UV-B induced expression of wax synthesis gene LbCYP96A15 in leaves of goji plants (Lycium barbarum) to improve powdery mildew resistance by Xiao Zhang, Jie Li, Xia Wen, Xin-bing Wang, Deng-pan Shen, Li-wei Ding, Jing He

“…Concurrently, the incidence of powdery mildew rose from 7.85 to 21.7% and 72.92%, while the disease index increased from 14.21 to 27.23 and 78.40, respectively. Transcriptomic data revealed that 122 differentially expressed genes (DEGs) were significantly enriched in the lipid metabolism pathway, with 26 DEGs specifically associated in the wax synthesis metabolic pathway. …”
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Identification of Serum miRNA-423-5p Expression Signature in Somatotroph Adenomas by Sida Zhao, Jianhua Li, Jie Feng, Zhenye Li, Qian Liu, Peng Lv, Fei Wang, Hua Gao, Yazhuo Zhang

“…From the exosomal miRNAs expression profiling, we found 169 miRNAs differently expressed between somatotroph adenomas and healthy pituitary samples (p< 0.05, FC > 2). …”
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Translational disease modeling of peripheral blood identifies type 2 diabetes biomarkers predictive of Alzheimer’s disease by Brendan K. Ball, Jee Hyun Park, Alexander M. Bergendorf, Elizabeth A. Proctor, Douglas K. Brubaker

“…Using TransComp-R, we combined peripheral blood-derived T2D and AD human transcriptomic data to identify T2D principal components predictive of AD status. …”
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Comparative evaluation of immunomodulatory cytokines for oncolytic therapy based on a high-efficient platform for oHSV1 reconstruction by Yingzheng Gao, Yufang Zou, Changjing Wu, Juan Tao, Zuqing Nie, Jinyuan Yan, Pengfei Wang, Xinwei Huang

“…Flow cytometry confirmed functional differences in immune activation: OV-IL15Fu expanding cytotoxic lymphocytes (CD8⁺ T/NK cells), OV-IFNG preferentially promote Th1 polarization and innate immune activation, and OV-GMCSF failed to activate T cells despite myeloid infiltration. …”
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RNAseq and targeted metabolomics implicate RIC8 in regulation of energy homeostasis, amino acid compartmentation, and asexual development in Neurospora crassa by Monique Quinn, Alexander J. Carrillo, Lida Halilovic, Katherine A. Borkovich

“…In this study, we used RNAseq and liquid chromatography-mass spectrometry (LC-MS) to profile the transcriptomes and metabolomes of N. crassa wild type, the Gα subunit mutants Δgna-1 and Δgna-3, and Δric8 strains. …”
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Unraveling shared diagnostic genes and cellular microenvironmental changes in endometriosis and recurrent implantation failure through multi-omics analysis by Dongxu Qin, Yongquan Zheng, Libo Wang, Zhenyi Lin, Yao Yao, Weidong Fei, Caihong Zheng

“…Single-cell analysis revealed significant differences in the expression of these diagnostic genes in fibroblasts between normal and disease states. …”
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Characterization and optimization of mnn11Δ-mediated enhancement in heterologous protein production in Kluyveromyces marxianus by Shihao Zhou, Pingping Wu, Haiyan Ren, Jungang Zhou, Yao Yu, Hong Lu

“…Supplementation of the synthetic medium with amino acids or low concentrations of yeast extract alleviated this growth defect, reducing the specific growth rate difference between wild-type strain and mnn11Δ cells from 65% to as little as 2%. …”
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Prognosis and immune landscape of bladder cancer can be predicted using a novel miRNA signature associated with cuproptosis by Zhilei Zhang, Fang Liu, Yongbo Yu, Fei Xie, Tao Zhu

“…We also investigated the differences in tumor mutation burden (TMB) and drug sensitivity between two groups. …”
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Xanthosine alleviates myocardial ischemia–reperfusion injury through attenuation of cardiomyocyte ferroptosis by Yang Xu, Wenfeng Zhou, Zhongguo Fan, Yiwei Cheng, Yujia Xiao, Yu Liu, Xinxin Li, Zhenjun Ji, Yi Fan, Genshan Ma

“…Integrated drug affinity responsive target stability (DARTS)-based drug target screening and RNA-seq transcriptomic profiling elucidate XTS-mediated mechanisms against I/R injury. …”
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Development and validation of a prognostic model based on m6A-related lncRNAs to predict prognosis for papillary renal cell cancer patients by Xianlu Zhang, Jiyuan Hu, Haoyuan Zheng, Jiayi Ren, Siyu Mu, Yiming Chen, Guoli Song, Ya-ang Chen, Gejun Zhang

“…Mutations in the SETD2 gene correlated with worse prognosis. Significant differences were observed in immune cell infiltration between the two risk groups. …”
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Species-specific gene regulatory network rewiring mediated by the GATA-type regulator NsdD in Aspergillus by Heungyun Moon, Mi-Kyung Lee, Junha Shin, Sung Chul Park, Julio C. Rivera Vazquez, Daniel Amador-Noguez, Nancy P. Keller, Hee-Soo Park, Kap-Hoon Han, Jae-Hyuk Yu

