Granulomatous lymphocytic interstitial lung disease in common variable immune deficiency: an in-depth clinical, immunological, functional and radiological exploration with a focus... by Mattia Moratti, Mattia Moratti, Gioacchino Schifino, Francesco Baccelli, Francesco Baccelli, Simona Ferrari, Elisabetta Magrini, Mirna Bassi, Aldo Guerrieri, Maurizio Zompatori, Marcello Lanari, Marcello Lanari, Francesca Conti, Francesca Conti

“…CMV infection in patients with GLILD on immunosuppressants resulted in favorable outcomes, underscoring the importance of personalized treatment strategies.ImplicationsThis study highlights novel immunological markers and clinical-radiological patterns as potential predictors for GLILD, advocating for their integration into diagnostic and monitoring frameworks to reduce reliance on invasive histopathology. …”
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Spatial and temporal epidemiology of SARS-CoV-2 virus lineages in Teesside, UK, in 2020: effects of socio-economic deprivation, weather, and lockdown on lineage dynamics by Moss, E.D., Rushton, S.P., Baker, P., Bashton, M., Crown, M.R., dos Santos, R.N., Nelson, A., O’Brien, S.J., Richards, Z., Sanderson, R.A., Yew, W.C., Young, G.R., McCann, C.M., Smith, D.L.

“…Methods: We examined the spatial and temporal patterns of COVID-19 in the Teesside sub-region of the UK, from January to December 2020, capturing the first two waves of the epidemic. …”
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Chemical Composition and Biological Activities of <i>Lagopsis supina</i> Extract: Antioxidant, Adipogenic, and Ani-Inflammatory Effects by Juhyun Choi, Duc Dat Le, Nayoung Roh, Jiseok Lee, Deumaya Shrestha, Thientam Dinh, Vinhquang Truong, Badamtsetseg Bazarragchaa, Soo-Yong Kim, Sung-Suk Suh, Mina Lee, Jong Bae Seo

“…Chemical profiling revealed eight major compound groups: glycosides, organic acids, terpenoids, flavonoids, phenylglycosides, phenolics, fatty acids, and others characterized by their mass fragmentation patterns, precursors, and UV absorption spectra. In silico analysis confirmed these compounds’ bioactivities, demonstrating strong interactions and binding affinities with antioxidant, adipogenic, and anti-inflammatory protein targets. …”
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Long COVID and its associations with burnout, anxiety, and depression among U. S. healthcare workers in the United States by Thanh-Huyen T. Vu, Miao Jenny Hua, Cerina Dubois, Judith T. Moskowitz, Amisha Wallia, Amisha Wallia, Amisha Wallia, Lisa R. Hirschhorn, Lisa R. Hirschhorn, John T. Wilkins, John T. Wilkins, Charlesnika T. Evans, Charlesnika T. Evans, Charlesnika T. Evans

“…Multivariable linear regression analyses revealed that Long COVID was significantly associated with higher OLBI scores (β = 2.20, p = 0.004), PROMIS anxiety scores (β = 2.64, p = 0.001) and PROMIS depression scores (β = 1.98, p = 0.011) compared to those who had COVID-19 but not Long COVID. Similar patterns of associations were observed when comparing the Long COVID group to those who never had COVID-19. …”
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A machine learning approach to risk-stratification of gastric cancer based on tumour-infiltrating immune cell profiles by Yanping Hu, Bo Wang, Chao Shi, Pengfei Ren, Chengjuan Zhang, Zhizhong Wang, Jiuzhou Zhao, Jiawen Zheng, Tingjie Wang, Bing Wei, He Zhang, Rentao Yu, Yihang Shen, Jie Ma, Yongjun Guo

“…Patients from the three clusters had varied pathologies, MMR statuses and TIIC distribution patterns (p < .05). Kaplan–Meier’s analysis showed that the prognosis of C3 was inferior compared to C1 and C2 (p = .0025). …”
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Rapid escalation and release of risks to forest ecosystems triggered by warming: Insights from tree growth synchrony in temperate forests by Liangjun Zhu, Danyang Yuan, J. Julio Camarero, David J. Cooper, Mai-He Li, Shuguang Liu, Xiaochun Wang, Paolo Cherubini

“…The growth synchrony variation patterns of the five species were highly consistent over time, although broadleaves exhibited higher synchrony than conifers, suggesting potential risks to forest resilience and stability under future climate change scenarios. …”
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Electroencephalographic differences between waking and sleeping periods in patients with prolonged disorders of consciousness at different levels of consciousness by Keke Li, Man Li, Wanqing Liu, Wanqing Liu, Yanzhi Wu, Fang Li, Jingwei Xie, Jingwei Xie, Jingwei Xie, Shaolong Zhou, Shaolong Zhou, Shaolong Zhou, Sen Wang, Yongkun Guo, Yongkun Guo, Yongkun Guo, Jiahui Pan, Xinjun Wang, Xinjun Wang, Xinjun Wang, Xinjun Wang

