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861
Insights into the diversity and conservation of the chB6 alloantigen
Published 2025-02-01“…The bursa of Fabricius has been a durable model of B lymphocyte development. Yet there are unique aspects of B- lymphocyte development in the bursa that remain to be elucidated, and these may reveal important functional differences in the avian system and distinct evolutionary mechanisms from the canonical murine and human models of B- lymphocyte development. …”
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862
Percutaneous mechanical circulatory support for acute right heart failure: A practical approach
Published 2025-08-01“…The manuscript highlights contemporary weaning strategies, emphasizing recovery of right ventricular function, stabilization of systemic haemodynamics, and restoration of end‐organ perfusion. …”
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863
Chimeric Antigen Receptor-Modified Immune Cells for Eradication of HIV Reservoirs
Published 2022-10-01“…The important research goals of creating CARs to modify natural killer (NK) and T cells are an attempt to enhance the functional effects of immune cells and restore the function of the immune system. …”
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864
Engineering extracellular matrix-based hydrogels for intervertebral disc regeneration
Published 2025-05-01“…In recent years, regenerative therapies have garnered attention for their potential to restore disc function by addressing the underlying biological alterations within the IVD. …”
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865
Implementing hydrogen oxidation reaction on Pt for controlling counter electrode processes
Published 2025-06-01“…The search for active, stable, and durable materials for electrochemical energy technologies requires increasing levels of precision to establish true structure-function relationships and guide materials design from atomic and molecular scale. …”
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866
Urinary bacteriophage cooperation with bacterial pathogens during human urinary tract infections supports lysogenic phage therapy
Published 2025-02-01“…Using human urine, model organisms, mass spectrometry, gene expression analysis, and the phage phenotype prediction model BACPHLIP, the results corroborated our hypotheses at the functional protein and gene levels. From a human health perspective, these data suggest that temperate phages may facilitate bacterial infections rather than function as protective agents. …”
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867
Plasma membrane-coated nanoparticles and membrane vesicles to orchestrate multimodal antitumor immunity
Published 2025-01-01“…Here, we hypothesized that the simultaneous input of more comprehensive signals would elicit more robust and durable effector T-cell functions.Methods We genetically engineered the leukemia cell line K562 to express BsAbs, costimulatory ligands, cytokines, and blocking antibodies against immune checkpoint molecules on the cell surface, from which we obtained plasma membrane fractions by mechanical homogenization and subsequent isolation steps. …”
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868
Memory T Cells, Recombinant Listeria monocytogenes, and Cancer Vaccines
Published 2025-07-01“…Memory T cells are essential for effective and durable immune responses, as they provide long-term immunological surveillance and rapid reactivity upon re-exposure to a given pathogen or cancer cell. …”
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869
Availability Optimization of Two-dimensional Warranty Products Under Imperfect Preventive Maintenance
Published 2021-01-01“…For complex and durable products such as automobiles and construction machinery, the quality and reliability characteristics of these products become more and more complex. …”
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870
Indirect restorations with digital workflow in hypomineralized permanent molars: A series of pediatric cases
Published 2024-12-01“…The results demonstrated excellent marginal adaptation, high fracture resistance, improved aesthetics, reduced dental sensitivity, enhanced chewing function, and better oral hygiene maintenance over a follow-up period of 6 to 24 months. …”
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871
Gene Silencing Therapies for Huntington’s Disease
Published 2025-05-01“…Mutant huntingtin (mHTT) imposes a toxic gain‑of‑function that progressively compromises neuronal circuitry, culminating in the distinctive triad of motor, cognitive and psychiatric symptoms. …”
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872
P31 | MORPHOLOGICAL AND ULTRASTRUCTURAL MARKERS OF RADIATION-INDUCED ADIPOSE TISSUE DAMAGE
Published 2025-08-01“…Our observations indicate that RT induces durable and extensive morpho-functional damage to the adipose organ, with a possible involvement in MS onset. …”
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873
The Comprehensive overview of the recent advancements in self-healing asphalt utilizing nano-technology
Published 2025-01-01“…The review also addressed the function of encapsulated healing agents that are distributed throughout the asphalt binder, such as rejuvenators and rejuvenating microcapsules. …”
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874
Simultaneous TGF-β and GITR pathway modulation promotes anti-tumor immunity in glioma
Published 2025-06-01“…Surviving mice resisted tumor re-challenge, indicating durable adaptive immunity. In summary, dual targeting of TGF-β and GITR pathways synergistically enhances anti-tumor immunity in glioblastoma. …”
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875
Utility of First Dorsal Metacarpal Artery Flap for Thumb Defects
Published 2022-12-01“…Background Reconstruction of thumb tip, while providing a durable and sensate flap, is a challenging task. It is important as thumb accounts for 50% of hand functions. …”
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876
A COMBINATION OF CHEEK FLAP, CARTILAGE INSERTION, AND FAT TRANSFER ON POST-TRAUMA LOWER EYELID ECTROPION RECONSTRUCTION
Published 2024-12-01“… • This method effectively addresses the challenges of cicatricial ectropion caused by injuries or burns, leading to improved, durable, and cost-effective outcomes in restoring eyelid function and volume. …”
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877
Nitrous oxide activates layer 5 prefrontal neurons via SK2 channel inhibition for antidepressant effect
Published 2025-04-01“…Abstract Nitrous oxide (N2O) induces rapid and durable antidepressant effects. The cellular and circuit mechanisms mediating this process are not known. …”
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878
Étude de trois grands tonneaux mis au jour à Reims/Durocortorum (Marne) : le savoir-faire des tonneliers antiques
Published 2020-12-01“…It contained a series of adjoining furnaces, but the function of this imposing complex, which was destroyed at the end of the 4th c. …”
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879
Tailored manganese oxide and nickel sulfide composites with MWCNTs as platinum-free electrodes for solar energy conversion
Published 2025-08-01“…The MnO and NiS components form mixed phase structures, MnO/Mn₃O₄ and NiS/Ni₃S₄, respectively, while multiwalled carbon nanotubes (MWCNTs) function as a conductive scaffold to enhance charge transport. …”
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880
The Nexus between International Humanitarian Law and Peacebuilding in Africa: A Comprehensive Assessment of Preventive Mechanisms
Published 2025-07-01“…The article highlights the urgency of preventing and mitigating these conflicts, thereby seeking to clarify how international humanitarian law and peacebuilding can function as complementary pillars in the pursuit of sustainable peace and security. …”
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