Elucidating the dynamic tumor microenvironment through deep transcriptomic analysis and therapeutic implication of MRE11 expression patterns in hepatocellular carcinoma by Ruiqiu Chen, Chaohui Xiao, Zizheng Wang, Guineng Zeng, Shaoming Song, Gong Zhang, Lin Zhu, Penghui Yang, Rong Liu

Get full text

Multiplex imaging analysis of the tumor immune microenvironment for guiding precision immunotherapy by Feng Liu, Feng Liu, Feng Liu, Guiqing Li, Guiqing Li, Yi Zheng, Yi Zheng, Yanxia Liu, Yanxia Liu, Kang Liu, Kang Liu

“…Despite current technical and analytical challenges, ongoing technological advancements and integration with emerging methods like spatial transcriptomics and super-resolution imaging promise broader clinical utility, ultimately improving patient outcomes in precision immunotherapy.…”
Get full text

KDM1A epigenetically enhances RAD51 expression to suppress the STING-associated anti-tumor immunity in esophageal squamous cell carcinoma by Qingyuan Yang, Shiyin Wei, Cen Qiu, Chenjie Han, Zunguo Du, Ning Wu

“…Cell growth was assessed by colony formation assays in vitro and subcutaneous xenograft models in vivo. High-throughput transcriptomics and spatial immune proteomics were performed using bulk RNA sequencing and digital spatial profiling techniques, respectively. …”
Get full text

The dual role of CXCL9/SPP1 polarized tumor-associated macrophages in modulating anti-tumor immunity in hepatocellular carcinoma by Yu Gu, Zhihui Zhang, Hao Huang, Wenyong Zhu, Hongjia Liu, Rongxin Zhang, Nan Weng, Xiao Sun

Get full text