Impact of COVID-19 Pandemic-Related Restrictions for Inpatients with Aphasia and Associated Cognitive Dysfunction: Lessons Learned from Patient Detention by Edwin Eshun, Killian Welch, Hannah Britton, Victoria Mayer, Fay Morrice, Charlotte Ogilvie, Helen Page, Jessie Pridmore, Alasdair FitzGerald

“…We describe two patients with a recent stroke or traumatic brain injury associated with aphasia and cognitive impairment who required detention (under the Mental Health Act) as well as some form of restraint during their inpatient rehabilitation. Each of these episodes of care occurred early into the COVID-19 pandemic and we speculate that the detention (and restraint) was attributable, at least in part, to the difficulty in comprehending COVID-19-related changes in patterns of staff interaction and the mandated social and visiting restrictions. …”
Get full text

Geospatial assessment of treeline shift in response to climate change in Langtang National Park, central Nepal by Sijar Bhatta, Chandani KC, Raju Chauhan, Saraswati Aryal, Dipak Khadka, Ramesh Prasad Sapkota

“…The Himalayan region harbors diverse treeline species but remains highly sensitive to even minor climate fluctuations, leading to shifts in forest distribution and recruitment patterns. This study examines treeline dynamics in response to climate change in Langtang National Park (LNP), Nepal, using remote sensing data, GIS techniques, and field observations. …”
Get full text

Transcriptome and miRNAome analyses uncover the regulatory role of miR6155 in trichome development of tobacco by Mengxiao Xu, Jianfeng Zhang, Lijun Meng, Huan Su, Zechao Qu, Jiemeng Tao, Peng Lu, Deshui Liu, Shizhou Yu, Chenfeng Hua, Jinbang Wang, Peijian Cao, Jingjing Jin

“…Abstract Background Glandular trichomes, which act as the first barrier against damage induced by insects and disease, can produce specialized metabolites that play important roles during plant development. However, the role played by microRNAs (miRNAs), which regulate many plant physiological processes, during trichome development is not unraveled in detail. …”
Get full text

Chromatin changes associated with neutrophil extracellular trap formation in whole blood reflect complex immune signaling by Justin Cayford, Brandi Atteberry, Akanksha Singh-Taylor, Andrew Retter, Andrew Retter, Andrew Retter, Benjamin P. Berman, Benjamin P. Berman, Theresa K. Kelly

“…We compared chromatin accessibility patterns in neutrophils following PMA treatment in isolation and whole blood to assess the impact of other immune cells and signaling environment.ResultsWhole blood PMA stimulation elicited consistent chromatin accessibility changes across donors, demonstrating organized chromatin decondensation during NET formation. …”
Get full text

The Role of RNA Polymerase II Contiguity and Long-Range Interactions in the Regulation of Gene Expression in Human Pluripotent Stem Cells by Livia Eiselleova, Viktor Lukjanov, Simon Farkas, David Svoboda, Karel Stepka, Irena Koutna

“…We also analyzed the distance distributions of these genes in the context of their positions in the nucleus and revealed that they tend to have similar patterns resembling normal distribution. Furthermore, we compared data created in vitro and in silico to assess the biological relevance of our results.…”
Get full text

Polka-dotted Stars: A Hierarchical Model for Mapping Stellar Surfaces Using Occultation Light Curves and the Case of TOI-3884 by Sabina Sagynbayeva, Will M. Farr, Brett M. Morris, Rodrigo Luger

“…When a planet crosses a spot during transit, it creates a distinctive change in the light curve that directly reveals spot properties. …”
Get full text

The evolution of aerosol mixing state derived from a field campaign in Beijing: implications for particle aging timescales in urban atmospheres by J. Liu, F. Zhang, J. Ren, L. Chen, A. Zhang, Z. Wang, S. Zou, H. Xu, X. Yue

“…Here, by using field measurements at a site in urban Beijing, we have identified four different real-time mixing patterns of size-resolved particles, which are defined as less hygroscopic (LH) internally mixed, externally mixed, transitional externally mixed and more hygroscopic (MH) internally mixed particles, with atmospheric fractions of 0 %–10 %, 20 %–46 %, 17 %–24 % and 27 %–56 %, respectively. …”
Get full text

High genotypic diversity of Rhinoviruses obtained from Tunisian children with severe acute respiratory infection by Sondes Haddad-Boubaker, Khaoula Mefteh, Chaima Mejri, Aida Bouaffsoun, Awatef El Moussi, Ilhem Boutiba, Khaled Mnif, Amin Slim, Amel Kechrid, Hanen Smaoui

“…This study describes epidemiological patterns and genotypic diversity of HRV in SARI cases during a two and half year’s study, in Northern Tunisia. …”
Get full text

Hemopexin regulates acute-phase inflammatory response against pathogenetic infections in black rockfish (Sebastes schlegelii) by Chengbin Gao, Peng Sun, Xin Cai, Mengyu Tian, Chao Li

“…The different expression patterns of SsHPX in microbial-challenged tissues and peripheral blood leukocytes (PBLs) were analyzed by RT-qPCR. …”
Get full text

Maternal air temperature exposure and risk of small vulnerable newborn: Identifying critical windows by Mingzhao Huang, Jian Fang, Yaqi Zhang, Luli Xu, Xiya Qin, Kai Chen, Zhiguo Xia, Jun Li, Lianting Hu, Xiaofeng Mu, Xiaoxuan Fan, Youjie Wang, Aifen Zhou, Chao Xiong

“…Conclusions: While the overall exposure-response relationship exhibits a U-shaped pattern throughout gestation, our findings reveal substantial heterogeneity in temperature sensitivity across developmental windows. …”
Get full text

