A trispecific antibody targeting EGFR/cMET/VEGF-A demonstrates multiple mechanisms of action to inhibit wild-type and mutant NSCLC animal models by Ying Jin, Ping Sun, Peng Chen, Yuqiang Xu, Guangmao Mu, Zhengxia Zha, Simin Wu, Meixia Fu, Hao Jiang, Sheng Huang, Fulai Zhou, Chao Han, Chao Han, Mark L. Chiu, Mark L. Chiu

“…In addition, TAVO412 had both EGFR/ cMET receptor degradation and enhanced Fc effector functions for tumor cell cytotoxicity. Moreover, TAVO412 in combination with osimertinib, lazertinib, docetaxel, and radiotherapy, resulted in complete and durable regression of NSCLC xenograft tumors.DiscussionThese findings highlight TAVO412 as a promising therapeutic agent with multiple mechanisms of action and strong potential for synergistic combinations in NSCLC treatment.…”
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Structural basis of a human antibody targeting SARS-CoV-2 nucleocapsid protein dimerization domain and interfering with RNA-binding by Shaojie Xue, Suhua He, Zhaoxia Huang, Mei Yang, Guowei Hu, Xiaoxue Chen, Qiuyue Chen, Wenying Zhou, Sixiao Lin, Shoudeng Chen

“…The structure reveals that nCoV400Fab engages multiple basic residues on the RNA-binding surface, forming a steric blockade that hinders vRNA binding. Functional assays demonstrate that nCoV400Fab disrupts both viral ribonucleoprotein (vRNP) assembly and RNA-induced condensate formation. …”
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<i>Festuca ovina</i> L. As a Monitor Plant Species of Traffic Air Along the Highway in of the City of Warsaw (Poland) by Agata Jędrzejuk, Filip Chyliński, Beata Fornal-Pieniak

“…In the urban environment dust particles form a major part of air pollutants and can affect the physiological functions of the plant. Plants proved to be very powerful tools in as-sessing environmental pollution because of their wide distribution. …”
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Manipulating electronic band of NiO/NiMoO4–x nanosheets as robust bifunctional catalyst for water splitting by Qiyu Liu, Jintao Zhang, Jinjun He, Peng Zhang, Zujin Yang, Xihong Lu

“…This work affords valuable insights into the development of durable and inexpensive bifunctional catalysts for electrocatalytic water splitting.…”
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Exploring Tension Fabric Structure and Material- A Review of The Bigo Arena and Denver International Airport by Merve Sumeyye Taha, Abdulmajeed Mamhusseini Asmaa, Shino Abdullah

“…The fact that tension fabric structures are light and durable, as well as visually pleasing, has become a reason for preference, especially in contemporary architecture. …”
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Regeneration of Insulin-Producing β Cells, Reduction in Inflammation and Oxidation Stress, and Improvement in Lipid Profile in a Type 1 Diabetes Rat Model by Intraperitoneal Inject... by Jassim M. Al-Hassan, Waleed M. Renno, Sosamma Oommen, Divya Nair, Bincy Maniyalil Paul, Bincy Mathew, Jijin Kumar, Afna Ummerkutty, Cecil Pace-Asciak

“…Type 1 diabetes (T1D) results from the autoimmune destruction of insulin-producing β-cells. The regeneration of durable insulin-producing β-cells remains a critical challenge. …”
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Recent Technological Advancements for Identifying and Exploiting Novel Sources of Pest and Disease Resistance for Peanut Improvement by Akshaya Kumar Biswal, Peggy Ozias-Akins, Carl Corley Holbrook

“…However, peanut lags behind other cereal crops in terms of phenomics and precision genetic techniques for their functional validation. In conclusion, recent technological advancements have significantly improved the efficiency and precision of peanut breeding for pest and disease resistance and hold great promise for developing durable and sustainable resistance in peanut cultivars, ultimately benefiting peanut farmers and consumers globally.…”
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An anisotropic strategy for developing polymer electrolytes endowing lithium metal batteries with electrochemo-mechanically stable interface by Jingren Gou, Kaixuan Cui, Suqing Wang, Zheng Zhang, Jiale Huang, Haihui Wang

“…Correspondingly, the Li | |LiFePO4 cells steadily operate over 1000 cycles, delivering durable capacity retention of 91% at 170 mA g-1. Furthermore, numerical modeling and density functional theory are combined to clarify the multiphysics interplay between the designed solid polymer electrolyte and lithium negative electrode. …”
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Catheter Injectable Multifunctional Biomaterial for the Treatment of Infected Enterocutaneous Fistulas by Jinjoo Kim, Zefu Zhang, Hassan Albadawi, Hyeongseop Keum, Joseph L. Mayer, Erin H. Graf, Rahmi Oklu

“…Here, 18NC75‐10P‐1IL is reported, which is a multi‐functional shear‐thinning hydrogel comprised of gelatin and nanosilicates for injectability, an ionic liquid for bactericidal effects, and platelet rich fibrin fraction for pro‐healing properties; this biomaterial is engineered for the treatment of ECFs. …”
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Shock Thermal Resistance of Parachute Fabrics by Jiří Militký, Jakub Wiener, Dana Křemenáková, Mohanapriya Venkataraman

