QSP modeling of loncastuximab tesirine with T-cell-dependent bispecific antibodies guides dose-regimen strategy by Yuezhe Li, A. Katharina Wilkins, Jimena Davis, Timothy Knab, Marie Toukam, Joseph P. Boni, Daniel C. Kirouac

“…Additive antitumor effects were predicted from the fourth cycle onward, with combination efficacy insensitive to loncastuximab tesirine dose reductions or patient lymphopenias. Results of the LOTIS-7 study (NCT04970901) will soon be available to assess these predictions.…”
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Natural surfactant fenugreek (Trigonella foenum-graecum) seeds based photogalvanic cell for solar energy conversion and storage by Meenakshi Jonwal, Pooran Koli, Rajendra Kumar

“…A more environmentally sustainable and an efficient Photogalvanic system based on Fenugreek seeds aqueous extract as natural surfactant (saponins), Cellobiose as reductant and Neutral Red dye as photosensitizer is developed to demonstrate a potent cell. …”
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Cortical microstructural abnormalities in dementia with Lewy bodies and their associations with Alzheimer’s disease copathologies by Elijah Mak, Robert I. Reid, Scott A. Przybelski, Angela J. Fought, Timothy G. Lesnick, Christopher G. Schwarz, Matthew L. Senjem, Sheelakumari Raghavan, Prashanthi Vemuri, Clifford R. Jack, Hoon Ki Min, Manoj K. Jain, Toji Miyagawa, Leah K. Forsberg, Julie A. Fields, Rodolfo Savica, Jonathan Graff-Radford, David T. Jones, Hugo Botha, Erik K. St. Louis, David S. Knopman, Vijay K. Ramanan, Dennis W. Dickson, Neill R. Graff-Radford, Gregory S. Day, Tanis J. Ferman, Ronald C. Petersen, Val J. Lowe, Bradley F. Boeve, John T. O’Brien, Kejal Kantarci

“…Compared to controls, DLB exhibited increased MD and FWF, reduced tNDI across multiple regions, and focal ODI reductions in the occipital cortex. Structural equation modeling revealed that APOE genotype influenced amyloid levels, which elevated tau, leading to microstructural injury. …”
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Controlling impurity transport in 5D gyrokinetic simulations using a transport barrier by G. Lo-Cascio, E. Gravier, M. Lesur, T. Réveillé, Y. Sarazin, X. Garbet, K. Lim, T. Rouyer, A. Guillevic

“…The transport barrier is induced by triggering E  ×  B shear via an external poloidal momentum source, thereby stabilizing ITG turbulence and reducing outward heat fluxes. These reductions in particle and heat fluxes due to the transport barrier lead to enhanced confinement, thereby steepening the ion temperature profiles and reducing the heat diffusivity of the main ion species (i.e. deuterium). …”
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The electrical performance of a single-axis sun tracking agrivoltaic system inside a polytunnel greenhouse by E. Magadley, M. Matar, R. Kabha, R. Korabi, A. Hajyahya, A. Abasi, H. Barhum, M. Attrash, R. Saabne, S. Asaly, I. Yehia

“…However, performance inside the greenhouse was limited by global horizontal irradiance reductions due to greenhouse covers and seasonal dust accumulation. …”
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Photoreduction of CO2 to CH4 over Efficient Z-Scheme γ-Fe2O3/g-C3N4 Composites by Thanh-Binh Nguyen, Thuy Hang Dinh Thi, Doan Pham Minh, Hien Bui Minh, Ngoc Quynh Nguyen Thi, Bang Nguyen Dinh

“…The photocatalytic activity of these materials was studied in the photoreduction of CO2 with H2O as the reductant in the gaseous phase. The composites exhibited excellent photoactivity compared to undoped g-C3N4. …”
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NLRP3 deficiency abrogates silica-induced neutrophil infiltration, pulmonary damage and fibrosis by Maggie Lam, Kristian T. Barry, Christopher J. Hodges, Christopher M. Harpur, James D. H. Ong, Sarah Rosli, Alison C. West, Lovisa Dousha, Paul J. Hertzog, Ashley Mansell, Michelle D. Tate

“…NLRP3-deficient mice displayed marked early reductions in silica-induced IL-1β and IL-18 levels in the airways. …”
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Characteristics of cerebral glucose metabolism in patients with cognitive impairment in multiple system atrophy by Bin Chen, Lingchao Li, Lin Bai, Min Zhao, Ying Chang, Shi Gao

“…Receiver operating characteristic (ROC) curves were used to analyze the ability of the rCMRglc of different brain regions to assess the cognitive status of MSA patients.ResultsCompared with the HC group, the MSA group showed diffuse reductions in glucose metabolism in the cerebellar regions, decreased metabolism in specific areas of the left inferior parietal lobule, right putamen, and left middle temporal gyrus, and increased metabolism in the left postcentral gyrus, right postcentral gyrus, left precuneus. …”
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Two decades of nutrient dynamics in Polish rivers: Long-term trends in nitrogen and phosphorus by Paweł Marcinkowski, Ignacy Kardel, Marek Giełczewski, Mikołaj Piniewski

“…The observed decreases in phosphorus are consistent with substantial reductions in TP loads from municipal wastewater treatment plants, while the increasing nitrogen trends are consistent with increased use of mineral fertilizers. …”
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The single-cell immune landscape of HIV-associated aggressive B-cell lymphoma by Xiaomei Zhang, Zailin Yang, Xiaoqing Xie, Jun Li, Qing Xiao, Guofa Xu, Ben Ma, Xudong Xie, Yi Liu, Liuyue Zhai, Yifeng Tang, Huihui Fu, Sanxiu He, Tingting Liu, Dehong Huang, Censi Zeng, Yixing Zhou, Renzhi Hu, Binling Guo, Chaoyu Wang, Shunsi Liang, Qin Luo, Jing Lv, Yingyu Nan, Jieping Li, Qiying Li, Shengqiang Wang, Yongzhong Wu, Yao Liu

“…Additionally, HAL exhibited senescence-like dysfunction in T cells, characterized by the reductions in regulatory activity of Treg and cytotoxic activity of CD8+ T cells, as well as decreases expression of IL7R genes and increases expression of FOS and FOSB genes. …”
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Case Report: Two cases of IgG4-related kidney disease with monoclonal gammopathy by Qian Dong, Xuanli Tang, Jiang Liu, Pengjie Xu

“…Interstitial inflammatory cells κ were scattered weakly positive, and λ was diffuse strong positive. Bone marrow aspiration did not show obvious plasmablast or abnormal plasma cell clones, but eosinophils were significantly elevated. …”
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