Evaluation of a single-use bioartificial liver (BAL) biocartridge consisting of cryopreservable alginate encapsulated liver cell spheroids as a component of HepatiCan™, a novel bio... by Eloy Erro, Tom Brookshaw, Barry Fuller, Sweta Chandel, Joana Mendonca da Silva, Elizaveta Zotova, Sherri-Ann Chalmers, Alfie Watt, Clare Selden

“…Additionally, increasing the number of orifices in the cross-patterned base plate design (B3) provided further benefits: maintaining homogeneity in fluid velocity distribution, whilst avoiding “dead-flow” zones. …”
Get full text

Daily rhythm of rumination in the goat (Capra hircus) is not driven by feeding by Mohammed El Mehdi M’hani, Younes Beniaich, Hicham Farsi, Mohammed Piro, Mohamed Rachid Achaâban, Paul Pévet, Etienne Challet, Khalid El Allali

“…Abstract Rumination shows a nocturnal rhythmic pattern in day-active ruminants. Although feeding has been shown to quantitatively modulate rumination, it is not clear yet if feeding rhythm plays a causal role in rumination rhythm. …”
Get full text

Dynamic behaviour and energy dissipation of offline air pockets in transient pipe flows by Yun-Jie Li, Ling Zhou, Zhao Li, Tong-Chuan Che, Pedro Jose Lee, Yan-Qing Lu, Yin-Ying Hu

“…The results reveal that the stability of the air-water interface depends on the decelerating distance of the jet in offline tube, explaining the instability phenomenon with lower water levels observed in experimental snapshots. The internal energy pattern suggests different energy dissipation mechanisms compared to the inline air pockets. …”
Get full text

TLR7 deficiency enhances inflammation in the URT but reduces LRT immunity following influenza A infection by Mark A. Miles, Sahan Jayawardena, Stella Liong, Felicia Liong, Gemma S. Trollope, John J. O’Leary, Doug A. Brooks, Stavros Selemidis

“…This study investigated the role of toll-like receptor 7 (TLR7), a key pattern recognition receptor that senses viral RNA and triggers antiviral and proinflammatory signaling to activate immune responses, in specifically shaping URT and LRT immune responses to IAV infection. …”
Get full text

The Impact of Increasing Seawater Temperatures over the Last 30 Years on the Reproductive Cycle of the Pearl Oyster <i>Pinctada radiata</i> (Leach, 1814) in the Arabian Gulf by Razan Khalifa, Radhouane Ben Hamadou, Bruno Welter Giraldes, Sandra Joaquim, Zainab Hizam, Shafeeq Hamza, Anne Bassères, Jean-Charles Massabuau, Alexandra Leitão

“…From May 2020 to April 2022, we found a well-defined seasonal reproductive pattern, with a narrow peak spawning period in April. …”
Get full text

Numerical validation of a novel cuttings bed impeller for extended reach horizontal wells by Chi Peng, Yao Xiao, Jianhong Fu, Quan Cao, Jiyun Zhang, Yu Su, Honglin Zhang, Xing Wan, Danzhu Zheng

“…To reduce the risk of downhole accidents resulting from poor wellbore cleaning during the drilling of extended reach horizontal wells, a new cuttings bed impeller is developed. …”
Get full text

Molecular structure and enzymatic mechanism of the human collagen hydroxylysine galactosyltransferase GLT25D1/COLGALT1 by Matteo De Marco, Sristi Raj Rai, Luigi Scietti, Daiana Mattoteia, Stefano Liberi, Elisabetta Moroni, Alberta Pinnola, Alice Vetrano, Claudio Iacobucci, Carlo Santambrogio, Giorgio Colombo, Federico Forneris

“…Abstract During collagen biosynthesis, lysine residues undergo extensive post-translational modifications through the alternate action of two distinct metal ion-dependent enzyme families (i.e., LH/PLODs and GLT25D/COLGALT), ultimately producing the highly conserved α-(1,2)-glucosyl-β-(1,O)-galactosyl-5-hydroxylysine pattern. …”
Get full text

Spatiotemporal Characteristics and Influencing Factors of PM_2.5 Levels in Lianyungang: Insights from a Multidimensional Analysis by Xue Li, Haihong He, Dewei Wang, Wenli Qiao, Chunli Liu, Yiming Sun, Lulu Li, Shuting Han, Guozhen Zha

“…The key findings include a marked seasonal pattern, with higher PM_2.5 levels during the winter months and lower concentrations in the summer, primarily driven by temperature, humidity, and precipitation. …”
Get full text

Effectiveness of Breast Cancer Awareness Month (BCAM) Before and After the COVID-19 Pandemic: Google Trends Analysis by Majed Ramadan, Walaa Alshekhi, Doaa Aboalola, Siham Aouabdi, Haneen Alzahrani, Abrar Ashi, Rawiah Alsiary

“…The objectives of this study are to investigate the popular pattern in seeking screening information of breast cancer in Saudi Arabia using Google Trends. …”
Get full text

In Situ Expression of Regulatory Cytokines by Heart Inflammatory Cells in Chagas' Disease Patients with Heart Failure by Denise Bertulucci Rocha Rodrigues, Marlene Antonia dos Reis, Audrey Romano, Sanívia Aparecida de Lima Pereira, Vicente de Paula Antunes Teixeira, Sebastião Tostes Junior, Virmondes Rodrigues

“…Subjects with HF presented higher levels of STAT4 mRNA, whereas FoxP3 and STAT6 levels were similar in the two groups. A Th1 cytokine pattern predominated in the cardiac inflammatory cell infiltrate of Chagas’ disease patients associated with HF. …”
Get full text