“…ObjectiveThis study aimed to explore differences in sleep electroencephalogram (EEG) patterns in individuals with prolonged disorders of consciousness, utilizing polysomnography (PSG) to assist in distinguishing between the vegetative state (VS)/unresponsive wakefulness syndrome (UWS) and the minimally conscious state (MCS), thereby reducing misdiagnosis rates and enhancing the quality of medical treatment.MethodsA total of 40 patients with prolonged disorders of consciousness (pDOC; 27 patients in the VS/UWS and 13 in the MCS) underwent polysomnography. …”
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The cost effectiveness of a multidomain intervention on physical, cognitive, vascular, dietary and psychosocial outcomes among community dwelling older adults with cognitive frailt... by Pavapriya Ponvel, Suzana Shahar, Devinder Kaur Ajit Singh, Arimi Fitri Mat Ludin, Ponnusamy Subramaniam, Norhayati Ibrahim, Hasnah Haron, Aniza Ismail, Chin Ai-Vyrn, Mazlyfarina Mohamad, Hidayah Fadzil, Norhayati Mustafa Khalid, A’isyah Mohammad Safien, Jamilah Mohammad Hanipah, Azyana Ibrahim, Jenni Lehtisalo, Miia Kivipelto, Francesca Mangialasche

“…The intervention led to significant improvements in selected parameters of cognitive function, physical performance, anthropometry, and dietary patterns (for all parameters, p < 0.05 for interaction time*group in repeat-measures ANOVA). …”
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Vestibular Aqueduct and Temporal Bone Radioanatomy in Patients With and Without Meniere Disease: A Retrospective Cross-Sectional Analysis With Implications for Endolymphatic Sac Su... by Jeanne Bernard, Dario Ebode, Priya Vishnumurthy, Antonino Maniaci, Maria-Pia Tuset, Mario Lentini, Ralph Haddad, Giannicola Iannella, Mary Daval, Justin Michel, Stéphane Gargula

“…Cluster analysis identified three anatomical patterns, with 61.5% of intractable Meniere ears versus 14.5% of controls and 41.6% of contralateral ears falling into the cluster characterized by smaller VA dimensions, shorter PSCC–dura distances, and deeper operculum positions. …”
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Drought-driven shifts in Eucommia ulmoides rhizosphere mycobiota and metabolites mediate host tolerance by Chenglong Li, Shuangshuang Hou, Jinling Li, Xueqian Zhang, Qingsong Ran, Yanfeng Han, Zhijie Wang, Chunbo Dong

“…Our data indicate that drought stress considerably altered the species richness and community composition of the E. ulmoides seedling rhizosphere mycobiota, affecting the co-occurrence patterns and the composition of core fungal taxa within the mycobiota. …”
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Persistence of Yellow fever virus outside the Amazon Basin, causing epidemics in Southeast Brazil, from 2016 to 2018. by Izabela Maurício de Rezende, Lívia Sacchetto, Érica Munhoz de Mello, Pedro Augusto Alves, Felipe Campos de Melo Iani, Talita Émile Ribeiro Adelino, Myrian Morato Duarte, Ana Luísa Furtado Cury, André Felipe Leal Bernardes, Tayrine Araújo Santos, Leonardo Soares Pereira, Maria Rita Teixeira Dutra, Dario Brock Ramalho, Benoit de Thoisy, Erna Geessien Kroon, Giliane de Souza Trindade, Betânia Paiva Drumond

“…The topology of lineage BR-YFV_2016/18 was congruent with epidemiological and temporal patterns of the ongoing epidemic. YFV isolates detected in 2016, in São Paulo state were located in the most basal position of the lineage, followed by the isolates from Minas Gerais and Espírito Santo obtained in 2017 and 2018. …”
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Allergen immunotherapy in Italy: How, when, and why—A real-world study conducted through a patient association by Giovanni Paoletti, MD, Emanuele Nappi, MD, Maria Chiara Bragato, MD, Paola Valli, MD, Mattia Giovannini, MD, Domenico Gargano, MD, Luca Pecoraro, MD, Deborah Diso, MSc, Simona Barbaglia, MSc, Giorgio Walter Canonica, MD, Enrico Heffler, MD, PhD

“…Understanding AIT utilization patterns might disclose information about why it is underused, thus providing valuable insights on how to broaden the positive impact it can have on the population. …”
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Seasonal Variations in the Structure and Function of the Gut Flora in Adult Male Rhesus Macaques Reared in Outdoor Colonies by Longbao Lv, Feiyan Zhang, Haimei Zhou, Wenxian Xiao, Yingzhou Hu, Wenchao Wang, Zhu Zhu, Fangming Zhu, Dongdong Qin, Xintian Hu

