke, acute heart failure. …”
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Predictors of uveitic macular edema and functional prognostic outcomes: real-life data from the international AIDA Network uveitis registry by Jurgen Sota, Germán Mejía-Salgado, Silvana Guerriero, Gaafar Ragab, Gaafar Ragab, Stefania Costi, Maria Pia Paroli, Andrea Hinojosa-Azaola, Giuseppe Lopalco, Luciana Breda, Henrique Ayres Mayrink Giardini, Alex Fonollosa, Maria Sole Chimenti, Antonio Vitale, Carla Gaggiano, Blanca Aguilar-Barrera, Laura Daniela Rodríguez-Camelo, Guillermo Arturo Guaracha-Basañez, Mohamed Tharwat Hegazy, Mohamed Tharwat Hegazy, Rosanna Dammacco, Valeria Albano, Eduardo Martín-Nares, Santiago Espinosa-Lugo, Mahmoud Ghanema, Maria Morrone, Saverio La Bella, Rafael Alves Cordeiro, Francesco Carubbi, Alessandro Conforti, Piero Ruscitti, Ibrahim AlMaglouth, Rosaria Talarico, Stefano Gentileschi, Petros P. Sfikakis, Valeria Caggiano, Matteo Piga, Adele Civino, Francesca Ricci, Maissa Thabet, Marcello Govoni, Abdurrahman Tufan, Francesca Crisafulli, Jessica Sbalchiero, Sulaiman M. Al-Mayouf, Angela Mauro, Angela Mauro, Soad Hashad, Soad Hashad, Francesca Minoia, Alma Nunzia Olivieri, Samar Tharwat, Samar Tharwat, Maria Cristina Maggio, Abdelhfeez Moshrif, Gian Domenico Sebastiani, Daniela Opris-Belinski, Gülen Hatemi, Gülen Hatemi, Haner Direskeneli, Fatma Alibaz-Öner, Lampros Fotis, José Hernández-Rodríguez, Giovanni Conti, Piercarlo Sarzi Puttini, Ombretta Viapiana, Annarita Giardina, Patrizia Barone, Kalpana Babu, Rana Hussein Amin, Perla Ayumi Kawakami-Campos, Vishali Gupta, Annamaria Iagnocco, Ali Şahin, Antonella Insalaco, Andrés González-García, Ezgi Deniz Batu, Ester Carreño, Emanuela Del Giudice, Cecilia Beatrice Chighizola, Cecilia Beatrice Chighizola, Fabrizio Conti, Alberto Balistreri, Bruno Frediani, Luca Cantarini, Alejandra de-la-Torre, Claudia Fabiani

“…Four variables were associated with ME development during NIU course: the non–anterior anatomical pattern (p < 0.0001, OR = 4.01), the presence of retinal vasculitis (p = 0.028, OR = 1.68), complications other than ME (p = 0.044, OR = 1.51) and immunosuppressive treatment (p = 0.010, OR 1.69) while the diagnosis of Behçet disease-related uveitis was less likely to be associated with ME development (p = 0.24, OR 0.545). …”
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Insights in biomarkers complexity and routine clinical practice for the diagnosis of thyroid nodules and cancer by Maria de Lurdes Godinho de Matos, Mafalda Pinto, Ana Gonçalves, Sule Canberk, Maria João Martins Bugalho, Paula Soares

“…RAS mutations are found in a broad spectrum of thyroid neoplasm, from benign to malignant follicular-patterned tumors, but do not increase the ability to distinguish benign from malignant lesions. …”
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Social Media Suicide Watch by Katherine Prothro

“…AI can be used to retrospectively analyze posts from individuals who died by suicide to identify patterns imperceptible to the human eye. These algorithms could then be applied to current users to more accurately identify at-risks populations. …”
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High-flow nasal cannula therapy versus continuous positive airway pressure for non-invasive respiratory support in paediatric critical care: the FIRST-ABC RCTs by Padmanabhan Ramnarayan, Alvin Richards-Belle, Karen Thomas, Laura Drikite, Zia Sadique, Silvia Moler Zapata, Robert Darnell, Carly Au, Peter J Davis, Izabella Orzechowska, Julie Lester, Kevin Morris, Millie Parke, Mark Peters, Sam Peters, Michelle Saull, Lyvonne Tume, Richard G Feltbower, Richard Grieve, Paul R Mouncey, David Harrison, Kathryn Rowan

