Establishing the best step-up treatments for children with uncontrolled asthma despite inhaled corticosteroids: the EINSTEIN systematic review, network meta-analysis and cost-effec... by Sofia Cividini, Ian Sinha, Giovanna Culeddu, Sarah Donegan, Michelle Maden, Katie Rose, Olivia Fulton, Dyfrig Hughes, Stephen Turner, Catrin Tudur Smith

“…We could not conduct NMA for any other outcome due to data limitations. Direct pairwise MA of a limited subset of two trials suggests a reduction in the mean QoL score, measured by the paediatric asthma QoL questionnaire (PAQLQ), for ICS + LABA compared to ICS medium [MD 95% confidence interval (CI) −0.91 (−1.53 to −0.29)], although the upper limit of the 95% CI includes values that would not be considered clinically important. …”
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Biomarkers associated with atherogenesis: current status and promising areas by M. A. Magruk, A. A. Mosikyan, A. Yu. Babenko

“…Its main advantages include stability and well-known reference intervals. Other molecules that can directly participate in the formation of atherosclerotic plaques or lead to their instability are also being studied as BMA. …”
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Initial Psychometric Evaluation of the Barth Syndrome Symptom Assessment (BTHS-SA) for Adolescents and Adults in a Phase 2 Clinical Study by Chad Gwaltney, Alan Shields, Emily Love, Sarah Ollis, Jonathan Stokes, Iyar Mazar, Ethan Arenson, Anthony Aiudi, R. J. Wirth, Carrie Houts

“…A similar pattern of relationships was observed when correlating changes in BTHS-SA scores to reference measures, including moderate to strong relationships between the BTHS-SA and direct patient reports of change (r = 0.81, 0.79, 0.82, and 0.80 between a global impression of change score and the 2 FS, 3 FS, 4 FS, and 5MS, respectively). …”
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Analysis of adverse events with ruxolitinib using real-world datasets and drug-interaction networks by Hideyuki Tanaka, Mika Maezawa, Mizuki Tanaka, Ryogo Umetsu, Sakiko Hirofuji, Koumi Miyasaka, Satoshi Nakao, Yuka Nokura, Moe Yamashita, Nanaka Ichihara, Kana Sugishita, Tomofumi Yamazaki, Kohei Shiota, Hirofumi Tamaki, Kazuhiro Iguchi, Mitsuhiro Nakamura

“…We also assessed 3015 human genes that directly or indirectly interact with ruxolitinib. The molecular complex detection plug-in of Cytoscape was used to detect 24 clusters. …”
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Targeted Next-Generation Sequencing in Pneumonia: Applications in the Detection of Responsible Pathogens, Antimicrobial Resistance, and Virulence by Liu B, Bao Z, Chen W, Xi X, Ge X, Zhou J, Zheng X, Zhang P, Deng W, Ding R, Zhou M, Fang J

“…According to the composite reference standards, the accuracy of tNGS in the detection of responsible pathogens was 0.852 (95% confidence interval 0.786– 0.918), which resembled that of mNGS and remarkably exceeded that of CMTs. …”
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Risk factors for neuroendocrine neoplasms: protocol for a case–control study based on a record linkage of registry and claims data by Nina Grundmann, Jacqueline Müller-Nordhorn, Ursula Berger, Sven Voigtländer, Ewan Donnachie, Martin Tauscher, Roman Gerlach, Amir Hakimhashemi, Martin Meyer

“…Another risk factor may be depressive disorders, which could increase the risk of neuroendocrine neoplasms either directly or mediated through associated risk behaviours and/or antidepressant medication. …”
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Efficacy of therapeutic interventions for idiopathic recurrent pregnancy loss: a systematic review and network meta-analysis by Jorge Lima, Jorge Lima, João Guerreiro, Miguel Ângelo-Dias, Sofia Silvério Serra, Teresa Costa, Natália Marto, João Feldman de Pinho, João Costa, Rodrigo Ruano, Gonçalo Silva Duarte, Gonçalo Silva Duarte

“…Overall, under placebo, 59% (95% confidence interval [CI] 51–67; I2 = 92%) of participants underwent successful live births, and 35% (95% CI 30–42, I2 = 86%) underwent miscarriages. …”
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First dose ChAdOx1 and BNT162b2 COVID-19 vaccinations and cerebral venous sinus thrombosis: A pooled self-controlled case series study of 11.6 million individuals in England, Scotl... by Steven Kerr, Mark Joy, Fatemeh Torabi, Stuart Bedston, Ashley Akbari, Utkarsh Agrawal, Jillian Beggs, Declan Bradley, Antony Chuter, Annemarie B Docherty, David Ford, Richard Hobbs, Srinivasa Vittal Katikireddi, Emily Lowthian, Simon de Lusignan, Ronan Lyons, James Marple, Colin McCowan, Dylan McGagh, Jim McMenamin, Emily Moore, Josephine-L K Murray, Rhiannon K Owen, Jiafeng Pan, Lewis Ritchie, Syed Ahmar Shah, Ting Shi, Sarah Stock, Ruby S M Tsang, Eleftheria Vasileiou, Mark Woolhouse, Colin R Simpson, Chris Robertson, Aziz Sheikh

