A multi-megabase copy number gain causes maternal transmission ratio distortion on mouse chromosome 2. by John P Didion, Andrew P Morgan, Amelia M-F Clayshulte, Rachel C Mcmullan, Liran Yadgary, Petko M Petkov, Timothy A Bell, Daniel M Gatti, James J Crowley, Kunjie Hua, David L Aylor, Ling Bai, Mark Calaway, Elissa J Chesler, John E French, Thomas R Geiger, Terry J Gooch, Theodore Garland, Alison H Harrill, Kent Hunter, Leonard McMillan, Matt Holt, Darla R Miller, Deborah A O'Brien, Kenneth Paigen, Wenqi Pan, Lucy B Rowe, Ginger D Shaw, Petr Simecek, Patrick F Sullivan, Karen L Svenson, George M Weinstock, David W Threadgill, Daniel Pomp, Gary A Churchill, Fernando Pardo-Manuel de Villena

“…R2d2 maps to a 900 kb interval, and the number of R2d copies varies from zero in classical strains (including the mouse reference genome) to more than 30 in wild-derived strains. …”
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Radionuclide imaging of HER2/neu expression in metastatic axillary lymph nodes in breast cancer patients: comparing the efficacy of [^99mTc]Tc-ADAPT6 and [^99mT... by О. D. Bragina, L. А. Tashireva, Е. Yu. Garbukov, М. А. Vostrikova, А. А. Romanova, S. М. Deyev, М. Е. Borodina, V. I. Chernov

“…Aim. To conduct a direct comparative analysis of single-photon emission computed tomography (SPECT-CT) with [99mTc]Tc-ADAPT6 and [99mTc]Tc-(HE)3-G3 in patients with HER2-positive breast cancer (BC) with axillary lymph node metastases. …”
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Early antenatal risk factors for births before arrival: An unmatched case–control study by Talia Rose Hubble, Manisha Nair, Christina Y. L. Aye, Sam Mathewlynn, Catherine Greenwood, Lawrence Impey

“…Better recognition of early factors may enable maternity staff to direct higher‐risk women towards specialized care services at an early point in their pregnancy, enabling time for clinical and social interventions.…”
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Prevalence of adenomyosis features in women scheduled for assisted reproductive treatment, using the Morphological Uterus Sonographic Assessment group definitions by Sara Alson, Ligita Jokubkiene, Emir Henic, Povilas Sladkevicius

“…Results At least one direct or indirect feature of adenomyosis was observed in 272 (23.4%, 95% confidence interval [CI] 21.0–25.9) women. …”
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Beyond LDL-C: discordant small dense LDL cholesterol stratifies hypertension risk in a Chinese longitudinal cohort by Xiaofei Wu, Chunfang Ma, Weihai Chen, Shan Liu, Hao Shen, Xiangxiang Li

“…Stratification by three LDL-C clinical thresholds and median values revealed individuals with low LDL-C but high sdLDL-C had the highest HTN risk (vs. low LDL-C/low sdLDL-C reference group in fully adjusted models). Despite strong correlation (Spearman’s r = 0.956), systematic biases between direct LDL-C and Sampson methods may limit clinical interchangeability. …”
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Asymmetry in the Prediction of Cojumps on Volatility and Its Reversal by Liling Deng, Zhiqiang Wang, Haifang Xiong

“…The asymmetry of volatility is an important feature of asset price changes, and studying the asymmetry of cojumps on volatility prediction can provide a reference for systemic risk monitoring. Based on high-frequency data of CSI 300 stock index and futures index, SSE Composite Index, and industry index, the influence of cojumps on volatility in different directions is analyzed by HAR model. …”
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Pharmacoeconomic assessment of antipsychotic treatment in outpatients with schizophrenia by I. A. Vilyum, B. V. Andreev, M. A. Proskurin, Yu. E. Balykina

“…When estimated for the use of 100% reference AA or the combined reference + reproduced AA, the treatment with CA  remained more economically effective, regardless of the simulated period.Conclusion. …”
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The association between age of menopause and type 2 diabetes: a systematic review and meta-analysis by Mansoureh Yazdkhasti, Kyana Jafarabady, Arman Shafiee, Samira Parvizi Omran, Zohre Mahmoodi, Sara Esmaeilzadeh, Touran Bahrami Babaheidari, Kourosh Kabir, Maral Peisepar, Mahmood Bakhtiyari

“…Methods and materials PubMed, Web of Science, Scopus, Science Direct, Google Scholar, and Cochrane were searched for studies that have evaluated the relationship between T2DM and age of menopause onset. …”
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Evaluation of lateral flow devices for rabies diagnosis in decomposed animal brain samples by Ryota Todoroki, Joely T. Ongtangco, Kazunori Kimitsuki, Nobuo Saito, Milagros R. Mananggit, Cornelio R. Velasco, Jaira D. Mauhay, Alyssa M. Garcia, Catalino S. Demetria, Yamada Kentaro, Akira Nishizono

“…Abstract Background The Direct Fluorescent Antibody Test (DFAT), the standard rabies confirmatory test, is less sensitive when used with decomposed brain samples, a frequent issue in rabies-endemic regions. …”
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CASNET2: evaluation of an electronic safety netting cancer toolkit for the primary care electronic health record: protocol for a pragmatic stepped-wedge RCT by Clare Bankhead, Rafael Perera, Simon de Lusignan, Ivelina Yonova, Susannah Fleming, Richard Hobbs, Brian D Nicholson, Yasemin Hirst, Afsana Bhuiya, Julian Sherlock

