CRISPR/Cas9-mediated simultaneous targeting of GmP34 and its homologs produces T-DNA-free soybean mutants with reduced allergenic potential by Dongwon Baek, Byung Jun Jin, Mi Suk Park, Ye Jin Cha, Tae Hee Han, Ye Na Jang, Su Bin Kim, Sang In Shim, Jong-Il Chung, Hyun Jin Chun, Min Chul Kim, Min Chul Kim, Min Chul Kim

“…Gene expression profiling revealed similar expression patterns of all three genes during seed maturation, indicating potential functional redundancy. …”
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Evolution Of Multidrug-Resistant Acinetobacter Baumannii Pneumonia In Years In Terms Of Tigecycline Treatment by Merve Mert Vahabi, Deniz Akyol, Deniz Dağ, Şevket Yeniyol, Olcay Buse Kenanoğlu, Oğuzhan Acet, Ayşe Uyan Önal, Uğur Önal, Seichan Ketentzi, Gamze Şanlıdağ, Gunel Quliyeva, Şükrü Dirik, Cansu Bulut Avşar, Derya Kaya, Şöhret Aydemir, Hüsnü Pullukçu, Meltem Taşbakan, Hilal Sipahi, Bilgin Arda, Oğuz Reşat Sipahi

“…BACKGROUND-AIM: Herein, we aimed to evaluate and compare the efficacy and susceptibility patterns of tigecycline in MDR A.baumannii pneumonia (MDRABP) in a recent vs retrospective cohort. …”
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Alpine peatland degradation enhances soil nitrogen losses and alters plant nitrogen uptake strategies: evidence from nitrogen isotopes by Xiaodong Zhang, Lijuan Cui, Xin Jia, Liang Yan, Yong Li, Zhongqing Yan, Kerou Zhang, Ao Yang, Yuechuan Niu, Enze Kang, Xiaoming Kang

“…Although the abundance of stable nitrogen isotopes (δ15N) has been widely used to trace nitrogen processes, their patterns and implications across degradation gradients are not well understood. …”
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Intra-familial transmission of Hepatitis B virus in a peri-urban community from the Democratic Republic of the Congo by Florence Cindibu Kalonji, Yu Nakagama, Evariste Tshibangu-Kabamba, Nadine Kayiba Kalenda, Shun Nakagama, Sachie Nakagama, Pathy Kamanga Nkolongo, Nestor Kalala-Tshituka, Alphonse Lufuluabu Mpemba, Faustin Ndjibu Mpoji, André Kabongu Kalala, Benjamin Muamba Mpoyi, Dieudonné Mumba Ngoyi, Natsuko Kaku, Yusuke Shimakawa, Ghislain Tumba Disashi, Yasutoshi Kido

“…Genotyping and phylogenetic analysis of preS/S sequences were performed to explore regional HBV diversity and transmission patterns. Results A total of 751 participants from 677 households were included. …”
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A prospective cluster randomized trial of an interventions bundle to reduce inappropriate antibiotic use for upper respiratory tract infections in the outpatient setting by Adeel A. Butt, Sherin Shams, Atika Jabeen, Asma Ali Al-Nuaimi, Jeyaram Illiayaraja Krishnan, Aimon B. Malik, Samah Saleem, Maryam Hassan Abdulaziz, Naheel Ismail Seyam, Kamran Aziz, Dalia Kandil, Anil G. Thomas, Hanaa Nafady-Hego, Muzna I. Lone, Jameela Al Ajmi, Zain A. Bhutta, Noora AlSulaiti, Wael E. Said Hussein, Sandy Semaan, Samya Ahmad Al-Abdulla, Mohamed Ghaith Al-Kuwari, Abdul-Badi Abou-Samra

“…Intervention Bundled 4-component intervention including extensive provider education, a decision support algorithm, option for deferred antibiotics prescription, and monthly feedback on prescription patterns, vs. a single randomly assigned intervention (decision support algorithm). …”
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A mobile app to improve adherence to colorectal cancer screening and post polypectomy surveillance guidelines by María A. Casas, Francisco Schlottmann, Leandro Steinberg, Xavier Bessa, Anna Serradesanferm, Angels Pozo, Sonia Torres, Antoni Castells, Francesc Balaguer, Jaume Grau, Lisandro Pereyra, María Pellisé

“…Users’ characteristics, consultation types, and patient data were analyzed to assess app’s implementation, usage patterns, and impact on CRC screening and surveillance outcomes. …”
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Peanut leaf transcriptomic dynamics reveals insights into the acclimation response to elevated carbon dioxide under semiarid conditions by Haydee Laza, Bishwoyog Bhattarai, Bishwoyog Bhattarai, Venugopal Mendu, Mark D. Burow, Mark D. Burow, Yves Emendack, Jacobo Sanchez, Aarti Gupta, Mostafa Abdelrahman, Lam-Son Phan Tran, David T. Tissue, Paxton Payton

