Proximally based sural artery flap for the reconstruction of soft tissue defects around the knee and proximal third of the leg in India: a clinical study by Lakshmi Palukuri, Sreedharala Srinivas, Dharmapuri Madhulika, Sanujit Pawde, Ajo Sebastian, Swathi Sankar, Sandeep Reddy Chintha

“…This flap consistently provided a thin, pliable, stable, and durable soft tissue cover over the defect with no functional deficit and minimal donor site morbidity. …”
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mRNA-1273 COVID-19 vaccine induces CD4+ T-cell responses among solid organ transplant recipients by Bethany Girard, Amparo L. Figueroa, Stephen C. De Rosa, M. Juliana McElrath, Jamil R. Azzi, Dina Stolman, Uma Siangphoe, Elizabeth de Windt, Jacqueline M. Miller, Rituparna Das, Frances Priddy

“…BackgroundCell-mediated immunity may provide durable protection against severe COVID-19, including among solid organ transplant recipients (SOTRs). …”
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Desmocollin-3 and Bladder Cancer by Chandreshwar P. Shukla, Nayan K. Jain, Michael A. O’Donnell, Kapil V. Vachhani, Rashmi Patel, Janki Patel, Rajiv Modi, Arpit Dheeraj, Jee Min Lee, Annah Rolig, Sanjay V. Malhotra, Bakulesh Khamar

“…DSC3-protein-expressing recurrent non-muscle-invasive bladder cancer (NMIBC) had a durable response to CADI-03, a DSC3-specific active immunotherapy. …”
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One arrow two eagles: Multifunctional nano-system for macrophage reprogramming and osteoclastogenesis inhibition against inflammatory osteolysis by Tong Sha, Ze Wang, Jinwei Li, Yahong Wu, Jinbiao Qiang, Zhenming Yang, Yue Hu, Kaijuan Zheng, Shuyu Zhang, Haizhu Sun, Andrew K. Whittaker, Bai Yang, Hongchen Sun, Quan Lin, Ce Shi

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Discontinuation of immune checkpoint inhibitors for reasons other than disease progression and the impact on relapse and survival of advanced melanoma patients. A systematic review... by Konstantinos Lallas, Eftychia Chatziioannou, Derya Durak, Georg Frey, Lina Maria Serna-Higuita, Marie-Lena Rasch, Athanassios Kyrgidis, Eleni Timotheadou, Zoe Apalla, Ulrike Leiter, Lukas Flatz, Lukas Flatz, Aimilios Lallas, Teresa Amaral, Teresa Amaral

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Sustained response to guselkumab regardless of baseline characteristics in patients with active psoriatic arthritis and inadequate response to TNF inhibitors: results from the phas... by Iain B McInnes, Laura C Coates, Philipp Sewerin, Frédéric Lavie, Mohamed Sharaf, Miriam Zimmermann, Michela Efficace

“…Response rates increased or were durable through week 48 within most subgroups.…”
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Biologically targeted dual adaptive and innate nano-Immunotherapy for clear cell renal cell carcinoma treatment by Kin Man Au, Siqing Li, Tian Zhang, Andrew Z. Wang

“…Despite recent advancements, the rates of durable response to immunotherapy remain low, and the toxicity profiles of treatment continue to be high. …”
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IMMUNE MECHANISMS FOR DEVELOPMENT OF CONTROLLED AND PARTIALLY CONTROLLED ASTHMA by T. I. Vitkina, T. P. Novgorodtseva, E. P. Kalinina, E. G. Lobanova, M. V. Antonyuk

“…The aim of present study was to analyze functional activity of Th1, Th2 и Th17 lymphocytes, and to determine features of inflammation in controlled and partly controlled asthma.We examined eighty-four BA patients that were divided into 2 groups, depending on the control of symptoms and the clinical course of BA. …”
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Revision quadriceps tendon repair: A case series and technique guide to a novel repair by Ellen Lutnick, Sophia Puertas, Mark Anders

“…In this four-case series, novel quadriceps tendon revision resulted in improved range of motion and durable repair for patients with recurrent rupture. …”
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Green synthesis of zinc oxide nanoparticles: A trifecta of antioxidant, antifungal, and catalytic excellence by Abraham Y. Danas, Ayomide H. Labulo, Abdullahi Usman, Ibrahim Hassan, Augustine D. Terna, Festus O. Ogungbemiro, David A. Oyinade, Ambo A. Idzi, Mojisola Owoseni, Maryam Isah, Rukayat A. Ashonibare, Kehinde A. Ojedola, Hafsat O. Dahiru, Zikhona Tywabi-Ngeva, Muhammad A. Said, Caroline A. Muaka

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The probiotic Bacillus subtilis BS50 decreases gastrointestinal symptoms in healthy adults: a randomized, double-blind, placebo-controlled trial by Sean M. Garvey, Eunice Mah, Traci M. Blonquist, Valerie N. Kaden, Jessica L. Spears

“…Durable spore-forming probiotics are increasingly formulated into foods, beverages, and dietary supplements. …”
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Machine learning–guided single-cell multiomics uncovers GDF15-driven immunosuppressive niches in NSCLC: A translational framework for overcoming anti-PD-1 resistance by Xianfei Zhang, Zhengxin Yin, Xueyu Chen, Nengchong Zhang, Shengjia Yu, Congcong Zhu, Lianggang Zhu, Liulan Shao, Bin Li, Runsen Jin, Hecheng Li