“…To address this gap, we have conducted network-based multiomics analyses in two distantly related species, Aspergillus nidulans and Aspergillus flavus. Transcriptomic profiling reveals that NsdD regulates gene expression in a cell type- and species-specific manner. …”
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Regulating chemoresistance and cancer stemness: the CDH17-YAP pathway in distinct cellular states of lung cancer CTC clusters by Zujun Que, Dan Qi, Yun Yang, Wang Yao, Jiajun Liu, Yan Li, Yuanyuan Yu, Luyao Wang, Fangfei Li, Ge Zhang, Erxi Wu, Jianhui Tian

“…CDH17 knockdown notably promoted the growth of CTC-TJH-01 xenografts and enhanced their sensitivity to cisplatin, although no significant difference was observed compared with those in the control group. …”
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Screened of long non-coding RNA related to wool development and fineness in Gansu alpine fine-wool sheep by Zhaohua He, Fangfang Zhao, Hongxian Sun, Jiang Hu, Jiqing Wang, Xiu Liu, Mingna Li, Zhiyun Hao, Zhidong Zhao, Bingang Shi, Feiyan Liu, Shaobin Li

“…The investigation utilized scanning electron microscopy and transcriptomic technology, focusing on two distinct types in Gansu alpine fine-wool sheep: coarse type (group C, MFD = 22.26 ± 0.69 μm, n = 6) and fine type (group F, MFD = 16.91 ± 0.29 μm, n = 6), which exhibit differing wool fiber diameters. …”
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Combining single-cell analysis and molecular docking techniques to construct a prognostic model for colon adenocarcinoma and uncovering inhibin subunit βb as a novel therapeutic ta... by Qinqing Wu, Qinqing Wu, Lu Ye, Yuwei Wu, Mengyu Zhao, Mengyu Zhao, Jiaxin Lu, Yanping Yu, Yanping Yu, Yixiao Niu, Yixiao Niu, Luxiao Zhang, Peijun Zuo, Peijun Zuo

“…Finally, we used gene knockout techniques to silence the key gene INHBB and explored its biological functions in vitro.ResultsIn our study, by analyzing the expression differences of ARGs, we successfully classified patients with COAD. …”
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Impacts of parental genomic divergence in non-syntenic regions on cotton heterosis by Chujun Huang, Yu Cheng, Yan Hu, Xuemei Zhang, Jinwen Chen, Ting Zhao, Zhanfeng Si, Yiwen Cao, Yiqian Li, Lei Fang, Xueying Guan, Tianzhen Zhang

“…SVs covered 97.26% of non-syntenic sequences and caused widespread gene expression differences in these regions, driving dynamic complementation of gene expression in the hybrid. …”
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Dissecting the genetic basis of response to salmonid alphavirus in Atlantic salmon by Domniki Manousi, Dorota Monika Jaskula, Fabian Grammes, Tim Martin Knutsen, Shahmir Naseer, Samuel AM Martin, Thomas Moen, Marie Saitou, Sigbjørn Lien

“…Additionally, another QTL on Ssa07 was detected, linked to infection-specific response. Transcriptomics analysis of the genes overlapping the Ssa03 QTL region revealed significant expression differences among three tandemly duplicated gig1-like genes, whereas allele-specific expression analysis detected several SNPs with putative functional impact on the particular genes. …”
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A comparative genomic study across 396 liver biopsies provides deep insight into FGF21 mode of action as a therapeutic agent in metabolic dysfunction‐associated steatotic liver dis... by Shifang Tang, Jürgen Borlak

“…To gain insight into FGF21 mode of action (MoA), we investigated the transcriptomes of MASLD liver biopsies in relation to FGF21 expression. …”
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Dietary protein re-alimentation following restriction improves protein deposition via changing amino acid metabolism and transcriptional profiling of muscle tissue in growing beef... by Jiaqi Wang, Chun Shen, Guangyong Zhao, Mark D. Hanigan, Mengmeng Li

“…However, there was no difference in microbial protein and plasma urea nitrogen concentrations. …”
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Potential physiological mechanisms behind variation in rainbow trout (Oncorhynchus mykiss) to biosynthesize EPA and DHA when reared on plant oil replacement feeds by Ken Overturf, Jason Abernathy, Dietmar Kültz, Jacob Bledsoe, Shawn Narum, Thomas Welker

“…The high performing group averaged 8.86 % for EPA+DHA muscle fatty acid ratios, the average group was 6.33 %, and the low performing group was 4.84 %. Transcriptomic and proteomic analysis of liver and muscle tissue was used to evaluate differences between these groups to identify potential mechanisms responsible for the trait. …”
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Pathogenic KCNH2-G53S variant in the PAS domain influences the electrophysiological phenotype in long QT syndrome type 2 by Dasom Mun, Ji-Young Kang, Malgeum Park, Gyeongseo Yoo, Nuri Yun, YouMi Hwang, YouMi Hwang, Boyoung Joung

“…KCNH2G53S hiPSC-CMs expressed less KCNH2 than normal CMs. Transcriptomic analysis of KCNH2G53S hiPSC-CMs revealed 3,857 differentially expressed genes, highlighting significant changes in pathways related to LQT2 development. …”
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