Transcriptomic Divergence and Associated Markers Between Genomic Lineages of Silver Catfish (Rhamdia quelen) by Néstor Ríos, Belén G. Pardo, Carlos Fernández, José Antonio Alvarez‐Dios, Paulino Martínez, Carmen Bouza, Graciela García

“…Skeletal muscle and brain expressed genes associated with growth were also identified. Transcriptomic differences suggestive of adaptation to temperature and salinity were revealed between North and South genomic lineages. …”
Get full text

Spatial transcriptomic analysis of tumor microenvironment in esophageal squamous cell carcinoma with HIV infection by Yuanli Zuo, Yang Jin, Gang Li, Yue Ming, Ting Fan, Yitong Pan, Xiaojun Yao, Yong Peng

“…However, the spatial cellular characteristics of HIV-related ESCC have not been explored, and the differences between HIV-ESCC and typical ESCC remain unclear. …”
Get full text

Genetic Adaptations of Soybean to Cold Stress Reveal Key Insights Through Transcriptomic Analysis by Xiulin Liu, Chunlei Zhang, Sobhi F. Lamlom, Kezhen Zhao, Ahmed M. Abdelghany, Xueyang Wang, Fengyi Zhang, Rongqiang Yuan, Dezhi Han, Bire Zha, Wencheng Lu, Honglei Ren, Bixian Zhang

“…Low temperatures greatly restrict the development, growth, and productivity of soybeans, with their effects differing across various cultivars. The present work investigated the transcriptome and physiological reactions of two soybean cultivars, namely “KD52” exhibiting cold tolerance and “DS17” displaying cold sensitivity, to cold stress across a precisely defined period. …”
Get full text

Transcriptomic sequencing and differential analysis of Kazakh horse muscles from various anatomical locations by Mierkadina· Wubulikasimu, Jiahao Liu, Xinkui Yao, Xinkui Yao, Jun Meng, Jun Meng, Jianwen Wang, Jianwen Wang, Yaqi Zeng, Yaqi Zeng, Linling Li, Wanlu Ren, Wanlu Ren

“…However, the gene expression differences across various muscle tissues of Kazakh horses have yet to be elucidated. …”
Get full text

Combined metabolomic and transcriptomic analysis reveals the key genes for triterpenoid biosynthesis in Cyclocarya paliurus by Duo Chen, Xupeng Chen, Xuehai Zheng, Jinmao Zhu, Ting Xue

Get full text

Combined Transcriptomic and Mendelian Randomisation Explores the Diagnostic Value of Ubiquitination-Related Genes in Sepsis by Bai X, Liu R, Tang Y, Yang L, Niu Z, Hu Y, Zhang L, Chen M

Get full text

Cross-tissue transcriptome-wide analysis reveals novel insights into thyroid cancer etiology by Yue Zhu, Yu Luo, Yuye Zhang, Yixuan Wang, Zhangqi Gu, Jinyan Liu, Ancheng Qin, Weifeng Qian

“…The study highlighted differences in the expression of significant genes in normal and thyroid cancer tissues at the transcriptome level and investigated their relationship with the tumor microenvironment. …”
Get full text

Genome-wide association and transcriptomic analysis and the identification of growth-related genes in Macrobrachium nipponense by Zijian Gao, Wenyi Zhang, Sufei Jiang, Hui Qiao, Yiwei Xiong, Shubo Jin, Hongtuo Fu

“…Of the 100 individuals, we sampled muscle tissue from a total of 18 female and male M. nipponense exhibiting large differences in growth rate for RNA-seq. Transcriptome analysis revealed a total of 27,996 unigenes; of these, 33 and 60 differentially expressed genes were identified from males and females, respectively. …”
Get full text

Targeted metabolomic and transcriptomic analyses provide insights into flavonoid biosynthesis in the grain of Foxtail millet by Zhenyan Ye, Na Qin, Senjie Fu, Huifang Zhang, Cancan Zhu, Shutao Dai, Ya Jing, Xin Wei, Chunyi Wang, Le Ju, Junxia Li

“…Comparative transcriptomic analysis demonstrated significant differences in the expression patterns of flavonoid biosynthesis-associated genes between the HF and LF groups. …”
Get full text

Integrated transcriptomics and metabolomics confirms the oxidative stress mechanism of hypothermia-induced neuronal necroptosis by Song-Jun Wang, Chao-Long Lu, Fu Zhang, Xue-Tong Dong, Xiao-Rui Su, Jing-Jing Sha, Bin Cong, Xia Liu

“…Flow cytometry and fluoro-jade C staining showed that low temperature caused necroptosis of cerebral cortical neurons. Transcriptomics identified 244 differential genes between hypothermia-exposed cortical tissue and control tissue. …”
Get full text

Identification of the clinical and genetic characteristics of gliomas with gene fusions by integrated genomic and transcriptomic analysis by Guo-zhong Yi, Hua-yang Zhang, Tian-shi Que, Shan-qiang Qu, Zhi-yong Li, Song-tao Qi, Wen-yan Feng, Guang-long Huang

“…The results showed no statistically significant differences were observed between fusion and non-fusion group of GBM and LGG. …”
Get full text

Predicting the Risk of Preterm Birth Throughout Pregnancy Based on a Novel Transcriptomic Signature by Yang Pan, Yuxin Ran, Dongni Huang, Nanlin Yin, Yanqing Wen, Yan Jiang, Yamin Liu, Hongbo Qi