“…Other outcomes include referrals rates and rates of direct access cancer investigation.Analysis of the clustered stepped-wedge design will model associations using a fixed effect for intervention condition of the cluster at each time step, a fixed effect for time and other covariates, and then include a random effect for practice and for patient to account for correlation between observations from the same centre and from the same participant.Ethics and dissemination Ethical approval has been obtained from the North West—Greater Manchester West National Health Service Research Ethics Committee (REC Reference 19/NW/0692). …”
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Prevalence and Pattern of Learning Disability in India: A Systematic Review and Meta-Analysis by Johny Kutty Joseph, Babitha K. Devu

“…The literature search was done using Boolean operators in databases such as PubMed, ProQuest, Cochrane, ScienceDirect, Google Scholar, and websites such as ResearchGate, Academia, and so on. …”
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Data science applied to the assessment of biological variation estimates by Marques-Garcia Fernando, Nieto-Librero Ana, Gonzalez-García Nerea, Tejedor-Ganduxé Xavier, Martinez-Bravo Cristina

“…In the clinical laboratory, the multiple applications of data science include the development of algorithms for obtaining population-based reference intervals or biological variation (BV) estimates. …”
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Field evaluation and impact on clinical management of a rapid diagnostic kit that detects dengue NS1, IgM and IgG. by Anne-Claire Andries, Veasna Duong, Chantha Ngan, Sivuth Ong, Rekol Huy, Kim Kim Sroin, Vantha Te, Bunthin Y, Patrich Lorn Try, Philippe Buchy

“…Nevertheless, Cambodian pediatricians in their daily practice relied on their clinical diagnosis and thus the false negative results obtained did not directly impact on the clinical management.…”
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The use of combined remote electronic monitoring and blood concentrations of antipsychotics for assessment of therapeutic adherence in patients with schizophrenia: results of a pro... by Petr Šilhán, Martin Hýža, Samuel Ambroš, Petr Dostálek, Jana Schwarzová, Tomáš Skřont, Denisa Perničková, Pavla Baarová, Martin Augustynek, Ivana Kacířová, Romana Uřinovská

“…Patients who correctly opened the dispenser at least in 80% of scheduled time points during the weekly interval and, at the same time, did not show a change in blood concentration of the antipsychotic by more than 30% in any direction, were considered adherent. …”
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Rapid and non-invasive analysis of paracetamol overdose using paper arrow-mass spectrometry: a prospective observational study by Yufeng Zhou, Silothabo Dliso, Jennie Craske, Andrea Gill, Louise Bracken, Kiran Landa, Philip Arnold, Laura Walker, Ionela Grasim, Gabrielle Seddon, Tao Chen, Andrew S. Davison, Tung-Ting Sham, Barry Smith, Daniel B. Hawcutt, Simon Maher

“…The CCC is 0.93, the mean difference with the reference test is − 0.14 mg/L, and the ratios compared to the reference test are 0.84–1.27 from correlated samples collected at 5 intervals over 4 h for each participant. …”
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Assessing the causal effect of inflammation‐related genes on myocarditis: A Mendelian randomization study by Huazhen Xiao, Hongkui Chen, Wenjia Liang, Yucheng Liu, Kaiyang Lin, Yansong Guo

“…Multivariable MR (MVMR) analysis further demonstrated a direct causal role of ADORA2B in preventing myocarditis. …”
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Pharmacoeconomic analysis of using typical and atypical antipsychotics in schizophrenia by I. A. Vilyum, B. V. Andreev, M. A. Proskurin, Yu. E. Balykina

“…When the use of 100% reference AA or the combined use of reference + reproduced AA was simulated, the treatment with kA remained more economically effective, regardless of the simulated period.Conclusion. …”
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Mendelian randomization study of serum uric acid levels and urate-lowering drugs on pulmonary arterial hypertension outcomes by Xiaoling Yao, Xin Cai, Shaoqin Zhang, Yuzheng Yang, Xiangyan Yang, Wukai Ma, Zong Jiang

“…However, urate-lowering drugs do not appear to have a direct causal effect on improving PAH. These findings provide a novel reference point for developing future therapeutic strategies for PAH.…”
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Changes in the hematology and blood metabolites of guinea pigs (Cavia porcellus) under intensive rearing system in humid tropical conditions by Daniel Paredes-López, Rizal Robles-Huaynate, Uriel Aldava-Pardave, Miguel Morales-Cauti

“…In serum, profiles of glucose, total protein (TP), albumin, total cholesterol (TC), triglycerides, total bilirubin (TB), and direct bilirubin (DB), alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were determined. …”
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High and low body mass index increases the risk of short-term postoperative complications following total shoulder arthroplasty by Salvatore Capotosto, MD, Matthew Kim, MD, Kenny Ling, MD, Alireza Nazemi, MD, Ryan Tantone, MD, Elizabeth Wang, MD, David E. Komatsu, PhD, Edward D. Wang, MD

“…Odds ratios (ORs) were reported with a 95% confidence interval. The level of statistical significance was set at P < .05. …”
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