Epstein-Barr Virus-associated Gastric Carcinoma by Bong Eun Lee

“…EBVaGC has characteristic genetic profiles that harbor a DNA methylation phenotype, frequent mutations in PIK3CA and ARID1A, and amplification of JAK2 and programmed death-ligand (PD-L)1/PD-L2. …”
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Accelerating the speed of innovative anti-tumor drugs to first-in-human trials incorporating key de-risk strategies by Yuqi Wang, Quan Quan, Camille Gleason, Helin Yu, Lujia Peng, Yanshen Kang, Ling Jiang, Kailun Wu, Jie Pan, Moxiyele Bao, Qing Zhu, Meiqi Yi, Ming Fang, Yue Zheng, Ling Qiu, Bin Xu, Xiang Li, Jinfeng Song, Jiamu Sun, Zheng Zhang, Zijun Su, Jara Lin, Yuanyuan Xie, April Xu, Xiling Song, Chichi Huang, Zhirong Shen, Lai Wang, Jing Song

“…This accomplishment can be a blueprint for non-COVID drug programs that approach the pace of drug development during the pandemic, with no adverse impact on the safety, quality, and late-stage development of biologics.…”
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Identification of parthanatos-related molecular subtypes and development of prognostic risk models in ovarian cancer based on multi-omics analysis by Xiaoying Qi, Changqing Jiang, Ning Wang, Yi Han, Tingting Liu, Liying Huang, Guangjie Yin

“…Parthanatos, a distinct caspase-independent form of programmed cell death mediated by poly (ADP-ribose) (PAR), plays a critical role in DNA damage response and tumor progression. …”
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Diversity of Sweet Basil Accessions from Croatian National Plant Gene Bank Based on Amplified Fragment Length Polymorphism Markers by Filip Varga, Monika Vidak, Zlatko Liber, Klaudija Carović-Stanko, Zlatko Šatović

“…These findings underscore the genetic potential within sweet basil accessions, offering valuable insights for future breeding programs aimed at selecting basil cultivars with tailored biochemical and morphological traits suited for pharmaceutical, culinary, and ornamental applications. …”
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Design of orthogonal genetic switches based on a crosstalk map of σs, anti‐σs, and promoters by Virgil A Rhodius, Thomas H Segall‐Shapiro, Brian D Sharon, Amar Ghodasara, Ekaterina Orlova, Hannah Tabakh, David H Burkhardt, Kevin Clancy, Todd C Peterson, Carol A Gross, Christopher A Voigt

“…DNA synthesis was used to build 86 ECF σs (two from every subgroup), their promoters, and 62 anti‐σs identified from the genomes of diverse bacteria. …”
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Development of real-time PCR methods for quality control detection of pathogenic bacteria in cosmetic preparations by Veronica Bolzon, Michela Bulfoni, Alessandro Nencioni, Emanuele Nencioni

“…The study highlights the necessity of standardized rt-PCR protocols aligned with international ISO guidelines to enhance its applicability in routine quality control programs. In conclusion, rt-PCR represents a significant advancement in microbial safety for food and cosmetics, offering a rapid, sensitive, and reliable alternative to conventional methods. …”
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Leveraging liquid biopsy to uncover resistance mechanisms and guide personalized immunotherapy by Zeinab Dalloul, Jana Grenel Briend, Mariama Diawara, Catherine Taylor, Rodney J. Ouellette

“…These agents restore the immune system capacity to fight cancer through blocking the action of major immune checkpoint proteins that suppress immune responses such as programmed cell death protein 1 (PD-1), programmed death-ligand 1 (PD-L1) and cytotoxic T-lymphocyte-associated protein 4 (CTLA-4), which tumors exploit for immune escape. …”
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Cervical cancer demystified: exploring epidemiology, risk factors, screening, treatment modalities, preventive measures, and the role of artificial intelligence by N. Mohammad, M. Khan, M. Maqsood, A. H. K. Naseeb

“…Additionally, HPV vaccination programs have significantly decreased the prevalence of high-risk HPV infections, contributing to a decline in cervical cancer cases. …”
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Gene regulatory network resource aids in predicting trans-acting regulators of biosynthetic gene clusters in Aspergillus fumigatus by Hye-won Seo, Jin Woo Bok, Nancy P. Keller

“…Uncovering novel regulators without any prior information is challenging. Computational programs have gained prominence in the field of secondary metabolite research due to their accuracy and ability to handle vast amounts of data, including DNA, RNA, and protein data. …”
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Synergistic optimization enhancing the precision and efficiency of cytosine base editors in poplar by Han Liu, Mengyu Zhang, Leiqian Sun, Yu Peng, Yu Sun, Yawei Fan, Hui Li, Di Liu, Hai Lu