“…The observation period consisted of an initial 90-day reference period, followed by a 2-week prerisk period directly prior to vaccination, and a 4-week risk period following vaccination. …”
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Mortality of Pneumocystis jirovecii pneumonia in intensive care units: a post-hoc analysis of an international multicenter study by ESGCIP and EFISG by Daniele Roberto Giacobbe, Silvia Dettori, Vincenzo Di Pilato, Erika Asperges, Lorenzo Ball, Enora Berti, Ola Blennow, Bianca Bruzzone, Laure Calvet, Federico Capra Marzani, Antonio Casabella, Sofia Choudaly, Anais Dartevel, Gennaro De Pascale, Gabriele Di Meco, Melissa Fallon, Louis-Marie Galerneau, Miguel Gallego, Mauro Giacomini, Adolfo González Saez, Luise Hänsel, Giancarlo Icardi, Philipp Koehler, Katrien Lagrou, Tobias Lahmer, Philip Lewis White, Laura Magnasco, Anna Marchese, Cristina Marelli, Mercedes Marín Arriaza, Ignacio Martin-Loeches, Armand Mekontso-Dessap, Malgorzata Mikulska, Marco Muccio, Alessandra Mularoni, Anna Nordlander, Julien Poissy, Giovanna Russelli, Alessio Signori, Carlo Tascini, Louis-Maxime Vaconsin, Joel Vargas, Antonio Vena, Joost Wauters, Paolo Pelosi, Jean-Francois Timsit, Matteo Bassetti

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Hydrocortisone, vitamin C, and thiamine may not improve the outcome of patients with sepsis or septic shock: a systematic review and meta-analysis by Zhuangli Li, Xiaoli Zhang, Yongliang Wu, Chao Xie, Chengjiang Liu, Xiuyu He, Zehua Wu, Guofang Hua, Yuedong Li

“…However, the use of vasopressors decreased significantly. Further direct head-to-head studies are needed.…”
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Simple methods for estimating confidence levels, or tentative probabilities, for hypotheses instead of values by Michael Wood

“…An alternative approach is to cite confidence intervals for a statistic of interest, but this does not directly tell readers how certain a hypothesis is. …”
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Investigation of Brash Ice (Overview) by K. E. Sazonov

“…The review shows that the main directions of research refer to three main topics. 1) Investigation of morphometrical brash ice characteristics in navigable channels and harbors, their variability under ambient factors. …”
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Bibliometric Analysis of Electrical and Electronic Equipment Production and Consumption in the Context of the Circular Economy by Ion Popa, Claudiu Cicea, Simona Cătălina Ștefan, Corina Marinescu, Daniel Botez

“…As for the limits of the research, they take into account the database that was subjected to the analysis (in the present paper, Web of Science), the software used, the writing language of the scientific production, and the analysis interval. The article concludes with future research directions. …”
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Open Innovation the Impact of Social Capital on Tourism Growth Through the Mediating Role of Open Innovation (Case study: The municipality of Khomam County) by Seyed Hamed Hashemi, Hossein Poorghasem

“…Social capital is the intangible value that an organization has in its social outcomes, relationships, learned processes, procedures, and inventions. This value is also referred to as "intellectual capital". In other words, social capital refers to the sum of all the information that a company has. …”
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Generation of Spiral Spin Density Vectors With A Circularly Polarized, Vortex Beam by Xiaoyan Pang, Wenhao Liu, Wenrui Miao

“…Spiral spin density vectors refer to the spiral trajectory of the spin density vectors in three dimensional (3D) space, and similar to the polarization Möbius strip, polarization knots and photonic wheel, are also special polarization structures in 3D optical field and only exist in three dimensions. …”
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Decision-Making Method Based on a Comprehensive Assessment of the Effectiveness of the Radio Frequency Spectrum by P. Yu. Lakizo

“…A model of the overall efficiency of using the radio frequency spectrum based on three types of efficiency has been proposed, and a scale of intervals for these types has been developed. An assessment of the efficiency of the radio frequency spectrum based on a reference network of cellular mobile communications has been performed. …”
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Sleep quality, sleep hygiene practices and their influencing factors among Malaysian university students: A cross-sectional study by Lakshme Shree Vijayan, Sharranesh Raja, Yeoh Yong Khang, Arvinder-Singh Harbaksh Singh

“…Introduction: Sleep quality refers to the subjective experience of sleep, encompassing aspects such as duration, depth and continuity. …”
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Observations of fin whales and vessels offshore oregon using fibre optic distributed acoustic sensing by Steve Horne, Anna L. Stork, Frantisek Stanek

“…Calls were found to be of two distinct types that are typical for fin whales and referred to as doublets. The calls typically alternate between the two types with an inter-call interval of approximately 15 seconds. …”
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QUERCETIN PHYSICAL-CHEMICAL CHARACTERISTICS’ DEFINITION by I. V. Kovalevska

“…The working out of the medicines on the basis of natural bioflavonoids, quercetin in particular, is a perspective direction of broading doctors’ remedy arsenal with polytropic effect. …”
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Piezoelectric Active Sensor Self-Diagnosis for Electromechanical Impedance Monitoring Using K-Means Clustering Analysis and Artificial Neural Network by Xie Jiang, Xin Zhang, Yuxiang Zhang

“…Piezoelectric sensor is a crucial part of electromechanical impedance technology whose state will directly affect the effectiveness and accuracy of structural health monitoring (SHM). …”
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