“…The use of polyester and polyamide fabrics for parachute constructions has a great advantage because, in comparison with classical silk-based parachutes, they are more durable and suitable for absorbing higher mechanical shocks. …”
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Enhancing irradiation tolerance and inducing superlubricity in MoS2/W multilayer film exposed to atomic oxygen by Xin Fan, Wenhao He, Zhenao Zhang, Bo He, Yanwen Lin, Qinsheng He, Liang-Feng Huang, Siming Ren, Zhibin Lu, Jibin Pu, Qunji Xue

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Solvent free UV curable waterborne polyurethane acrylate coatings with enhanced hydrophobicity induced by a semi interpenetrating polymer network by Ali Reza Banan

“…Abstract This study presents the synthesis and characterization of solvent-free, UV-curable waterborne polyurethane-acrylate (WPUA) coatings using a semi-interpenetrating polymer network (sIPN) technique, aiming to develop durable, high-performance eco-friendly coatings. The WPUA formulations consisted of a urethane backbone created from polytetrahydrofuran (PTHF) and isophorone diisocyanate (IPDI), combined with urethane dimethacrylate (UDMA) to introduce acrylate functionality. …”
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Wastewater Treatment Using a Combination of <i>Pumpkin seed</i> Waste After Extraction of Essential Oils (Bio-Coagulant) and Ferric Chloride (Chemical Coagulant): Optimization and... by Abderrezzaq Benalia, Ouiem Baatache, Katr Enada Zerguine, Amel Khediri, Kerroum Derbal, Nawal Ferroudj, Amel Khalfaoui, Antonio Pizzi

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The Application of Single-Cell Technologies for Vaccine Development Against Viral Infections by Hong Nhi Nguyen, Isabel O. Vanderzee, Fei Wen

“…Despite these innovations, a persistent challenge remains: the inherent complexity and heterogeneity of immune responses continue to impede efforts to achieve consistently effective and durable protection across diverse populations. Single-cell technologies have emerged as transformative tools for dissecting this immune heterogeneity, providing comprehensive and granular insights into cellular phenotypes, functional states, and dynamic host–pathogen interactions. …”
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Exploring nanofillers: Enhancing properties in biopolymer food packaging materials—A comprehensive review by Venkteshwar Yadav, Dharm Pal, Anil Kumar Poonia

“…Additionally, the advantages and limitations associated with nanofiller incorporation are critically evaluated. With their unique functional properties, nanofillers hold great potential to replace conventional plastics, promote sustainable packaging solutions, and contribute to environmental remediation efforts. …”
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Pelvic injury and acute respiratory distress syndrome in the patients, suffering severe combined trauma by F. I. Ibrahimov

“…Before the surgical intervention in the patients, suffering decompensated form of ARDS, on the first order a durable (minimally 24 h) correction of vital functions and the main parameters of homeostasis is needed, аs well as the conduction of measures, aimed on the patient’s savage and survival.…”
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Virological efficacy in cerebrospinal fluid and neurocognitive status in patients with long-term monotherapy based on lopinavir/ritonavir: an exploratory study. by José R Santos, José A Muñoz-Moreno, José Moltó, Anna Prats, Adrià Curran, Pere Domingo, Josep M Llibre, Daniel R McClernon, Isabel Bravo, Jaume Canet, Victoria Watson, David Back, Bonaventura Clotet

“…Findings for HIV-1 replication in CSF and neurocognitive status indicate that this strategy seems to be safe for CNS functioning.…”
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IL-12 mRNA-LNP promotes dermal resident memory CD4+ T cell development by Anabel Zabala-Peñafiel, Claudia Gonzalez-Lombana, Mohamad-Gabriel Alameh, Lais A. Sacramento, Zhirong Mou, Anthony T. Phan, Emily A. Aunins, Ying K. Tam, Jude E. Uzonna, Drew Weissman, Christopher A. Hunter, Phillip Scott

“…Additionally, higher numbers of dTrm cells were maintained in the skin, and mice exhibited functional immunity indicated by a delayed hypersensitivity response and protection upon challenge with Leishmania. …”
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Development of a Multitype Wireless Sensor Network for the Large-Scale Structure of the National Stadium in China by Yanbin Shen, Pengcheng Yang, Pengfei Zhang, Yaozhi Luo, Yujia Mei, Huaqiang Cheng, Li Jin, Chenyu Liang, Qiaqin Wang, Zhouneng Zhong

“…The monitoring module design consists of four functions: sensing, processing, wireless communication, and energy management. …”
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Advancing CAR-based cell therapies for solid tumours: challenges, therapeutic strategies, and perspectives by Sarkar Sardar Azeez, Raya Kh. Yashooa, Shukur Wasman Smail, Abbas Salihi, Azhin Saber Ali, Sami Mamand, Christer Janson

“…By integrating novel cellular platforms and combination approaches, we seek to provide insights into optimising CAR-cell therapies for durable responses in solid malignancies.…”
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