“…Abstract CRISPR/Cas9 genome editing technology, particularly cytosine base editing (CBE) systems, emerges as a powerful tool for precise genomic modification in plants, offering transformative applications across agricultural and forestry research and breeding programs. …”
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Evaluation of ebony as a potential selectable marker for genetic sexing in Aedes aegypti by Katerina Nikolouli, Austin Compton, Zhijian Jake Tu, Kostas Bourtzis

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Consistent trends from different methods for monitoring SARS-CoV-2 in urban wastewater during a 29-month longitudinal study by Janine McCalder, Janine McCalder, Jangwoo Lee, Jangwoo Lee, Judy Qiu, Qiaozhi Li, Linnet Immaraj, Nicole Acosta, María A. Bautista, Melissa Wilson, Barbara Waddell, Kristine Du, Aito Ueno, Rhonda Clark, Rhonda Clark, Alexander Krusina, Danielle A. Southern, Tyler Williamson, Tyler Williamson, Chloe Papparis, Paul Montesclaros, Lance Non, September Stefani, Gail Visser, Puja Pradhan, Norma Ruecker, John Conly, John Conly, John Conly, John Conly, John Conly, John Conly, Steve Hrudey, Kevin Frankowski, Bonita Lee, Bonita Lee, Michael D. Parkins, Michael D. Parkins, Michael D. Parkins, Xiaoli Pang, Xiaoli Pang, Casey R. J. Hubert

“…As this emerging technology is used more routinely, investigators should prioritize consistent application of a given workflow to a high-quality standard over time, whereas focusing on all testing programs adopting identical workflows and methods may be unnecessary.…”
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Locoregional Hyperthermia in Cancer Treatment: A Narrative Review with Updates and Perspectives by Giammaria Fiorentini, Donatella Sarti, Andrea Mambrini, Gianmaria Mattioli, Massimo Bonucci, Laura Ginocchi, Giuseppe Cristina, Girolamo Ranieri, Salvatore Bonanno, Carlo Milandri, Roberto Nani, Patrizia Dentico, Grazia Lazzari, Antonella Ciabattoni, Caterina Fiorentini

“…The applicability of RHT in the treatment and supportive care of tumors has been discussed for years in many publications. …”
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Comprehensive Analysis of the Complete Mitochondrial Genome of <i>Paeonia ludlowii</i> Reveals a Dual-Circular Structure and Extensive Inter-Organellar Gene Transfer by Zhefei Zeng, Zhengyan Zhang, Ngawang Norbu, Ngawang Bonjor, Xin Tan, Shutong Zhang, Norzin Tso, Junwei Wang, La Qiong

“…However, its mitochondrial genome remains understudied, limiting insights into its evolutionary mechanisms and constraining conservation genetics applications and molecular breeding programs. We present the first complete assembly and comprehensive analysis of the <i>P. ludlowii</i> mitochondrial genome. …”
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Pharmaceutical properties of novel 3-((diisopropylamino)methyl)-5-(4-((4-(dimethylamino) benzylidene) imino) phenyl)-1,3,4-oxadiazole-2(3 H)-thione by Khalida F. Al-azawi, Butheina A. Hasoon, Raid A. Ismail, Khetam H. Rasool, Majid S. Jabir, Suaad S. Shaker, Kareem H. Jawad, Ahmed Mutanabbi Abdula, Suresh Ghotekar, Ayman A. Swelum

“…The findings suggest that the novel chemical compound possesses potent antibacterial properties and exhibits significant anticancer activity by interacting with DNA and inducing apoptosis in cancer cells. These results highlight the potential clinical applications of the compound in treating infections and cancer. …”
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The impact of GBSSI inactivation on starch structure and functionality in EMS-induced mutant lines of wheat by Sujon Kumar, Yulong Li, Jia Zheng, Jing Liu, Qiang Xu, Yazhou Zhang, Huaping Tang, Pengfei Qi, Mei Deng, Jian Ma, Guoyue Chen, Yuming Wei, Youliang Zheng, Qiantao Jiang

“…These findings suggest that the Wx-abd line represents a valuable genetic resource for wheat breeding programs focused on improving starch quality for food production, with its high agronomic performance making it suitable for further breeding applications.…”
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Evidencias empíricas de regularidades estadísticas y leyes de potencia en los genomas de Arabidopsis thaliana, Oriza sativa y Mus musculus Empirical evidences of statistical regula... by Martha I Almanza P., Karina López-López, Pedro A Moreno, Carlos E Téllez T.

“…The study points out that the power laws have a buffer roll in the biological variation laws and provide DNA sequences organization quantitative measurements which are defining the identity of the genome. …”
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