“…However, our new approach based on the comparative relative percentage change per individual category across stages revealed new insights into the gene expression patterns of biological functional groups, highlighting the relevance of the C-related pathways regulated by elevated [CO2].DiscussionThe photosynthesis analysis showed that 1) The light reaction was the most upregulated pathway by elevated [CO2] during water stress, 2) Photorespiration was downregulated across all stages, 3) Sucrose synthesis genes were upregulated by elevated [CO2] before stress, 4) Starch synthesis genes were upregulated by elevated [CO2] under drought periods, and 5) CO2 regulation of sucrose and starch degradation was critical under drought periods. …”
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Ontogeny of Fetal Cardiometabolic Pathways: The Potential Role of Cortisol and Thyroid Hormones in Driving the Transition from Preterm to Near-Term Heart Development in Sheep by Reza Amanollahi, Stacey L. Holman, Melanie R. Bertossa, Ashley S. Meakin, Kent L. Thornburg, I. Caroline McMillen, Michael D. Wiese, Mitchell C. Lock, Janna L. Morrison

“…Understanding hormonal and molecular changes during the transition from preterm to near-term gestation is essential for investigating how pregnancy complications impact fetal heart development and contribute to long-term cardiovascular risks for offspring. …”
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Emerging contaminants in stormwater: Tire-derived chemicals, pharmaceuticals, and heavy metals detected in a United Arab Emirates extreme weather event by Jonathan Navarro Ramos, Lara Dronjak, Sofian Kanan, Md Maruf Mortula, Joshua S. Wallace, Fatin Samara, Ning Dai, Diana S. Aga

“…Climate change is associated with the intensification of weather patterns, including extreme weather events of historically arid regions such as the United Arab Emirates (UAE). …”
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Body Roundness Index Trajectories and the Risk of Cancer: A Cohort Study by Yue Chen, Yiming Wang, Xin Zheng, Tong Liu, Chenan Liu, Shiqi Lin, Hailun Xie, Jinyu Shi, Xiaoyue Liu, Xiangming Ma, Li Deng, Shouling Wu, Hanping Shi

“…Based on the changes in participants' BRI during the period from 2006 to 2010, three BRI trajectory patterns were identified: low‐stable, medium‐stable, and high‐stable. …”
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Pathobiological characterization of a novel duck picornavirus in duck in China by Jitong Li, Junfeng Lv, Tong Zhu, Yuehua Gao, Feng Hu, Kexiang Yu, Minxun Song, Jianlin Wang, Bai Wei, Min Kang, Yufeng Li

“…A TaqMan fluorescence quantitative PCR method was utilized to detect the proliferation and shedding patterns of the virus within the ducks, while the SYBR Green I fluorescence quantitative PCR method was used to assess cytokine expression levels in the organs. …”
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Long-term impact on cardiopulmonary function and quality of life among patients recovered from SARS-CoV-2 infection in a 6-month follow-up period in Lima, Peru: FUNCTION cohort stu... by Carlos Seas, Larissa Otero, Eduardo Gotuzzo, Fernando Mejia, Rodrigo Cachay, Takashi Watanabe-Tejada, Katiuska Cuno, Marcela Gil-Zacarias, Carolina Coombes, Isabel Ballena, Felix Medina, Oscar Gayoso

“…Introduction The sequelae of COVID-19 have been described as a multisystemic condition, with a great impact on the cardiovascular and pulmonary systems with abnormalities in pulmonary function tests, such as lower diffusing capacity of the lung for carbon monoxide (DLco) levels and pathological patterns in spirometry; persistence of radiological lesions; cardiac involvement such as myocarditis and pericarditis; and an increase in mental disorders such as anxiety and depression. …”
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High concordance of human immunodeficiency virus-1 genotypic drug resistance generated from paired cerebrospinal fluid and plasma in antiretroviral therapy -naive or -experienced p... by Xizi Deng, Jiaojiao Li, Ruiying He, Yingfen Wen, Yaqing Lin, Liya Li, Xuemei Ling, Fengyu Hu, Linghua Li, Yun Lan

