Molecular characterization of colorectal cancer (CRC) using next generation sequencing (NGS) in bridging the gap between research and clinical practice: from biomarker discovery to... by Hafeez Abiola Afolabi, Salzihan Md Salleh, Zaidi Zakaria, Ch’ng Ewe Seng, Siti Norasikin Mohd Nafi, Ahmad Aizat Bin Abdul Aziz, Wan Mohd Nazri Wan Zainon, Ahmad Adebayo Irekola, Yusuf Wada, Sameer Badri Al-Mhanna, Rashidat Folashade Elesho

“…Using Illumina BaseSpace and Illumina Variant interpreter, generated FastQ data were treated for annotation, alignment, and mapping with reference genome. …”
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Effectiveness of a tailored forest package of interventions, including topical repellents, in reducing malaria incidence in Myanmar by Kyawt Mon Win, John E. Gimnig, Nay Yi Yi Linn, Feliciano Monti, Nu Nu Khin, William A. Hawley, Jimee Hwang, Ryan E. Wiegand, Ersin Topcuoglu, Alexander Moran, Khin Lin, Hsu Thadar, Aye Aye Myint, Kyaw Myint Tun

“…While there is evidence that networks of community-based malaria workers and insecticide-treated nets (ITNs) can reduce malaria transmission in a variety of settings, evidence for the effectiveness of other interventions, such as topical repellents, is limited. …”
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A short-term clinical evaluation of immediate implant placement in periodontitis patients by Guojiang Li, Guojiang Li, Xufeng Chen, Xufeng Chen, Yujia Feng, Ying Lu, Wanlin Liao, Rui Huang, Ejiao Yang, Renfa Lai, Renfa Lai, Zhiqiang Feng, Zhiqiang Feng

“…Preoperative assessments showed a significant increase in P-PDD, CAL, and MBL with greater disease severity (p < 0.001). One-year follow-up data indicated an implant survival rate of 97.86%, with Kaplan-Meier survival analysis revealing significantly lower survival rates in Stage IV and Grade C patients (p < 0.05). …”
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Clinical and survival differences between second primary and first primary nasopharyngeal carcinoma in a retrospective study by Xin Huang, Ying Kong, Tianyu Wu, Zhen Meng, Min Kang

“…Materials and methods We retrospectively analyzed data from patients with multiple primary cancers involving NPC between 2012 and 2023. …”
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APPLICATION OF INTEGRAL EVALUATION SCALES IN PATIENTS WITH WIDESPREAD PURULENT PERITONITIS by Ярослав Миронович Лещишин, Андрей Игоревич Баранов, Константин Владимирович Потехин, Сергей Александрович Ярощук, Юрий Викторович Валуйских

“…We studied the medical records of patients who were treated with the diagnosis: common purulent peritonitis in the period from 2013 to 2018. …”
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Distinctive chromosomal, mutational and transcriptional profiling in colon versus rectal cancers by Maria Teresa De Angelis, Antonia Rizzuto, Angela Amaddeo, Carlo Sagnelli, Niccolò Vono, Michela Reda, Valentina Lise, Luca Parrillo, Carmela De Marco, Donatella Malanga, Gianluca Santamaria, Giuseppe Viglietto

“…Abstract Background Colorectal cancer (CRC) encompasses tumors arising in the colon (CC) and rectum (RC), often treated as a single disease despite emerging evidence of biological divergence. …”
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Analysis of the risk of oncological adverse events associated with infliximab in combination with azathioprine compared to monotherapy: insights from the FAERS database by Qian Qiao, Qian Qiao, Qian Qiao, Jiachen Sun, Jiachen Sun, Jiachen Sun, Ya Zheng, Ya Zheng, Yingying Mi, Yingying Mi, Yingying Mi, Yanan Gong, Yanan Gong, Jiahui Liu, Jiahui Liu, Jiahui Liu, Wenyue Rui, Wenyue Rui, Wenyue Rui, Yumei Ma, Yumei Ma, Yumei Ma, Yongning Zhou, Yongning Zhou, Min Liu, Min Liu