“…The seasonal variations that occur in the gut microbiota of healthy adult rhesus monkeys kept in outdoor groups under conventional rearing patterns and how these variations are affected by environmental variables are relatively poorly understood. …”
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Differential Cortical Responses of Functional and Sensory Electrical Stimulation in Closed-Loop Tremor Suppression for Parkinson&#x2019;s Disease by Xiaoqi Zhao, Tinglan Huang, Mengyue Jin, Hongbo Zhao, Yu Shi, Yanlin Wang, Xiao Shen, Zhen Li, Qingqing Shi, Xiaodong Zhu, Lin Meng

“…These distinct cortical response patterns were significantly correlated with tremor suppression performance (FES <inline-formula> <tex-math notation="LaTeX">$\beta $ </tex-math></inline-formula>-ERD: r = -0.629, p = 0.012; SES <inline-formula> <tex-math notation="LaTeX">$\beta $ </tex-math></inline-formula>-ERS: r = 0.679, p = 0.005). …”
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Crop-livestock-climate nexus: intensification pathways under different climate realizations in the Sahel, West Africa by Seyni Salack, Sheick Ahmed Khalil S B Sangare, Elidaa K Daku, Koufanou Hien, Aminou Mohamed Sawadogo, Safiétou Sanfo, Kehinde O Ogunjobi

“…Competition between crops and livestock farming systems escalates due to changing land use patterns driven by climate change in the Sahel of West Africa’s, particularly the Volta and Niger River basins. …”
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Widening gap in life expectancy between patients with heart failure living in most and least deprived areas: a longitudinal cohort study by O. I. Brown, M. Drozd, H. MacGowan, M. McGinlay, R. Burgess, S. Straw, A. D. Simms, V. K. Gatenby, A. Sengupta, A. M. N. Walker, C. Saunderson, M. F. Paton, K. I. Bridge, J. Gierula, K. K. Witte, R. M. Cubbon, M. T. Kearney

“…However, in the context of improved medical and device therapy for HF, it is unknown whether the influence of socioeconomic deprivation on HF outcomes is changing over time, especially in relation to evolving life expectancy patterns in the general population. Therefore, we aimed to describe temporal trends in the association of socioeconomic deprivation with loss of actuarially predicted life expectancy amongst ambulatory patients with HF. …”
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Assessing the role of genotype by environment interaction of winter wheat cultivars using envirotyping techniques in North China by Haiwang Yue, Yanbing Wang, Zhaoyang Chen, Jiashuai Zhu, Partha Pratim Behera, Pengcheng Liu, Haoxiang Yang, Jianwei Wei, Junzhou Bu, Xuwen Jiang, Xuwen Jiang, Wujun Ma

“…Accurate yield estimation depends on understanding the patterns of GEI in multi-environment trials (METs).MethodsFrom 2014 to 2018, continuous experiments were conducted in the Heilonggang region of the North China Plain (NCP), evaluating 71 winter wheat genotypes across 16 locations over five years. …”
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Cropland encroachment on ecological land in Mainland Southeast Asia leads to massive carbon emissions by Danni Su, Kun Yang, Zongqi Peng, Run Sun, Mingfeng Zhang, Xiaofang Yang, Lusha Ma, Jingcong Ma

“…This study simulated MSEA’s land use patterns under SSP1-RCP2.6, SSP2-RCP4.5, and SSP5-RCP8.5 using the PLUS model with data from 1992 to 2022. …”
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Annual dialysis data report 2022, Japanese Society for Dialysis Therapy (JSDT) Renal Data Registry by Norio Hanafusa, Masanori Abe, Nobuhiko Joki, Junichi Hoshino, Masatomo Taniguchi, Kan Kikuchi, Takeshi Hasegawa, Shunsuke Goto, Tetsuya Ogawa, Eiichiro Kanda, Shigeru Nakai, Toshihide Naganuma, Kenichiro Miura, Atsushi Wada, Yoshiaki Takemoto

“…The results obtained for each condition provide evidence for developing more clinically effective practice patterns for these conditions.…”
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Analysis of ROH Characteristics Across Generations in Grassland-Thoroughbred Horses and Identification of Loci Associated with Athletic Traits by Wenqi Ding, Wendian Gong, Tugeqin Bou, Lin Shi, Yanan Lin, Xiaoyuan Shi, Zheng Li, Huize Wu, Manglai Dugarjaviin, Dongyi Bai

“…Using the SNP dataset, we analyzed the number and length distribution patterns of runs of homozygosity (ROHs) in the genomes of different generational groups of Grassland-Thoroughbreds. …”
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