“…Methods. Blood transcriptome data of pregnant women were obtained from the Gene Expression Omnibus database. …”
Get full text

Aging and head and neck cancer insights from single cell and spatial transcriptomic analyses by Yi Pei, Zhuying Mou, Lai Jiang, Jinyan Yang, Yuheng Gu, Jie Min, Lingyi Sunzhang, Nan Xiong, Xiang Xu, Hao Chi, Ke Xu, Sinian Liu, Huiyan Luo

“…For the spatial transcriptome data, SCTransform and RunPCA were applied to examine the metabolic activities of the cells. …”
Get full text

Transcriptomic Signature of Frailty in Older Patients With Cardiovascular Disease Undergoing Cardiac Surgery or TAVI by Omar Baritello, Simon H. Sündermann, Kristian Espinosa‐Garnica, Jörg Kempfert, Markus Jähnert, Nick L. Beetz, Dominik Geisel, Jasmin Gaugel, Julia Rominger, Ursula Müller‐Werdan, Catrin Herpich, Kristina Norman, Alexandra Chadt, Hadi Al‐Hasani, Heinz Völler, Annett Salzwedel, Heike Vogel

“…In total, 37 patients (59%) experienced ≥ 1 complication (e.g., need of transfusion, atrial fibrillation and delirium); one patient died. Based on transcriptome data, 10 overlapping genes between all physical frailty phenotypes were identified, with S100A1 showing the strongest differences in expression level (e.g., handgrip R2adj = 0.579; p = 0.001). …”
Get full text

Differential effects of Mediterranean vs. Western diets on coronary atherosclerosis and peripheral artery transcriptomics by Aya Jamal Abusheikha, Corbin S. C Johnson, Noah Snyder-Mackler, Noah Snyder-Mackler, Noah Snyder-Mackler, Kip D. Zimmerman, Kip D. Zimmerman, Jacob D. Negrey, Jacob D. Negrey, Kenneth L. Chiou, Kenneth L. Chiou, Brett M. Frye, Brett M. Frye, Timothy D. Howard, Timothy D. Howard, Carol A. Shively, Thomas C. Register, Thomas C. Register

“…The effects of Western diet were observed primarily in the coronary and iliac arteries, whereas social status differences were observed primarily in the carotid arteries. …”
Get full text

Integrated transcriptomic and metabolomic analyses elucidate the mechanism by which grafting impacts potassium utilization efficiency in tobacco by Lulu Niu, Wei Hu, Fazhan Wang, Majid Shaker, Xin Yang

“…This study revealing for the first time how grafting improves potassium utilization efficiency through combined transcriptome and metabolome analysis. Results This study selected Wufeng NO. 2, a potassium-efficient variety, and Yunyan 87, a main cultivar, as the research subjects to investigate the underlying reasons for differential potassium utilization efficiency among different tobacco rootstocks through transcriptome and metabolic data analysis of grafted tobacco. …”
Get full text

Integrated analysis of the transcriptome and hormone metabolome elucidates the regulatory mechanisms governing walnut bud germination by Kai Zhao, Xiaofan Wu, Bo Liang, Shuang Gao, Jieyan Yang, Yan Bai, Yaru Wang, Xin Tian, Fang Wang, Xiuqing Yang

“…By assessing hormone levels and gene expression at different developmental stages, we pinpointed potential regulatory genes and critical hormones associated with bud germination. …”
Get full text

Lipopolysaccharide-induced changes in the hepatic transcriptome revealed breed-specific response in St. Croix and Suffolk sheep by Samanthia R. Johnson, Kelsey L. Bentley, Scott A. Bowdridge, Scott A. Bowdridge, Ibukun M. Ogunade

“…This study aimed to investigate breed-specific differences in the liver transcriptomic response to lipopolysaccharide (LPS) in St. …”
Get full text

Combined metabolome and transcriptome analysis revealed that MSTN regulated the process of bovine fatty acid metabolism in gut by Li Gao, Yong Ma, Lili Wang, Hao Wu, Ruobing Kang, Guangpeng Li, Lei Yang, Tong Wen

“…This study aims to reveal how MSTN affects the metabolism process by regulating gut metabolites.MethodsCombined analysis of jejunal contents metabolome and jejunal tissue transcriptome was used to compare the differences in intestinal metabolites and intestinal tissue gene expression between MSTN mutant and wild-type bovines.ResultsMetabolomic analysis identified that compared to wild-type bovine, the abundance of 304 metabolites were significantly changed in MSTN mutant cattle including 142 upregulated and 162 downregulated. …”
Get full text

Exploring the molecular basis of efficient feed utilization in low residual feed intake slow-growing ducks based on breast muscle transcriptome by Lei Wu, Zhong Zhuang, Wenqian Jia, Yongpeng Li, Yijia Lu, Minghong Xu, Hao Bai, Zhixiu Wang, Guobin Chang, Yong Jiang

“…Thirty high RFI (HRFI) and 30 low RFI (LRFI) birds were selected to evaluate their growth performance, carcass characteristics, and muscle development. Transcriptome and weighted gene co-expression correlation network analyses of pectoral muscles were conducted on six LRFI and six HRFI ducks. …”
Get full text