“…ObjectiveThis study aimed to evaluate the risk of tumor formation with infliximab or azathioprine monotherapy versus their combination, using the FDA Adverse Event Reporting System (FAERS) database.MethodsData were extracted from the FAERS database for patients treated with infliximab, azathioprine, and combination therapy from Q1 2004 to Q2 2024. …”
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Effects of Simplified Antihypertensive Treatment Algorithm on Hypertension Management and Hypertension-Related Death in Resource-Constricted Primary Care Setting between 1997 and 2... by Mulalibieke Heizhati, Nanfang Li, Qiaoyan Shi, Xiaoguang Yao, Delian Zhang, Keming Zhou, Menghui Wang, Junli Hu, Gulinuer Duiyimuhan, Wen Jiang, Jing Hong, Le Sun

“…Program effects were evaluated using the data collected in various ways including cross-sectional screenings to population ≥30 years between 1998 and 2015 by comparing treatment and control rates of hypertension, changes in blood pressure (BP) levels and distribution, and proportion of case/total and NCD death for CVD and stroke. …”
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EFFECTS OF A CONVENTIONAL CHELATOR-MODIFIED ANTI-INTEGRIN PEPTIDE ON GLIOBLASTOMA CELL PROLIFERATION AND MIGRATION by Juliana Carron, Gabriella Fraiji Melo, Flávio Lopes Alves, João Ernesto Carvalho, Ana Lucia Tasca Gois Ruiz, Leonardo Lima Fuscaldi, Luciana Malavolta, Carmen Silvia Passos Lima

“…An invasive pattern being a GB hallmark, our data suggests that the DOTA-C6-anti-integrin peptide may aid in developing a GB theranostic agent. …”
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Comprehensive Evaluation of Several Treatment Combinations Used to Manage Acute Respiratory Infections in Routine Paediatric Practice by E. G. Kondyurina, A. L. Zaplatnikov, T. N. Yelkina, E. I. Burtseva, O. A. Gribanova, N. I. Pirozhkova, G. A. Mingalimova, I. O. Tyuleneva, S. V. Trushakova, E. A. Mukasheva

“…The patients were randomised into 2 groups (Ergoferon (group 1): 41 subjects and Kagocel (group 2): 40 subjects) with similar distribution of sex, age, baseline clinical data, and time of treatment initiation. …”
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Quality and composition control of complex TCM preparations through a novel “Herbs-in vivo Compounds-Targets-Pathways” network methodology: The case of Lianhuaqingwen capsules by Simian Chen, Hui Qi, Chunyan Zhu, Yiheng Zhao, Bo Jiao, Yun Tan, Yuexin Yang, Tongxing Wang, Yunlong Hou, Binxin Dai, Dandan Zhang, Hairong Zhang, Junyu Zhang, Xiaojuan Jiang, Xiaodan Guo, Xiaoyu Qian, Caixia Yuan, Xue Bai, Jiayun Chen, Suping Wang, Yu Cai, Jiarou Zhong, Yunqi Li, Qianqian Zhang, Zhenhua Jia, Caisheng Wu

“…Ultrahigh-performance liquid chromatography coupled with high-resolution mass spectrometry (UPLC-HRMS) identified 505 compounds in LHQW-treated rats. Additionally, absorption, distribution, metabolism, and excretion (ADME) profiles were plotted for 27 primary components of LHQW. …”
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Win Ratio in Biomedical Science: A Bibliometric Analysis by Zhenyu Li, MSc, Aliya Izumi, HBSc, Dominique Vervoort, MD, MPH, CPH, MBA, Anika Ranadive, HBSc, Subodh Verma, MD, Stephen E. Fremes, MD, MSc

“…Methods: Biomedical articles indexed in Web of Science and PubMed were retrieved for 2012-2024. Data extraction included bibliometric information and content details. …”
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Analysis of genetic tendencies in fruit traits of macadamia hybrid F1 generation by LI Zhiqiang, WU Chao, MA Jing, LI Tingyu, LI Yang, TAO Liang, GONG Lidan