“…However, the HIV-1 drug resistance patterns in the central nervous system (CNS) have been poorly studied.ObjectiveWe aimed to compare HIV-1 genotypes and drug resistance mutations (DRMs) derived from the cerebrospinal fluid (CSF) and plasma of antiretroviral therapy (ART)-naive or -experienced patients.MethodsThe matched CSF and plasma samples from 59 patients with HIV were subjected to HIV proteinase (PR), reverse transcriptase (RT), and integrase (IN) gene sequencing. …”
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Application-based remote interstage home monitoring for infants with shunt- or duct-dependent pulmonary perfusion by Lisa-Maria Rosenthal, Lisa-Maria Rosenthal, Lisa-Maria Rosenthal, Friederike Danne, Sophie de Belsunce, Lisa Spath, Chiara-Aiyleen Badur, Joachim Photiadis, Felix Berger, Felix Berger, Katharina Schmitt, Katharina Schmitt, Katharina Schmitt

“…A median of 353 (IQR 351–743) data entries were sent per patient during IHM of which 0.8% (IQR 0.3–1.9) were pathological. …”
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The Mkx- TGF-β pathway induced the development of the myodural bridge complex in SD rats by Ji-Hang Li, Ji-Hang Li, Wen-Bin Jiang, Lu Zhang, Yun-Feng Liu, Yi-Tong Sun, Hua-Xun Lai, M. Adeel Alam Shah, Wei Ma, Chan Li, Campbell Gilmore, Jian-Fei Zhang, Hong-Jin Sui

“…ObjectiveThe myodural bridge complex (MDBC) is a tendon-like structure highly conserved during vertebrate evolution, suggesting it plays an important physiological role. …”
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Risk Communication and Community Engagement (RCCE) implementations to control cholera outbreak in Oromia region, Ethiopia by Dabesa Gobena, Esayas Kebede Gudina, Getahun Fetensa, Tizta Tilahun Degfie, Tessema Debela, Afework Tamiru, Zenebu Begna Bayissa, Dereje Diriba, Tarekegn Sarbessa, Daniel Bekele, Natinel Teferi, Achalu Layesa, Abate Zewdie, Dawit Worku Ayele, Meron Debebe Mersha, Chala Bafikadu, Senahara Korsa Wake, Lemi Abebe, Tesfaye Kebebew, Tefera Goshu, Birhanu Kenate, Yadeta Dessie, Zeleke Mekonnen

“…Abstract Background Oromia regional state experiencing cholera outbreaks in a protracted pattern despite various interventions at local and regional levels. …”
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Clinical Utility of Induced Sputum and Bronchoalveolar Lavage Cultures in Diagnosing Nontuberculous Mycobacterial Pulmonary Disease by Maria Angela Licata, Paola Mencarini, Annelisa Mastrobattista, Serena Maria Carli, Carlotta Cerva, Silvia Mosti, Raffaella Libertone, Alberto Zolezzi, Pietro Vittozzi, Carla Nisii, Antonio Mazzarelli, Angela Cannas, Assunta Navarra, Stefania Ianniello, Rocco Trisolini, Delia Goletti, Fabrizio Palmieri, Gina Gualano

“…Among 33 patients with a fibro-cavitary radiological pattern, 65% of IS (35/54) were culture-positive for NTM, whereas 94% of cases (31/33) had a positive culture for NTM from BAL (<i>p</i> = 0.002). …”
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Comparative Proteomic Analysis of Popcorn Genotypes Identifies Differentially Accumulated Proteins Associated with Resistance Pathways to Southern Leaf Blight Disease by Caio Cézar Guedes Corrêa, Tatiana Santos Barroso, Lucas Rodrigues Xavier, Vitor Batista Pinto, Ricardo Souza Reis, Guilherme Ferreira Pena, Claudete Santa-Catarina, Marcelo Vivas, Antonio Teixeira do Amaral Júnior, Vanildo Silveira

“…Eighteen DAPs exhibited the same regulatory pattern in both the SLB-resistant and SLB-susceptible genotypes at four (R4/S4) and ten (R10/S10) DAI. …”
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The TALE class homeobox gene Smed-prep defines the anterior compartment for head regeneration. by Daniel A Felix, A Aziz Aboobaker

“…Here, Smed-prep, encoding a TALE class homeodomain, is described as the first gene necessary for correct anterior fate and patterning during planarian regeneration. Smed-prep is expressed at high levels in the anterior portion of whole animals, and Smed-prep(RNAi) leads to loss of the whole brain during anterior regeneration, but not during lateral regeneration or homeostasis in intact worms. …”
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Dynamic changes and drives of surface urban heat islands in China by Qiumeng Zhang, Baoquan Jia, Tong Li, Yarong Yang, Youxin Fang

“…This study leveraged long-term MODIS land surface temperature data, delving into the temporal variations and spatial patterns of surface urban heat island intensity (SUHII) across 1444 counties in China from both annual and seasonal time scales, as well as from national and climatic zone spatial dimensions. …”
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