“…Recommendations for research Recommendation 1 Secondary analyses exploring patient characteristics and patterns of physiological parameters that predict treatment failure, including intubation. …”
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A Systematic Review on the Use of Big Data in Tourism by Jafar Ahangaran, Abbas Sadeghnia

“…Big data analytics enables the analysis of historical data, seasonal patterns and market trends for better decision making (Xiang, 2017). …”
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Improving health-promoting workplaces through interdisciplinary approaches. The example of WISEWORK-C, a cluster of five work and health projects within Horizon-Europe by Deborah De Moortel, Michelle C Turner, Ella Arensman, Alex Binh Vinh Duc Nguyen, Víctor Gonzalez

“…The Index will help identify risk patterns and guide the design of tailored interventions that promote physical and mental health throughout the working life course. …”
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Improving outcomes for people with autism spectrum disorders by reducing mental health problems: the IAMHealth research programme including one RCT by Emily Simonoff, Gillian Baird, Bryony Beresford, Tony Charman, Martin Knapp, Andrew Pickles, Carol Povey, Tom Purser, Paramala Santosh, Vicky Slonims, Stephen Scott

“…Concurrent, convergent and discriminant validity was supported by the pattern of correlations with other measures. Limitations There were relatively low completion rates by children, adolescents, and young adults, as well as teachers, in comparison with parents, meaning that a full psychometric profile could only be generated for the parent version. …”
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Enhanced recovery pathway for older people with hip fracture and cognitive impairment in acute hospitals: the PERFECTED research programme including an RCT by Chris Fox, Simon P Hammond, Lee Shepstone, Fiona Poland, Catherine Henderson, Tamara Backhouse, Bridget Penhale, Simon Donell, Martin Knapp, Douglas Lewins, Alasdair MacLullich, Martyn Patel, Opinder Sahota, Toby O Smith, Justin Waring, Jane L Cross

“…Comparing agreement in the data, we found sources agreed on ‘non-use’, but suitable informant over- and under-reporting of ‘use’ compared with hospital records did not follow a consistent pattern. Comparing SIR ‘hospital use’ over the 3-month periods pre-baseline and pre-6-month follow-up were identical at both assessments. …”
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Clinical and cost-effectiveness of paramedics working in general practice: a mixed-methods realist evaluation by Matthew Booker, Sarah Voss, Nicky Harris, William Hollingworth, Nouf Jeynes, Hazel Taylor, Kirsty Garfield, Helen Baxter, Jonathan Benger, Andy Gibson, Trudy Goodenough, Justin Jagosh, Kim Kirby, Cathy Liddiard, Alyesha Proctor, Sarah Purdy, Behnaz Schofield, Hannah Stott, Grace Scrimgeour, Nicola Walsh

“…Retrospective cohort component The retrospective cohort component showed that paramedic-led care had relatively little association with the patterns of subsequent patient care, with the possible exception of increased rates of prescribing. …”
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Integrating Palliative Care and Heart Failure: the PalliatHeartSynthesis realist synthesis by Tracey McConnell, Carolyn Blair, Geoff Wong, Claire Duddy, Clare Howie, Loreena Hill, Joanne Reid

“…Consolidation of sources of evidence: when findings from different documents had similarities, a judgement was made as to whether these similarities could adequately form patterns to inform the development of context–mechanism–outcome configurations (CMOcs) and programme theory, or whether there were nuances that required highlighting, and for what purpose. …”
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Human immunodeficiency virus prevention and testing strategies among men who have sex with men in the UK: the PANTHEON research programme including the SELPHI RCT by Janey Sewell, T Charles Witzel, David Dunn, Fiona Lampe, Fiona Burns, Peter Weatherburn, Sheena McCormack, Leanne McCabe, Alec Miners, Valentina Cambiano, Roger Pebody, Roy Trevelion, Nadia Hanum, Andrew Phillips, Alison Rodger

“…The Synthesis model was calibrated using longitudinal patterns of condom-less sex, particularly around the time of HIV infection, changes in risk behaviour as a result of receiving a diagnosis of HIV in MSM, and the proportion of men likely to have been infected by a long-term partner, so that the cost-effectiveness of all relevant prevention activities could be estimated. …”
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