“…The statistical indicators included the coefficient of variation (CV), mid-parent heterosis (MPV), high-parent heterosis (BPH), low-parent heterosis (LPH), and the relative heritability of the male parent (af) and female parent (am). Frequency distribution and correlation plots of the fruit-related traits were treated using Origin 2021 and R, respectively. …”
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EFFECT OF THE THERAPEUTIC-PREVENTIVE COMPLEX ON THE PARAMETERS OF GLUTATHIONE SYSTEM AND GLUTATHIONE-DEPENDENT ENZYMES OF THE ORAL FLUID IN CHILDREN WITH CHRONIC CATARRHAL GINGIVIT... by L.F. Kaskova, V.A. Honcharenko

“…A number of methods to treat chronic catarrhal gingivitis in children including the treatment of the background of diabetes mellitus was proposed the scientists. …”
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Debonding Analysis Model and Experimental Investigations on FRP Plates Reinforced SHCC Beams Under Three-point Bending by HU Jihong, SUN Mingqing, WANG Yingjun, CHEN Jianzhong, HUANG Wei

“…The results showed reasonable agreement with the experimental data, indicating that the approach can be applied to the analysis of this type of new civil engineering structure.…”
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Effects of melatonin and palmitic acid on the wax content of mango leaf epidermis by WU Jingbo, HUANG Yuyu, WU Xiao, WANG Peng, GU Chao, YIN Hao, QI Kaijie, ZHAN Rulin, ZHANG Shaoling

“…The wax content and chemical composition of mango leaf epidermis were analyzed and determined by gas chromatography-mass spectrometry (GC-MS), and statistical data were analyzed to investigate the influence of exogenous reagents on the wax of leaf epidermis. …”
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Multimodal versus non-contrast computed tomography for assessment of acute ischaemic stroke: the PRACTISE RCT by Keith W Muir, Salwa El Tawil, Alex McConnachie, Alicia Murray, Ian Ford, Grant Mair, Joanna Wardlaw

“…Main outcome measures Proportion treated with intravenous thrombolytic therapy (primary outcome). …”
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Evaluation of parenting interventions for those with additional health and social care needs during pregnancy: THRIVE a multi-arm RCT with embedded economic and process components by Marion Henderson, Anja Wittkowski, Katie Buston, Karen Crawford, Alice MacLachlan, Alex McConnachie, Emma McIntosh, Claudia-Martina Messow, Catherine Nixon, Rosaleen O’Brien, Shona Shinwell, Daniel Wight, Yiqiao Xin, Rachel Calam, Ruth Dundas, James Law, Helen Minnis, Lucy Thompson, Philip Wilson

“…A coding framework was then agreed by RO and KB and discussed/refined with the THRIVE PE subgroup, based on the key questions for the PE, developed prior to implementation, with the addition of novel areas identified through data collection. Recruitment data collection and analysis Participants were recruited to THRIVE over 53 months from January 2014 to May 2018. …”
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Internet and telephone intervention to support patients discontinuing long-term antidepressants in primary care: the REDUCE research programme including RCT by Tony Kendrick, Beth Stuart, Hannah Bowers, Mahboobeh Haji Sadeghi, Helen Page, Christopher Dowrick, Michael Moore, Mark Gabbay, Geraldine Leydon, Guiqing Lily Yao, Shihua Zhu, Paul Little, Gareth Griffiths, Glyn Lewis, Carl May, Joanna Moncrieff, Chris F Johnson, Una Macleod, Simon Gilbody, Rachel Dewar-Haggart, Samantha Williams, Wendy O’Brien, Riya Tiwari, Catherine Woods, Tasneem Patel, Naila Khan, Emma Maund, Nadja van Ginneken, Amy Din, Claire Reidy, Rebecca Lucier, Bryan Palmer, Taeko Becque, Yumna Masood, Natalie Thompson, Ellen van Leeuwen, Marta Glowacka, Adam WA Geraghty

“…Ideally, coding, study selection, data extraction and bias assessment would be done independently by two reviewers. …”
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