“…Immune checkpoint blockade (ICB) has transformed non-small cell lung cancer (NSCLC) treatment, but durable clinical responses remain limited, underscoring the need for robust predictive biomarkers. …”
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Cell-specific nanoengineering strategy to disrupt tolerogenic signaling from myeloid-derived suppressor cells and invigorate antitumor immunity in pancreatic cancer by Nilesh U. Deshpande, Anna Bianchi, Haleh Amirian, Iago De Castro Silva, Christine I. Rafie, Bapurao Surnar, Karthik Rajkumar, Akash Ashokan, Ifeanyichukwu C. Ogobuiro, Manan Patel, Erietta Stelekati, Shanta Dhar, Jashodeep Datta

“…Abstract Pancreatic ductal adenocarcinoma (PDAC) is characterized by intratumoral abundance of neutrophilic/polymorphonuclear myeloid-derived suppressor cells (PMN-MDSC) which exert anti-T-cell functions through multiple mechanisms, especially JAK2/STAT3-regulated arginase activity. …”
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International perspective on social cognition in schizophrenia: current stage and the next steps by Silvia Corbera, Matthew M. Kurtz, Amélie M. Achim, Giulia Agostoni, Isabelle Amado, Michal Assaf, Stefano Barlati, Margherita Bechi, Roberto Cavallaro, Satoru Ikezawa, Hiroki Okano, Ryo Okubo, Rafael Penadés, Takashi Uchino, Antonio Vita, Yuji Yamada, Morris D Bell

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A Sociological Study of Monetary Attitudes among Citizens of Tehran by Nahid Abdoli, Asadollah Babaiefard

“…Currently, the cultural and social functions of money—understood as a "fait social total"—are undergoing significant changes. …”
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Defects in the necroptosis machinery are a cancer resistance mechanism to checkpoint inhibitor immunotherapy by Katja Steiger, Peter May, Florian Bassermann, Anna Sax, Stefan Enssle, Nardine Soliman, Tatiana Nedelko, Giada Mandracci, Fabian Stögbauer, Laura Joachim, Christof Winter, Nadia El Khawanky, Hendrik Poeck, Simon Heidegger

“…However, it is unclear to which extent functional necroptosis in tumor cells contributes to ICI immunotherapy.Methods With genetically engineered tumor cell lines that lack specific components of the necroptosis machinery (mixed lineage kinase domain-like pseudokinase (MLKL), receptor interacting protein kinase 3 (RIPK3)), we addressed the importance of necroptotic tumor cell death for the efficacy of ICI immunotherapy in murine models. …”
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Multiplexed immune profiling and 3D co-culture assays to assess the individual checkpoint therapy response in head and neck squamous cell carcinoma by Verena Schweihofer, Verena Schweihofer, Daniela Schulz, Daniela Schulz, Raquel Blazquez, Gero Brockhoff, Gero Brockhoff, Tobias Ettl, Tobias Ettl, Mathias Fiedler, Mathias Fiedler, Sina Heimer, Sina Heimer, Juliane Schikora, Richard J. Bauer, Richard J. Bauer, Anja Kathrin Wege, Anja Kathrin Wege

“…Individual changes in soluble factor release (e.g., Gal-9, sPD-L1, sCD25, and sTIM-3) was noticeable upon co-culture under immune checkpoint therapy.ConclusionsThis study provides proof-of-principle data suggesting that a combined multiplexed marker profiling and a functional 3D co-culture assay may help to explore predictive ICI response for HNSCC patients in the future. …”
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Radiomic features of PET/CT imaging of large B cell lymphoma lesions predicts CAR T cell therapy efficacy by Yoganand Balagurunathan, Zhouping Wei, Jin Qi, Zachary Thompson, Erin Dean, Erin Dean, Hong Lu, Hong Lu, Saran Vardhanabhuti, Salvatore Corallo, Jung W. Choi, Jenny J. Kim, Mike Mattie, Michael Jain, Frederick L. Locke

“…Principal component (PC) analysis was performed to reduce the dimensionality in feature-based functional categories: size (n=38), shape (n=9), and texture (n=259). …”
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Knee-Sparing Resection and Reconstruction Surgery for Bone Sarcoma Using 3D-Surgical Approach: Average of 5-Year Follow-Up by Amit Benady, Noy Yehiel, Ortal Segal, Omri Merose, Amir Sterenheim, Osnat Sher, Ben Efrima, Eran Golden, Yair Gortzak, Solomon Dadia

“…As personalized healthcare and additive manufacturing continue to advance, the future of orthopedic oncology will likely see more precise, durable, and biologically integrated implants, further improving patient outcomes.…”
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Midterm Outcomes of Transfibular Total Ankle Arthroplasty: Clinical and Radiographic Analysis of 130 Cases with Minimum 5-Year Follow-Up by Jonathan Day MD, Amanda N. Fletcher MD, MSc, Morgan Motsay BS, Maggie K. Manchester BS, Mark Arthur MD, Zijun Zhang PhD, MD, Lew C. Schon MD

“…PROMs included: 12-item Short Form Health Survey (SF-12) physical (PCS) and mental (MCS) component scores, Ankle Osteoarthritis Scale (OAS), and Visual Analog Scale (VAS). Functional outcomes included range of motion (ROM) measured on weightbearing ROM radiographs. …”
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